PNLIP (pancreatic lipase)

Gene
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5406
Gene name Gene Name - the full gene name approved by the HGNC.
Pancreatic lipase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PNLIP
Synonyms (NCBI Gene) Gene synonyms aliases
PL, PNLIPD, PTL
Disease Acronyms (UniProt) Disease acronyms from UniProt database
PNLIPD
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q25.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all(2)
SNP ID Visualize variation Clinical significance Consequence
rs746000327 C>T Pathogenic Coding sequence variant, missense variant
rs765879360 G>A,C Likely-pathogenic Missense variant, coding sequence variant, stop gained
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT019061 hsa-miR-335-5p Microarray 18185580
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all(14)
GO ID Ontology Definition Evidence Reference
GO:0001523 Process Retinoid metabolic process TAS
GO:0004806 Function Triglyceride lipase activity IBA 21873635
GO:0004806 Function Triglyceride lipase activity ISS
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
246600 9155 ENSG00000175535
Protein
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
UniProt ID P16233
Protein name Pancreatic triacylglycerol lipase (PL) (PTL) (Pancreatic lipase) (EC 3.1.1.3)
Protein function Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emu
PDB 1GPL , 1LPA , 1LPB , 1N8S
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00151 Lipase 17 → 352 Lipase Domain
PF01477 PLAT 357 → 463 PLAT/LH2 domain Domain
Sequence
Sequence length 465
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
  KEGG   Reactome
  Glycerolipid metabolism
Metabolic pathways
Pancreatic secretion
Fat digestion and absorption
Vitamin digestion and absorption 		  Digestion of dietary lipid
Retinoid metabolism and transport