Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5364
Gene name	Plexin B1
Gene symbol	PLXNB1
Synonyms (NCBI Gene)	PLEXIN-B1PLXN5SEP
Chromosome	3
Chromosome location	3p21.31

Show/Hide all (35)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005765	hsa-miR-214-3p	GFP reporter assayImmunohistochemistryqRT-PCRWestern blot	21216304
MIRT005765	hsa-miR-214-3p	GFP reporter assayImmunohistochemistryqRT-PCRWestern blot	21216304
MIRT005765	hsa-miR-214-3p	Microarray;Other	19859982
MIRT1243801	hsa-miR-1193	CLIP-seq
MIRT1243802	hsa-miR-1265	CLIP-seq
MIRT1243803	hsa-miR-142-3p	CLIP-seq
MIRT1243804	hsa-miR-2392	CLIP-seq
MIRT1243805	hsa-miR-3135	CLIP-seq
MIRT1243806	hsa-miR-3183	CLIP-seq
MIRT1243807	hsa-miR-3667-3p	CLIP-seq
MIRT1243808	hsa-miR-3675-5p	CLIP-seq
MIRT1243809	hsa-miR-3677-5p	CLIP-seq
MIRT1243810	hsa-miR-3684	CLIP-seq
MIRT1243811	hsa-miR-4270	CLIP-seq
MIRT1243812	hsa-miR-4279	CLIP-seq
MIRT1243813	hsa-miR-4283	CLIP-seq
MIRT1243814	hsa-miR-4441	CLIP-seq
MIRT1243815	hsa-miR-4489	CLIP-seq
MIRT1243816	hsa-miR-4723-3p	CLIP-seq
MIRT1243802	hsa-miR-1265	CLIP-seq
MIRT1243817	hsa-miR-15a	CLIP-seq
MIRT1243818	hsa-miR-15b	CLIP-seq
MIRT1243819	hsa-miR-16	CLIP-seq
MIRT1243820	hsa-miR-195	CLIP-seq
MIRT1243804	hsa-miR-2392	CLIP-seq
MIRT1243821	hsa-miR-3688-5p	CLIP-seq
MIRT1243822	hsa-miR-3922-5p	CLIP-seq
MIRT1243823	hsa-miR-424	CLIP-seq
MIRT1243811	hsa-miR-4270	CLIP-seq
MIRT1243814	hsa-miR-4441	CLIP-seq
MIRT1243824	hsa-miR-4660	CLIP-seq
MIRT1243825	hsa-miR-4753-5p	CLIP-seq
MIRT1243826	hsa-miR-4764-5p	CLIP-seq
MIRT1243827	hsa-miR-497	CLIP-seq
MIRT1243828	hsa-miR-885-3p	CLIP-seq

Show/Hide all (55)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002116	Component	Semaphorin receptor complex	IBA
GO:0002116	Component	Semaphorin receptor complex	IDA	19843518
GO:0002116	Component	Semaphorin receptor complex	IEA
GO:0002116	Component	Semaphorin receptor complex	ISS
GO:0002116	Component	Semaphorin receptor complex	TAS	19909241
GO:0004888	Function	Transmembrane signaling receptor activity	NAS	10520995
GO:0005096	Function	GTPase activator activity	TAS
GO:0005515	Function	Protein binding	IPI	12730235, 14732713, 15184888, 15218527, 19843518, 20877282, 22404908, 25531777, 29040270
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	19843518
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	10520995
GO:0005886	Component	Plasma membrane	TAS
GO:0007162	Process	Negative regulation of cell adhesion	IBA
GO:0007162	Process	Negative regulation of cell adhesion	IDA	15218527
GO:0007162	Process	Negative regulation of cell adhesion	IEA
GO:0007416	Process	Synapse assembly	IBA
GO:0008360	Process	Regulation of cell shape	IBA
GO:0008360	Process	Regulation of cell shape	IDA	19843518
GO:0008360	Process	Regulation of cell shape	IEA
GO:0016020	Component	Membrane	IEA
GO:0016477	Process	Cell migration	NAS	10520995
GO:0017154	Function	Semaphorin receptor activity	IBA
GO:0017154	Function	Semaphorin receptor activity	IDA	19843518
GO:0017154	Function	Semaphorin receptor activity	IEA
GO:0017154	Function	Semaphorin receptor activity	ISS
GO:0017154	Function	Semaphorin receptor activity	TAS	10520995
GO:0030215	Function	Semaphorin receptor binding	TAS	10520995
GO:0030334	Process	Regulation of cell migration	IBA
GO:0032794	Function	GTPase activating protein binding	IEA
GO:0032794	Function	GTPase activating protein binding	ISS
GO:0033689	Process	Negative regulation of osteoblast proliferation	IEA
GO:0033689	Process	Negative regulation of osteoblast proliferation	ISS
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IEA
GO:0035025	Process	Positive regulation of Rho protein signal transduction	ISS
GO:0035556	Process	Intracellular signal transduction	NAS	10520995
GO:0043547	Process	Positive regulation of GTPase activity	ISS
GO:0043931	Process	Ossification involved in bone maturation	IEA
GO:0043931	Process	Ossification involved in bone maturation	ISS
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0048812	Process	Neuron projection morphogenesis	IEA
GO:0048812	Process	Neuron projection morphogenesis	ISS
GO:0050772	Process	Positive regulation of axonogenesis	IBA
GO:0050772	Process	Positive regulation of axonogenesis	IEA
GO:0051493	Process	Regulation of cytoskeleton organization	IDA	19843518
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IDA	15218527, 19843518
GO:0071526	Process	Semaphorin-plexin signaling pathway	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	ISS
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1904862	Process	Inhibitory synapse assembly	IEA
GO:1904862	Process	Inhibitory synapse assembly	ISS

MIM	HGNC	e!Ensembl
601053	9103	ENSG00000164050

O43157

Protein name

Plexin-B1 (Semaphorin receptor SEP)

Protein function

Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA ac

PDB

2JPH , 2OS6 , 2R2O , 2REX , 3HM6 , 3OL2 , 3SU8 , 3SUA , 5B4W , 7VF3 , 7VG7 , 8B3K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01403	Sema	37 → 460	Sema domain	Family
PF01437	PSI	481 → 534	Plexin repeat	Family
PF17960	TIG_plexin	540 → 627	TIG domain	Domain
PF18020	TIG_2	921 → 1020	TIG domain found in plexin	Domain
PF01833	TIG	1070 → 1159	IPT/TIG domain	Domain
PF01833	TIG	1162 → 1248	IPT/TIG domain	Domain
PF01833	TIG	1252 → 1374	IPT/TIG domain	Domain
PF08337	Plexin_cytopl	1562 → 2102	Plexin cytoplasmic RasGAP domain	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver. {ECO:0000269|PubMed:8570614}.

Sequence

MPALGPALLQALWAGWVLTLQPLPPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSP
GLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCE
QRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGG
IPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQ
SRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQAAAVATSREVAHGEVLFAAFSSA
APPTVGRPPSAAAGASGASALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAYIEYDV
NSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAF
LGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVA
SCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGPEQWLWSFQPELGCLQVAAMS
PANISREETREVFLSVPDLPPLWPGESYSCHFGEHQSPALLTGSGVMCPSPDPSEAPVLP
RGADYVSVSVELRFGAVVIAKTSLSFYDCVAVTELRPSAQCQACVSSRWGCNWCVWQHLC
THKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTAT
ASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRP
SATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPATVPATTFPGAMGSVKPALD
WLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQYDTPGL
WELEEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLE
VVVEARVECEPPPDTQCHVTCQQHQLSYEALQPELRVGLFLRRAGRLRVDSAEGLHVVLY
DCSVGHGDCSRCQTAMPQYGCVWCEGERPRCVTREACGEAEAVATQCPAPLIHSVEPLTG
PVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVAGA
TAVEVPGRGRGVSEHDFAYQDPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVG
DQPCHLLPEQQSEQLRCETSPRPTPATLPVAVWFGATERRLQRGQFKYTLDPNITSAGPT
KSFLSGGREICVRGQNLDVVQTPRIRVTVVSRMLQPSQGLGRRRRVVPETACSLGPSCSS
QQFEEPCHVNSSQLITCRTPALPGLPEDPWVRVEFILDNLVFDFATLNPTPFSYEADPTL
QPLNPEDPTMPFRHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPP
VEQPLPRHHALREAPDSLPEFTVQMGNLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLL
ALGVIIIVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLG
SGIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFI
HTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTE
TVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLL
REDVEYRPLTLNALLAVGPGAGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDP
RTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPCLTKHVLRE
NQDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLT
RLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNS
LPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYAR
DIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYD
QIITALEEDGTAQKMQLGYRLQQIAAAVENKVTDL

Sequence length

2135

Interactions

View interactions

	KEGG		Reactome
	Axon guidance		G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs767726203	RCV004557894
Gastric cancer	Benign	rs141235519	RCV005907392
Hepatocellular carcinoma	Benign	rs61729215	RCV005913356
PLXNB1-related disorder	Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign	rs2038207611, rs571547770, rs1479550150, rs764270397, rs963461084, rs188697214, rs2529720342, rs35741089, rs146977900, rs61729217, rs984282538, rs61729213, rs112016313, rs377100211, rs200565688 View all (35 more)	RCV003397694 RCV003417029 RCV003405940 RCV003421186 RCV003400038 RCV003422497 RCV003397787 RCV003907030 RCV003921416 RCV003907305 RCV003924138 RCV003917289 RCV003931892 RCV003981707 RCV003974147 RCV003964517 RCV003974243 RCV003974271 RCV003897396 RCV003967321 RCV003944549 RCV003961607 RCV003919471 RCV003924546 RCV003924582 RCV003951688 RCV003931406 RCV003937010 RCV003956962 RCV003957049 RCV003944784 RCV003922086 RCV003932141 RCV003934199 RCV003959446 RCV003972310 RCV003969225 RCV004731591 RCV003903163 RCV003970702 RCV003970703 RCV003933243 RCV003905915 RCV003905916 RCV003970854 RCV003953336 RCV003920614 RCV003930620 RCV003920597 RCV003940500 RCV003940775
Sarcoma	Benign	rs141235519	RCV005907391
Thymoma	Benign	rs141235519	RCV005907393
Thyroid cancer, nonmedullary, 1	Likely benign	rs142945989	RCV005939404

Show/Hide Text Mining Associations (32)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	29908079
Aortic Aneurysm Thoracic	Associate	31035427
Breast Neoplasms	Associate	18275816
Carcinoma Hepatocellular	Associate	17511039
Carcinoma Pancreatic Ductal	Associate	21812859
Cognition Disorders	Associate	29908079
Colitis Ulcerative	Stimulate	39596507
Colorectal Neoplasms	Associate	27456345
Coronary Artery Disease	Associate	33381571
Head and Neck Neoplasms	Associate	24114199
Hereditary Breast and Ovarian Cancer Syndrome	Associate	19940359
Inflammation	Associate	33381571
Insulin Resistance	Associate	34670012
Leukemia Lymphocytic Chronic B Cell	Associate	15613544
Leukemia Myeloid Acute	Associate	38186215
Lung Neoplasms	Associate	37901456
Lymphatic Metastasis	Associate	21059203, 21812859, 27456345
Lymphoma	Associate	37406814
Lymphoma Primary Effusion	Associate	28407694
Melanoma	Associate	20164843
Melanoma	Inhibit	22189792
Mucocutaneous Lymph Node Syndrome	Stimulate	33381571
Neoplasm Invasiveness	Associate	27456345
Neoplasm Metastasis	Inhibit	20164843
Neoplasm Metastasis	Associate	21812859
Neoplasms	Associate	18024597, 18275816, 21059203, 22476930, 27456345, 31861264, 34535749
Neoplasms	Inhibit	20164843, 22189792
Osteosarcoma	Associate	34854398
Ovarian Neoplasms	Associate	21059203, 28893231
Pancreatic Neoplasms	Associate	21812859
Prostatic Neoplasms	Associate	18024597, 31861264, 37563360
Reperfusion Injury	Inhibit	32977749

PLXNB1 (plexin B1)