RAB4B (RAB4B, member RAS oncogene family)

Gene

• Entrez ID: 53916
• Gene name: RAB4B, member RAS oncogene family
• Gene symbol: RAB4B
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19q13.2
• Summary: RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016915	hsa-miR-335-5p	Microarray	18185580
MIRT1284997	hsa-miR-1197	CLIP-seq
MIRT1284998	hsa-miR-1258	CLIP-seq
MIRT1284999	hsa-miR-1266	CLIP-seq
MIRT1285000	hsa-miR-15a	CLIP-seq
MIRT1285001	hsa-miR-15b	CLIP-seq
MIRT1285002	hsa-miR-16	CLIP-seq
MIRT1285003	hsa-miR-195	CLIP-seq
MIRT1285004	hsa-miR-1972	CLIP-seq
MIRT1285005	hsa-miR-214	CLIP-seq
MIRT1285006	hsa-miR-24	CLIP-seq
MIRT1285007	hsa-miR-30a	CLIP-seq
MIRT1285008	hsa-miR-30b	CLIP-seq
MIRT1285009	hsa-miR-30c	CLIP-seq
MIRT1285010	hsa-miR-30d	CLIP-seq
MIRT1285011	hsa-miR-30e	CLIP-seq
MIRT1285012	hsa-miR-3115	CLIP-seq
MIRT1285013	hsa-miR-3117-3p	CLIP-seq
MIRT1285014	hsa-miR-3122	CLIP-seq
MIRT1285015	hsa-miR-3125	CLIP-seq
MIRT1285016	hsa-miR-3127-3p	CLIP-seq
MIRT1285017	hsa-miR-3127-5p	CLIP-seq
MIRT1285018	hsa-miR-3155	CLIP-seq
MIRT1285019	hsa-miR-3155b	CLIP-seq
MIRT1285020	hsa-miR-3170	CLIP-seq
MIRT1285021	hsa-miR-3179	CLIP-seq
MIRT1285022	hsa-miR-3189-5p	CLIP-seq
MIRT1285023	hsa-miR-3202	CLIP-seq
MIRT1285024	hsa-miR-3619-5p	CLIP-seq
MIRT1285025	hsa-miR-3663-5p	CLIP-seq
MIRT1285026	hsa-miR-3664-3p	CLIP-seq
MIRT1285027	hsa-miR-3675-5p	CLIP-seq
MIRT1285028	hsa-miR-3679-3p	CLIP-seq
MIRT1285029	hsa-miR-3688-5p	CLIP-seq
MIRT1285030	hsa-miR-3689a-3p	CLIP-seq
MIRT1285031	hsa-miR-3689c	CLIP-seq
MIRT1285032	hsa-miR-3913-5p	CLIP-seq
MIRT1285033	hsa-miR-3916	CLIP-seq
MIRT1285034	hsa-miR-3934	CLIP-seq
MIRT1285035	hsa-miR-424	CLIP-seq
MIRT1285036	hsa-miR-4264	CLIP-seq
MIRT1285037	hsa-miR-4278	CLIP-seq
MIRT1285038	hsa-miR-4284	CLIP-seq
MIRT1285039	hsa-miR-4300	CLIP-seq
MIRT1285040	hsa-miR-431	CLIP-seq
MIRT1285041	hsa-miR-4436b-3p	CLIP-seq
MIRT1285042	hsa-miR-4462	CLIP-seq
MIRT1285043	hsa-miR-4518	CLIP-seq
MIRT1285044	hsa-miR-4640-5p	CLIP-seq
MIRT1285045	hsa-miR-4662a-5p	CLIP-seq
MIRT1285046	hsa-miR-4681	CLIP-seq
MIRT1285047	hsa-miR-4685-5p	CLIP-seq
MIRT1285048	hsa-miR-4716-3p	CLIP-seq
MIRT1285049	hsa-miR-4725-5p	CLIP-seq
MIRT1285050	hsa-miR-4726-5p	CLIP-seq
MIRT1285051	hsa-miR-4733-3p	CLIP-seq
MIRT1285052	hsa-miR-4736	CLIP-seq
MIRT1285053	hsa-miR-4747-5p	CLIP-seq
MIRT1285054	hsa-miR-4755-3p	CLIP-seq
MIRT1285055	hsa-miR-4758-3p	CLIP-seq
MIRT1285056	hsa-miR-484	CLIP-seq
MIRT1285057	hsa-miR-497	CLIP-seq
MIRT1285058	hsa-miR-504	CLIP-seq
MIRT1285059	hsa-miR-552	CLIP-seq
MIRT1285060	hsa-miR-584	CLIP-seq
MIRT1285061	hsa-miR-622	CLIP-seq
MIRT1285062	hsa-miR-635	CLIP-seq
MIRT1285063	hsa-miR-657	CLIP-seq
MIRT1285064	hsa-miR-761	CLIP-seq
MIRT1285065	hsa-miR-920	CLIP-seq
MIRT1285005	hsa-miR-214	CLIP-seq
MIRT2084591	hsa-miR-3150a-3p	CLIP-seq
MIRT2084592	hsa-miR-3175	CLIP-seq
MIRT1285024	hsa-miR-3619-5p	CLIP-seq
MIRT1285028	hsa-miR-3679-3p	CLIP-seq
MIRT2084593	hsa-miR-3918	CLIP-seq
MIRT2084594	hsa-miR-4259	CLIP-seq
MIRT1285044	hsa-miR-4640-5p	CLIP-seq
MIRT2084595	hsa-miR-4661-5p	CLIP-seq
MIRT1285050	hsa-miR-4726-5p	CLIP-seq
MIRT2084596	hsa-miR-571	CLIP-seq
MIRT1285064	hsa-miR-761	CLIP-seq
MIRT2084597	hsa-miR-939	CLIP-seq
MIRT1284999	hsa-miR-1266	CLIP-seq
MIRT1285000	hsa-miR-15a	CLIP-seq
MIRT1285001	hsa-miR-15b	CLIP-seq
MIRT1285002	hsa-miR-16	CLIP-seq
MIRT1285003	hsa-miR-195	CLIP-seq
MIRT1285004	hsa-miR-1972	CLIP-seq
MIRT1285005	hsa-miR-214	CLIP-seq
MIRT1285014	hsa-miR-3122	CLIP-seq
MIRT1285015	hsa-miR-3125	CLIP-seq
MIRT1285018	hsa-miR-3155	CLIP-seq
MIRT1285019	hsa-miR-3155b	CLIP-seq
MIRT1285020	hsa-miR-3170	CLIP-seq
MIRT1285024	hsa-miR-3619-5p	CLIP-seq
MIRT1285025	hsa-miR-3663-5p	CLIP-seq
MIRT1285026	hsa-miR-3664-3p	CLIP-seq
MIRT1285030	hsa-miR-3689a-3p	CLIP-seq
MIRT1285031	hsa-miR-3689c	CLIP-seq
MIRT1285032	hsa-miR-3913-5p	CLIP-seq
MIRT1285033	hsa-miR-3916	CLIP-seq
MIRT1285035	hsa-miR-424	CLIP-seq
MIRT1285039	hsa-miR-4300	CLIP-seq
MIRT1285043	hsa-miR-4518	CLIP-seq
MIRT1285044	hsa-miR-4640-5p	CLIP-seq
MIRT1285045	hsa-miR-4662a-5p	CLIP-seq
MIRT1285046	hsa-miR-4681	CLIP-seq
MIRT1285048	hsa-miR-4716-3p	CLIP-seq
MIRT1285049	hsa-miR-4725-5p	CLIP-seq
MIRT1285050	hsa-miR-4726-5p	CLIP-seq
MIRT1285051	hsa-miR-4733-3p	CLIP-seq
MIRT1285055	hsa-miR-4758-3p	CLIP-seq
MIRT1285056	hsa-miR-484	CLIP-seq
MIRT1285057	hsa-miR-497	CLIP-seq
MIRT1285058	hsa-miR-504	CLIP-seq
MIRT1285062	hsa-miR-635	CLIP-seq
MIRT1285064	hsa-miR-761	CLIP-seq
MIRT1285065	hsa-miR-920	CLIP-seq
MIRT1285005	hsa-miR-214	CLIP-seq
MIRT1285024	hsa-miR-3619-5p	CLIP-seq
MIRT1285028	hsa-miR-3679-3p	CLIP-seq
MIRT2084593	hsa-miR-3918	CLIP-seq
MIRT1285044	hsa-miR-4640-5p	CLIP-seq
MIRT2084595	hsa-miR-4661-5p	CLIP-seq
MIRT1285050	hsa-miR-4726-5p	CLIP-seq
MIRT1285064	hsa-miR-761	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CIITA	Unknown	17175541

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IDA	20534812
GO:0003924	Function	GTPase activity	IEA
GO:0003925	Function	G protein activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030100	Process	Regulation of endocytosis	IBA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0030667	Component	Secretory granule membrane	TAS
GO:0031901	Component	Early endosome membrane	IDA	20534812
GO:0031901	Component	Early endosome membrane	IEA
GO:0032482	Process	Rab protein signal transduction	IEA
GO:0032593	Component	Insulin-responsive compartment	IBA
GO:0032593	Component	Insulin-responsive compartment	IDA	19590752
GO:0034058	Process	Endosomal vesicle fusion	IDA	20534812
GO:0034498	Process	Early endosome to Golgi transport	IDA	36282215
GO:0046323	Process	D-glucose import	IMP	19590752
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	19590752
GO:0055037	Component	Recycling endosome	IBA
GO:0055037	Component	Recycling endosome	IDA	19590752

Other IDs

• MIM: 612945
• HGNC: 9782
• e!Ensembl: ENSG00000167578

Protein

• UniProt ID: P61018
• Protein name: Ras-related protein Rab-4B (EC 3.6.5.2)
• Protein function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
• PDB: 2O52
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00071	Ras	10 → 171	Ras family	Domain

• Sequence:

  MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQ
  IWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCG
  NKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDP
  ERMGSGIQYGDASLRQLRQPRSAQAVAPQPCGC

• Sequence length: 213

Pathways

Reactome:

Neutrophil degranulation
RAB geranylgeranylation
MET receptor recycling