Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	53918
Gene name Gene Name - the full gene name approved by the HGNC.	Pelota mRNA surveillance and ribosome rescue factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PELO
Synonyms (NCBI Gene) Gene synonyms aliases	CGI-17, PRO1770
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q11.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]

Show/Hide all(154)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031869	hsa-miR-16-5p	Proteomics	18668040
MIRT050281	hsa-miR-25-3p	CLASH	23622248
MIRT046857	hsa-miR-221-3p	CLASH	23622248
MIRT641445	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT641444	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT641443	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT641442	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT641441	hsa-miR-331-5p	HITS-CLIP	23824327
MIRT641440	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT641439	hsa-miR-6509-5p	HITS-CLIP	23824327
MIRT641437	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT641438	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT641436	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT641445	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT641444	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT641443	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT641442	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT641441	hsa-miR-331-5p	HITS-CLIP	23824327
MIRT641440	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT641439	hsa-miR-6509-5p	HITS-CLIP	23824327
MIRT641437	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT641438	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT641436	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT471347	hsa-miR-561-3p	PAR-CLIP	23592263
MIRT471346	hsa-miR-548ao-3p	PAR-CLIP	23592263
MIRT471345	hsa-miR-6768-5p	PAR-CLIP	23592263
MIRT471344	hsa-miR-34c-3p	PAR-CLIP	23592263
MIRT471343	hsa-miR-4999-3p	PAR-CLIP	23592263
MIRT641445	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT641444	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT641443	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT641442	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT641441	hsa-miR-331-5p	HITS-CLIP	23824327
MIRT641440	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT641439	hsa-miR-6509-5p	HITS-CLIP	23824327
MIRT641437	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT641438	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT641436	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT641445	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT641444	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT641443	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT641442	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT641441	hsa-miR-331-5p	HITS-CLIP	23824327
MIRT641440	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT641439	hsa-miR-6509-5p	HITS-CLIP	23824327
MIRT641437	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT641438	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT641436	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT471347	hsa-miR-561-3p	PAR-CLIP	23592263
MIRT471346	hsa-miR-548ao-3p	PAR-CLIP	23592263
MIRT471345	hsa-miR-6768-5p	PAR-CLIP	23592263
MIRT471344	hsa-miR-34c-3p	PAR-CLIP	23592263
MIRT471343	hsa-miR-4999-3p	PAR-CLIP	23592263
MIRT1224887	hsa-miR-106a	CLIP-seq
MIRT1224888	hsa-miR-106b	CLIP-seq
MIRT1224889	hsa-miR-1183	CLIP-seq
MIRT1224890	hsa-miR-1270	CLIP-seq
MIRT1224891	hsa-miR-132	CLIP-seq
MIRT1224892	hsa-miR-17	CLIP-seq
MIRT1224893	hsa-miR-194	CLIP-seq
MIRT1224894	hsa-miR-20a	CLIP-seq
MIRT1224895	hsa-miR-20b	CLIP-seq
MIRT1224896	hsa-miR-212	CLIP-seq
MIRT1224897	hsa-miR-216a	CLIP-seq
MIRT1224898	hsa-miR-216b	CLIP-seq
MIRT1224899	hsa-miR-3160-5p	CLIP-seq
MIRT1224900	hsa-miR-3613-3p	CLIP-seq
MIRT1224901	hsa-miR-3617	CLIP-seq
MIRT1224902	hsa-miR-4251	CLIP-seq
MIRT1224903	hsa-miR-4280	CLIP-seq
MIRT1224904	hsa-miR-4426	CLIP-seq
MIRT1224905	hsa-miR-4428	CLIP-seq
MIRT1224906	hsa-miR-4457	CLIP-seq
MIRT1224907	hsa-miR-4496	CLIP-seq
MIRT1224908	hsa-miR-4647	CLIP-seq
MIRT1224909	hsa-miR-4652-3p	CLIP-seq
MIRT1224910	hsa-miR-4662a-5p	CLIP-seq
MIRT1224911	hsa-miR-4662b	CLIP-seq
MIRT1224912	hsa-miR-4663	CLIP-seq
MIRT1224913	hsa-miR-4683	CLIP-seq
MIRT1224914	hsa-miR-4728-3p	CLIP-seq
MIRT1224915	hsa-miR-513b	CLIP-seq
MIRT1224916	hsa-miR-519d	CLIP-seq
MIRT1224917	hsa-miR-539	CLIP-seq
MIRT1224918	hsa-miR-548c-3p	CLIP-seq
MIRT1224919	hsa-miR-548t	CLIP-seq
MIRT1224920	hsa-miR-605	CLIP-seq
MIRT1224921	hsa-miR-620	CLIP-seq
MIRT1224922	hsa-miR-641	CLIP-seq
MIRT1224923	hsa-miR-651	CLIP-seq
MIRT1224924	hsa-miR-93	CLIP-seq
MIRT1224889	hsa-miR-1183	CLIP-seq
MIRT1224891	hsa-miR-132	CLIP-seq
MIRT1224893	hsa-miR-194	CLIP-seq
MIRT1224896	hsa-miR-212	CLIP-seq
MIRT2065603	hsa-miR-330-3p	CLIP-seq
MIRT1224902	hsa-miR-4251	CLIP-seq
MIRT2065604	hsa-miR-4302	CLIP-seq
MIRT2065605	hsa-miR-4422	CLIP-seq
MIRT1224906	hsa-miR-4457	CLIP-seq
MIRT2065606	hsa-miR-452	CLIP-seq
MIRT1224912	hsa-miR-4663	CLIP-seq
MIRT2065607	hsa-miR-4676-3p	CLIP-seq
MIRT1224914	hsa-miR-4728-3p	CLIP-seq
MIRT1224915	hsa-miR-513b	CLIP-seq
MIRT1224917	hsa-miR-539	CLIP-seq
MIRT2065608	hsa-miR-548a-3p	CLIP-seq
MIRT2065609	hsa-miR-548e	CLIP-seq
MIRT2065610	hsa-miR-548f	CLIP-seq
MIRT2065611	hsa-miR-548g	CLIP-seq
MIRT2065612	hsa-miR-607	CLIP-seq
MIRT1224923	hsa-miR-651	CLIP-seq
MIRT2293427	hsa-miR-186	CLIP-seq
MIRT2293428	hsa-miR-3133	CLIP-seq
MIRT2293429	hsa-miR-590-3p	CLIP-seq
MIRT1224903	hsa-miR-4280	CLIP-seq
MIRT2456251	hsa-miR-4705	CLIP-seq
MIRT2456252	hsa-miR-4719	CLIP-seq
MIRT1224889	hsa-miR-1183	CLIP-seq
MIRT1224891	hsa-miR-132	CLIP-seq
MIRT1224893	hsa-miR-194	CLIP-seq
MIRT1224896	hsa-miR-212	CLIP-seq
MIRT2591507	hsa-miR-219-5p	CLIP-seq
MIRT1224902	hsa-miR-4251	CLIP-seq
MIRT2591508	hsa-miR-4261	CLIP-seq
MIRT1224906	hsa-miR-4457	CLIP-seq
MIRT1224907	hsa-miR-4496	CLIP-seq
MIRT1224912	hsa-miR-4663	CLIP-seq
MIRT1224914	hsa-miR-4728-3p	CLIP-seq
MIRT2591509	hsa-miR-4731-3p	CLIP-seq
MIRT2591510	hsa-miR-4782-3p	CLIP-seq
MIRT2591511	hsa-miR-4801	CLIP-seq
MIRT1224915	hsa-miR-513b	CLIP-seq
MIRT1224917	hsa-miR-539	CLIP-seq
MIRT2293429	hsa-miR-590-3p	CLIP-seq
MIRT1224923	hsa-miR-651	CLIP-seq
MIRT1224889	hsa-miR-1183	CLIP-seq
MIRT1224891	hsa-miR-132	CLIP-seq
MIRT1224893	hsa-miR-194	CLIP-seq
MIRT1224896	hsa-miR-212	CLIP-seq
MIRT2591507	hsa-miR-219-5p	CLIP-seq
MIRT1224902	hsa-miR-4251	CLIP-seq
MIRT2591508	hsa-miR-4261	CLIP-seq
MIRT1224906	hsa-miR-4457	CLIP-seq
MIRT1224907	hsa-miR-4496	CLIP-seq
MIRT1224912	hsa-miR-4663	CLIP-seq
MIRT1224914	hsa-miR-4728-3p	CLIP-seq
MIRT2591509	hsa-miR-4731-3p	CLIP-seq
MIRT2591510	hsa-miR-4782-3p	CLIP-seq
MIRT2591511	hsa-miR-4801	CLIP-seq
MIRT1224915	hsa-miR-513b	CLIP-seq
MIRT1224917	hsa-miR-539	CLIP-seq
MIRT2293429	hsa-miR-590-3p	CLIP-seq
MIRT1224923	hsa-miR-651	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
SP1	Unknown	17669516

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001833	Process	Inner cell mass cell proliferation	IEA
GO:0005515	Function	Protein binding	IPI	20406461, 25277244, 25416956, 31515488, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0007492	Process	Endoderm development	IEA
GO:0019827	Process	Stem cell population maintenance	IEA
GO:0022626	Component	Cytosolic ribosome	IDA	27863242
GO:0030513	Process	Positive regulation of BMP signaling pathway	IEA
GO:0032790	Process	Ribosome disassembly	IBA
GO:0032790	Process	Ribosome disassembly	IDA	21448132
GO:0043022	Function	Ribosome binding	IDA	27543824, 27863242
GO:0046872	Function	Metal ion binding	IEA
GO:0051276	Process	Chromosome organization	IEA
GO:0051301	Process	Cell division	IEA
GO:0060231	Process	Mesenchymal to epithelial transition	IEA
GO:0060589	Function	Nucleoside-triphosphatase regulator activity	IDA	27863242
GO:0070481	Process	Nuclear-transcribed mRNA catabolic process, non-stop decay	IEA
GO:0070651	Process	Nonfunctional rRNA decay	IBA
GO:0070966	Process	Nuclear-transcribed mRNA catabolic process, no-go decay	IBA
GO:0070966	Process	Nuclear-transcribed mRNA catabolic process, no-go decay	IDA	23667253, 27543824, 27863242
GO:0070966	Process	Nuclear-transcribed mRNA catabolic process, no-go decay	IEA
GO:0071025	Process	RNA surveillance	IEA
GO:0072344	Process	Rescue of stalled ribosome	IDA	21448132, 27863242
GO:0170011	Function	Stalled ribosome sensor activity	IDA	27863242
GO:1990533	Component	Dom34-Hbs1 complex	IDA	27863242

MIM	HGNC	e!Ensembl
605757	8829	ENSG00000152684

Protein

UniProt ID

Q9BRX2

Protein name

Protein pelota homolog (hPelota) (Protein Dom34 homolog)

Protein function

Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27543824, PubMed:27863242). In the Pelota-HBS1L complex, PELO recognizes ribo

PDB

1X52 , 5EO3 , 5LZW , 5LZX , 5LZY , 5LZZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03463	eRF1_1	1 → 129	eRF1 domain 1	Domain
PF03464	eRF1_2	136 → 268	eRF1 domain 2	Domain
PF03465	eRF1_3	271 → 370	eRF1 domain 3	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:11060452}.

Sequence

MKLVRKNIEKDNAGQVTLVPEEPEDMWHTYNLVQVGDSLRASTIRKVQTESSTGSVGSNR
VRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTIELEPNRQFTLAKKQWDSV
VLERIEQACDPAWSADVAAVVMQEGLAHICLVTPSMTLTRAKVEVNIPRKRKGNCSQHDR
ALERFYEQVVQAIQRHIHFDVVKCILVASPGFVREQFCDYLFQQAVKTDNKLLLENRSKF
LQVHASSGHKYSLKEALCDPTVASRLSDTKAAGEVKALDDFYKMLQHEPDRAFYGLKQVE
KANEAMAIDTLLISDELFRHQDVATRSRYVRLVDSVKENAGTVRIFSSLHVSGEQLSQLT
GVAAILRFPVPELSDQEGDSSSEED

Sequence length

385

Interactions

View interactions

	KEGG
	mRNA surveillance pathway

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes, Type 2 diabetes or prostate cancer (pleiotropy), Type 2 diabetes or schizophrenia (pleiotropy)	N/A	N/A	GWAS
Glaucoma	Glaucoma	N/A	N/A	GWAS

PELO (pelota mRNA surveillance and ribosome rescue factor)