PNMT (phenylethanolamine N-methyltransferase)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID 5409
Gene name Phenylethanolamine N-methyltransferase
Gene symbol PNMT
Synonyms (NCBI Gene)
PENTPNMTase
Chromosome 17
Chromosome location 17q12
Summary The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a
miRNA miRNA information provided by mirtarbase database.
1
Gene miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all (1)
miRTarBase ID miRNA Experiments Reference
MIRT029157 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
Gene miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all (14)
GO ID Ontology Definition Evidence Reference
GO:0004603 Function Phenylethanolamine N-methyltransferase activity IBA
GO:0004603 Function Phenylethanolamine N-methyltransferase activity IDA 8812853
GO:0004603 Function Phenylethanolamine N-methyltransferase activity IEA
GO:0004603 Function Phenylethanolamine N-methyltransferase activity IMP 16277617, 20496117
GO:0004603 Function Phenylethanolamine N-methyltransferase activity TAS 2835776
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
171190 9160 ENSG00000141744
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P11086
Protein name Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase)
Protein function Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117). Other substrates include phenylethanolamine and octopamine (PubMed:16277617,
PDB 1HNN , 1N7I , 1N7J , 1YZ3 , 2AN3 , 2AN4 , 2AN5 , 2G70 , 2G71 , 2G72 , 2G8N , 2OBF , 2ONY , 2ONZ , 2OPB , 3HCA , 3HCB , 3HCC , 3HCD , 3HCE , 3HCF , 3KPJ , 3KPU , 3KPV , 3KPW , 3KPY , 3KQM , 3KQO , 3KQP , 3KQQ , 3KQS , 3KQT , 3KQV , 3KQW , 3KQY , 3KR0 , 3KR1 , 3KR2 , 4DM3 , 4MIK , 4MQ4 , 6WS1 , 7TWU , 7TX2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01234 NNMT_PNMT_TEMT 14 → 279 NNMT/PNMT/TEMT family Family
Sequence
Sequence length 282
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways
  KEGG  Reactome
  Tyrosine metabolism
Metabolic pathways 		  Catecholamine biosynthesis