Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5396
Gene name Gene Name - the full gene name approved by the HGNC.	Paired related homeobox 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PRRX1
Synonyms (NCBI Gene) Gene synonyms aliases	AGOTC, PHOX1, PMX1, PRX-1, PRX1
Disease Acronyms (UniProt) Disease acronyms from UniProt database	AGOTC
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q24.2
Summary Summary of gene provided in NCBI Entrez Gene.	The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein r

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SNP ID	Visualize variation	Clinical significance	Consequence
rs387906667	T>C	Pathogenic	Coding sequence variant, missense variant
rs398122375	A>-,AAAAA	Pathogenic	Coding sequence variant, frameshift variant
rs1571354325	G>C	Pathogenic	Coding sequence variant, 3 prime UTR variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022167	hsa-miR-124-3p	Microarray	18668037
MIRT022167	hsa-miR-124-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705396
MIRT022167	hsa-miR-124-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705396
MIRT022167	hsa-miR-124-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705396
MIRT022167	hsa-miR-124-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705396
MIRT022167	hsa-miR-124-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705396
MIRT022167	hsa-miR-124-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705396
MIRT022167	hsa-miR-124-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705396
MIRT022167	hsa-miR-124-3p	qRT-PCR, Luciferase reporter assay, Western blot	24705396
MIRT541963	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT555202	hsa-miR-382-3p	HITS-CLIP	21572407
MIRT510928	hsa-miR-378j	HITS-CLIP	21572407
MIRT510927	hsa-miR-6839-5p	HITS-CLIP	21572407
MIRT707304	hsa-miR-9-5p	HITS-CLIP	21572407
MIRT510926	hsa-miR-3201	HITS-CLIP	21572407
MIRT510925	hsa-miR-4791	HITS-CLIP	21572407
MIRT510924	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT510923	hsa-miR-1299	HITS-CLIP	21572407
MIRT510922	hsa-miR-516b-5p	HITS-CLIP	21572407
MIRT510921	hsa-miR-4782-5p	HITS-CLIP	21572407
MIRT510920	hsa-miR-5706	HITS-CLIP	21572407
MIRT521621	hsa-miR-6844	HITS-CLIP	21572407
MIRT510929	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT541963	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT555202	hsa-miR-382-3p	HITS-CLIP	21572407
MIRT510928	hsa-miR-378j	HITS-CLIP	21572407
MIRT510927	hsa-miR-6839-5p	HITS-CLIP	21572407
MIRT510926	hsa-miR-3201	HITS-CLIP	21572407
MIRT510925	hsa-miR-4791	HITS-CLIP	21572407
MIRT510924	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT510923	hsa-miR-1299	HITS-CLIP	21572407
MIRT510922	hsa-miR-516b-5p	HITS-CLIP	21572407
MIRT510921	hsa-miR-4782-5p	HITS-CLIP	21572407
MIRT510920	hsa-miR-5706	HITS-CLIP	21572407
MIRT510929	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT555202	hsa-miR-382-3p	PAR-CLIP	21572407
MIRT510928	hsa-miR-378j	PAR-CLIP	21572407
MIRT510927	hsa-miR-6839-5p	PAR-CLIP	21572407
MIRT510926	hsa-miR-3201	PAR-CLIP	21572407
MIRT510925	hsa-miR-4791	PAR-CLIP	21572407
MIRT510924	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT510923	hsa-miR-1299	PAR-CLIP	21572407
MIRT510922	hsa-miR-516b-5p	PAR-CLIP	21572407
MIRT510921	hsa-miR-4782-5p	PAR-CLIP	21572407
MIRT510920	hsa-miR-5706	PAR-CLIP	21572407
MIRT510929	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT541963	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT510924	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT510929	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT510929	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT510928	hsa-miR-378j	PAR-CLIP	23446348
MIRT510927	hsa-miR-6839-5p	PAR-CLIP	23446348
MIRT510926	hsa-miR-3201	PAR-CLIP	23446348
MIRT510925	hsa-miR-4791	PAR-CLIP	23446348
MIRT510924	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510923	hsa-miR-1299	PAR-CLIP	23446348
MIRT510922	hsa-miR-516b-5p	PAR-CLIP	23446348
MIRT510921	hsa-miR-4782-5p	PAR-CLIP	23446348
MIRT510920	hsa-miR-5706	PAR-CLIP	23446348
MIRT521621	hsa-miR-6844	PAR-CLIP	23446348
MIRT510929	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT510928	hsa-miR-378j	PAR-CLIP	23446348
MIRT510927	hsa-miR-6839-5p	PAR-CLIP	23446348
MIRT510926	hsa-miR-3201	PAR-CLIP	23446348
MIRT510925	hsa-miR-4791	PAR-CLIP	23446348
MIRT510924	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510923	hsa-miR-1299	PAR-CLIP	23446348
MIRT510922	hsa-miR-516b-5p	PAR-CLIP	23446348
MIRT510921	hsa-miR-4782-5p	PAR-CLIP	23446348
MIRT510920	hsa-miR-5706	PAR-CLIP	23446348
MIRT732202	hsa-miR-106b-5p	Luciferase reporter assay, Western blot	26617763
MIRT732202	hsa-miR-106b-5p	Luciferase reporter assay, Western blot	26617763
MIRT732451	hsa-miR-485-5p	Immunohistochemistry (IHC), Luciferase reporter assay, qRT-PCR, Western blotting	33620119
MIRT735297	hsa-miR-330-3p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), Immunohistochemistry (IHC), qRT-PCR	32368097
MIRT541963	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT555202	hsa-miR-382-3p	HITS-CLIP	21572407
MIRT510928	hsa-miR-378j	HITS-CLIP	21572407
MIRT510927	hsa-miR-6839-5p	HITS-CLIP	21572407
MIRT707304	hsa-miR-9-5p	HITS-CLIP	21572407
MIRT510926	hsa-miR-3201	HITS-CLIP	21572407
MIRT510925	hsa-miR-4791	HITS-CLIP	21572407
MIRT510924	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT510923	hsa-miR-1299	HITS-CLIP	21572407
MIRT510922	hsa-miR-516b-5p	HITS-CLIP	21572407
MIRT510921	hsa-miR-4782-5p	HITS-CLIP	21572407
MIRT510920	hsa-miR-5706	HITS-CLIP	21572407
MIRT521621	hsa-miR-6844	HITS-CLIP	21572407
MIRT510929	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT541963	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT555202	hsa-miR-382-3p	HITS-CLIP	21572407
MIRT510928	hsa-miR-378j	HITS-CLIP	21572407
MIRT510927	hsa-miR-6839-5p	HITS-CLIP	21572407
MIRT510926	hsa-miR-3201	HITS-CLIP	21572407
MIRT510925	hsa-miR-4791	HITS-CLIP	21572407
MIRT510924	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT510923	hsa-miR-1299	HITS-CLIP	21572407
MIRT510922	hsa-miR-516b-5p	HITS-CLIP	21572407
MIRT510921	hsa-miR-4782-5p	HITS-CLIP	21572407
MIRT510920	hsa-miR-5706	HITS-CLIP	21572407
MIRT510929	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT555202	hsa-miR-382-3p	PAR-CLIP	21572407
MIRT510928	hsa-miR-378j	PAR-CLIP	21572407
MIRT510927	hsa-miR-6839-5p	PAR-CLIP	21572407
MIRT510926	hsa-miR-3201	PAR-CLIP	21572407
MIRT510925	hsa-miR-4791	PAR-CLIP	21572407
MIRT510924	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT510923	hsa-miR-1299	PAR-CLIP	21572407
MIRT510922	hsa-miR-516b-5p	PAR-CLIP	21572407
MIRT510921	hsa-miR-4782-5p	PAR-CLIP	21572407
MIRT510920	hsa-miR-5706	PAR-CLIP	21572407
MIRT510929	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT541963	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT510924	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT510929	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT510929	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT510928	hsa-miR-378j	PAR-CLIP	23446348
MIRT510927	hsa-miR-6839-5p	PAR-CLIP	23446348
MIRT510926	hsa-miR-3201	PAR-CLIP	23446348
MIRT510925	hsa-miR-4791	PAR-CLIP	23446348
MIRT510924	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510923	hsa-miR-1299	PAR-CLIP	23446348
MIRT510922	hsa-miR-516b-5p	PAR-CLIP	23446348
MIRT510921	hsa-miR-4782-5p	PAR-CLIP	23446348
MIRT510920	hsa-miR-5706	PAR-CLIP	23446348
MIRT521621	hsa-miR-6844	PAR-CLIP	23446348
MIRT510929	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT510928	hsa-miR-378j	PAR-CLIP	23446348
MIRT510927	hsa-miR-6839-5p	PAR-CLIP	23446348
MIRT510926	hsa-miR-3201	PAR-CLIP	23446348
MIRT510925	hsa-miR-4791	PAR-CLIP	23446348
MIRT510924	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510923	hsa-miR-1299	PAR-CLIP	23446348
MIRT510922	hsa-miR-516b-5p	PAR-CLIP	23446348
MIRT510921	hsa-miR-4782-5p	PAR-CLIP	23446348
MIRT510920	hsa-miR-5706	PAR-CLIP	23446348
MIRT1268317	hsa-miR-124	CLIP-seq
MIRT1268318	hsa-miR-1279	CLIP-seq
MIRT1268319	hsa-miR-1293	CLIP-seq
MIRT1268320	hsa-miR-1587	CLIP-seq
MIRT1268321	hsa-miR-2681	CLIP-seq
MIRT1268322	hsa-miR-3714	CLIP-seq
MIRT1268323	hsa-miR-3910	CLIP-seq
MIRT1268324	hsa-miR-4417	CLIP-seq
MIRT1268325	hsa-miR-4483	CLIP-seq
MIRT1268326	hsa-miR-4492	CLIP-seq
MIRT1268327	hsa-miR-4498	CLIP-seq
MIRT1268328	hsa-miR-455-5p	CLIP-seq
MIRT1268329	hsa-miR-4651	CLIP-seq
MIRT1268330	hsa-miR-4656	CLIP-seq
MIRT1268331	hsa-miR-4675	CLIP-seq
MIRT1268332	hsa-miR-4677-3p	CLIP-seq
MIRT1268333	hsa-miR-4741	CLIP-seq
MIRT1268334	hsa-miR-506	CLIP-seq
MIRT1268335	hsa-miR-541	CLIP-seq
MIRT1268336	hsa-miR-550a	CLIP-seq
MIRT1268337	hsa-miR-555	CLIP-seq
MIRT1268338	hsa-miR-608	CLIP-seq
MIRT1268339	hsa-miR-654-5p	CLIP-seq
MIRT1268340	hsa-miR-762	CLIP-seq
MIRT1268341	hsa-miR-1226	CLIP-seq
MIRT1268342	hsa-miR-1257	CLIP-seq
MIRT1268343	hsa-miR-15a	CLIP-seq
MIRT1268344	hsa-miR-15b	CLIP-seq
MIRT1268345	hsa-miR-16	CLIP-seq
MIRT1268346	hsa-miR-1825	CLIP-seq
MIRT1268347	hsa-miR-195	CLIP-seq
MIRT1268348	hsa-miR-197	CLIP-seq
MIRT1268349	hsa-miR-199a-5p	CLIP-seq
MIRT1268350	hsa-miR-199b-5p	CLIP-seq
MIRT1268351	hsa-miR-3119	CLIP-seq
MIRT1268352	hsa-miR-424	CLIP-seq
MIRT1268353	hsa-miR-4468	CLIP-seq
MIRT1268354	hsa-miR-4519	CLIP-seq
MIRT1268355	hsa-miR-451b	CLIP-seq
MIRT1268356	hsa-miR-4530	CLIP-seq
MIRT1268357	hsa-miR-455-3p	CLIP-seq
MIRT1268358	hsa-miR-4733-3p	CLIP-seq
MIRT1268359	hsa-miR-497	CLIP-seq
MIRT1268360	hsa-miR-548u	CLIP-seq
MIRT1268361	hsa-miR-634	CLIP-seq
MIRT1552617	hsa-miR-1179	CLIP-seq
MIRT1552618	hsa-miR-3120-3p	CLIP-seq
MIRT1268355	hsa-miR-451b	CLIP-seq
MIRT1268351	hsa-miR-3119	CLIP-seq
MIRT2078849	hsa-miR-1236	CLIP-seq
MIRT1268319	hsa-miR-1293	CLIP-seq
MIRT1268320	hsa-miR-1587	CLIP-seq
MIRT1268324	hsa-miR-4417	CLIP-seq
MIRT1268325	hsa-miR-4483	CLIP-seq
MIRT1268326	hsa-miR-4492	CLIP-seq
MIRT1268327	hsa-miR-4498	CLIP-seq
MIRT1268329	hsa-miR-4651	CLIP-seq
MIRT1268330	hsa-miR-4656	CLIP-seq
MIRT1268331	hsa-miR-4675	CLIP-seq
MIRT1268333	hsa-miR-4741	CLIP-seq
MIRT2078850	hsa-miR-4753-3p	CLIP-seq
MIRT1268335	hsa-miR-541	CLIP-seq
MIRT1268338	hsa-miR-608	CLIP-seq
MIRT1268339	hsa-miR-654-5p	CLIP-seq
MIRT1268340	hsa-miR-762	CLIP-seq
MIRT2305096	hsa-let-7a	CLIP-seq
MIRT2305097	hsa-let-7b	CLIP-seq
MIRT2305098	hsa-let-7c	CLIP-seq
MIRT2305099	hsa-let-7d	CLIP-seq
MIRT2305100	hsa-let-7e	CLIP-seq
MIRT2305101	hsa-let-7f	CLIP-seq
MIRT2305102	hsa-let-7g	CLIP-seq
MIRT2305103	hsa-let-7i	CLIP-seq
MIRT1268341	hsa-miR-1226	CLIP-seq
MIRT2305104	hsa-miR-1294	CLIP-seq
MIRT1268348	hsa-miR-197	CLIP-seq
MIRT2305105	hsa-miR-202	CLIP-seq
MIRT2305106	hsa-miR-2117	CLIP-seq
MIRT2305107	hsa-miR-22	CLIP-seq
MIRT2305108	hsa-miR-3649	CLIP-seq
MIRT2305109	hsa-miR-371-5p	CLIP-seq
MIRT2305110	hsa-miR-371b-5p	CLIP-seq
MIRT2305111	hsa-miR-4273	CLIP-seq
MIRT2305112	hsa-miR-4316	CLIP-seq
MIRT2305113	hsa-miR-4458	CLIP-seq
MIRT2305114	hsa-miR-4477a	CLIP-seq
MIRT2305115	hsa-miR-4500	CLIP-seq
MIRT1268332	hsa-miR-4677-3p	CLIP-seq
MIRT1268358	hsa-miR-4733-3p	CLIP-seq
MIRT2305116	hsa-miR-4795-3p	CLIP-seq
MIRT2305117	hsa-miR-492	CLIP-seq
MIRT2305118	hsa-miR-513c	CLIP-seq
MIRT2305119	hsa-miR-514b-5p	CLIP-seq
MIRT2305120	hsa-miR-98	CLIP-seq
MIRT2602195	hsa-miR-1261	CLIP-seq
MIRT2602196	hsa-miR-1283	CLIP-seq
MIRT2602197	hsa-miR-1292	CLIP-seq
MIRT2602198	hsa-miR-1321	CLIP-seq
MIRT2602199	hsa-miR-1827	CLIP-seq
MIRT2602200	hsa-miR-2053	CLIP-seq
MIRT2305107	hsa-miR-22	CLIP-seq
MIRT2602201	hsa-miR-31	CLIP-seq
MIRT2602202	hsa-miR-3115	CLIP-seq
MIRT2602203	hsa-miR-3128	CLIP-seq
MIRT2602204	hsa-miR-3156-5p	CLIP-seq
MIRT2602205	hsa-miR-3157-3p	CLIP-seq
MIRT2602206	hsa-miR-3161	CLIP-seq
MIRT2602207	hsa-miR-323-5p	CLIP-seq
MIRT2602208	hsa-miR-3622b-5p	CLIP-seq
MIRT2602209	hsa-miR-3646	CLIP-seq
MIRT2602210	hsa-miR-3652	CLIP-seq
MIRT2305109	hsa-miR-371-5p	CLIP-seq
MIRT2305110	hsa-miR-371b-5p	CLIP-seq
MIRT1268323	hsa-miR-3910	CLIP-seq
MIRT2602211	hsa-miR-3928	CLIP-seq
MIRT2602212	hsa-miR-3940-5p	CLIP-seq
MIRT2602213	hsa-miR-412	CLIP-seq
MIRT2602214	hsa-miR-4259	CLIP-seq
MIRT2602215	hsa-miR-4275	CLIP-seq
MIRT2602216	hsa-miR-4282	CLIP-seq
MIRT2602217	hsa-miR-4419a	CLIP-seq
MIRT2602218	hsa-miR-4422	CLIP-seq
MIRT2602219	hsa-miR-4430	CLIP-seq
MIRT2602220	hsa-miR-4461	CLIP-seq
MIRT2602221	hsa-miR-4471	CLIP-seq
MIRT2602222	hsa-miR-4494	CLIP-seq
MIRT2602223	hsa-miR-4505	CLIP-seq
MIRT2602224	hsa-miR-4507	CLIP-seq
MIRT2602225	hsa-miR-4510	CLIP-seq
MIRT1268355	hsa-miR-451b	CLIP-seq
MIRT2602226	hsa-miR-4642	CLIP-seq
MIRT2602227	hsa-miR-4646-5p	CLIP-seq
MIRT2602228	hsa-miR-4703-3p	CLIP-seq
MIRT2602229	hsa-miR-4715-5p	CLIP-seq
MIRT2602230	hsa-miR-4720-3p	CLIP-seq
MIRT2602231	hsa-miR-4733-5p	CLIP-seq
MIRT2602232	hsa-miR-4739	CLIP-seq
MIRT2602233	hsa-miR-4756-5p	CLIP-seq
MIRT2602234	hsa-miR-499a-5p	CLIP-seq
MIRT2305118	hsa-miR-513c	CLIP-seq
MIRT2305119	hsa-miR-514b-5p	CLIP-seq
MIRT2602235	hsa-miR-520d-5p	CLIP-seq
MIRT2602236	hsa-miR-524-5p	CLIP-seq
MIRT2602237	hsa-miR-548aa	CLIP-seq
MIRT2602238	hsa-miR-548c-3p	CLIP-seq
MIRT2602239	hsa-miR-549	CLIP-seq
MIRT2602240	hsa-miR-579	CLIP-seq
MIRT2602241	hsa-miR-629	CLIP-seq
MIRT2602242	hsa-miR-643	CLIP-seq
MIRT2602243	hsa-miR-668	CLIP-seq
MIRT2602244	hsa-miR-765	CLIP-seq
MIRT2602245	hsa-miR-876-3p	CLIP-seq
MIRT2602246	hsa-miR-892b	CLIP-seq
MIRT2602195	hsa-miR-1261	CLIP-seq
MIRT2602196	hsa-miR-1283	CLIP-seq
MIRT2602197	hsa-miR-1292	CLIP-seq
MIRT2602198	hsa-miR-1321	CLIP-seq
MIRT2602199	hsa-miR-1827	CLIP-seq
MIRT2688781	hsa-miR-1910	CLIP-seq
MIRT2305107	hsa-miR-22	CLIP-seq
MIRT2602201	hsa-miR-31	CLIP-seq
MIRT2602202	hsa-miR-3115	CLIP-seq
MIRT2602203	hsa-miR-3128	CLIP-seq
MIRT2602204	hsa-miR-3156-5p	CLIP-seq
MIRT2602205	hsa-miR-3157-3p	CLIP-seq
MIRT2602206	hsa-miR-3161	CLIP-seq
MIRT2602207	hsa-miR-323-5p	CLIP-seq
MIRT2688782	hsa-miR-34b	CLIP-seq
MIRT2602208	hsa-miR-3622b-5p	CLIP-seq
MIRT2602209	hsa-miR-3646	CLIP-seq
MIRT2602210	hsa-miR-3652	CLIP-seq
MIRT2305109	hsa-miR-371-5p	CLIP-seq
MIRT2305110	hsa-miR-371b-5p	CLIP-seq
MIRT1268323	hsa-miR-3910	CLIP-seq
MIRT2602211	hsa-miR-3928	CLIP-seq
MIRT2602212	hsa-miR-3940-5p	CLIP-seq
MIRT2602213	hsa-miR-412	CLIP-seq
MIRT2602214	hsa-miR-4259	CLIP-seq
MIRT2602215	hsa-miR-4275	CLIP-seq
MIRT2602216	hsa-miR-4282	CLIP-seq
MIRT2602217	hsa-miR-4419a	CLIP-seq
MIRT2602218	hsa-miR-4422	CLIP-seq
MIRT2602219	hsa-miR-4430	CLIP-seq
MIRT2602220	hsa-miR-4461	CLIP-seq
MIRT2602221	hsa-miR-4471	CLIP-seq
MIRT2602222	hsa-miR-4494	CLIP-seq
MIRT2602223	hsa-miR-4505	CLIP-seq
MIRT2602224	hsa-miR-4507	CLIP-seq
MIRT2602225	hsa-miR-4510	CLIP-seq
MIRT1268355	hsa-miR-451b	CLIP-seq
MIRT1268357	hsa-miR-455-3p	CLIP-seq
MIRT2602226	hsa-miR-4642	CLIP-seq
MIRT2602227	hsa-miR-4646-5p	CLIP-seq
MIRT2688783	hsa-miR-4694-3p	CLIP-seq
MIRT2602228	hsa-miR-4703-3p	CLIP-seq
MIRT2602229	hsa-miR-4715-5p	CLIP-seq
MIRT2602230	hsa-miR-4720-3p	CLIP-seq
MIRT2602231	hsa-miR-4733-5p	CLIP-seq
MIRT2602232	hsa-miR-4739	CLIP-seq
MIRT2602233	hsa-miR-4756-5p	CLIP-seq
MIRT2602234	hsa-miR-499a-5p	CLIP-seq
MIRT2305118	hsa-miR-513c	CLIP-seq
MIRT2305119	hsa-miR-514b-5p	CLIP-seq
MIRT2602235	hsa-miR-520d-5p	CLIP-seq
MIRT2602236	hsa-miR-524-5p	CLIP-seq
MIRT2602237	hsa-miR-548aa	CLIP-seq
MIRT2602238	hsa-miR-548c-3p	CLIP-seq
MIRT2602239	hsa-miR-549	CLIP-seq
MIRT2688784	hsa-miR-561	CLIP-seq
MIRT2602240	hsa-miR-579	CLIP-seq
MIRT2602241	hsa-miR-629	CLIP-seq
MIRT2688785	hsa-miR-640	CLIP-seq
MIRT2602242	hsa-miR-643	CLIP-seq
MIRT2602243	hsa-miR-668	CLIP-seq
MIRT2688786	hsa-miR-7	CLIP-seq
MIRT2602244	hsa-miR-765	CLIP-seq
MIRT2602245	hsa-miR-876-3p	CLIP-seq
MIRT2602246	hsa-miR-892b	CLIP-seq
MIRT2688787	hsa-miR-944	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
SRF	Unknown	18604245

Show/Hide all(29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	1509260
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001102	Function	RNA polymerase II activating transcription factor binding	IPI	9334314
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	9334314
GO:0002053	Process	Positive regulation of mesenchymal cell proliferation	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0030326	Process	Embryonic limb morphogenesis	IEA
GO:0042472	Process	Inner ear morphogenesis	IEA
GO:0042474	Process	Middle ear morphogenesis	IEA
GO:0045880	Process	Positive regulation of smoothened signaling pathway	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048664	Process	Neuron fate determination	IEA
GO:0048701	Process	Embryonic cranial skeleton morphogenesis	IEA
GO:0048844	Process	Artery morphogenesis	IEA
GO:0051216	Process	Cartilage development	IEA
GO:0060021	Process	Roof of mouth development	IEA
GO:0070570	Process	Regulation of neuron projection regeneration	IEA
GO:0071837	Function	HMG box domain binding	IEA
GO:0097150	Process	Neuronal stem cell population maintenance	IEA
GO:0100026	Process	Positive regulation of DNA repair by transcription from RNA polymerase II promoter	IDA	9334314

MIM	HGNC	e!Ensembl
167420	9142	ENSG00000116132

Protein

UniProt ID

P54821

Protein name

Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1)

Protein function

Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	95 → 151	Homeodomain	Domain
PF03826	OAR	219 → 236	OAR motif	Motif

Tissue specificity

TISSUE SPECIFICITY: [Isoform 1]: Widely expressed in embryonic and adult tissues, with highest levels in skeletal muscle. Isoform 1 is either expressed at similar or higher levels compared to isoform 2 in all embryonic tissues but skeletal muscle and hear

Sequence

MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADENVGEA
GRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPD
AFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIV
PRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQ
VPTVN

Sequence length

245

Interactions

View interactions

Show/Hide Causal Diseases (8)

Disease term	Disease name	dbSNP ID	References
Causal
Agenesis of corpus callosum	Agenesis of corpus callosum	rs754914260, rs1057519053, rs1057519056, rs1057519054, rs1057519055, rs1057519057, rs1384496494, rs1599017933
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557 View all (6 more)	22544366, 29892015, 28416818
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	28736931
Hearing loss	Conductive hearing loss	rs267607135, rs267606855, rs779841884, rs267606854, rs28942097, rs121908073, rs121908076, rs74315289, rs121908144, rs111033313, rs74315437, rs121908348, rs121908349, rs121908350, rs397515359 View all (184 more)
Holoprosencephaly	Holoprosencephaly	rs121917878, rs121917879, rs121917880, rs1572624159, rs137853021, rs397515364, rs397515365, rs2147483647, rs121909067, rs121909070, rs199476093, rs28936675, rs104894044, rs104894045, rs104894040 View all (76 more)
Hypertension	Hypertensive disease	rs13306026	22566498
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	19208208
Situs inversus	Situs inversus totalis	rs528302390, rs1596264554

Show/Hide Unknown Diseases (8)

Disease term	Disease name	References	Source
Unknown
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	22544366	ClinVar
Otocephaly	agnathia-otocephaly complex		GenCC
Multiple Congenital Anomalies	multiple congenital anomalies/dysmorphic syndrome-intellectual disability		GenCC
Craniosynostosis	craniosynostosis		GenCC
Atrial Fibrillation	Atrial Fibrillation		GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus		GWAS
Cardioembolic Stroke	Cardioembolic Stroke		GWAS
Otosclerosis	Otosclerosis		GWAS

Show/Hide Text Mining Associations (32)

Disease Name	Relationship Type	References
Associations from Text Mining
Atrial Fibrillation	Associate	24239840, 25953654, 29545482, 34845933
Breast Neoplasms	Associate	23807160, 32945446
Carcinogenesis	Associate	38308202
Carcinoma Adenoid Cystic	Associate	29424489, 35032368
Carcinoma Hepatocellular	Stimulate	34496784
Carcinoma Hepatocellular	Associate	36968142
Carcinoma Non Small Cell Lung	Associate	33316778, 33530259
Carcinoma Renal Cell	Associate	31490389
Colorectal Neoplasms	Associate	23807160, 24705396, 26617763, 34286520, 36968142
Diabetic Nephropathies	Associate	30132841
Dysgnathia complex	Associate	32100971
Eosinophilic Esophagitis	Associate	39343172
Esophageal Squamous Cell Carcinoma	Associate	37866660
Glioma	Stimulate	32857719
Glioma	Associate	34214250
Glut1 Deficiency Syndrome	Associate	34967278
Inflammation	Associate	34967278, 35281030
Insulin Resistance	Associate	29986096
Leukemia Myeloid	Associate	10397741
Leukemia Myeloid Acute	Associate	10397741
Lymphatic Metastasis	Associate	31490389
Lymphatic Metastasis	Stimulate	32862590
Neoplasm Metastasis	Associate	23807160, 26272668, 31490389, 35281030
Neoplasms	Associate	26272668, 26929985, 31008539, 33530259, 35281030, 39896800
Neoplasms	Inhibit	31490389
Non Muscle Invasive Bladder Neoplasms	Associate	26929985, 32786144
Ovarian Neoplasms	Associate	33563317
Stomach Neoplasms	Associate	32862590
Tuberculosis Multidrug Resistant	Stimulate	32945446
Urinary Bladder Neoplasms	Associate	33204728
Uveal melanoma	Associate	35281030
Vascular Diseases	Associate	16782755

PRRX1 (paired related homeobox 1)