Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	53916
Gene name Gene Name - the full gene name approved by the HGNC.	RAB4B, member RAS oncogene family
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RAB4B
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009]

Show/Hide all(127)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016915	hsa-miR-335-5p	Microarray	18185580
MIRT1284997	hsa-miR-1197	CLIP-seq
MIRT1284998	hsa-miR-1258	CLIP-seq
MIRT1284999	hsa-miR-1266	CLIP-seq
MIRT1285000	hsa-miR-15a	CLIP-seq
MIRT1285001	hsa-miR-15b	CLIP-seq
MIRT1285002	hsa-miR-16	CLIP-seq
MIRT1285003	hsa-miR-195	CLIP-seq
MIRT1285004	hsa-miR-1972	CLIP-seq
MIRT1285005	hsa-miR-214	CLIP-seq
MIRT1285006	hsa-miR-24	CLIP-seq
MIRT1285007	hsa-miR-30a	CLIP-seq
MIRT1285008	hsa-miR-30b	CLIP-seq
MIRT1285009	hsa-miR-30c	CLIP-seq
MIRT1285010	hsa-miR-30d	CLIP-seq
MIRT1285011	hsa-miR-30e	CLIP-seq
MIRT1285012	hsa-miR-3115	CLIP-seq
MIRT1285013	hsa-miR-3117-3p	CLIP-seq
MIRT1285014	hsa-miR-3122	CLIP-seq
MIRT1285015	hsa-miR-3125	CLIP-seq
MIRT1285016	hsa-miR-3127-3p	CLIP-seq
MIRT1285017	hsa-miR-3127-5p	CLIP-seq
MIRT1285018	hsa-miR-3155	CLIP-seq
MIRT1285019	hsa-miR-3155b	CLIP-seq
MIRT1285020	hsa-miR-3170	CLIP-seq
MIRT1285021	hsa-miR-3179	CLIP-seq
MIRT1285022	hsa-miR-3189-5p	CLIP-seq
MIRT1285023	hsa-miR-3202	CLIP-seq
MIRT1285024	hsa-miR-3619-5p	CLIP-seq
MIRT1285025	hsa-miR-3663-5p	CLIP-seq
MIRT1285026	hsa-miR-3664-3p	CLIP-seq
MIRT1285027	hsa-miR-3675-5p	CLIP-seq
MIRT1285028	hsa-miR-3679-3p	CLIP-seq
MIRT1285029	hsa-miR-3688-5p	CLIP-seq
MIRT1285030	hsa-miR-3689a-3p	CLIP-seq
MIRT1285031	hsa-miR-3689c	CLIP-seq
MIRT1285032	hsa-miR-3913-5p	CLIP-seq
MIRT1285033	hsa-miR-3916	CLIP-seq
MIRT1285034	hsa-miR-3934	CLIP-seq
MIRT1285035	hsa-miR-424	CLIP-seq
MIRT1285036	hsa-miR-4264	CLIP-seq
MIRT1285037	hsa-miR-4278	CLIP-seq
MIRT1285038	hsa-miR-4284	CLIP-seq
MIRT1285039	hsa-miR-4300	CLIP-seq
MIRT1285040	hsa-miR-431	CLIP-seq
MIRT1285041	hsa-miR-4436b-3p	CLIP-seq
MIRT1285042	hsa-miR-4462	CLIP-seq
MIRT1285043	hsa-miR-4518	CLIP-seq
MIRT1285044	hsa-miR-4640-5p	CLIP-seq
MIRT1285045	hsa-miR-4662a-5p	CLIP-seq
MIRT1285046	hsa-miR-4681	CLIP-seq
MIRT1285047	hsa-miR-4685-5p	CLIP-seq
MIRT1285048	hsa-miR-4716-3p	CLIP-seq
MIRT1285049	hsa-miR-4725-5p	CLIP-seq
MIRT1285050	hsa-miR-4726-5p	CLIP-seq
MIRT1285051	hsa-miR-4733-3p	CLIP-seq
MIRT1285052	hsa-miR-4736	CLIP-seq
MIRT1285053	hsa-miR-4747-5p	CLIP-seq
MIRT1285054	hsa-miR-4755-3p	CLIP-seq
MIRT1285055	hsa-miR-4758-3p	CLIP-seq
MIRT1285056	hsa-miR-484	CLIP-seq
MIRT1285057	hsa-miR-497	CLIP-seq
MIRT1285058	hsa-miR-504	CLIP-seq
MIRT1285059	hsa-miR-552	CLIP-seq
MIRT1285060	hsa-miR-584	CLIP-seq
MIRT1285061	hsa-miR-622	CLIP-seq
MIRT1285062	hsa-miR-635	CLIP-seq
MIRT1285063	hsa-miR-657	CLIP-seq
MIRT1285064	hsa-miR-761	CLIP-seq
MIRT1285065	hsa-miR-920	CLIP-seq
MIRT1285005	hsa-miR-214	CLIP-seq
MIRT2084591	hsa-miR-3150a-3p	CLIP-seq
MIRT2084592	hsa-miR-3175	CLIP-seq
MIRT1285024	hsa-miR-3619-5p	CLIP-seq
MIRT1285028	hsa-miR-3679-3p	CLIP-seq
MIRT2084593	hsa-miR-3918	CLIP-seq
MIRT2084594	hsa-miR-4259	CLIP-seq
MIRT1285044	hsa-miR-4640-5p	CLIP-seq
MIRT2084595	hsa-miR-4661-5p	CLIP-seq
MIRT1285050	hsa-miR-4726-5p	CLIP-seq
MIRT2084596	hsa-miR-571	CLIP-seq
MIRT1285064	hsa-miR-761	CLIP-seq
MIRT2084597	hsa-miR-939	CLIP-seq
MIRT1284999	hsa-miR-1266	CLIP-seq
MIRT1285000	hsa-miR-15a	CLIP-seq
MIRT1285001	hsa-miR-15b	CLIP-seq
MIRT1285002	hsa-miR-16	CLIP-seq
MIRT1285003	hsa-miR-195	CLIP-seq
MIRT1285004	hsa-miR-1972	CLIP-seq
MIRT1285005	hsa-miR-214	CLIP-seq
MIRT1285014	hsa-miR-3122	CLIP-seq
MIRT1285015	hsa-miR-3125	CLIP-seq
MIRT1285018	hsa-miR-3155	CLIP-seq
MIRT1285019	hsa-miR-3155b	CLIP-seq
MIRT1285020	hsa-miR-3170	CLIP-seq
MIRT1285024	hsa-miR-3619-5p	CLIP-seq
MIRT1285025	hsa-miR-3663-5p	CLIP-seq
MIRT1285026	hsa-miR-3664-3p	CLIP-seq
MIRT1285030	hsa-miR-3689a-3p	CLIP-seq
MIRT1285031	hsa-miR-3689c	CLIP-seq
MIRT1285032	hsa-miR-3913-5p	CLIP-seq
MIRT1285033	hsa-miR-3916	CLIP-seq
MIRT1285035	hsa-miR-424	CLIP-seq
MIRT1285039	hsa-miR-4300	CLIP-seq
MIRT1285043	hsa-miR-4518	CLIP-seq
MIRT1285044	hsa-miR-4640-5p	CLIP-seq
MIRT1285045	hsa-miR-4662a-5p	CLIP-seq
MIRT1285046	hsa-miR-4681	CLIP-seq
MIRT1285048	hsa-miR-4716-3p	CLIP-seq
MIRT1285049	hsa-miR-4725-5p	CLIP-seq
MIRT1285050	hsa-miR-4726-5p	CLIP-seq
MIRT1285051	hsa-miR-4733-3p	CLIP-seq
MIRT1285055	hsa-miR-4758-3p	CLIP-seq
MIRT1285056	hsa-miR-484	CLIP-seq
MIRT1285057	hsa-miR-497	CLIP-seq
MIRT1285058	hsa-miR-504	CLIP-seq
MIRT1285062	hsa-miR-635	CLIP-seq
MIRT1285064	hsa-miR-761	CLIP-seq
MIRT1285065	hsa-miR-920	CLIP-seq
MIRT1285005	hsa-miR-214	CLIP-seq
MIRT1285024	hsa-miR-3619-5p	CLIP-seq
MIRT1285028	hsa-miR-3679-3p	CLIP-seq
MIRT2084593	hsa-miR-3918	CLIP-seq
MIRT1285044	hsa-miR-4640-5p	CLIP-seq
MIRT2084595	hsa-miR-4661-5p	CLIP-seq
MIRT1285050	hsa-miR-4726-5p	CLIP-seq
MIRT1285064	hsa-miR-761	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
CIITA	Unknown	17175541

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IDA	20534812
GO:0003924	Function	GTPase activity	IEA
GO:0003925	Function	G protein activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030100	Process	Regulation of endocytosis	IBA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0030667	Component	Secretory granule membrane	TAS
GO:0031901	Component	Early endosome membrane	IDA	20534812
GO:0031901	Component	Early endosome membrane	IEA
GO:0032482	Process	Rab protein signal transduction	IEA
GO:0032593	Component	Insulin-responsive compartment	IBA
GO:0032593	Component	Insulin-responsive compartment	IDA	19590752
GO:0034058	Process	Endosomal vesicle fusion	IDA	20534812
GO:0034498	Process	Early endosome to Golgi transport	IDA	36282215
GO:0046323	Process	D-glucose import	IMP	19590752
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	19590752
GO:0055037	Component	Recycling endosome	IBA
GO:0055037	Component	Recycling endosome	IDA	19590752

MIM	HGNC	e!Ensembl
612945	9782	ENSG00000167578

Protein

UniProt ID

P61018

Protein name

Ras-related protein Rab-4B (EC 3.6.5.2)

Protein function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r

PDB

2O52

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00071	Ras	10 → 171	Ras family	Domain

Sequence

MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQ
IWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCG
NKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDP
ERMGSGIQYGDASLRQLRQPRSAQAVAPQPCGC

Sequence length

213

Interactions

View interactions

	Reactome
			Neutrophil degranulation RAB geranylgeranylation MET receptor recycling

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Breast Cancer	Plasma letrozole concentrations in letrozole treated hormone-receptor-positive breast cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenomatous Polyposis Coli	Associate	28306719
Carcinoma Hepatocellular	Stimulate	12450215
Colorectal Neoplasms	Associate	28306719
Infections	Associate	29946045
Lymphoma B Cell	Associate	21854084
Polyps	Associate	28306719
Pulmonary Disease Chronic Obstructive	Associate	23936167
Synovitis	Associate	29968759

RAB4B (RAB4B, member RAS oncogene family)