Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	53938
Gene name Gene Name - the full gene name approved by the HGNC.	Peptidylprolyl isomerase like 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PPIL3
Synonyms (NCBI Gene) Gene synonyms aliases	CYPJ
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q33.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events

Show/Hide all(108)

miRTarBase ID	miRNA	Experiments	Reference
MIRT531280	hsa-miR-4789-3p	PAR-CLIP	22012620
MIRT531279	hsa-miR-4643	PAR-CLIP	22012620
MIRT531278	hsa-miR-875-5p	PAR-CLIP	22012620
MIRT531277	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT531276	hsa-miR-103b	PAR-CLIP	22012620
MIRT531275	hsa-miR-8060	PAR-CLIP	22012620
MIRT531274	hsa-miR-4729	PAR-CLIP	22012620
MIRT531273	hsa-miR-4670-3p	PAR-CLIP	22012620
MIRT531272	hsa-miR-6853-3p	PAR-CLIP	22012620
MIRT531271	hsa-miR-466	PAR-CLIP	22012620
MIRT531270	hsa-let-7a-3p	PAR-CLIP	22012620
MIRT531269	hsa-let-7b-3p	PAR-CLIP	22012620
MIRT531268	hsa-let-7f-1-3p	PAR-CLIP	22012620
MIRT531267	hsa-miR-98-3p	PAR-CLIP	22012620
MIRT531266	hsa-miR-4789-5p	PAR-CLIP	22012620
MIRT531265	hsa-let-7f-2-3p	PAR-CLIP	22012620
MIRT531264	hsa-miR-1185-1-3p	PAR-CLIP	22012620
MIRT531263	hsa-miR-1185-2-3p	PAR-CLIP	22012620
MIRT531262	hsa-miR-3144-3p	PAR-CLIP	22012620
MIRT531261	hsa-miR-5007-3p	PAR-CLIP	22012620
MIRT531260	hsa-miR-5696	PAR-CLIP	22012620
MIRT531259	hsa-miR-579-3p	PAR-CLIP	22012620
MIRT531258	hsa-miR-664b-3p	PAR-CLIP	22012620
MIRT531280	hsa-miR-4789-3p	PAR-CLIP	22012620
MIRT531279	hsa-miR-4643	PAR-CLIP	22012620
MIRT531278	hsa-miR-875-5p	PAR-CLIP	22012620
MIRT531277	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT531276	hsa-miR-103b	PAR-CLIP	22012620
MIRT531275	hsa-miR-8060	PAR-CLIP	22012620
MIRT531274	hsa-miR-4729	PAR-CLIP	22012620
MIRT531273	hsa-miR-4670-3p	PAR-CLIP	22012620
MIRT531272	hsa-miR-6853-3p	PAR-CLIP	22012620
MIRT531271	hsa-miR-466	PAR-CLIP	22012620
MIRT531270	hsa-let-7a-3p	PAR-CLIP	22012620
MIRT531269	hsa-let-7b-3p	PAR-CLIP	22012620
MIRT531268	hsa-let-7f-1-3p	PAR-CLIP	22012620
MIRT531267	hsa-miR-98-3p	PAR-CLIP	22012620
MIRT531266	hsa-miR-4789-5p	PAR-CLIP	22012620
MIRT531265	hsa-let-7f-2-3p	PAR-CLIP	22012620
MIRT531264	hsa-miR-1185-1-3p	PAR-CLIP	22012620
MIRT531263	hsa-miR-1185-2-3p	PAR-CLIP	22012620
MIRT531262	hsa-miR-3144-3p	PAR-CLIP	22012620
MIRT531261	hsa-miR-5007-3p	PAR-CLIP	22012620
MIRT531260	hsa-miR-5696	PAR-CLIP	22012620
MIRT531259	hsa-miR-579-3p	PAR-CLIP	22012620
MIRT531258	hsa-miR-664b-3p	PAR-CLIP	22012620
MIRT1253234	hsa-miR-1263	CLIP-seq
MIRT1253235	hsa-miR-1322	CLIP-seq
MIRT1253236	hsa-miR-298	CLIP-seq
MIRT1253237	hsa-miR-30a	CLIP-seq
MIRT1253238	hsa-miR-30b	CLIP-seq
MIRT1253239	hsa-miR-30c	CLIP-seq
MIRT1253240	hsa-miR-30d	CLIP-seq
MIRT1253241	hsa-miR-30e	CLIP-seq
MIRT1253242	hsa-miR-376a	CLIP-seq
MIRT1253243	hsa-miR-376b	CLIP-seq
MIRT1253234	hsa-miR-1263	CLIP-seq
MIRT1253244	hsa-miR-1304	CLIP-seq
MIRT1253245	hsa-miR-1972	CLIP-seq
MIRT1253246	hsa-miR-2467-5p	CLIP-seq
MIRT1253247	hsa-miR-3188	CLIP-seq
MIRT1253248	hsa-miR-3613-3p	CLIP-seq
MIRT1253249	hsa-miR-3646	CLIP-seq
MIRT1253250	hsa-miR-3662	CLIP-seq
MIRT1253251	hsa-miR-371b-5p	CLIP-seq
MIRT1253242	hsa-miR-376a	CLIP-seq
MIRT1253243	hsa-miR-376b	CLIP-seq
MIRT1253252	hsa-miR-380	CLIP-seq
MIRT1253253	hsa-miR-3929	CLIP-seq
MIRT1253254	hsa-miR-3975	CLIP-seq
MIRT1253255	hsa-miR-4325	CLIP-seq
MIRT1253256	hsa-miR-4419b	CLIP-seq
MIRT1253257	hsa-miR-4478	CLIP-seq
MIRT1253258	hsa-miR-4495	CLIP-seq
MIRT1253259	hsa-miR-4650-5p	CLIP-seq
MIRT1253260	hsa-miR-4663	CLIP-seq
MIRT1253261	hsa-miR-4717-5p	CLIP-seq
MIRT1253262	hsa-miR-4763-5p	CLIP-seq
MIRT1253263	hsa-miR-4793-3p	CLIP-seq
MIRT1253264	hsa-miR-485-5p	CLIP-seq
MIRT1253265	hsa-miR-548c-3p	CLIP-seq
MIRT1253266	hsa-miR-888	CLIP-seq
MIRT1253236	hsa-miR-298	CLIP-seq
MIRT1253237	hsa-miR-30a	CLIP-seq
MIRT1253238	hsa-miR-30b	CLIP-seq
MIRT1253239	hsa-miR-30c	CLIP-seq
MIRT1253240	hsa-miR-30d	CLIP-seq
MIRT1253241	hsa-miR-30e	CLIP-seq
MIRT1253248	hsa-miR-3613-3p	CLIP-seq
MIRT1253251	hsa-miR-371b-5p	CLIP-seq
MIRT1253262	hsa-miR-4763-5p	CLIP-seq
MIRT1253266	hsa-miR-888	CLIP-seq
MIRT2598240	hsa-miR-198	CLIP-seq
MIRT2598241	hsa-miR-2355-3p	CLIP-seq
MIRT2598242	hsa-miR-338-3p	CLIP-seq
MIRT2598243	hsa-miR-4530	CLIP-seq
MIRT2598244	hsa-miR-4646-3p	CLIP-seq
MIRT2598245	hsa-miR-487a	CLIP-seq
MIRT2598246	hsa-miR-548aa	CLIP-seq
MIRT2598247	hsa-miR-595	CLIP-seq
MIRT2598240	hsa-miR-198	CLIP-seq
MIRT2598241	hsa-miR-2355-3p	CLIP-seq
MIRT2598242	hsa-miR-338-3p	CLIP-seq
MIRT2598243	hsa-miR-4530	CLIP-seq
MIRT2598244	hsa-miR-4646-3p	CLIP-seq
MIRT2598245	hsa-miR-487a	CLIP-seq
MIRT2598246	hsa-miR-548aa	CLIP-seq
MIRT2598247	hsa-miR-595	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IBA
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 18474220, 22365833, 25416956, 32296183, 33961781
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016853	Function	Isomerase activity	IEA
GO:0071013	Component	Catalytic step 2 spliceosome	IBA
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638

MIM	HGNC	e!Ensembl
615811	9262	ENSG00000240344

Protein

UniProt ID

Q9H2H8

Protein name

Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Cyclophilin J) (CyPJ) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3)

Protein function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

PDB

1XYH , 2OJU , 2OK3 , 8C6J

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00160	Pro_isomerase	2 → 154	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Detected at low levels. {ECO:0000269|PubMed:11435694}.

Sequence

MSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCIFHRNIKGFMVQTGDPTGTG
RGGNSIWGKKFEDEYSEYLKHNVRGVVSMANNGPNTNGSQFFITYGKQPHLDMKYTVFGK
VIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFAQ

Sequence length

161

Interactions

View interactions

	Reactome
			mRNA Splicing - Major Pathway

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Breast cancer	Breast cancer (estrogen-receptor negative)	N/A	N/A	GWAS
Carcinoma	Basal cell carcinoma	N/A	N/A	GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Arthritis Rheumatoid	Associate	29193869
Breast Neoplasms	Associate	27117709, 32965163
Neoplasms	Associate	40642086
Urinary Bladder Neoplasms	Associate	40642086

PPIL3 (peptidylprolyl isomerase like 3)