Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	53826
Gene name Gene Name - the full gene name approved by the HGNC.	FXYD domain containing ion transport regulator 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FXYD6
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q23.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have b

Show/Hide all(99)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025043	hsa-miR-181a-5p	Microarray	17612493
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	27418678
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	27418678
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	27418678
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	27418678
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	27418678
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT1007512	hsa-miR-1183	CLIP-seq
MIRT1007513	hsa-miR-1909	CLIP-seq
MIRT1007514	hsa-miR-3199	CLIP-seq
MIRT1007515	hsa-miR-377	CLIP-seq
MIRT1007516	hsa-miR-4704-3p	CLIP-seq
MIRT1007517	hsa-miR-499-3p	CLIP-seq
MIRT1007518	hsa-miR-140-3p	CLIP-seq
MIRT1007519	hsa-miR-4766-3p	CLIP-seq
MIRT1007520	hsa-miR-548p	CLIP-seq
MIRT2232228	hsa-miR-1470	CLIP-seq
MIRT1007515	hsa-miR-377	CLIP-seq
MIRT2232229	hsa-miR-4287	CLIP-seq
MIRT2232230	hsa-miR-4469	CLIP-seq
MIRT2232231	hsa-miR-4667-3p	CLIP-seq
MIRT2232232	hsa-miR-4685-3p	CLIP-seq
MIRT1007516	hsa-miR-4704-3p	CLIP-seq
MIRT2232233	hsa-miR-4757-5p	CLIP-seq
MIRT1007517	hsa-miR-499-3p	CLIP-seq
MIRT2232234	hsa-miR-767-3p	CLIP-seq
MIRT1007515	hsa-miR-377	CLIP-seq
MIRT1007516	hsa-miR-4704-3p	CLIP-seq

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	IEA
GO:0006814	Process	Sodium ion transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0017080	Function	Sodium channel regulator activity	IBA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0043269	Process	Regulation of monoatomic ion transport	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099106	Function	Ion channel regulator activity	IEA
GO:1903278	Process	Positive regulation of sodium ion export across plasma membrane	IBA

MIM	HGNC	e!Ensembl
606683	4030	ENSG00000137726

Protein

UniProt ID

Q9H0Q3

Protein name

FXYD domain-containing ion transport regulator 6 (Phosphohippolin)

Protein function

Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Reduces the apparent affinity for int

PDB

8D3U , 8D3V , 8D3W , 8D3X , 8D3Y

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02038	ATP1G1_PLM_MAT8	25 → 71	ATP1G1/PLM/MAT8 family	Family

Sequence

MELVLVFLCSLLAPMVLASAAEKEKEMDPFHYDYQTLRIGGLVFAVVLFSVGILLILSRR
CKCSFNQKPRAPGDEEAQVENLITANATEPQKAEN

Sequence length

Interactions

View interactions

	Reactome
			Ion homeostasis Ion transport by P-type ATPases

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alternating hemiplegia of childhood	Associate	29895895
Carcinoma Hepatocellular	Associate	36038676
Colorectal Neoplasms	Associate	23721165
Colorectal Neoplasms	Inhibit	34212047
Developmental Disabilities	Associate	29895895
Glioma	Inhibit	38093622
Neoplasm Metastasis	Associate	29364472
Neoplasms	Associate	32793117
Osteosarcoma	Associate	29364472
Thyroid Neoplasms	Associate	32793117

FXYD6 (FXYD domain containing ion transport regulator 6)