ACP5 (acid phosphatase 5, tartrate resistant)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54
Gene name Gene Name - the full gene name approved by the HGNC.
Acid phosphatase 5, tartrate resistant
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ACP5
Synonyms (NCBI Gene) Gene synonyms aliases
HPAP, TRACP5a, TRACP5b, TRAP, TRAcP, TrATPase
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by Re
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
miRTarBase ID miRNA Experiments Reference
MIRT763263 hsa-miR-23a CLIP-seq
MIRT763264 hsa-miR-23b CLIP-seq
MIRT763265 hsa-miR-23c CLIP-seq
MIRT763266 hsa-miR-4643 CLIP-seq
MIRT763267 hsa-miR-4716-5p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
MITF Activation 11481336;15737031
SPI1 Activation 11481336
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001503 Process Ossification IBA 21873635
GO:0003993 Function Acid phosphatase activity IBA 21873635
GO:0005764 Component Lysosome IEA
GO:0005829 Component Cytosol TAS
GO:0006771 Process Riboflavin metabolic process TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
171640 124 ENSG00000102575
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P13686
Protein name Tartrate-resistant acid phosphatase type 5 (TR-AP) (EC 3.1.3.2) (Tartrate-resistant acid ATPase) (TrATPase) (Type 5 acid phosphatase)
Protein function Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
PDB 1WAR , 2BQ8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00149 Metallophos 26 → 244 Calcineurin-like phosphoesterase Domain
Sequence
Sequence length 325
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Riboflavin metabolism
Metabolic pathways
Lysosome
Osteoclast differentiation
Rheumatoid arthritis 		  Vitamin B2 (riboflavin) metabolism
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (9)
Causal
Disease term Disease name dbSNP ID References
Arthritis Juvenile arthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470
Autoinflammatory disease Autoinflammatory disorder rs777759523, rs121434352, rs28940578, rs28940580, rs121908146, rs121908148, rs121908150, rs80338807, rs121908679, rs104895319, rs104894176, rs28933973, rs28933376, rs137854447, rs61736587
View all (32 more)		 21217752
Hyperparathyroidism Hyperparathyroidism, Secondary rs28942098, rs121434262, rs80356649, rs121434264, rs587776558, rs587776559, rs121909259, rs104893689, rs28936684, rs104893690, rs869320729, rs104893700, rs104893705, rs104893707, rs104893709
View all (14 more)		 22373954, 21985997
Hypothyroidism Hypothyroidism rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912
View all (22 more)
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Otitis media Recurrent otitis media ClinVar
Show/Hide Text Mining Associations (31)
Associations from Text Mining
Disease Name Relationship Type References
Autoimmune Diseases Associate 26346816
Bone Resorption Associate 21467819, 38139307
Breast Neoplasms Associate 20416078, 26632898, 28915803, 32521854
Carcinoma Giant Cell Associate 35697931
Colorectal Neoplasms Associate 33795653
Combined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia Associate 26951490, 37382551
Giant Cell Tumor of Bone Associate 25193435, 36725001
Growth Disorders Associate 26789720
Heart Failure Associate 30557359
Immune System Diseases Associate 37382551