MBD3 (methyl-CpG binding domain protein 3)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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53615 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Methyl-CpG binding domain protein 3 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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MBD3 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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Chromosome
Chromosome number
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19 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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19p13.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encod |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | O95983 | ||||||||||||||||||||
| Protein name | Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) | ||||||||||||||||||||
| Protein function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947 | ||||||||||||||||||||
| PDB | 2MB7 , 6CC8 , 6CCG , 6CEU , 6CEV | ||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 291 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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