MBD3 (methyl-CpG binding domain protein 3)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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53615 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Methyl-CpG binding domain protein 3 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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MBD3 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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Chromosome
Chromosome number
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19 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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19p13.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encod |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||||||||||||
UniProt ID | O95983 | ||||||||||||||||||||
Protein name | Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) | ||||||||||||||||||||
Protein function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947 | ||||||||||||||||||||
PDB | 2MB7 , 6CC8 , 6CCG , 6CEU , 6CEV | ||||||||||||||||||||
Family and domains |
Pfam
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Sequence |
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Sequence length | 291 | ||||||||||||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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