PCBP3 (poly(rC) binding protein 3)

Gene

• Entrez ID: 54039
• Gene name: Poly(rC) binding protein 3
• Gene symbol: PCBP3
• Synonyms (NCBI Gene): ALPHA-CP3, PCBP3-OT1, PCBP3OT
• Chromosome: 21
• Chromosome location: 21q22.3
• Summary: This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and h

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018087	hsa-miR-335-5p	Microarray	18185580
MIRT029600	hsa-miR-26b-5p	Microarray	19088304
MIRT1216541	hsa-miR-338-5p	CLIP-seq
MIRT1216542	hsa-miR-4263	CLIP-seq
MIRT1216543	hsa-miR-4799-5p	CLIP-seq
MIRT1216544	hsa-miR-576-5p	CLIP-seq
MIRT1216545	hsa-miR-1207-5p	CLIP-seq
MIRT1216546	hsa-miR-1262	CLIP-seq
MIRT1216547	hsa-miR-3128	CLIP-seq
MIRT1216548	hsa-miR-3665	CLIP-seq
MIRT1216549	hsa-miR-4701-3p	CLIP-seq
MIRT1216550	hsa-miR-4720-5p	CLIP-seq
MIRT1216551	hsa-miR-4736	CLIP-seq
MIRT1216552	hsa-miR-4763-3p	CLIP-seq
MIRT1216553	hsa-miR-4799-3p	CLIP-seq
MIRT1216554	hsa-miR-760	CLIP-seq
MIRT2465807	hsa-miR-4797-5p	CLIP-seq
MIRT2465808	hsa-miR-759	CLIP-seq
MIRT2588571	hsa-miR-217	CLIP-seq
MIRT2588572	hsa-miR-224	CLIP-seq
MIRT1216541	hsa-miR-338-5p	CLIP-seq
MIRT1216542	hsa-miR-4263	CLIP-seq
MIRT1216543	hsa-miR-4799-5p	CLIP-seq
MIRT2588573	hsa-miR-483-5p	CLIP-seq
MIRT1216544	hsa-miR-576-5p	CLIP-seq
MIRT1216541	hsa-miR-338-5p	CLIP-seq
MIRT1216542	hsa-miR-4263	CLIP-seq
MIRT1216543	hsa-miR-4799-5p	CLIP-seq
MIRT1216544	hsa-miR-576-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	NAS	10936052
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	HDA	16780588
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	HDA	16780588
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0016071	Process	MRNA metabolic process	NAS
GO:0039694	Process	Viral RNA genome replication	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:1990829	Function	C-rich single-stranded DNA binding	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 608502
• HGNC: 8651
• e!Ensembl: ENSG00000183570

Protein

• UniProt ID: P57721
• Protein name: Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1)
• Protein function: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00013	KH_1	47 → 109	KH domain	Domain
  PF00013	KH_1	131 → 195	KH domain	Domain
  PF00013	KH_1	295 → 359	KH domain	Domain

• Sequence:

  MGEGDAFWAPSVLPHSTLSTLSHHPQPQFGRRMESKVSEGGLNVTLTIRLLMHGKEVGSI
  IGKKGETVKKMREESGARINISEGNCPERIVTITGPTDAIFKAFAMIAYKFEEDIINSMS
  NSPATSKPPVTLRLVVPASQCGSLIGKGGSKIKEIRESTGAQVQVAGDMLPNSTERAVTI
  SGTPDAIIQCVKQICVVMLESPPKGATIPYRPKPASTPVIFAGGQAYTIQGQYAIPHPDQ
  LTKLHQLAMQQTPFPPLGQTNPAFPGEKLPLHSSEEAQNLMGQSSGLDASPPASTHELTI
  PNDLIGCIIGRQGTKINEIRQMSGAQIKIANATEGSSERQITITGTPANISLAQYLINAR
  LTSEVTGMGTL

• Sequence length: 371

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cervical cancer	Likely benign	rs548673780	RCV005871468
Colon adenocarcinoma	Likely benign	rs548673780	RCV005871465
Colorectal cancer	Likely benign	rs548673780	RCV005871471
Gastric cancer	Likely benign	rs548673780	RCV005871472
Glioma susceptibility 1	Likely benign	rs548673780	RCV005871466
Malignant lymphoma, large B-cell, diffuse	Likely benign	rs548673780	RCV005871470
Malignant tumor of esophagus	Likely benign	rs548673780	RCV005871467
Melanoma	Likely benign	rs548673780	RCV005871473
PCBP3-related disorder	Likely benign; Benign	rs548673780, rs2277812, rs440207, rs145892465, rs148366893, rs371045522, rs61736689, rs113211675	RCV003979747 RCV003979791 RCV003982351 RCV003931640 RCV003954434 RCV003967207 RCV003976501 RCV003916092 RCV003955887
Uveal melanoma	Likely benign	rs548673780	RCV005871469

Associations from Text Mining
Disease Name	Relationship Type	References
Chromosome 21 monosomy	Associate	35361402
Pancreatic Neoplasms	Associate	35920801
Pulmonary Disease Chronic Obstructive	Associate	30694715
Sarcoma Kaposi	Associate	40016701