Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene Gene ontology Other IDs Protein Pathways
Entrez ID	5407
Gene name	Pancreatic lipase related protein 1
Gene symbol	PNLIPRP1
Synonyms (NCBI Gene)	PLRP1
Chromosome	10
Chromosome location	10q25.3

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004465	Function	Lipoprotein lipase activity	IBA
GO:0004806	Function	Triacylglycerol lipase activity	TAS	1379598
GO:0005509	Function	Calcium ion binding	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS	1379598
GO:0005615	Component	Extracellular space	IDA	19824014
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006633	Process	Fatty acid biosynthetic process	IBA
GO:0008970	Function	Phospholipase A1 activity	IBA
GO:0016298	Function	Lipase activity	IDA	19824014
GO:0019433	Process	Triglyceride catabolic process	IBA
GO:0034375	Process	High-density lipoprotein particle remodeling	IBA
GO:0042632	Process	Cholesterol homeostasis	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0052689	Function	Carboxylic ester hydrolase activity	IEA

MIM	HGNC	e!Ensembl
604422	9156	ENSG00000187021

P54315

Protein name

Inactive pancreatic lipase-related protein 1 (PL-RP1)

Protein function

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity). {ECO:0000250, ECO:0000269|Pub

PDB

2PPL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00151	Lipase	18 → 353	Lipase	Domain
PF01477	PLAT	358 → 465	PLAT/LH2 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Pancreas. {ECO:0000269|PubMed:1379598}.

Sequence

MLIFWTITLFLLGAAKGKEVCYEDLGCFSDTEPWGGTAIRPLKILPWSPEKIGTRFLLYT
NENPNNFQILLLSDPSTIEASNFQMDRKTRFIIHGFIDKGDESWVTDMCKKLFEVEEVNC
ICVDWKKGSQATYTQAANNVRVVGAQVAQMLDILLTEYSYPPSKVHLIGHSLGAHVAGEA
GSKTPGLSRITGLDPVEASFESTPEEVRLDPSDADFVDVIHTDAAPLIPFLGFGTNQQMG
HLDFFPNGGESMPGCKKNALSQIVDLDGIWAGTRDFVACNHLRSYKYYLESILNPDGFAA
YPCTSYKSFESDKCFPCPDQGCPQMGHYADKFAGRTSEEQQKFFLNTGEASNFARWRYGV
SITLSGRTATGQIKVALFGNKGNTHQYSIFRGILKPGSTHSYEFDAKLDVGTIEKVKFLW
NNNVINPTLPKVGATKITVQKGEEKTVYNFCSEDTVREDTLLTLTPC

Sequence length

467

Interactions

View interactions

	KEGG		Reactome
	Glycerolipid metabolism Metabolic pathways Pancreatic secretion Fat digestion and absorption		Digestion of dietary lipid

PNLIPRP1 (pancreatic lipase related protein 1)