Gene Gene information from NCBI Gene database.
Entrez ID 53615
Gene name Methyl-CpG binding domain protein 3
Gene symbol MBD3
Synonyms (NCBI Gene)
-
Chromosome 19
Chromosome location 19p13.3
Summary DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encod
miRNA miRNA information provided by mirtarbase database.
504
miRTarBase ID miRNA Experiments Reference
MIRT022788 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT037081 hsa-miR-877-3p CLASH 23622248
MIRT625053 hsa-miR-508-5p HITS-CLIP 23824327
MIRT625052 hsa-miR-1288-5p HITS-CLIP 23824327
MIRT625051 hsa-miR-1273g-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
38
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA
GO:0000785 Component Chromatin HDA 16217013
GO:0000785 Component Chromatin IEA
GO:0000792 Component Heterochromatin IEA
GO:0001701 Process In utero embryonic development IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603573 6918 ENSG00000071655
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95983
Protein name Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3)
Protein function Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947
PDB 2MB7 , 6CC8 , 6CCG , 6CEU , 6CEV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01429 MBD 1 72 Methyl-CpG binding domain Domain
PF16564 MBDa 79 148 p55-binding region of Methyl-CpG-binding domain proteins MBD Domain
PF14048 MBD_C 152 243 C-terminal domain of methyl-CpG binding protein 2 and 3 Family
Sequence
Sequence length 291
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  ATP-dependent chromatin remodeling   HDACs deacetylate histones
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription