Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	53833
Gene name	Interleukin 20 receptor subunit beta
Gene symbol	IL20RB
Synonyms (NCBI Gene)	DIRS1FNDC6IL-20R-betaIL-20R2IL-20RB
Chromosome	3
Chromosome location	3q22.3
Summary	IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]

185

Show/Hide all (185)

miRTarBase ID	miRNA	Experiments	Reference
MIRT714139	hsa-miR-224-5p	HITS-CLIP	19536157
MIRT714138	hsa-miR-5003-3p	HITS-CLIP	19536157
MIRT714137	hsa-miR-296-3p	HITS-CLIP	19536157
MIRT714136	hsa-miR-6823-5p	HITS-CLIP	19536157
MIRT714135	hsa-miR-6840-3p	HITS-CLIP	19536157
MIRT714134	hsa-miR-1915-3p	HITS-CLIP	19536157
MIRT714133	hsa-miR-6764-5p	HITS-CLIP	19536157
MIRT714132	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT714131	hsa-miR-5187-5p	HITS-CLIP	19536157
MIRT714130	hsa-miR-7977	HITS-CLIP	19536157
MIRT714129	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT483899	hsa-miR-1183	PAR-CLIP	20371350
MIRT483898	hsa-miR-5586-3p	PAR-CLIP	20371350
MIRT483897	hsa-miR-4494	PAR-CLIP	20371350
MIRT483896	hsa-miR-499b-5p	PAR-CLIP	20371350
MIRT483895	hsa-miR-4704-3p	PAR-CLIP	20371350
MIRT483893	hsa-miR-5187-3p	PAR-CLIP	20371350
MIRT483894	hsa-miR-15b-3p	PAR-CLIP	20371350
MIRT483892	hsa-miR-6832-5p	PAR-CLIP	20371350
MIRT483891	hsa-miR-4732-5p	PAR-CLIP	20371350
MIRT544829	hsa-miR-6879-3p	PAR-CLIP	20371350
MIRT489323	hsa-miR-597-5p	PAR-CLIP	20371350
MIRT483890	hsa-miR-7161-5p	PAR-CLIP	20371350
MIRT483899	hsa-miR-1183	PAR-CLIP	21572407
MIRT483898	hsa-miR-5586-3p	PAR-CLIP	21572407
MIRT483897	hsa-miR-4494	PAR-CLIP	21572407
MIRT483896	hsa-miR-499b-5p	PAR-CLIP	21572407
MIRT483895	hsa-miR-4704-3p	PAR-CLIP	21572407
MIRT483893	hsa-miR-5187-3p	PAR-CLIP	21572407
MIRT483894	hsa-miR-15b-3p	PAR-CLIP	21572407
MIRT483892	hsa-miR-6832-5p	PAR-CLIP	21572407
MIRT483891	hsa-miR-4732-5p	PAR-CLIP	21572407
MIRT544829	hsa-miR-6879-3p	PAR-CLIP	21572407
MIRT489323	hsa-miR-597-5p	PAR-CLIP	21572407
MIRT483890	hsa-miR-7161-5p	PAR-CLIP	21572407
MIRT513082	hsa-miR-603	PAR-CLIP	21572407
MIRT513078	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT513081	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT513080	hsa-miR-6760-3p	PAR-CLIP	21572407
MIRT513079	hsa-miR-8064	PAR-CLIP	21572407
MIRT513076	hsa-miR-505-3p	PAR-CLIP	21572407
MIRT513078	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT513077	hsa-miR-582-5p	PAR-CLIP	21572407
MIRT513076	hsa-miR-505-3p	PAR-CLIP	21572407
MIRT513082	hsa-miR-603	PAR-CLIP	22012620
MIRT513078	hsa-miR-101-3p	PAR-CLIP	22012620
MIRT513081	hsa-miR-144-3p	PAR-CLIP	22012620
MIRT513080	hsa-miR-6760-3p	PAR-CLIP	22012620
MIRT513079	hsa-miR-8064	PAR-CLIP	22012620
MIRT513076	hsa-miR-505-3p	PAR-CLIP	22012620
MIRT513078	hsa-miR-101-3p	PAR-CLIP	22012620
MIRT513077	hsa-miR-582-5p	PAR-CLIP	22012620
MIRT513076	hsa-miR-505-3p	PAR-CLIP	22012620
MIRT513082	hsa-miR-603	PAR-CLIP	23446348
MIRT513078	hsa-miR-101-3p	PAR-CLIP	23446348
MIRT513081	hsa-miR-144-3p	PAR-CLIP	23446348
MIRT513080	hsa-miR-6760-3p	PAR-CLIP	23446348
MIRT513079	hsa-miR-8064	PAR-CLIP	23446348
MIRT513076	hsa-miR-505-3p	PAR-CLIP	23446348
MIRT513078	hsa-miR-101-3p	PAR-CLIP	23446348
MIRT513077	hsa-miR-582-5p	PAR-CLIP	23446348
MIRT513076	hsa-miR-505-3p	PAR-CLIP	23446348
MIRT483899	hsa-miR-1183	PAR-CLIP	23592263
MIRT483898	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT483897	hsa-miR-4494	PAR-CLIP	23592263
MIRT483896	hsa-miR-499b-5p	PAR-CLIP	23592263
MIRT483895	hsa-miR-4704-3p	PAR-CLIP	23592263
MIRT483893	hsa-miR-5187-3p	PAR-CLIP	23592263
MIRT483894	hsa-miR-15b-3p	PAR-CLIP	23592263
MIRT483892	hsa-miR-6832-5p	PAR-CLIP	23592263
MIRT483891	hsa-miR-4732-5p	PAR-CLIP	23592263
MIRT489323	hsa-miR-597-5p	PAR-CLIP	23592263
MIRT483890	hsa-miR-7161-5p	PAR-CLIP	23592263
MIRT483899	hsa-miR-1183	PAR-CLIP	23592263
MIRT483898	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT483897	hsa-miR-4494	PAR-CLIP	23592263
MIRT483896	hsa-miR-499b-5p	PAR-CLIP	23592263
MIRT483895	hsa-miR-4704-3p	PAR-CLIP	23592263
MIRT483893	hsa-miR-5187-3p	PAR-CLIP	23592263
MIRT483894	hsa-miR-15b-3p	PAR-CLIP	23592263
MIRT483892	hsa-miR-6832-5p	PAR-CLIP	23592263
MIRT483891	hsa-miR-4732-5p	PAR-CLIP	23592263
MIRT483890	hsa-miR-7161-5p	PAR-CLIP	23592263
MIRT714139	hsa-miR-224-5p	HITS-CLIP	19536157
MIRT714138	hsa-miR-5003-3p	HITS-CLIP	19536157
MIRT714137	hsa-miR-296-3p	HITS-CLIP	19536157
MIRT714136	hsa-miR-6823-5p	HITS-CLIP	19536157
MIRT714135	hsa-miR-6840-3p	HITS-CLIP	19536157
MIRT714134	hsa-miR-1915-3p	HITS-CLIP	19536157
MIRT714133	hsa-miR-6764-5p	HITS-CLIP	19536157
MIRT714132	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT714131	hsa-miR-5187-5p	HITS-CLIP	19536157
MIRT714130	hsa-miR-7977	HITS-CLIP	19536157
MIRT714129	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT483899	hsa-miR-1183	PAR-CLIP	20371350
MIRT483898	hsa-miR-5586-3p	PAR-CLIP	20371350
MIRT483897	hsa-miR-4494	PAR-CLIP	20371350
MIRT483896	hsa-miR-499b-5p	PAR-CLIP	20371350
MIRT483895	hsa-miR-4704-3p	PAR-CLIP	20371350
MIRT483893	hsa-miR-5187-3p	PAR-CLIP	20371350
MIRT483894	hsa-miR-15b-3p	PAR-CLIP	20371350
MIRT483892	hsa-miR-6832-5p	PAR-CLIP	20371350
MIRT483891	hsa-miR-4732-5p	PAR-CLIP	20371350
MIRT544829	hsa-miR-6879-3p	PAR-CLIP	20371350
MIRT489323	hsa-miR-597-5p	PAR-CLIP	20371350
MIRT483890	hsa-miR-7161-5p	PAR-CLIP	20371350
MIRT483899	hsa-miR-1183	PAR-CLIP	21572407
MIRT483898	hsa-miR-5586-3p	PAR-CLIP	21572407
MIRT483897	hsa-miR-4494	PAR-CLIP	21572407
MIRT483896	hsa-miR-499b-5p	PAR-CLIP	21572407
MIRT483895	hsa-miR-4704-3p	PAR-CLIP	21572407
MIRT483893	hsa-miR-5187-3p	PAR-CLIP	21572407
MIRT483894	hsa-miR-15b-3p	PAR-CLIP	21572407
MIRT483892	hsa-miR-6832-5p	PAR-CLIP	21572407
MIRT483891	hsa-miR-4732-5p	PAR-CLIP	21572407
MIRT544829	hsa-miR-6879-3p	PAR-CLIP	21572407
MIRT489323	hsa-miR-597-5p	PAR-CLIP	21572407
MIRT483890	hsa-miR-7161-5p	PAR-CLIP	21572407
MIRT513082	hsa-miR-603	PAR-CLIP	21572407
MIRT513078	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT513081	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT513080	hsa-miR-6760-3p	PAR-CLIP	21572407
MIRT513079	hsa-miR-8064	PAR-CLIP	21572407
MIRT513076	hsa-miR-505-3p	PAR-CLIP	21572407
MIRT513078	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT513077	hsa-miR-582-5p	PAR-CLIP	21572407
MIRT513076	hsa-miR-505-3p	PAR-CLIP	21572407
MIRT513082	hsa-miR-603	PAR-CLIP	22012620
MIRT513078	hsa-miR-101-3p	PAR-CLIP	22012620
MIRT513081	hsa-miR-144-3p	PAR-CLIP	22012620
MIRT513080	hsa-miR-6760-3p	PAR-CLIP	22012620
MIRT513079	hsa-miR-8064	PAR-CLIP	22012620
MIRT513076	hsa-miR-505-3p	PAR-CLIP	22012620
MIRT513078	hsa-miR-101-3p	PAR-CLIP	22012620
MIRT513077	hsa-miR-582-5p	PAR-CLIP	22012620
MIRT513076	hsa-miR-505-3p	PAR-CLIP	22012620
MIRT513082	hsa-miR-603	PAR-CLIP	23446348
MIRT513078	hsa-miR-101-3p	PAR-CLIP	23446348
MIRT513081	hsa-miR-144-3p	PAR-CLIP	23446348
MIRT513080	hsa-miR-6760-3p	PAR-CLIP	23446348
MIRT513079	hsa-miR-8064	PAR-CLIP	23446348
MIRT513076	hsa-miR-505-3p	PAR-CLIP	23446348
MIRT513078	hsa-miR-101-3p	PAR-CLIP	23446348
MIRT513077	hsa-miR-582-5p	PAR-CLIP	23446348
MIRT513076	hsa-miR-505-3p	PAR-CLIP	23446348
MIRT483899	hsa-miR-1183	PAR-CLIP	23592263
MIRT483898	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT483897	hsa-miR-4494	PAR-CLIP	23592263
MIRT483896	hsa-miR-499b-5p	PAR-CLIP	23592263
MIRT483895	hsa-miR-4704-3p	PAR-CLIP	23592263
MIRT483893	hsa-miR-5187-3p	PAR-CLIP	23592263
MIRT483894	hsa-miR-15b-3p	PAR-CLIP	23592263
MIRT483892	hsa-miR-6832-5p	PAR-CLIP	23592263
MIRT483891	hsa-miR-4732-5p	PAR-CLIP	23592263
MIRT489323	hsa-miR-597-5p	PAR-CLIP	23592263
MIRT483890	hsa-miR-7161-5p	PAR-CLIP	23592263
MIRT483899	hsa-miR-1183	PAR-CLIP	23592263
MIRT483898	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT483897	hsa-miR-4494	PAR-CLIP	23592263
MIRT483896	hsa-miR-499b-5p	PAR-CLIP	23592263
MIRT483895	hsa-miR-4704-3p	PAR-CLIP	23592263
MIRT483893	hsa-miR-5187-3p	PAR-CLIP	23592263
MIRT483894	hsa-miR-15b-3p	PAR-CLIP	23592263
MIRT483892	hsa-miR-6832-5p	PAR-CLIP	23592263
MIRT483891	hsa-miR-4732-5p	PAR-CLIP	23592263
MIRT483890	hsa-miR-7161-5p	PAR-CLIP	23592263
MIRT1064509	hsa-miR-101	CLIP-seq
MIRT1064510	hsa-miR-144	CLIP-seq
MIRT1064511	hsa-miR-3065-5p	CLIP-seq
MIRT1064512	hsa-miR-3686	CLIP-seq
MIRT1064513	hsa-miR-495	CLIP-seq
MIRT1064514	hsa-miR-505	CLIP-seq
MIRT1064515	hsa-miR-544	CLIP-seq
MIRT1064516	hsa-miR-617	CLIP-seq
MIRT2247672	hsa-miR-4691-5p	CLIP-seq
MIRT2247673	hsa-miR-4778-5p	CLIP-seq
MIRT2451742	hsa-miR-1245b-3p	CLIP-seq
MIRT2451743	hsa-miR-361-3p	CLIP-seq
MIRT2451744	hsa-miR-3679-3p	CLIP-seq
MIRT2451745	hsa-miR-539	CLIP-seq
MIRT2451746	hsa-miR-885-5p	CLIP-seq
MIRT2551103	hsa-miR-1251	CLIP-seq
MIRT2551104	hsa-miR-3614-3p	CLIP-seq
MIRT2551105	hsa-miR-4755-5p	CLIP-seq
MIRT2551106	hsa-miR-642a	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001808	Process	Negative regulation of type IV hypersensitivity	IEA
GO:0002437	Process	Inflammatory response to antigenic stimulus	IEA
GO:0002765	Process	Immune response-inhibiting signal transduction	IEA
GO:0004896	Function	Cytokine receptor activity	IBA
GO:0005515	Function	Protein binding	IPI	22802649, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA
GO:0032689	Process	Negative regulation of type II interferon production	IEA
GO:0032703	Process	Negative regulation of interleukin-2 production	IEA
GO:0032733	Process	Positive regulation of interleukin-10 production	IEA
GO:0032753	Process	Positive regulation of interleukin-4 production	IEA
GO:0042015	Function	Interleukin-20 binding	IBA
GO:0042015	Function	Interleukin-20 binding	IEA
GO:0042098	Process	T cell proliferation	IEA
GO:0042130	Process	Negative regulation of T cell proliferation	IEA
GO:0043029	Process	T cell homeostasis	IEA
GO:0048873	Process	Homeostasis of number of cells within a tissue	IEA
GO:0050863	Process	Regulation of T cell activation	IEA
GO:0160165	Process	CD8-positive, alpha-beta T cell homeostasis	IEA

MIM	HGNC	e!Ensembl
605621	6004	ENSG00000174564

Q6UXL0

Protein name

Interleukin-20 receptor subunit beta (IL-20 receptor subunit beta) (IL-20R-beta) (IL-20RB) (Fibronectin type III domain containing 6) (FNDC6) (IL-20R2)

Protein function

The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

PDB

4DOH , 6DF3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01108	Tissue_fac	15 → 124	Tissue factor	Family
PF09294	Interfer-bind	136 → 227	Interferon-alpha/beta receptor, fibronectin type III	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin. {ECO:0000269|PubMed:11163236}.

Sequence

MQTFTMVLEEIWTSLFMWFFYALIPCLLTDEVAILPAPQNLSVLSTNMKHLLMWSPVIAP
GETVYYSVEYQGEYESLYTSHIWIPSSWCSLTEGPECDVTDDITATVPYNLRVRATLGSQ
TSAWSILKHPFNRNSTILTRPGMEITKDGFHLVIELEDLGPQFEFLVAYWRREPGAEEHV
KMVRSGGIPVHLETMEPGAAYCVKAQTFVKAIGRYSAFSQTECVEVQGEAIPLVLALFAF
VGFMLILVVVPLFVWKMGRLLQYSCCPVVVLPDTLKITNSPQKLISCRREEVDACATAVM
SPEELLRAWIS

Sequence length

311

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway		Interleukin-20 family signaling

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign	rs244405	RCV005908140
Clear cell carcinoma of kidney	Benign	rs244405	RCV005908141
Colorectal cancer	Benign	rs244405	RCV005908142
Gastric cancer	Benign	rs244405	RCV005908143
Ovarian serous cystadenocarcinoma	Benign	rs244405	RCV005908144

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	34497605
Azoospermia	Associate	37854191
Carcinoma Renal Cell	Associate	31489573, 35883015, 39247556
Carcinoma Renal Cell	Stimulate	35299868
COVID 19	Stimulate	36163397
Drug Related Side Effects and Adverse Reactions	Associate	39247556
Friedreich Ataxia	Associate	39519164
Glaucoma	Associate	24455976
Glaucoma Open Angle	Associate	24455976
Lung Neoplasms	Stimulate	36006737
Melanoma	Associate	36553569
Mouth Diseases	Inhibit	16645593
Multiple Sclerosis	Associate	35008743
Neoplasms	Associate	31489573, 35299868, 35874683, 36006737
Pancreatic Neoplasms	Associate	33253517, 34143198, 38098005

IL20RB (interleukin 20 receptor subunit beta)