Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	53826
Gene name	FXYD domain containing ion transport regulator 6
Gene symbol	FXYD6
Synonyms (NCBI Gene)	-
Chromosome	11
Chromosome location	11q23.3
Summary	This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have b

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025043	hsa-miR-181a-5p	Microarray	17612493
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	27418678
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	27418678
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	27418678
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	27418678
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	27418678
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT1007512	hsa-miR-1183	CLIP-seq
MIRT1007513	hsa-miR-1909	CLIP-seq
MIRT1007514	hsa-miR-3199	CLIP-seq
MIRT1007515	hsa-miR-377	CLIP-seq
MIRT1007516	hsa-miR-4704-3p	CLIP-seq
MIRT1007517	hsa-miR-499-3p	CLIP-seq
MIRT1007518	hsa-miR-140-3p	CLIP-seq
MIRT1007519	hsa-miR-4766-3p	CLIP-seq
MIRT1007520	hsa-miR-548p	CLIP-seq
MIRT2232228	hsa-miR-1470	CLIP-seq
MIRT1007515	hsa-miR-377	CLIP-seq
MIRT2232229	hsa-miR-4287	CLIP-seq
MIRT2232230	hsa-miR-4469	CLIP-seq
MIRT2232231	hsa-miR-4667-3p	CLIP-seq
MIRT2232232	hsa-miR-4685-3p	CLIP-seq
MIRT1007516	hsa-miR-4704-3p	CLIP-seq
MIRT2232233	hsa-miR-4757-5p	CLIP-seq
MIRT1007517	hsa-miR-499-3p	CLIP-seq
MIRT2232234	hsa-miR-767-3p	CLIP-seq
MIRT1007515	hsa-miR-377	CLIP-seq
MIRT1007516	hsa-miR-4704-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	IEA
GO:0006814	Process	Sodium ion transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0017080	Function	Sodium channel regulator activity	IBA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0043269	Process	Regulation of monoatomic ion transport	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099106	Function	Ion channel regulator activity	IEA
GO:1903278	Process	Positive regulation of sodium ion export across plasma membrane	IBA

MIM	HGNC	e!Ensembl
606683	4030	ENSG00000137726

Q9H0Q3

Protein name

FXYD domain-containing ion transport regulator 6 (Phosphohippolin)

Protein function

Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Reduces the apparent affinity for int

PDB

8D3U , 8D3V , 8D3W , 8D3X , 8D3Y

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02038	ATP1G1_PLM_MAT8	25 → 71	ATP1G1/PLM/MAT8 family	Family

Sequence

MELVLVFLCSLLAPMVLASAAEKEKEMDPFHYDYQTLRIGGLVFAVVLFSVGILLILSRR
CKCSFNQKPRAPGDEEAQVENLITANATEPQKAEN

Sequence length

Interactions

View interactions

	Reactome
			Ion homeostasis Ion transport by P-type ATPases

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
LEUKEMIA, MYELOID, ACUTE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Alternating hemiplegia of childhood	Associate	29895895	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	36038676	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	23721165	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Inhibit	34212047	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Associate	29895895	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Inhibit	38093622	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	29364472	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	32793117	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Associate	29364472	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Associate	32793117	★★★★★ ★☆☆☆☆ Found in Text Mining only

FXYD6 (FXYD domain containing ion transport regulator 6)