IL20RA (interleukin 20 receptor subunit alpha)

Gene

• Entrez ID: 53832
• Gene name: Interleukin 20 receptor subunit alpha
• Gene symbol: IL20RA
• Synonyms (NCBI Gene): CRF2-8, IL-20R-alpha, IL-20R1, IL-20RA
• Chromosome: 6
• Chromosome location: 6q23.3
• Summary: This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisti

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029093	hsa-miR-26b-5p	Microarray	19088304
MIRT1064490	hsa-miR-1236	CLIP-seq
MIRT1064491	hsa-miR-1262	CLIP-seq
MIRT1064492	hsa-miR-2054	CLIP-seq
MIRT1064493	hsa-miR-3115	CLIP-seq
MIRT1064494	hsa-miR-3180-5p	CLIP-seq
MIRT1064495	hsa-miR-3675-3p	CLIP-seq
MIRT1064496	hsa-miR-3689a-5p	CLIP-seq
MIRT1064497	hsa-miR-3689b	CLIP-seq
MIRT1064498	hsa-miR-3689e	CLIP-seq
MIRT1064499	hsa-miR-3689f	CLIP-seq
MIRT1064500	hsa-miR-380	CLIP-seq
MIRT1064501	hsa-miR-4289	CLIP-seq
MIRT1064502	hsa-miR-4307	CLIP-seq
MIRT1064503	hsa-miR-4636	CLIP-seq
MIRT1064504	hsa-miR-4701-3p	CLIP-seq
MIRT1064505	hsa-miR-508-5p	CLIP-seq
MIRT1064506	hsa-miR-520a-5p	CLIP-seq
MIRT1064507	hsa-miR-525-5p	CLIP-seq
MIRT1064508	hsa-miR-942	CLIP-seq
MIRT1550115	hsa-miR-3171	CLIP-seq
MIRT1550116	hsa-miR-493	CLIP-seq
MIRT1550117	hsa-miR-550a	CLIP-seq
MIRT1550118	hsa-miR-630	CLIP-seq
MIRT1064505	hsa-miR-508-5p	CLIP-seq
MIRT2015339	hsa-miR-580	CLIP-seq
MIRT1550115	hsa-miR-3171	CLIP-seq
MIRT1550116	hsa-miR-493	CLIP-seq
MIRT1550117	hsa-miR-550a	CLIP-seq
MIRT1550118	hsa-miR-630	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004896	Function	Cytokine receptor activity	IBA
GO:0005515	Function	Protein binding	IPI	22802649
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0042015	Function	Interleukin-20 binding	IBA
GO:0042015	Function	Interleukin-20 binding	IEA
GO:0045124	Process	Regulation of bone resorption	IEA
GO:2001244	Process	Positive regulation of intrinsic apoptotic signaling pathway	IEA

Other IDs

• MIM: 605620
• HGNC: 6003
• e!Ensembl: ENSG00000016402

Protein

• UniProt ID: Q9UHF4
• Protein name: Interleukin-20 receptor subunit alpha (IL-20 receptor subunit alpha) (IL-20R-alpha) (IL-20RA) (Cytokine receptor class-II member 8) (Cytokine receptor family 2 member 8) (CRF2-8) (IL-20R1) (ZcytoR7)
• Protein function: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.
• PDB: 4DOH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01108	Tissue_fac	14 → 123	Tissue factor	Family
  PF09294	Interfer-bind	135 → 240	Interferon-alpha/beta receptor, fibronectin type III	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin. {ECO:0000269|PubMed:11163236, ECO:0000269|PubMed:14764663}.
• Sequence:

  MRAPGRPALRPLPLPPLLLLLLAAPWGRAVPCVSGGLPKPANITFLSINMKNVLQWTPPE
  GLQGVKVTYTVQYFIYGQKKWLNKSECRNINRTYCDLSAETSDYEHQYYAKVKAIWGTKC
  SKWAESGRFYPFLETQIGPPEVALTTDEKSISVVLTAPEKWKRNPEDLPVSMQQIYSNLK
  YNVSVLNTKSNRTWSQCVTNHTLVLTWLEPNTLYCVHVESFVPGPPRRAQPSEKQCARTL
  KDQSSEFKAKIIFWYVLPVSITVFLFSVMGYSIYRYIHVGKEKHPANLILIYGNEFDKRF
  FVPAEKIVINFITLNISDDSKISHQDMSLLGKSSDVSSLNDPQPSGNLRPPQEEEEVKHL
  GYASHLMEIFCDSEENTEGTSLTQQESLSRTIPPDKTVIEYEYDVRTTDICAGPEEQELS
  LQEEVSTQGTLLESQAALAVLGPQTLQYSYTPQLQDLDPLAQEHTDSEEGPEEEPSTTLV
  DWDPQTGRLCIPSLSSFDQDSEGCEPSEGDGLGEEGLLSRLYEEPAPDRPPGENETYLMQ
  FMEEWGLYVQMEN

• Sequence length: 553

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
JAK-STAT signaling pathway

Reactome:

Interleukin-20 family signaling