PLD2 (phospholipase D2)

Gene

• Entrez ID: 5338
• Gene name: Phospholipase D2
• Gene symbol: PLD2
• Synonyms (NCBI Gene): PLD1C
• Chromosome: 17
• Chromosome location: 17p13.2
• Summary: The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localize

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT054650	hsa-miR-203a-3p	Immunofluorescence, Luciferase reporter assay, Western blot	26787840
MIRT1240253	hsa-miR-1291	CLIP-seq
MIRT1240254	hsa-miR-1302	CLIP-seq
MIRT1240255	hsa-miR-1470	CLIP-seq
MIRT1240256	hsa-miR-1587	CLIP-seq
MIRT1240257	hsa-miR-3119	CLIP-seq
MIRT1240258	hsa-miR-3192	CLIP-seq
MIRT1240259	hsa-miR-3591-5p	CLIP-seq
MIRT1240260	hsa-miR-362-5p	CLIP-seq
MIRT1240261	hsa-miR-3667-3p	CLIP-seq
MIRT1240262	hsa-miR-3689a-3p	CLIP-seq
MIRT1240263	hsa-miR-3689c	CLIP-seq
MIRT1240264	hsa-miR-3908	CLIP-seq
MIRT1240265	hsa-miR-4292	CLIP-seq
MIRT1240266	hsa-miR-4298	CLIP-seq
MIRT1240267	hsa-miR-4492	CLIP-seq
MIRT1240268	hsa-miR-4498	CLIP-seq
MIRT1240269	hsa-miR-4505	CLIP-seq
MIRT1240270	hsa-miR-4656	CLIP-seq
MIRT1240271	hsa-miR-4667-3p	CLIP-seq
MIRT1240272	hsa-miR-4675	CLIP-seq
MIRT1240273	hsa-miR-4728-5p	CLIP-seq
MIRT1240274	hsa-miR-4741	CLIP-seq
MIRT1240275	hsa-miR-500b	CLIP-seq
MIRT1240276	hsa-miR-501-5p	CLIP-seq
MIRT1240277	hsa-miR-520d-5p	CLIP-seq
MIRT1240278	hsa-miR-524-5p	CLIP-seq
MIRT1240279	hsa-miR-642a	CLIP-seq
MIRT1240280	hsa-miR-762	CLIP-seq
MIRT1240281	hsa-miR-885-3p	CLIP-seq
MIRT1240282	hsa-miR-887	CLIP-seq
MIRT2070659	hsa-miR-1255a	CLIP-seq
MIRT2070660	hsa-miR-1255b	CLIP-seq
MIRT2070661	hsa-miR-1909	CLIP-seq
MIRT2070662	hsa-miR-3670	CLIP-seq
MIRT2070663	hsa-miR-4525	CLIP-seq
MIRT2070664	hsa-miR-556-5p	CLIP-seq
MIRT2297809	hsa-miR-1285	CLIP-seq
MIRT2297810	hsa-miR-138	CLIP-seq
MIRT2297811	hsa-miR-140-5p	CLIP-seq
MIRT1240255	hsa-miR-1470	CLIP-seq
MIRT1240256	hsa-miR-1587	CLIP-seq
MIRT2297812	hsa-miR-214	CLIP-seq
MIRT2297813	hsa-miR-3187-5p	CLIP-seq
MIRT1240258	hsa-miR-3192	CLIP-seq
MIRT1240264	hsa-miR-3908	CLIP-seq
MIRT2297814	hsa-miR-4270	CLIP-seq
MIRT2297815	hsa-miR-4279	CLIP-seq
MIRT2297816	hsa-miR-4325	CLIP-seq
MIRT2297817	hsa-miR-4441	CLIP-seq
MIRT1240267	hsa-miR-4492	CLIP-seq
MIRT1240268	hsa-miR-4498	CLIP-seq
MIRT1240269	hsa-miR-4505	CLIP-seq
MIRT1240270	hsa-miR-4656	CLIP-seq
MIRT1240271	hsa-miR-4667-3p	CLIP-seq
MIRT1240272	hsa-miR-4675	CLIP-seq
MIRT1240274	hsa-miR-4741	CLIP-seq
MIRT2297818	hsa-miR-507	CLIP-seq
MIRT1240277	hsa-miR-520d-5p	CLIP-seq
MIRT1240278	hsa-miR-524-5p	CLIP-seq
MIRT2297819	hsa-miR-557	CLIP-seq
MIRT2297820	hsa-miR-612	CLIP-seq
MIRT1240279	hsa-miR-642a	CLIP-seq
MIRT2297821	hsa-miR-761	CLIP-seq
MIRT1240280	hsa-miR-762	CLIP-seq
MIRT1240281	hsa-miR-885-3p	CLIP-seq
MIRT1240282	hsa-miR-887	CLIP-seq
MIRT1240253	hsa-miR-1291	CLIP-seq
MIRT1240254	hsa-miR-1302	CLIP-seq
MIRT2456629	hsa-miR-1321	CLIP-seq
MIRT2297814	hsa-miR-4270	CLIP-seq
MIRT1240265	hsa-miR-4292	CLIP-seq
MIRT1240266	hsa-miR-4298	CLIP-seq
MIRT2297817	hsa-miR-4441	CLIP-seq
MIRT1240273	hsa-miR-4728-5p	CLIP-seq
MIRT2456630	hsa-miR-4739	CLIP-seq
MIRT2456631	hsa-miR-4756-5p	CLIP-seq
MIRT2297809	hsa-miR-1285	CLIP-seq
MIRT2070661	hsa-miR-1909	CLIP-seq
MIRT2297812	hsa-miR-214	CLIP-seq
MIRT2297813	hsa-miR-3187-5p	CLIP-seq
MIRT2297816	hsa-miR-4325	CLIP-seq
MIRT2070663	hsa-miR-4525	CLIP-seq
MIRT2297818	hsa-miR-507	CLIP-seq
MIRT2297819	hsa-miR-557	CLIP-seq
MIRT2297820	hsa-miR-612	CLIP-seq
MIRT2297821	hsa-miR-761	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004630	Function	Phospholipase D activity	IEA
GO:0005515	Function	Protein binding	IPI	16407827, 17276458, 17853892, 22106281, 32814053
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006654	Process	Phosphatidic acid biosynthetic process	TAS
GO:0007010	Process	Cytoskeleton organization	TAS	9395408
GO:0007264	Process	Small GTPase mediated signal transduction	TAS	9582313
GO:0016042	Process	Lipid catabolic process	IEA
GO:0035091	Function	Phosphatidylinositol binding	IEA
GO:0036465	Process	Synaptic vesicle recycling	TAS	24252804
GO:0038096	Process	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
GO:0048017	Process	Inositol lipid-mediated signaling	IEA
GO:0048870	Process	Cell motility	IBA	21873635
GO:0070290	Function	N-acylphosphatidylethanolamine-specific phospholipase D activity	IEA
GO:0098793	Component	Presynapse	IEA

Other IDs

• MIM: 602384
• HGNC: 9068
• e!Ensembl: ENSG00000129219

Protein

• UniProt ID: O14939
• Protein name: Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2)
• Protein function: Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity).
• PDB: 6OHM, 6OHO, 6OHP, 6OHQ, 6OHS, 7SVP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00787	PX	90 → 192	PX domain	Domain
  PF00614	PLDc	437 → 464	Phospholipase D Active site motif	Family
  PF13091	PLDc_2	626 → 802	PLD-like domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9582313}.
• Sequence:

  MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFA
  PGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVL
  MSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYR
  NYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVV
  KDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQAR
  WWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIF
  ITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRAL
  MLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSE
  SAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPW
  RDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQ
  CTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDE
  IVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHR
  LKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLL
  GKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICD
  DFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQ
  GHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT

• Sequence length: 933

Pathways

KEGG:

Glycerophospholipid metabolism
Ether lipid metabolism
Metabolic pathways
Ras signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Endocytosis
Fc gamma R-mediated phagocytosis
Glutamatergic synapse
GnRH signaling pathway
Parathyroid hormone synthesis, secretion and action
Pathways in cancer
Chemical carcinogenesis - reactive oxygen species
Pancreatic cancer
Choline metabolism in cancer

Reactome:

Synthesis of PA
Role of phospholipids in phagocytosis

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Unknown
Disease term	Disease name	Evidence	References	Source
Systemic lupus erythematosus	Systemic lupus erythematosus			GWAS
Alzheimer disease	Alzheimer disease			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Arthritis Psoriatic	Associate	21400035
Astrocytoma	Associate	17640750
Bowen's Disease	Stimulate	28656282
Breast Neoplasms	Associate	22960035, 23238254, 23989060
Breast Neoplasms	Stimulate	26781944
Carcinogenesis	Associate	31673104
Carcinoma Basal Cell	Inhibit	21400035
Carcinoma Squamous Cell	Associate	28656282
Colorectal Neoplasms	Associate	21944249, 25475140
Glioblastoma	Associate	32074974
Hypoxia	Associate	17640750
Inflammation	Associate	40124273
Keratosis Actinic	Stimulate	28656282
Leukemia Myeloid	Associate	22094461
Lupus Erythematosus Systemic	Associate	33927069
Lupus Nephritis	Associate	33927069
Lymphoma Non Hodgkin	Associate	36362078
Neoplasms	Associate	23238254, 26781944, 28656282
Ovarian Neoplasms	Associate	36362078
Pancreatitis	Associate	40124273
Primary Myelofibrosis	Associate	27341078
Prostatic Neoplasms	Associate	31673104
Psoriasis	Associate	21400035
Sarcoma Ewing	Associate	15919668
Skin Neoplasms	Associate	21400035
Thyroid Cancer Papillary	Associate	18498667