Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
53635
Gene name Gene Name - the full gene name approved by the HGNC.
PTOV1 extended AT-hook containing adaptor protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PTOV1
Synonyms (NCBI Gene) Gene synonyms aliases
ACID2, PTOV-1
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.33
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT045949 hsa-miR-125b-5p CLASH 23622248
MIRT044008 hsa-miR-378a-5p CLASH 23622248
MIRT1273766 hsa-miR-1288 CLIP-seq
MIRT1273767 hsa-miR-3144-5p CLIP-seq
MIRT1273768 hsa-miR-3189-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005654 Component Nucleoplasm IDA
GO:0005667 Component Transcription regulator complex IBA 21873635
GO:0005886 Component Plasma membrane IEA
GO:0045944 Process Positive regulation of transcription by RNA polymerase II IBA 21873635
GO:0048471 Component Perinuclear region of cytoplasm IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610195 9632 ENSG00000104960
Protein
UniProt ID Q86YD1
Protein name Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2)
Protein function May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF11232 Med25 89 238 Mediator complex subunit 25 PTOV activation and synapsin 2 Domain
PF11232 Med25 254 399 Mediator complex subunit 25 PTOV activation and synapsin 2 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in brain, heart, kidney, liver, placenta, skeletal muscle and small intestine. {ECO:0000269|PubMed:11313889}.
Sequence
Sequence length 416
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
21364753
Associations from Text Mining
Disease Name Relationship Type References
Atrophy Associate 22507319
Breast Neoplasms Associate 24947166, 34131286
Carcinogenesis Associate 28651486
Carcinoma Hepatocellular Associate 25634174
Carcinoma Ovarian Epithelial Associate 25270739
Diabetes Mellitus Type 2 Associate 40141237
Esophageal Squamous Cell Carcinoma Associate 28651486
Lymphatic Metastasis Associate 26305455
Nasopharyngeal Carcinoma Associate 26305455
Neoplasms Associate 24947166, 25270739, 26305455, 26992242, 28651486, 34440306, 34654719, 34918668