Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	54093
Gene name Gene Name - the full gene name approved by the HGNC.	SET domain containing 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SETD4
Synonyms (NCBI Gene) Gene synonyms aliases	C21orf18, C21orf27
Chromosome Chromosome number	21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	21q22.12

Show/Hide all(118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004168	hsa-miR-192-5p	Microarray	16822819
MIRT004226	hsa-miR-346	Microarray	16822819
MIRT038999	hsa-let-7a-3p	CLASH	23622248
MIRT1340149	hsa-miR-1200	CLIP-seq
MIRT1340150	hsa-miR-1286	CLIP-seq
MIRT1340151	hsa-miR-1470	CLIP-seq
MIRT1340152	hsa-miR-1913	CLIP-seq
MIRT1340153	hsa-miR-1914	CLIP-seq
MIRT1340154	hsa-miR-214	CLIP-seq
MIRT1340155	hsa-miR-2682	CLIP-seq
MIRT1340156	hsa-miR-2861	CLIP-seq
MIRT1340157	hsa-miR-300	CLIP-seq
MIRT1340158	hsa-miR-3153	CLIP-seq
MIRT1340159	hsa-miR-324-3p	CLIP-seq
MIRT1340160	hsa-miR-3619-5p	CLIP-seq
MIRT1340161	hsa-miR-381	CLIP-seq
MIRT1340162	hsa-miR-3922-5p	CLIP-seq
MIRT1340163	hsa-miR-3944-5p	CLIP-seq
MIRT1340164	hsa-miR-4281	CLIP-seq
MIRT1340165	hsa-miR-4286	CLIP-seq
MIRT1340166	hsa-miR-4313	CLIP-seq
MIRT1340167	hsa-miR-4324	CLIP-seq
MIRT1340168	hsa-miR-449c	CLIP-seq
MIRT1340169	hsa-miR-4514	CLIP-seq
MIRT1340170	hsa-miR-4530	CLIP-seq
MIRT1340171	hsa-miR-4649-3p	CLIP-seq
MIRT1340172	hsa-miR-4666-3p	CLIP-seq
MIRT1340173	hsa-miR-4692	CLIP-seq
MIRT1340174	hsa-miR-4700-3p	CLIP-seq
MIRT1340175	hsa-miR-4717-5p	CLIP-seq
MIRT1340176	hsa-miR-4722-5p	CLIP-seq
MIRT1340177	hsa-miR-4749-3p	CLIP-seq
MIRT1340178	hsa-miR-4753-5p	CLIP-seq
MIRT1340179	hsa-miR-4763-5p	CLIP-seq
MIRT1340180	hsa-miR-539	CLIP-seq
MIRT1340181	hsa-miR-544b	CLIP-seq
MIRT1340182	hsa-miR-561	CLIP-seq
MIRT1340183	hsa-miR-579	CLIP-seq
MIRT1340184	hsa-miR-634	CLIP-seq
MIRT1340185	hsa-miR-649	CLIP-seq
MIRT1340186	hsa-miR-761	CLIP-seq
MIRT2100526	hsa-miR-1272	CLIP-seq
MIRT1340150	hsa-miR-1286	CLIP-seq
MIRT2100527	hsa-miR-1324	CLIP-seq
MIRT2100528	hsa-miR-3166	CLIP-seq
MIRT1340163	hsa-miR-3944-5p	CLIP-seq
MIRT1340176	hsa-miR-4722-5p	CLIP-seq
MIRT2100529	hsa-miR-4724-5p	CLIP-seq
MIRT2325230	hsa-miR-1207-3p	CLIP-seq
MIRT2325231	hsa-miR-128	CLIP-seq
MIRT2325232	hsa-miR-149	CLIP-seq
MIRT2325233	hsa-miR-27a	CLIP-seq
MIRT2325234	hsa-miR-27b	CLIP-seq
MIRT2325235	hsa-miR-3064-5p	CLIP-seq
MIRT2325236	hsa-miR-604	CLIP-seq
MIRT2325237	hsa-miR-647	CLIP-seq
MIRT2394258	hsa-miR-105	CLIP-seq
MIRT2394259	hsa-miR-3689d	CLIP-seq
MIRT2394260	hsa-miR-3942-3p	CLIP-seq
MIRT2394261	hsa-miR-4257	CLIP-seq
MIRT2394258	hsa-miR-105	CLIP-seq
MIRT2620973	hsa-miR-1255a	CLIP-seq
MIRT2620974	hsa-miR-1255b	CLIP-seq
MIRT2620975	hsa-miR-1273d	CLIP-seq
MIRT2620976	hsa-miR-1276	CLIP-seq
MIRT2620977	hsa-miR-1280	CLIP-seq
MIRT1340150	hsa-miR-1286	CLIP-seq
MIRT2100527	hsa-miR-1324	CLIP-seq
MIRT2620978	hsa-miR-136	CLIP-seq
MIRT2620979	hsa-miR-140-3p	CLIP-seq
MIRT1340152	hsa-miR-1913	CLIP-seq
MIRT2620980	hsa-miR-198	CLIP-seq
MIRT2620981	hsa-miR-2355-5p	CLIP-seq
MIRT2325235	hsa-miR-3064-5p	CLIP-seq
MIRT2620982	hsa-miR-3120-3p	CLIP-seq
MIRT2100528	hsa-miR-3166	CLIP-seq
MIRT2620983	hsa-miR-3181	CLIP-seq
MIRT2620984	hsa-miR-3189-5p	CLIP-seq
MIRT1340159	hsa-miR-324-3p	CLIP-seq
MIRT2620985	hsa-miR-330-3p	CLIP-seq
MIRT2620986	hsa-miR-361-5p	CLIP-seq
MIRT2620987	hsa-miR-3667-5p	CLIP-seq
MIRT2620988	hsa-miR-3671	CLIP-seq
MIRT1340163	hsa-miR-3944-5p	CLIP-seq
MIRT2620989	hsa-miR-3978	CLIP-seq
MIRT2620990	hsa-miR-409-5p	CLIP-seq
MIRT2620991	hsa-miR-4267	CLIP-seq
MIRT2620992	hsa-miR-4290	CLIP-seq
MIRT2620993	hsa-miR-4639-3p	CLIP-seq
MIRT1340176	hsa-miR-4722-5p	CLIP-seq
MIRT2100529	hsa-miR-4724-5p	CLIP-seq
MIRT2620994	hsa-miR-4726-3p	CLIP-seq
MIRT1340177	hsa-miR-4749-3p	CLIP-seq
MIRT2620995	hsa-miR-4758-3p	CLIP-seq
MIRT1340179	hsa-miR-4763-5p	CLIP-seq
MIRT2620996	hsa-miR-522	CLIP-seq
MIRT2620997	hsa-miR-607	CLIP-seq
MIRT2620973	hsa-miR-1255a	CLIP-seq
MIRT2620974	hsa-miR-1255b	CLIP-seq
MIRT2620975	hsa-miR-1273d	CLIP-seq
MIRT2620977	hsa-miR-1280	CLIP-seq
MIRT1340150	hsa-miR-1286	CLIP-seq
MIRT2100527	hsa-miR-1324	CLIP-seq
MIRT1340152	hsa-miR-1913	CLIP-seq
MIRT2620981	hsa-miR-2355-5p	CLIP-seq
MIRT2100528	hsa-miR-3166	CLIP-seq
MIRT2620984	hsa-miR-3189-5p	CLIP-seq
MIRT1340159	hsa-miR-324-3p	CLIP-seq
MIRT2620986	hsa-miR-361-5p	CLIP-seq
MIRT1340163	hsa-miR-3944-5p	CLIP-seq
MIRT2620989	hsa-miR-3978	CLIP-seq
MIRT2620991	hsa-miR-4267	CLIP-seq
MIRT1340176	hsa-miR-4722-5p	CLIP-seq
MIRT2100529	hsa-miR-4724-5p	CLIP-seq
MIRT2620994	hsa-miR-4726-3p	CLIP-seq
MIRT1340177	hsa-miR-4749-3p	CLIP-seq
MIRT2620995	hsa-miR-4758-3p	CLIP-seq
MIRT1340179	hsa-miR-4763-5p	CLIP-seq

Show/Hide all(5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IDA	24738023
GO:0005829	Component	Cytosol	IDA	24738023
GO:0016279	Function	Protein-lysine N-methyltransferase activity	IBA	21873635
GO:0018023	Process	Peptidyl-lysine trimethylation	IBA	21873635
GO:0018026	Process	Peptidyl-lysine monomethylation	IBA	21873635

MIM	HGNC	e!Ensembl
620995	1258	ENSG00000185917

Protein

UniProt ID

Q9NVD3

Protein name

SET domain-containing protein 4 (EC 2.1.1.-) (EC 2.1.1.364)

Protein function

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins (PubMed:31308046, PubMed:35545041, PubMed:37926288). Via its catalytic activity, regulates many processes, including cell proliferation, cell differentiati

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00856	SET	59 → 273	SET domain	Family
PF09273	Rubis-subs-bind	309 → 425	Rubisco LSMT substrate-binding	Domain

Sequence

MQKGKGRTSRIRRRKLCGSSESRGVNESHKSEFIELRKWLKARKFQDSNLAPACFPGTGR
GLMSQTSLQEGQMIISLPESCLLTTDTVIRSYLGAYITKWKPPPSPLLALCTFLVSEKHA
GHRSLWKPYLEILPKAYTCPVCLEPEVVNLLPKSLKAKAEEQRAHVQEFFASSRDFFSSL
QPLFAEAVDSIFSYSALLWAWCTVNTRAVYLRPRQRECLSAEPDTCALAPYLDLLNHSPH
VQVKAAFNEETHSYEIRTTSRWRKHEEVFICYGPHDNQRLFLEYGFVSVHNPHACVYVSR
EILVKYLPSTDKQMDKKISILKDHGYIENLTFGWDGPSWRLLTALKLLCLEAEKFTCWKK
VLLGEVISDTNEKTSLDIAQKICYYFIEETNAVLQKVSHMKDEKEALINQLTLVESLWTE
ELKILRASAETLHSLQTAFT

Sequence length

440

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800 View all (467 more)

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Hepatocellular	Associate	24696725
Choriocarcinoma Non gestational	Associate	35655916
Prostatic Neoplasms	Inhibit	37879429

SETD4 (SET domain containing 4)