Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5364
Gene name Gene Name - the full gene name approved by the HGNC.	Plexin B1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PLXNB1
Synonyms (NCBI Gene) Gene synonyms aliases	PLEXIN-B1, PLXN5, SEP
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p21.31

Show/Hide all(35)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005765	hsa-miR-214-3p	GFP reporter assay, Immunohistochemistry, qRT-PCR, Western blot	21216304
MIRT005765	hsa-miR-214-3p	GFP reporter assay, Immunohistochemistry, qRT-PCR, Western blot	21216304
MIRT005765	hsa-miR-214-3p	Microarray;Other	19859982
MIRT1243801	hsa-miR-1193	CLIP-seq
MIRT1243802	hsa-miR-1265	CLIP-seq
MIRT1243803	hsa-miR-142-3p	CLIP-seq
MIRT1243804	hsa-miR-2392	CLIP-seq
MIRT1243805	hsa-miR-3135	CLIP-seq
MIRT1243806	hsa-miR-3183	CLIP-seq
MIRT1243807	hsa-miR-3667-3p	CLIP-seq
MIRT1243808	hsa-miR-3675-5p	CLIP-seq
MIRT1243809	hsa-miR-3677-5p	CLIP-seq
MIRT1243810	hsa-miR-3684	CLIP-seq
MIRT1243811	hsa-miR-4270	CLIP-seq
MIRT1243812	hsa-miR-4279	CLIP-seq
MIRT1243813	hsa-miR-4283	CLIP-seq
MIRT1243814	hsa-miR-4441	CLIP-seq
MIRT1243815	hsa-miR-4489	CLIP-seq
MIRT1243816	hsa-miR-4723-3p	CLIP-seq
MIRT1243802	hsa-miR-1265	CLIP-seq
MIRT1243817	hsa-miR-15a	CLIP-seq
MIRT1243818	hsa-miR-15b	CLIP-seq
MIRT1243819	hsa-miR-16	CLIP-seq
MIRT1243820	hsa-miR-195	CLIP-seq
MIRT1243804	hsa-miR-2392	CLIP-seq
MIRT1243821	hsa-miR-3688-5p	CLIP-seq
MIRT1243822	hsa-miR-3922-5p	CLIP-seq
MIRT1243823	hsa-miR-424	CLIP-seq
MIRT1243811	hsa-miR-4270	CLIP-seq
MIRT1243814	hsa-miR-4441	CLIP-seq
MIRT1243824	hsa-miR-4660	CLIP-seq
MIRT1243825	hsa-miR-4753-5p	CLIP-seq
MIRT1243826	hsa-miR-4764-5p	CLIP-seq
MIRT1243827	hsa-miR-497	CLIP-seq
MIRT1243828	hsa-miR-885-3p	CLIP-seq

Show/Hide all(38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002116	Component	Semaphorin receptor complex	IBA	21873635
GO:0002116	Component	Semaphorin receptor complex	IDA	19843518
GO:0002116	Component	Semaphorin receptor complex	TAS	19909241
GO:0004888	Function	Transmembrane signaling receptor activity	NAS	10520995
GO:0005096	Function	GTPase activator activity	TAS
GO:0005515	Function	Protein binding	IPI	12730235, 14732713, 15184888, 15218527, 19843518, 20877282, 22404908, 29040270
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	19843518
GO:0005887	Component	Integral component of plasma membrane	NAS	10520995
GO:0007162	Process	Negative regulation of cell adhesion	IBA	21873635
GO:0007162	Process	Negative regulation of cell adhesion	IDA	15218527
GO:0007165	Process	Signal transduction	TAS	8570614
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0008360	Process	Regulation of cell shape	IBA	21873635
GO:0008360	Process	Regulation of cell shape	IDA	19843518
GO:0014068	Process	Positive regulation of phosphatidylinositol 3-kinase signaling	ISS
GO:0016477	Process	Cell migration	NAS	10520995
GO:0017154	Function	Semaphorin receptor activity	IBA	21873635
GO:0017154	Function	Semaphorin receptor activity	IDA	19843518
GO:0017154	Function	Semaphorin receptor activity	TAS	10520995
GO:0030215	Function	Semaphorin receptor binding	TAS	10520995
GO:0030334	Process	Regulation of cell migration	IBA	21873635
GO:0032794	Function	GTPase activating protein binding	ISS
GO:0033689	Process	Negative regulation of osteoblast proliferation	ISS
GO:0035556	Process	Intracellular signal transduction	NAS	10520995
GO:0038023	Function	Signaling receptor activity	TAS	8570614
GO:0043087	Process	Regulation of GTPase activity	IBA	21873635
GO:0043547	Process	Positive regulation of GTPase activity	ISS
GO:0043931	Process	Ossification involved in bone maturation	ISS
GO:0048812	Process	Neuron projection morphogenesis	ISS
GO:0050772	Process	Positive regulation of axonogenesis	IBA	21873635
GO:0051493	Process	Regulation of cytoskeleton organization	IDA	19843518
GO:0071526	Process	Semaphorin-plexin signaling pathway	IDA	15218527, 19843518
GO:1900220	Process	Semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis	ISS
GO:1902287	Process	Semaphorin-plexin signaling pathway involved in axon guidance	IBA	21873635
GO:1904862	Process	Inhibitory synapse assembly	ISS

MIM	HGNC	e!Ensembl
601053	9103	ENSG00000164050

Protein

UniProt ID

O43157

Protein name

Plexin-B1 (Semaphorin receptor SEP)

Protein function

Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA ac

PDB

2JPH , 2OS6 , 2R2O , 2REX , 3HM6 , 3OL2 , 3SU8 , 3SUA , 5B4W , 7VF3 , 7VG7 , 8B3K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01403	Sema	37 → 460	Sema domain	Family
PF01437	PSI	481 → 534	Plexin repeat	Family
PF17960	TIG_plexin	540 → 627	TIG domain	Domain
PF18020	TIG_2	921 → 1020	TIG domain found in plexin	Domain
PF01833	TIG	1070 → 1159	IPT/TIG domain	Domain
PF01833	TIG	1162 → 1248	IPT/TIG domain	Domain
PF01833	TIG	1252 → 1374	IPT/TIG domain	Domain
PF08337	Plexin_cytopl	1562 → 2102	Plexin cytoplasmic RasGAP domain	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver. {ECO:0000269|PubMed:8570614}.

Sequence

MPALGPALLQALWAGWVLTLQPLPPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSP
GLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCE
QRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGG
IPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQ
SRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQAAAVATSREVAHGEVLFAAFSSA
APPTVGRPPSAAAGASGASALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAYIEYDV
NSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAF
LGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVA
SCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGPEQWLWSFQPELGCLQVAAMS
PANISREETREVFLSVPDLPPLWPGESYSCHFGEHQSPALLTGSGVMCPSPDPSEAPVLP
RGADYVSVSVELRFGAVVIAKTSLSFYDCVAVTELRPSAQCQACVSSRWGCNWCVWQHLC
THKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTAT
ASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRP
SATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPATVPATTFPGAMGSVKPALD
WLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQYDTPGL
WELEEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLE
VVVEARVECEPPPDTQCHVTCQQHQLSYEALQPELRVGLFLRRAGRLRVDSAEGLHVVLY
DCSVGHGDCSRCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTG
PVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVAGA
TAVEVPGRGRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVG
DQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRGQFKYTLDPNITSAGPT
KSFLSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRRRVVPETACSLGPSCSS
QQFEEPCHVNSSQLITCRTPALPGLPEDPWVRVEFILDNLVFDFATLNPTPFSYEADPTL
QPLNPEDPTMPFRHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPP
VEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLL
ALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLG
SGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFI
HTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTE
TVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLL
REDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDP
RTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRE
NQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLT
RLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNS
LPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYAR
DIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYD
QIITALEEDGTAQKMQLGYRLQQIAAAVENKVTDL

Sequence length

2135

Interactions

View interactions

	KEGG		Reactome
	Axon guidance		G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)
Neurodevelopmental disorders	Neurodevelopmental Disorders	rs869312846, rs869312840, rs869312848, rs869312849, rs869312845, rs886041956, rs1064795110, rs1555762734, rs1555764992, rs1568512728, rs1568532361, rs1595472741, rs1595472764, rs1595476797, rs1016320330, rs1595127294, rs1600392059 View all (2 more)	28191889

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Myocardial Infarction	Myocardial Infarction			GWAS

Show/Hide Text Mining Associations (32)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	29908079
Aortic Aneurysm Thoracic	Associate	31035427
Breast Neoplasms	Associate	18275816
Carcinoma Hepatocellular	Associate	17511039
Carcinoma Pancreatic Ductal	Associate	21812859
Cognition Disorders	Associate	29908079
Colitis Ulcerative	Stimulate	39596507
Colorectal Neoplasms	Associate	27456345
Coronary Artery Disease	Associate	33381571
Head and Neck Neoplasms	Associate	24114199
Hereditary Breast and Ovarian Cancer Syndrome	Associate	19940359
Inflammation	Associate	33381571
Insulin Resistance	Associate	34670012
Leukemia Lymphocytic Chronic B Cell	Associate	15613544
Leukemia Myeloid Acute	Associate	38186215
Lung Neoplasms	Associate	37901456
Lymphatic Metastasis	Associate	21059203, 21812859, 27456345
Lymphoma	Associate	37406814
Lymphoma Primary Effusion	Associate	28407694
Melanoma	Associate	20164843
Melanoma	Inhibit	22189792
Mucocutaneous Lymph Node Syndrome	Stimulate	33381571
Neoplasm Invasiveness	Associate	27456345
Neoplasm Metastasis	Inhibit	20164843
Neoplasm Metastasis	Associate	21812859
Neoplasms	Associate	18024597, 18275816, 21059203, 22476930, 27456345, 31861264, 34535749
Neoplasms	Inhibit	20164843, 22189792
Osteosarcoma	Associate	34854398
Ovarian Neoplasms	Associate	21059203, 28893231
Pancreatic Neoplasms	Associate	21812859
Prostatic Neoplasms	Associate	18024597, 31861264, 37563360
Reperfusion Injury	Inhibit	32977749

PLXNB1 (plexin B1)