Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5362
Gene name Gene Name - the full gene name approved by the HGNC.	Plexin A2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PLXNA2
Synonyms (NCBI Gene) Gene synonyms aliases	OCT, PLXN2
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q32.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphori

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1553277591	C>T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023176	hsa-miR-124-3p	Microarray	18668037
MIRT030349	hsa-miR-26b-5p	Microarray	19088304
MIRT722530	hsa-miR-4717-3p	HITS-CLIP	19536157
MIRT722529	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT722528	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT722527	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT722526	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT722525	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT722524	hsa-miR-1976	HITS-CLIP	19536157
MIRT722523	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT722522	hsa-miR-204-3p	HITS-CLIP	19536157
MIRT722521	hsa-miR-4646-5p	HITS-CLIP	19536157
MIRT722520	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT722519	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT722518	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT535119	hsa-miR-103b	PAR-CLIP	22012620
MIRT535117	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT535115	hsa-miR-3663-5p	PAR-CLIP	22012620
MIRT535116	hsa-miR-6131	PAR-CLIP	22012620
MIRT535114	hsa-miR-601	PAR-CLIP	22012620
MIRT535113	hsa-miR-7977	PAR-CLIP	22012620
MIRT443379	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT443378	hsa-miR-6758-5p	PAR-CLIP	22100165
MIRT443377	hsa-miR-6856-5p	PAR-CLIP	22100165
MIRT443376	hsa-miR-6760-5p	PAR-CLIP	22100165
MIRT443374	hsa-miR-4270	PAR-CLIP	22100165
MIRT443375	hsa-miR-4441	PAR-CLIP	22100165
MIRT443373	hsa-miR-6754-5p	PAR-CLIP	22100165
MIRT443372	hsa-miR-1253	PAR-CLIP	22100165
MIRT443371	hsa-miR-5189-3p	PAR-CLIP	22100165
MIRT443370	hsa-miR-4434	PAR-CLIP	22100165
MIRT443369	hsa-miR-4516	PAR-CLIP	22100165
MIRT443368	hsa-miR-5703	PAR-CLIP	22100165
MIRT443367	hsa-miR-6878-5p	PAR-CLIP	22100165
MIRT443366	hsa-miR-3202	PAR-CLIP	22100165
MIRT722530	hsa-miR-4717-3p	HITS-CLIP	19536157
MIRT722529	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT722528	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT722527	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT722526	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT722525	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT722524	hsa-miR-1976	HITS-CLIP	19536157
MIRT722523	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT722522	hsa-miR-204-3p	HITS-CLIP	19536157
MIRT722521	hsa-miR-4646-5p	HITS-CLIP	19536157
MIRT722520	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT722519	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT722518	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT535119	hsa-miR-103b	PAR-CLIP	22012620
MIRT535117	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT535115	hsa-miR-3663-5p	PAR-CLIP	22012620
MIRT535116	hsa-miR-6131	PAR-CLIP	22012620
MIRT535114	hsa-miR-601	PAR-CLIP	22012620
MIRT535113	hsa-miR-7977	PAR-CLIP	22012620
MIRT443379	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT443378	hsa-miR-6758-5p	PAR-CLIP	22100165
MIRT443377	hsa-miR-6856-5p	PAR-CLIP	22100165
MIRT443376	hsa-miR-6760-5p	PAR-CLIP	22100165
MIRT443374	hsa-miR-4270	PAR-CLIP	22100165
MIRT443375	hsa-miR-4441	PAR-CLIP	22100165
MIRT443373	hsa-miR-6754-5p	PAR-CLIP	22100165
MIRT443372	hsa-miR-1253	PAR-CLIP	22100165
MIRT443371	hsa-miR-5189-3p	PAR-CLIP	22100165
MIRT443370	hsa-miR-4434	PAR-CLIP	22100165
MIRT443369	hsa-miR-4516	PAR-CLIP	22100165
MIRT443368	hsa-miR-5703	PAR-CLIP	22100165
MIRT443367	hsa-miR-6878-5p	PAR-CLIP	22100165
MIRT443366	hsa-miR-3202	PAR-CLIP	22100165
MIRT1243605	hsa-miR-1207-3p	CLIP-seq
MIRT1243606	hsa-miR-1252	CLIP-seq
MIRT1243607	hsa-miR-1254	CLIP-seq
MIRT1243608	hsa-miR-15a	CLIP-seq
MIRT1243609	hsa-miR-15b	CLIP-seq
MIRT1243610	hsa-miR-16	CLIP-seq
MIRT1243611	hsa-miR-1825	CLIP-seq
MIRT1243612	hsa-miR-1827	CLIP-seq
MIRT1243613	hsa-miR-1909	CLIP-seq
MIRT1243614	hsa-miR-195	CLIP-seq
MIRT1243615	hsa-miR-199a-5p	CLIP-seq
MIRT1243616	hsa-miR-199b-5p	CLIP-seq
MIRT1243617	hsa-miR-204	CLIP-seq
MIRT1243618	hsa-miR-211	CLIP-seq
MIRT1243619	hsa-miR-214	CLIP-seq
MIRT1243620	hsa-miR-2355-3p	CLIP-seq
MIRT1243621	hsa-miR-299-3p	CLIP-seq
MIRT1243622	hsa-miR-3116	CLIP-seq
MIRT1243623	hsa-miR-3159	CLIP-seq
MIRT1243624	hsa-miR-33a	CLIP-seq
MIRT1243625	hsa-miR-33b	CLIP-seq
MIRT1243626	hsa-miR-3611	CLIP-seq
MIRT1243627	hsa-miR-3612	CLIP-seq
MIRT1243628	hsa-miR-3619-5p	CLIP-seq
MIRT1243629	hsa-miR-3689a-3p	CLIP-seq
MIRT1243630	hsa-miR-3689c	CLIP-seq
MIRT1243631	hsa-miR-3690	CLIP-seq
MIRT1243632	hsa-miR-3911	CLIP-seq
MIRT1243633	hsa-miR-3919	CLIP-seq
MIRT1243634	hsa-miR-3928	CLIP-seq
MIRT1243635	hsa-miR-3974	CLIP-seq
MIRT1243636	hsa-miR-424	CLIP-seq
MIRT1243637	hsa-miR-4267	CLIP-seq
MIRT1243638	hsa-miR-4326	CLIP-seq
MIRT1243639	hsa-miR-4436b-3p	CLIP-seq
MIRT1243640	hsa-miR-4436b-5p	CLIP-seq
MIRT1243641	hsa-miR-4446-5p	CLIP-seq
MIRT1243642	hsa-miR-4473	CLIP-seq
MIRT1243643	hsa-miR-4476	CLIP-seq
MIRT1243644	hsa-miR-4477b	CLIP-seq
MIRT1243645	hsa-miR-4539	CLIP-seq
MIRT1243646	hsa-miR-4638-3p	CLIP-seq
MIRT1243647	hsa-miR-4640-5p	CLIP-seq
MIRT1243648	hsa-miR-4648	CLIP-seq
MIRT1243649	hsa-miR-4654	CLIP-seq
MIRT1243650	hsa-miR-4671-3p	CLIP-seq
MIRT1243651	hsa-miR-4677-3p	CLIP-seq
MIRT1243652	hsa-miR-4679	CLIP-seq
MIRT1243653	hsa-miR-4698	CLIP-seq
MIRT1243654	hsa-miR-4726-5p	CLIP-seq
MIRT1243655	hsa-miR-4728-5p	CLIP-seq
MIRT1243656	hsa-miR-4755-5p	CLIP-seq
MIRT1243657	hsa-miR-4760-3p	CLIP-seq
MIRT1243658	hsa-miR-4769-5p	CLIP-seq
MIRT1243659	hsa-miR-4786-3p	CLIP-seq
MIRT1243660	hsa-miR-4793-5p	CLIP-seq
MIRT1243661	hsa-miR-497	CLIP-seq
MIRT1243662	hsa-miR-5095	CLIP-seq
MIRT1243663	hsa-miR-541	CLIP-seq
MIRT1243664	hsa-miR-548ag	CLIP-seq
MIRT1243665	hsa-miR-548ai	CLIP-seq
MIRT1243666	hsa-miR-552	CLIP-seq
MIRT1243667	hsa-miR-579	CLIP-seq
MIRT1243668	hsa-miR-623	CLIP-seq
MIRT1243669	hsa-miR-650	CLIP-seq
MIRT1243670	hsa-miR-651	CLIP-seq
MIRT1243671	hsa-miR-653	CLIP-seq
MIRT1243672	hsa-miR-654-5p	CLIP-seq
MIRT1243673	hsa-miR-676	CLIP-seq
MIRT1243674	hsa-miR-761	CLIP-seq
MIRT1243675	hsa-miR-765	CLIP-seq
MIRT2071999	hsa-miR-1273e	CLIP-seq
MIRT2072000	hsa-miR-1297	CLIP-seq
MIRT2072001	hsa-miR-137	CLIP-seq
MIRT1243608	hsa-miR-15a	CLIP-seq
MIRT1243609	hsa-miR-15b	CLIP-seq
MIRT1243610	hsa-miR-16	CLIP-seq
MIRT2072002	hsa-miR-185	CLIP-seq
MIRT1243614	hsa-miR-195	CLIP-seq
MIRT2072003	hsa-miR-203	CLIP-seq
MIRT2072004	hsa-miR-2355-5p	CLIP-seq
MIRT2072005	hsa-miR-26a	CLIP-seq
MIRT2072006	hsa-miR-26b	CLIP-seq
MIRT2072007	hsa-miR-298	CLIP-seq
MIRT2072008	hsa-miR-3614-5p	CLIP-seq
MIRT2072009	hsa-miR-3679-3p	CLIP-seq
MIRT1243636	hsa-miR-424	CLIP-seq
MIRT2072010	hsa-miR-4306	CLIP-seq
MIRT2072011	hsa-miR-4327	CLIP-seq
MIRT2072012	hsa-miR-4465	CLIP-seq
MIRT2072013	hsa-miR-4480	CLIP-seq
MIRT2072014	hsa-miR-4644	CLIP-seq
MIRT2072015	hsa-miR-4680-5p	CLIP-seq
MIRT2072016	hsa-miR-4718	CLIP-seq
MIRT1243661	hsa-miR-497	CLIP-seq
MIRT2299023	hsa-let-7a	CLIP-seq
MIRT2299024	hsa-let-7b	CLIP-seq
MIRT2299025	hsa-let-7c	CLIP-seq
MIRT2299026	hsa-let-7d	CLIP-seq
MIRT2299027	hsa-let-7e	CLIP-seq
MIRT2299028	hsa-let-7f	CLIP-seq
MIRT2299029	hsa-let-7g	CLIP-seq
MIRT2299030	hsa-let-7i	CLIP-seq
MIRT1243605	hsa-miR-1207-3p	CLIP-seq
MIRT2299031	hsa-miR-1233	CLIP-seq
MIRT2299032	hsa-miR-1236	CLIP-seq
MIRT1243606	hsa-miR-1252	CLIP-seq
MIRT1243607	hsa-miR-1254	CLIP-seq
MIRT1243608	hsa-miR-15a	CLIP-seq
MIRT1243609	hsa-miR-15b	CLIP-seq
MIRT1243610	hsa-miR-16	CLIP-seq
MIRT1243611	hsa-miR-1825	CLIP-seq
MIRT1243612	hsa-miR-1827	CLIP-seq
MIRT2072002	hsa-miR-185	CLIP-seq
MIRT2299033	hsa-miR-1915	CLIP-seq
MIRT1243614	hsa-miR-195	CLIP-seq
MIRT1243615	hsa-miR-199a-5p	CLIP-seq
MIRT1243616	hsa-miR-199b-5p	CLIP-seq
MIRT1243619	hsa-miR-214	CLIP-seq
MIRT1243620	hsa-miR-2355-3p	CLIP-seq
MIRT2072004	hsa-miR-2355-5p	CLIP-seq
MIRT2299034	hsa-miR-2392	CLIP-seq
MIRT2072007	hsa-miR-298	CLIP-seq
MIRT2299035	hsa-miR-299-5p	CLIP-seq
MIRT1243622	hsa-miR-3116	CLIP-seq
MIRT2299036	hsa-miR-3173-5p	CLIP-seq
MIRT1243628	hsa-miR-3619-5p	CLIP-seq
MIRT2299037	hsa-miR-3622a-3p	CLIP-seq
MIRT2299038	hsa-miR-3622b-3p	CLIP-seq
MIRT2299039	hsa-miR-3667-3p	CLIP-seq
MIRT2299040	hsa-miR-3678-3p	CLIP-seq
MIRT2072009	hsa-miR-3679-3p	CLIP-seq
MIRT2299041	hsa-miR-3689d	CLIP-seq
MIRT2299042	hsa-miR-370	CLIP-seq
MIRT2299043	hsa-miR-3909	CLIP-seq
MIRT2299044	hsa-miR-3925-3p	CLIP-seq
MIRT2299045	hsa-miR-3978	CLIP-seq
MIRT1243636	hsa-miR-424	CLIP-seq
MIRT2072010	hsa-miR-4306	CLIP-seq
MIRT2299046	hsa-miR-432	CLIP-seq
MIRT2072011	hsa-miR-4327	CLIP-seq
MIRT2299047	hsa-miR-4329	CLIP-seq
MIRT2299048	hsa-miR-4422	CLIP-seq
MIRT1243640	hsa-miR-4436b-5p	CLIP-seq
MIRT2299049	hsa-miR-4443	CLIP-seq
MIRT1243641	hsa-miR-4446-5p	CLIP-seq
MIRT2299050	hsa-miR-4458	CLIP-seq
MIRT2299051	hsa-miR-4500	CLIP-seq
MIRT1243647	hsa-miR-4640-5p	CLIP-seq
MIRT2072014	hsa-miR-4644	CLIP-seq
MIRT2299052	hsa-miR-4699-3p	CLIP-seq
MIRT1243654	hsa-miR-4726-5p	CLIP-seq
MIRT2299053	hsa-miR-4773	CLIP-seq
MIRT1243661	hsa-miR-497	CLIP-seq
MIRT2299054	hsa-miR-508-5p	CLIP-seq
MIRT2299055	hsa-miR-512-3p	CLIP-seq
MIRT2299056	hsa-miR-550a	CLIP-seq
MIRT2299057	hsa-miR-564	CLIP-seq
MIRT2299058	hsa-miR-615-5p	CLIP-seq
MIRT2299059	hsa-miR-661	CLIP-seq
MIRT1243673	hsa-miR-676	CLIP-seq
MIRT1243674	hsa-miR-761	CLIP-seq
MIRT2299060	hsa-miR-890	CLIP-seq
MIRT2299061	hsa-miR-922	CLIP-seq
MIRT2299062	hsa-miR-98	CLIP-seq
MIRT2299032	hsa-miR-1236	CLIP-seq
MIRT2299033	hsa-miR-1915	CLIP-seq
MIRT2392713	hsa-miR-3064-5p	CLIP-seq
MIRT2072008	hsa-miR-3614-5p	CLIP-seq
MIRT2392714	hsa-miR-423-3p	CLIP-seq
MIRT2299048	hsa-miR-4422	CLIP-seq
MIRT2299049	hsa-miR-4443	CLIP-seq
MIRT2392715	hsa-miR-4487	CLIP-seq
MIRT2392716	hsa-miR-4633-3p	CLIP-seq
MIRT2392717	hsa-miR-4726-3p	CLIP-seq
MIRT2392718	hsa-miR-604	CLIP-seq
MIRT2392719	hsa-miR-642a	CLIP-seq
MIRT2392720	hsa-miR-647	CLIP-seq
MIRT2299060	hsa-miR-890	CLIP-seq
MIRT2595949	hsa-miR-4713-5p	CLIP-seq
MIRT2595950	hsa-miR-548b-3p	CLIP-seq
MIRT2595949	hsa-miR-4713-5p	CLIP-seq
MIRT2595950	hsa-miR-548b-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001756	Process	Somitogenesis	IEA
GO:0002116	Component	Semaphorin receptor complex	IBA
GO:0002116	Component	Semaphorin receptor complex	TAS	19909241
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	12372285
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0007416	Process	Synapse assembly	IBA
GO:0009653	Process	Anatomical structure morphogenesis	IEA
GO:0016020	Component	Membrane	IEA
GO:0017154	Function	Semaphorin receptor activity	IBA
GO:0017154	Function	Semaphorin receptor activity	IEA
GO:0017154	Function	Semaphorin receptor activity	ISS
GO:0021915	Process	Neural tube development	IEA
GO:0021935	Process	Cerebellar granule cell precursor tangential migration	IEA
GO:0030334	Process	Regulation of cell migration	IBA
GO:0030334	Process	Regulation of cell migration	IEA
GO:0030334	Process	Regulation of cell migration	ISS
GO:0035295	Process	Tube development	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0048513	Process	Animal organ development	IEA
GO:0051642	Process	Centrosome localization	IEA
GO:0060037	Process	Pharyngeal system development	IEA
GO:0060174	Process	Limb bud formation	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	ISS

MIM	HGNC	e!Ensembl
601054	9100	ENSG00000076356

Protein

UniProt ID

O75051

Protein name

Plexin-A2 (Semaphorin receptor OCT)

Protein function

Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex c

PDB

3Q3J

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01403	Sema	52 → 489	Sema domain	Family
PF01437	PSI	510 → 560	Plexin repeat	Family
PF17960	TIG_plexin	565 → 654	TIG domain	Domain
PF18020	TIG_2	708 → 802	TIG domain found in plexin	Domain
PF01437	PSI	803 → 856	Plexin repeat	Family
PF01833	TIG	858 → 951	IPT/TIG domain	Domain
PF01833	TIG	954 → 1037	IPT/TIG domain	Domain
PF01833	TIG	1041 → 1139	IPT/TIG domain	Domain
PF01833	TIG	1143 → 1228	IPT/TIG domain	Domain
PF08337	Plexin_cytopl	1311 → 1864	Plexin cytoplasmic RasGAP domain	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in fetal brain. {ECO:0000269|PubMed:8570614}.

Sequence

MEQRRPWPRALEVDSRSVVLLSVVWVLLAPPAAGMPQFSTFHSENRDWTFNHLTVHQGTG
AVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTNNVNKLLIID
YSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDG
KLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFD
IFYIYGFASGGFVYFLTVQPETPEGVAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGC
TRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQKQYHHPPDDSALCAFPI
RAINLQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVE
GLTLYTTSRDRMTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVLKDGS
PILRDMAFSIDQRYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRR
DKCQQAWEPNRFAASISQCVSLAVHPSSISVSEHSRLLSLVVSDAPDLSAGIACAFGNLT
EVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQ
LCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINISEDCPQLVPTEEILIPVGEVKPI
TLKARNLPQPQSGQRGYECVLNIQGAIHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVD
FAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADRKFECGWCSGERRCTLHQHCTS
PSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVP
CTPLPGEYIIAEQIVCEMGHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLN
PIRGPESGGTMVTITGHYLGAGSSVAVYLGNQTCEFYGRSMSEIVCVSPPSSNGLGPVPV
SVSVDRAHVDSNLQFEYIDDPRVQRIEPEWSIASGHTPLTITGFNLDVIQEPRIRVKFNG
KESVNVCKVVNTTTLTCLAPSLTTDYRPGLDTVERPDEFGFVFNNVQSLLIYNDTKFIYY
PNPTFELLSPTGVLDQKPGSPIILKGKNLCPPASGGAKLNYTVLIGETPCAVTVSETQLL
CEPPNLTGQHKVMVHVGGMVFSPGSVSVISDSLLTLPAIVSIAAGGSLLLIIVIIVLIAY
KRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTY
AMRVLFPGIEDHPVLRELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSM
RDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTN
WFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTL
ILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRI
ARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISR
YDSSFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYLTR
LLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKS
NCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLY
AKDIPSYKSWVERYYADIAKLPAISDQDMNAYLAEQSRLHAVEFNMLSALNEIYSYVSKY
SEELIGALEQDEQARRQRLAYKVEQLINAMSIES

Sequence length

1894

Interactions

View interactions

	KEGG		Reactome
	Axon guidance		Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling

Show/Hide Unknown Diseases (5)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Inflammatory Bowel Disease	Inflammatory bowel disease	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Neurodevelopmental Disorders	complex neurodevelopmental disorder	N/A	N/A	GenCC
Restless Legs Syndrome	Restless legs syndrome	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alstrom Syndrome	Associate	28112973
Beckwith Wiedemann Syndrome	Associate	21863054
Bietti Crystalline Dystrophy	Associate	35791149
Carcinoma Embryonal	Associate	12841847
Glioblastoma	Associate	36658114
Leukemia	Associate	12384147
Macular Degeneration	Associate	27099955
Neoplasms	Associate	36658114
Obesity	Associate	39743445
Retinal Diseases	Associate	27099955
Retinitis Pigmentosa	Associate	35295047
Tetralogy of Fallot	Associate	22912587
Weight Loss	Associate	39743445

PLXNA2 (plexin A2)