Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	53826
Gene name Gene Name - the full gene name approved by the HGNC.	FXYD domain containing ion transport regulator 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FXYD6
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q23.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have b

Show/Hide all(99)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025043	hsa-miR-181a-5p	Microarray	17612493
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	27418678
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	27418678
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	27418678
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	27418678
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	27418678
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT609317	hsa-miR-8485	HITS-CLIP	23824327
MIRT609316	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609315	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609314	hsa-miR-3689d	HITS-CLIP	23824327
MIRT609313	hsa-miR-6851-5p	HITS-CLIP	23824327
MIRT609312	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT609311	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT1007512	hsa-miR-1183	CLIP-seq
MIRT1007513	hsa-miR-1909	CLIP-seq
MIRT1007514	hsa-miR-3199	CLIP-seq
MIRT1007515	hsa-miR-377	CLIP-seq
MIRT1007516	hsa-miR-4704-3p	CLIP-seq
MIRT1007517	hsa-miR-499-3p	CLIP-seq
MIRT1007518	hsa-miR-140-3p	CLIP-seq
MIRT1007519	hsa-miR-4766-3p	CLIP-seq
MIRT1007520	hsa-miR-548p	CLIP-seq
MIRT2232228	hsa-miR-1470	CLIP-seq
MIRT1007515	hsa-miR-377	CLIP-seq
MIRT2232229	hsa-miR-4287	CLIP-seq
MIRT2232230	hsa-miR-4469	CLIP-seq
MIRT2232231	hsa-miR-4667-3p	CLIP-seq
MIRT2232232	hsa-miR-4685-3p	CLIP-seq
MIRT1007516	hsa-miR-4704-3p	CLIP-seq
MIRT2232233	hsa-miR-4757-5p	CLIP-seq
MIRT1007517	hsa-miR-499-3p	CLIP-seq
MIRT2232234	hsa-miR-767-3p	CLIP-seq
MIRT1007515	hsa-miR-377	CLIP-seq
MIRT1007516	hsa-miR-4704-3p	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0008150	Process	Biological_process	ND
GO:0016021	Component	Integral component of membrane	IEA
GO:0017080	Function	Sodium channel regulator activity	IBA	21873635
GO:0034220	Process	Ion transmembrane transport	TAS
GO:0099106	Function	Ion channel regulator activity	IEA
GO:1903779	Process	Regulation of cardiac conduction	TAS
GO:2000649	Process	Regulation of sodium ion transmembrane transporter activity	IBA	21873635

MIM	HGNC	e!Ensembl
606683	4030	ENSG00000137726

Protein

UniProt ID

Q9H0Q3

Protein name

FXYD domain-containing ion transport regulator 6 (Phosphohippolin)

Protein function

Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Reduces the apparent affinity for int

PDB

8D3U , 8D3V , 8D3W , 8D3X , 8D3Y

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02038	ATP1G1_PLM_MAT8	25 → 71	ATP1G1/PLM/MAT8 family	Family

Sequence

MELVLVFLCSLLAPMVLASAAEKEKEMDPFHYDYQTLRIGGLVFAVVLFSVGILLILSRR
CKCSFNQKPRAPGDEEAQVENLITANATEPQKAEN

Sequence length

Interactions

View interactions

	Reactome
			Ion homeostasis Ion transport by P-type ATPases

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2)	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	17330099
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	18455306, 17357072, 20468077, 21216238, 20149392

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Diabetes	Diabetes			GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining
Alternating hemiplegia of childhood	Associate	29895895
Carcinoma Hepatocellular	Associate	36038676
Colorectal Neoplasms	Associate	23721165
Colorectal Neoplasms	Inhibit	34212047
Developmental Disabilities	Associate	29895895
Glioma	Inhibit	38093622
Neoplasm Metastasis	Associate	29364472
Neoplasms	Associate	32793117
Osteosarcoma	Associate	29364472
Thyroid Neoplasms	Associate	32793117

FXYD6 (FXYD domain containing ion transport regulator 6)