Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
53981
Gene name Gene Name - the full gene name approved by the HGNC.
Cleavage and polyadenylation specific factor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CPSF2
Synonyms (NCBI Gene) Gene synonyms aliases
CPSF100
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.12
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT044892 hsa-miR-193a-3p CLASH 23622248
MIRT677316 hsa-miR-4519 HITS-CLIP 23824327
MIRT677315 hsa-miR-383-3p HITS-CLIP 23824327
MIRT677314 hsa-miR-3937 HITS-CLIP 23824327
MIRT677313 hsa-miR-5693 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding IBA
GO:0003723 Function RNA binding IEA
GO:0005515 Function Protein binding IPI 18288197, 18688255, 26496610, 33961781, 35177536
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606028 2325 ENSG00000165934
Protein
UniProt ID Q9P2I0
Protein name Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit)
Protein function Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cl
PDB 6URG , 6V4X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16661 Lactamase_B_6 22 199 Metallo-beta-lactamase superfamily domain Domain
PF10996 Beta-Casp 243 368 Beta-Casp domain Domain
PF07521 RMMBL 528 591 Zn-dependent metallo-hydrolase RNA specificity domain Motif
PF13299 CPSF100_C 608 779 Cleavage and polyadenylation factor 2 C-terminal Family
Sequence
Sequence length 782
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  mRNA surveillance pathway   Transport of Mature mRNA Derived from an Intronless Transcript
mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Processing of Intronless Pre-mRNAs
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Myopia Myopia N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Cerebral Infarction Associate 34103026
Diabetes Mellitus Associate 34103026
Ischemic Attack Transient Associate 34103026
Ischemic Stroke Associate 34103026
Neoplasms Inhibit 24654752
Personality Disorders Inhibit 24654752
Thyroid Cancer Papillary Associate 24654752
Thyroid Neoplasms Inhibit 24654752