Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	5341
Gene name	Pleckstrin
Gene symbol	PLEK
Synonyms (NCBI Gene)	P47PLEK1
Chromosome	2
Chromosome location	2p14

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miRTarBase ID	miRNA	Experiments	Reference
MIRT532353	hsa-miR-3923	PAR-CLIP	22012620
MIRT532352	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT532351	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT532350	hsa-miR-5696	PAR-CLIP	22012620
MIRT532349	hsa-miR-579-3p	PAR-CLIP	22012620
MIRT532348	hsa-miR-664b-3p	PAR-CLIP	22012620
MIRT532347	hsa-miR-520a-5p	PAR-CLIP	22012620
MIRT532346	hsa-miR-525-5p	PAR-CLIP	22012620
MIRT532345	hsa-miR-183-3p	PAR-CLIP	22012620
MIRT532344	hsa-miR-4452	PAR-CLIP	22012620
MIRT532343	hsa-miR-3180-5p	PAR-CLIP	22012620
MIRT532342	hsa-miR-6875-3p	PAR-CLIP	22012620
MIRT532341	hsa-miR-4659a-3p	PAR-CLIP	22012620
MIRT532340	hsa-miR-4659b-3p	PAR-CLIP	22012620
MIRT532353	hsa-miR-3923	PAR-CLIP	22012620
MIRT532352	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT532351	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT532350	hsa-miR-5696	PAR-CLIP	22012620
MIRT532349	hsa-miR-579-3p	PAR-CLIP	22012620
MIRT532348	hsa-miR-664b-3p	PAR-CLIP	22012620
MIRT532347	hsa-miR-520a-5p	PAR-CLIP	22012620
MIRT532346	hsa-miR-525-5p	PAR-CLIP	22012620
MIRT532345	hsa-miR-183-3p	PAR-CLIP	22012620
MIRT532344	hsa-miR-4452	PAR-CLIP	22012620
MIRT532343	hsa-miR-3180-5p	PAR-CLIP	22012620
MIRT532342	hsa-miR-6875-3p	PAR-CLIP	22012620
MIRT532341	hsa-miR-4659a-3p	PAR-CLIP	22012620
MIRT532340	hsa-miR-4659b-3p	PAR-CLIP	22012620
MIRT1240704	hsa-miR-1229	CLIP-seq
MIRT1240705	hsa-miR-1343	CLIP-seq
MIRT1240706	hsa-miR-148a	CLIP-seq
MIRT1240707	hsa-miR-148b	CLIP-seq
MIRT1240708	hsa-miR-152	CLIP-seq
MIRT1240709	hsa-miR-3074-5p	CLIP-seq
MIRT1240710	hsa-miR-3124-3p	CLIP-seq
MIRT1240711	hsa-miR-3613-5p	CLIP-seq
MIRT1240712	hsa-miR-3690	CLIP-seq
MIRT1240713	hsa-miR-4254	CLIP-seq
MIRT1240714	hsa-miR-4493	CLIP-seq
MIRT1240715	hsa-miR-4650-5p	CLIP-seq
MIRT1240716	hsa-miR-4699-5p	CLIP-seq
MIRT1240717	hsa-miR-4709-3p	CLIP-seq
MIRT1240718	hsa-miR-4753-5p	CLIP-seq
MIRT1240719	hsa-miR-4757-5p	CLIP-seq
MIRT1240720	hsa-miR-579	CLIP-seq
MIRT1240721	hsa-miR-582-5p	CLIP-seq
MIRT1240722	hsa-miR-600	CLIP-seq
MIRT1240720	hsa-miR-579	CLIP-seq
MIRT1240720	hsa-miR-579	CLIP-seq
MIRT2070770	hsa-miR-4506	CLIP-seq
MIRT2297937	hsa-miR-1323	CLIP-seq
MIRT2297938	hsa-miR-2467-5p	CLIP-seq
MIRT2297939	hsa-miR-3188	CLIP-seq
MIRT2297940	hsa-miR-3975	CLIP-seq
MIRT2297941	hsa-miR-4649-3p	CLIP-seq
MIRT2297942	hsa-miR-485-5p	CLIP-seq
MIRT2297943	hsa-miR-539	CLIP-seq
MIRT2297944	hsa-miR-548o	CLIP-seq
MIRT2297945	hsa-miR-558	CLIP-seq
MIRT1240720	hsa-miR-579	CLIP-seq
MIRT2456632	hsa-miR-4330	CLIP-seq
MIRT2456633	hsa-miR-4749-3p	CLIP-seq
MIRT2595395	hsa-miR-1226	CLIP-seq
MIRT2595396	hsa-miR-197	CLIP-seq
MIRT2595397	hsa-miR-2682	CLIP-seq
MIRT2456632	hsa-miR-4330	CLIP-seq
MIRT2595398	hsa-miR-449c	CLIP-seq
MIRT2595399	hsa-miR-4514	CLIP-seq
MIRT2595400	hsa-miR-4645-5p	CLIP-seq
MIRT1240715	hsa-miR-4650-5p	CLIP-seq
MIRT2595401	hsa-miR-4673	CLIP-seq
MIRT2595402	hsa-miR-4692	CLIP-seq
MIRT2595403	hsa-miR-4733-3p	CLIP-seq
MIRT2456633	hsa-miR-4749-3p	CLIP-seq
MIRT2595395	hsa-miR-1226	CLIP-seq
MIRT2688060	hsa-miR-146a	CLIP-seq
MIRT2688061	hsa-miR-146b-5p	CLIP-seq
MIRT2595396	hsa-miR-197	CLIP-seq
MIRT2595397	hsa-miR-2682	CLIP-seq
MIRT2688062	hsa-miR-4434	CLIP-seq
MIRT2595398	hsa-miR-449c	CLIP-seq
MIRT2595399	hsa-miR-4514	CLIP-seq
MIRT2688063	hsa-miR-4516	CLIP-seq
MIRT2688064	hsa-miR-4531	CLIP-seq
MIRT2595400	hsa-miR-4645-5p	CLIP-seq
MIRT1240715	hsa-miR-4650-5p	CLIP-seq
MIRT2595401	hsa-miR-4673	CLIP-seq
MIRT2595402	hsa-miR-4692	CLIP-seq
MIRT1240716	hsa-miR-4699-5p	CLIP-seq
MIRT2595403	hsa-miR-4733-3p	CLIP-seq
MIRT2688065	hsa-miR-642a	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002244	Process	Hematopoietic progenitor cell differentiation	IEP	2768345
GO:0002576	Process	Platelet degranulation	IDA	7559487
GO:0002576	Process	Platelet degranulation	IEA
GO:0005080	Function	Protein kinase C binding	IDA	8615792
GO:0005515	Function	Protein binding	IPI	8999861, 19722192, 28514442, 33961781
GO:0005576	Component	Extracellular region	TAS
GO:0005737	Component	Cytoplasm	IDA	8694752, 9060471
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0006904	Process	Vesicle docking involved in exocytosis	IEA
GO:0006904	Process	Vesicle docking involved in exocytosis	ISS
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	ISS
GO:0007229	Process	Integrin-mediated signaling pathway	IDA	10995449
GO:0010572	Process	Positive regulation of platelet activation	IEA
GO:0010572	Process	Positive regulation of platelet activation	ISS
GO:0010920	Process	Negative regulation of inositol phosphate biosynthetic process	IDA	7782310
GO:0016020	Component	Membrane	HDA	19946888
GO:0019211	Function	Phosphatase activator activity	IDA	8999861
GO:0030030	Process	Cell projection organization	IDA	9060471
GO:0030036	Process	Actin cytoskeleton organization	IBA
GO:0030036	Process	Actin cytoskeleton organization	IDA	10497244
GO:0030836	Process	Positive regulation of actin filament depolymerization	IDA	10497244
GO:0030836	Process	Positive regulation of actin filament depolymerization	IEA
GO:0030845	Process	Phospholipase C-inhibiting G protein-coupled receptor signaling pathway	IDA	7782310
GO:0030866	Process	Cortical actin cytoskeleton organization	IDA	10497244
GO:0031529	Process	Ruffle organization	IDA	10497244
GO:0032233	Process	Positive regulation of actin filament bundle assembly	IDA	10497244
GO:0032587	Component	Ruffle membrane	IDA	9060471
GO:0033625	Process	Positive regulation of integrin activation	IEA
GO:0033625	Process	Positive regulation of integrin activation	ISS
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0042803	Function	Protein homodimerization activity	IDA	8694752
GO:0043325	Function	Phosphatidylinositol-3,4-bisphosphate binding	IDA	15698571
GO:0043647	Process	Inositol phosphate metabolic process	IDA	8999861
GO:0044089	Process	Positive regulation of cellular component biogenesis	IEA
GO:0045744	Process	Negative regulation of G protein-coupled receptor signaling pathway	IDA	7782310
GO:0050849	Process	Negative regulation of calcium-mediated signaling	NAS	8999861
GO:0060305	Process	Regulation of cell diameter	IDA	10995449
GO:0070493	Process	Thrombin-activated receptor signaling pathway	IDA	7782310
GO:0070493	Process	Thrombin-activated receptor signaling pathway	IEA
GO:0070495	Process	Negative regulation of thrombin-activated receptor signaling pathway	IDA	7559487
GO:0070527	Process	Platelet aggregation	HMP	23382103
GO:0070527	Process	Platelet aggregation	IEA
GO:0070527	Process	Platelet aggregation	ISS
GO:0070560	Process	Protein secretion by platelet	IEA
GO:0070560	Process	Protein secretion by platelet	ISS

MIM	HGNC	e!Ensembl
173570	9070	ENSG00000115956

P08567

Protein name

Pleckstrin (Platelet 47 kDa protein) (p47)

Protein function

Major protein kinase C substrate of platelets.

PDB

1PLS , 1W4M , 1X05 , 1XX0 , 1ZM0 , 2CSO , 2I5C , 2I5F

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	5 → 101	PH domain	Domain
PF00610	DEP	139 → 219	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Domain
PF00169	PH	245 → 347	PH domain	Domain

Sequence

MEPKRIREGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQ
DFGKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCIEGGQKFARKSTRRSIRL
PETIDLGALYLSMKDTEKGIKELNLEKDKKIFNHCFTGNCVIDWLVSNQSVRNRQEGLMI
ASSLLNEGYLQPAGDMSKSAVDGTAENPFLDNPDAFYYFPDSGFFCEENSSDDDVILKEE
FRGVIIKQGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAGAEDPLGAIHLRGCVVTSV
ESNSNGRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAIQMASRTGK

Sequence length

350

Interactions

View interactions

	Reactome
			Platelet degranulation

PLEK (pleckstrin)