Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5336
Gene name	Phospholipase C gamma 2
Gene symbol	PLCG2
Synonyms (NCBI Gene)	APLAIDFCAS3PLC-IVPLC-gamma-2
Chromosome	16
Chromosome location	16q23.3
Summary	The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 an

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SNP ID	Visualize variation	Clinical significance	Consequence
rs189301790	C>T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs397514562	C>A	Pathogenic	Missense variant, coding sequence variant
rs1057519831	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1057519832	A>C,G,T	Likely-pathogenic	Coding sequence variant, missense variant, synonymous variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019144	hsa-miR-335-5p	Microarray	18185580
MIRT654989	hsa-miR-4680-3p	HITS-CLIP	23824327
MIRT654988	hsa-miR-4703-3p	HITS-CLIP	23824327
MIRT654987	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT654986	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT654985	hsa-miR-4420	HITS-CLIP	23824327
MIRT654984	hsa-miR-4452	HITS-CLIP	23824327
MIRT654983	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT654981	hsa-miR-3674	HITS-CLIP	23824327
MIRT499428	hsa-miR-6732-3p	HITS-CLIP	24906430
MIRT499427	hsa-miR-5683	HITS-CLIP	24906430
MIRT499425	hsa-miR-504-5p	HITS-CLIP	24906430
MIRT499424	hsa-miR-383-5p	HITS-CLIP	24906430
MIRT499423	hsa-miR-6858-3p	HITS-CLIP	24906430
MIRT499422	hsa-miR-4676-5p	HITS-CLIP	24906430
MIRT499421	hsa-miR-575	HITS-CLIP	24906430
MIRT499418	hsa-miR-6890-5p	HITS-CLIP	24906430
MIRT499416	hsa-miR-1288-5p	HITS-CLIP	24906430
MIRT499415	hsa-miR-1224-3p	HITS-CLIP	24906430
MIRT499414	hsa-miR-1249-3p	HITS-CLIP	24906430
MIRT499396	hsa-miR-3194-5p	HITS-CLIP	24906430
MIRT499392	hsa-miR-6717-5p	HITS-CLIP	24906430
MIRT499391	hsa-miR-8053	HITS-CLIP	24906430
MIRT499386	hsa-miR-342-5p	HITS-CLIP	24906430
MIRT499385	hsa-miR-4664-5p	HITS-CLIP	24906430
MIRT499384	hsa-miR-4651	HITS-CLIP	24906430
MIRT499383	hsa-miR-608	HITS-CLIP	24906430
MIRT499382	hsa-miR-6747-5p	HITS-CLIP	24906430
MIRT499379	hsa-miR-542-3p	HITS-CLIP	24906430
MIRT499377	hsa-miR-6726-3p	HITS-CLIP	24906430
MIRT499374	hsa-miR-6737-5p	HITS-CLIP	24906430
MIRT499373	hsa-miR-6812-5p	HITS-CLIP	24906430
MIRT499372	hsa-miR-6819-5p	HITS-CLIP	24906430
MIRT499428	hsa-miR-6732-3p	HITS-CLIP	24906430
MIRT499427	hsa-miR-5683	HITS-CLIP	24906430
MIRT499425	hsa-miR-504-5p	HITS-CLIP	24906430
MIRT499424	hsa-miR-383-5p	HITS-CLIP	24906430
MIRT499423	hsa-miR-6858-3p	HITS-CLIP	24906430
MIRT499422	hsa-miR-4676-5p	HITS-CLIP	24906430
MIRT499421	hsa-miR-575	HITS-CLIP	24906430
MIRT499418	hsa-miR-6890-5p	HITS-CLIP	24906430
MIRT499416	hsa-miR-1288-5p	HITS-CLIP	24906430
MIRT499415	hsa-miR-1224-3p	HITS-CLIP	24906430
MIRT499414	hsa-miR-1249-3p	HITS-CLIP	24906430
MIRT499396	hsa-miR-3194-5p	HITS-CLIP	24906430
MIRT499392	hsa-miR-6717-5p	HITS-CLIP	24906430
MIRT499391	hsa-miR-8053	HITS-CLIP	24906430
MIRT499386	hsa-miR-342-5p	HITS-CLIP	24906430
MIRT499385	hsa-miR-4664-5p	HITS-CLIP	24906430
MIRT499384	hsa-miR-4651	HITS-CLIP	24906430
MIRT499383	hsa-miR-608	HITS-CLIP	24906430
MIRT499382	hsa-miR-6747-5p	HITS-CLIP	24906430
MIRT499379	hsa-miR-542-3p	HITS-CLIP	24906430
MIRT499377	hsa-miR-6726-3p	HITS-CLIP	24906430
MIRT499374	hsa-miR-6737-5p	HITS-CLIP	24906430
MIRT499373	hsa-miR-6812-5p	HITS-CLIP	24906430
MIRT499372	hsa-miR-6819-5p	HITS-CLIP	24906430
MIRT499428	hsa-miR-6732-3p	HITS-CLIP	24906430
MIRT499427	hsa-miR-5683	HITS-CLIP	24906430
MIRT499425	hsa-miR-504-5p	HITS-CLIP	24906430
MIRT499424	hsa-miR-383-5p	HITS-CLIP	24906430
MIRT499423	hsa-miR-6858-3p	HITS-CLIP	24906430
MIRT499422	hsa-miR-4676-5p	HITS-CLIP	24906430
MIRT499421	hsa-miR-575	HITS-CLIP	24906430
MIRT499418	hsa-miR-6890-5p	HITS-CLIP	24906430
MIRT499416	hsa-miR-1288-5p	HITS-CLIP	24906430
MIRT499415	hsa-miR-1224-3p	HITS-CLIP	24906430
MIRT499414	hsa-miR-1249-3p	HITS-CLIP	24906430
MIRT499396	hsa-miR-3194-5p	HITS-CLIP	24906430
MIRT499392	hsa-miR-6717-5p	HITS-CLIP	24906430
MIRT499391	hsa-miR-8053	HITS-CLIP	24906430
MIRT499386	hsa-miR-342-5p	HITS-CLIP	24906430
MIRT499385	hsa-miR-4664-5p	HITS-CLIP	24906430
MIRT499384	hsa-miR-4651	HITS-CLIP	24906430
MIRT499383	hsa-miR-608	HITS-CLIP	24906430
MIRT499382	hsa-miR-6747-5p	HITS-CLIP	24906430
MIRT499379	hsa-miR-542-3p	HITS-CLIP	24906430
MIRT499377	hsa-miR-6726-3p	HITS-CLIP	24906430
MIRT499374	hsa-miR-6737-5p	HITS-CLIP	24906430
MIRT499373	hsa-miR-6812-5p	HITS-CLIP	24906430
MIRT499372	hsa-miR-6819-5p	HITS-CLIP	24906430
MIRT499428	hsa-miR-6732-3p	HITS-CLIP	24906430
MIRT499427	hsa-miR-5683	HITS-CLIP	24906430
MIRT499425	hsa-miR-504-5p	HITS-CLIP	24906430
MIRT499424	hsa-miR-383-5p	HITS-CLIP	24906430
MIRT499423	hsa-miR-6858-3p	HITS-CLIP	24906430
MIRT499422	hsa-miR-4676-5p	HITS-CLIP	24906430
MIRT499421	hsa-miR-575	HITS-CLIP	24906430
MIRT499418	hsa-miR-6890-5p	HITS-CLIP	24906430
MIRT499416	hsa-miR-1288-5p	HITS-CLIP	24906430
MIRT499415	hsa-miR-1224-3p	HITS-CLIP	24906430
MIRT499414	hsa-miR-1249-3p	HITS-CLIP	24906430
MIRT499396	hsa-miR-3194-5p	HITS-CLIP	24906430
MIRT499392	hsa-miR-6717-5p	HITS-CLIP	24906430
MIRT499391	hsa-miR-8053	HITS-CLIP	24906430
MIRT499386	hsa-miR-342-5p	HITS-CLIP	24906430
MIRT499385	hsa-miR-4664-5p	HITS-CLIP	24906430
MIRT499384	hsa-miR-4651	HITS-CLIP	24906430
MIRT499383	hsa-miR-608	HITS-CLIP	24906430
MIRT499382	hsa-miR-6747-5p	HITS-CLIP	24906430
MIRT499379	hsa-miR-542-3p	HITS-CLIP	24906430
MIRT499377	hsa-miR-6726-3p	HITS-CLIP	24906430
MIRT499374	hsa-miR-6737-5p	HITS-CLIP	24906430
MIRT499373	hsa-miR-6812-5p	HITS-CLIP	24906430
MIRT499372	hsa-miR-6819-5p	HITS-CLIP	24906430
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	20371350
MIRT499427	hsa-miR-5683	PAR-CLIP	20371350
MIRT499425	hsa-miR-504-5p	PAR-CLIP	20371350
MIRT499424	hsa-miR-383-5p	PAR-CLIP	20371350
MIRT499423	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT499422	hsa-miR-4676-5p	PAR-CLIP	20371350
MIRT499421	hsa-miR-575	PAR-CLIP	20371350
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	20371350
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	20371350
MIRT499415	hsa-miR-1224-3p	PAR-CLIP	20371350
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	20371350
MIRT499396	hsa-miR-3194-5p	PAR-CLIP	20371350
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	20371350
MIRT499391	hsa-miR-8053	PAR-CLIP	20371350
MIRT499386	hsa-miR-342-5p	PAR-CLIP	20371350
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	20371350
MIRT499384	hsa-miR-4651	PAR-CLIP	20371350
MIRT499383	hsa-miR-608	PAR-CLIP	20371350
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	20371350
MIRT499379	hsa-miR-542-3p	PAR-CLIP	20371350
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	20371350
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	20371350
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	20371350
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	20371350
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	22012620
MIRT499427	hsa-miR-5683	PAR-CLIP	22012620
MIRT499425	hsa-miR-504-5p	PAR-CLIP	22012620
MIRT499424	hsa-miR-383-5p	PAR-CLIP	22012620
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	22012620
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	22012620
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	22012620
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	22012620
MIRT499391	hsa-miR-8053	PAR-CLIP	22012620
MIRT499386	hsa-miR-342-5p	PAR-CLIP	22012620
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	22012620
MIRT499384	hsa-miR-4651	PAR-CLIP	22012620
MIRT499383	hsa-miR-608	PAR-CLIP	22012620
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	22012620
MIRT499379	hsa-miR-542-3p	PAR-CLIP	22012620
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	22012620
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	22012620
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	22012620
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	22012620
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	23446348
MIRT499427	hsa-miR-5683	PAR-CLIP	23446348
MIRT499425	hsa-miR-504-5p	PAR-CLIP	23446348
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	23446348
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	23446348
MIRT499391	hsa-miR-8053	PAR-CLIP	23446348
MIRT499386	hsa-miR-342-5p	PAR-CLIP	23446348
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	23446348
MIRT499384	hsa-miR-4651	PAR-CLIP	23446348
MIRT499383	hsa-miR-608	PAR-CLIP	23446348
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	23446348
MIRT499379	hsa-miR-542-3p	PAR-CLIP	23446348
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	23446348
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	23446348
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	23446348
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	23446348
MIRT499426	hsa-miR-4802-3p	PAR-CLIP	23446348
MIRT499420	hsa-miR-4476	PAR-CLIP	23446348
MIRT499419	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT499417	hsa-miR-4717-3p	PAR-CLIP	23446348
MIRT499413	hsa-miR-6746-5p	PAR-CLIP	23446348
MIRT499412	hsa-miR-3179	PAR-CLIP	23446348
MIRT499411	hsa-miR-3126-5p	PAR-CLIP	23446348
MIRT499410	hsa-miR-6875-5p	PAR-CLIP	23446348
MIRT499409	hsa-let-7a-5p	PAR-CLIP	23446348
MIRT499408	hsa-let-7b-5p	PAR-CLIP	23446348
MIRT499407	hsa-let-7c-5p	PAR-CLIP	23446348
MIRT499406	hsa-let-7d-5p	PAR-CLIP	23446348
MIRT499405	hsa-let-7e-5p	PAR-CLIP	23446348
MIRT499404	hsa-let-7f-5p	PAR-CLIP	23446348
MIRT499403	hsa-let-7g-5p	PAR-CLIP	23446348
MIRT499402	hsa-let-7i-5p	PAR-CLIP	23446348
MIRT499401	hsa-miR-4458	PAR-CLIP	23446348
MIRT499400	hsa-miR-4500	PAR-CLIP	23446348
MIRT499399	hsa-miR-98-5p	PAR-CLIP	23446348
MIRT499398	hsa-miR-202-3p	PAR-CLIP	23446348
MIRT499397	hsa-miR-5589-3p	PAR-CLIP	23446348
MIRT499395	hsa-miR-3202	PAR-CLIP	23446348
MIRT499394	hsa-miR-1249-5p	PAR-CLIP	23446348
MIRT499393	hsa-miR-6797-5p	PAR-CLIP	23446348
MIRT499390	hsa-miR-149-3p	PAR-CLIP	23446348
MIRT499389	hsa-miR-4728-5p	PAR-CLIP	23446348
MIRT499388	hsa-miR-6785-5p	PAR-CLIP	23446348
MIRT499387	hsa-miR-6883-5p	PAR-CLIP	23446348
MIRT499381	hsa-miR-4710	PAR-CLIP	23446348
MIRT499380	hsa-miR-8065	PAR-CLIP	23446348
MIRT499378	hsa-miR-1294	PAR-CLIP	23446348
MIRT499376	hsa-miR-425-3p	PAR-CLIP	23446348
MIRT499375	hsa-miR-6771-5p	PAR-CLIP	23446348
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	24398324
MIRT499427	hsa-miR-5683	PAR-CLIP	24398324
MIRT499426	hsa-miR-4802-3p	PAR-CLIP	24398324
MIRT499425	hsa-miR-504-5p	PAR-CLIP	24398324
MIRT499424	hsa-miR-383-5p	PAR-CLIP	24398324
MIRT499423	hsa-miR-6858-3p	PAR-CLIP	24398324
MIRT499422	hsa-miR-4676-5p	PAR-CLIP	24398324
MIRT499421	hsa-miR-575	PAR-CLIP	24398324
MIRT499420	hsa-miR-4476	PAR-CLIP	24398324
MIRT499419	hsa-miR-6876-5p	PAR-CLIP	24398324
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	24398324
MIRT499417	hsa-miR-4717-3p	PAR-CLIP	24398324
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	24398324
MIRT499415	hsa-miR-1224-3p	PAR-CLIP	24398324
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	24398324
MIRT499413	hsa-miR-6746-5p	PAR-CLIP	24398324
MIRT499412	hsa-miR-3179	PAR-CLIP	24398324
MIRT499411	hsa-miR-3126-5p	PAR-CLIP	24398324
MIRT499410	hsa-miR-6875-5p	PAR-CLIP	24398324
MIRT499409	hsa-let-7a-5p	PAR-CLIP	24398324
MIRT499408	hsa-let-7b-5p	PAR-CLIP	24398324
MIRT499407	hsa-let-7c-5p	PAR-CLIP	24398324
MIRT499406	hsa-let-7d-5p	PAR-CLIP	24398324
MIRT499405	hsa-let-7e-5p	PAR-CLIP	24398324
MIRT499404	hsa-let-7f-5p	PAR-CLIP	24398324
MIRT499403	hsa-let-7g-5p	PAR-CLIP	24398324
MIRT499402	hsa-let-7i-5p	PAR-CLIP	24398324
MIRT499401	hsa-miR-4458	PAR-CLIP	24398324
MIRT499400	hsa-miR-4500	PAR-CLIP	24398324
MIRT499399	hsa-miR-98-5p	PAR-CLIP	24398324
MIRT499398	hsa-miR-202-3p	PAR-CLIP	24398324
MIRT499397	hsa-miR-5589-3p	PAR-CLIP	24398324
MIRT499396	hsa-miR-3194-5p	PAR-CLIP	24398324
MIRT499395	hsa-miR-3202	PAR-CLIP	24398324
MIRT499394	hsa-miR-1249-5p	PAR-CLIP	24398324
MIRT499393	hsa-miR-6797-5p	PAR-CLIP	24398324
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	24398324
MIRT499391	hsa-miR-8053	PAR-CLIP	24398324
MIRT499390	hsa-miR-149-3p	PAR-CLIP	24398324
MIRT499389	hsa-miR-4728-5p	PAR-CLIP	24398324
MIRT499388	hsa-miR-6785-5p	PAR-CLIP	24398324
MIRT499387	hsa-miR-6883-5p	PAR-CLIP	24398324
MIRT499386	hsa-miR-342-5p	PAR-CLIP	24398324
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	24398324
MIRT499384	hsa-miR-4651	PAR-CLIP	24398324
MIRT499383	hsa-miR-608	PAR-CLIP	24398324
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	24398324
MIRT499381	hsa-miR-4710	PAR-CLIP	24398324
MIRT499380	hsa-miR-8065	PAR-CLIP	24398324
MIRT499379	hsa-miR-542-3p	PAR-CLIP	24398324
MIRT499378	hsa-miR-1294	PAR-CLIP	24398324
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	24398324
MIRT499376	hsa-miR-425-3p	PAR-CLIP	24398324
MIRT499375	hsa-miR-6771-5p	PAR-CLIP	24398324
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	24398324
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	24398324
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	24398324
MIRT499415	hsa-miR-1224-3p	PAR-CLIP	26701625
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	26701625
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	26701625
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	26701625
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	26701625
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	26701625
MIRT499396	hsa-miR-3194-5p	PAR-CLIP	26701625
MIRT499386	hsa-miR-342-5p	PAR-CLIP	26701625
MIRT499386	hsa-miR-342-5p	PAR-CLIP	26701625
MIRT499386	hsa-miR-342-5p	PAR-CLIP	26701625
MIRT499386	hsa-miR-342-5p	PAR-CLIP	26701625
MIRT499424	hsa-miR-383-5p	PAR-CLIP	26701625
MIRT499384	hsa-miR-4651	PAR-CLIP	26701625
MIRT499384	hsa-miR-4651	PAR-CLIP	26701625
MIRT499384	hsa-miR-4651	PAR-CLIP	26701625
MIRT499384	hsa-miR-4651	PAR-CLIP	26701625
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	26701625
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	26701625
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	26701625
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	26701625
MIRT499422	hsa-miR-4676-5p	PAR-CLIP	26701625
MIRT499425	hsa-miR-504-5p	PAR-CLIP	26701625
MIRT499425	hsa-miR-504-5p	PAR-CLIP	26701625
MIRT499425	hsa-miR-504-5p	PAR-CLIP	26701625
MIRT499425	hsa-miR-504-5p	PAR-CLIP	26701625
MIRT499379	hsa-miR-542-3p	PAR-CLIP	26701625
MIRT499379	hsa-miR-542-3p	PAR-CLIP	26701625
MIRT499379	hsa-miR-542-3p	PAR-CLIP	26701625
MIRT499379	hsa-miR-542-3p	PAR-CLIP	26701625
MIRT499427	hsa-miR-5683	PAR-CLIP	26701625
MIRT499427	hsa-miR-5683	PAR-CLIP	26701625
MIRT499427	hsa-miR-5683	PAR-CLIP	26701625
MIRT499427	hsa-miR-5683	PAR-CLIP	26701625
MIRT499421	hsa-miR-575	PAR-CLIP	26701625
MIRT499383	hsa-miR-608	PAR-CLIP	26701625
MIRT499383	hsa-miR-608	PAR-CLIP	26701625
MIRT499383	hsa-miR-608	PAR-CLIP	26701625
MIRT499383	hsa-miR-608	PAR-CLIP	26701625
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	26701625
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	26701625
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	26701625
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	26701625
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	26701625
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	26701625
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	26701625
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	26701625
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	26701625
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	26701625
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	26701625
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	26701625
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	26701625
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	26701625
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	26701625
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	26701625
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	26701625
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	26701625
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	26701625
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	26701625
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	26701625
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	26701625
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	26701625
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	26701625
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	26701625
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	26701625
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	26701625
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	26701625
MIRT499423	hsa-miR-6858-3p	PAR-CLIP	26701625
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	26701625
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	26701625
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	26701625
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	26701625
MIRT499391	hsa-miR-8053	PAR-CLIP	26701625
MIRT499391	hsa-miR-8053	PAR-CLIP	26701625
MIRT499391	hsa-miR-8053	PAR-CLIP	26701625
MIRT499391	hsa-miR-8053	PAR-CLIP	26701625
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	27292025
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	27292025
MIRT499396	hsa-miR-3194-5p	PAR-CLIP	27292025
MIRT499386	hsa-miR-342-5p	PAR-CLIP	27292025
MIRT499424	hsa-miR-383-5p	PAR-CLIP	27292025
MIRT499384	hsa-miR-4651	PAR-CLIP	27292025
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	27292025
MIRT499422	hsa-miR-4676-5p	PAR-CLIP	27292025
MIRT499425	hsa-miR-504-5p	PAR-CLIP	27292025
MIRT499379	hsa-miR-542-3p	PAR-CLIP	27292025
MIRT499427	hsa-miR-5683	PAR-CLIP	27292025
MIRT499421	hsa-miR-575	PAR-CLIP	27292025
MIRT499383	hsa-miR-608	PAR-CLIP	27292025
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	27292025
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	27292025
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	27292025
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	27292025
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	27292025
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	27292025
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	27292025
MIRT499423	hsa-miR-6858-3p	PAR-CLIP	27292025
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	27292025
MIRT499391	hsa-miR-8053	PAR-CLIP	27292025
MIRT499415	hsa-miR-1224-3p	HITS-CLIP	27418678
MIRT499414	hsa-miR-1249-3p	HITS-CLIP	27418678
MIRT499416	hsa-miR-1288-5p	HITS-CLIP	27418678
MIRT499396	hsa-miR-3194-5p	HITS-CLIP	27418678
MIRT499386	hsa-miR-342-5p	HITS-CLIP	27418678
MIRT499424	hsa-miR-383-5p	HITS-CLIP	27418678
MIRT499384	hsa-miR-4651	HITS-CLIP	27418678
MIRT499385	hsa-miR-4664-5p	HITS-CLIP	27418678
MIRT499422	hsa-miR-4676-5p	HITS-CLIP	27418678
MIRT499425	hsa-miR-504-5p	HITS-CLIP	27418678
MIRT499379	hsa-miR-542-3p	HITS-CLIP	27418678
MIRT499427	hsa-miR-5683	HITS-CLIP	27418678
MIRT499421	hsa-miR-575	HITS-CLIP	27418678
MIRT499383	hsa-miR-608	HITS-CLIP	27418678
MIRT499392	hsa-miR-6717-5p	HITS-CLIP	27418678
MIRT499377	hsa-miR-6726-3p	HITS-CLIP	27418678
MIRT499428	hsa-miR-6732-3p	HITS-CLIP	27418678
MIRT499374	hsa-miR-6737-5p	HITS-CLIP	27418678
MIRT499382	hsa-miR-6747-5p	HITS-CLIP	27418678
MIRT499373	hsa-miR-6812-5p	HITS-CLIP	27418678
MIRT499372	hsa-miR-6819-5p	HITS-CLIP	27418678
MIRT499423	hsa-miR-6858-3p	HITS-CLIP	27418678
MIRT499418	hsa-miR-6890-5p	HITS-CLIP	27418678
MIRT499391	hsa-miR-8053	HITS-CLIP	27418678
MIRT654989	hsa-miR-4680-3p	HITS-CLIP	23824327
MIRT654988	hsa-miR-4703-3p	HITS-CLIP	23824327
MIRT654987	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT654986	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT654985	hsa-miR-4420	HITS-CLIP	23824327
MIRT654984	hsa-miR-4452	HITS-CLIP	23824327
MIRT654983	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT654981	hsa-miR-3674	HITS-CLIP	23824327
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	20371350
MIRT499427	hsa-miR-5683	PAR-CLIP	20371350
MIRT499425	hsa-miR-504-5p	PAR-CLIP	20371350
MIRT499424	hsa-miR-383-5p	PAR-CLIP	20371350
MIRT499423	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT499422	hsa-miR-4676-5p	PAR-CLIP	20371350
MIRT499421	hsa-miR-575	PAR-CLIP	20371350
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	20371350
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	20371350
MIRT499415	hsa-miR-1224-3p	PAR-CLIP	20371350
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	20371350
MIRT499396	hsa-miR-3194-5p	PAR-CLIP	20371350
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	20371350
MIRT499391	hsa-miR-8053	PAR-CLIP	20371350
MIRT499386	hsa-miR-342-5p	PAR-CLIP	20371350
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	20371350
MIRT499384	hsa-miR-4651	PAR-CLIP	20371350
MIRT499383	hsa-miR-608	PAR-CLIP	20371350
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	20371350
MIRT499379	hsa-miR-542-3p	PAR-CLIP	20371350
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	20371350
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	20371350
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	20371350
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	20371350
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	22012620
MIRT499427	hsa-miR-5683	PAR-CLIP	22012620
MIRT499425	hsa-miR-504-5p	PAR-CLIP	22012620
MIRT499424	hsa-miR-383-5p	PAR-CLIP	22012620
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	22012620
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	22012620
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	22012620
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	22012620
MIRT499391	hsa-miR-8053	PAR-CLIP	22012620
MIRT499386	hsa-miR-342-5p	PAR-CLIP	22012620
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	22012620
MIRT499384	hsa-miR-4651	PAR-CLIP	22012620
MIRT499383	hsa-miR-608	PAR-CLIP	22012620
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	22012620
MIRT499379	hsa-miR-542-3p	PAR-CLIP	22012620
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	22012620
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	22012620
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	22012620
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	22012620
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	23446348
MIRT499427	hsa-miR-5683	PAR-CLIP	23446348
MIRT499425	hsa-miR-504-5p	PAR-CLIP	23446348
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	23446348
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	23446348
MIRT499391	hsa-miR-8053	PAR-CLIP	23446348
MIRT499386	hsa-miR-342-5p	PAR-CLIP	23446348
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	23446348
MIRT499384	hsa-miR-4651	PAR-CLIP	23446348
MIRT499383	hsa-miR-608	PAR-CLIP	23446348
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	23446348
MIRT499379	hsa-miR-542-3p	PAR-CLIP	23446348
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	23446348
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	23446348
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	23446348
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	23446348
MIRT499426	hsa-miR-4802-3p	PAR-CLIP	23446348
MIRT499420	hsa-miR-4476	PAR-CLIP	23446348
MIRT499419	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT499417	hsa-miR-4717-3p	PAR-CLIP	23446348
MIRT499413	hsa-miR-6746-5p	PAR-CLIP	23446348
MIRT499412	hsa-miR-3179	PAR-CLIP	23446348
MIRT499411	hsa-miR-3126-5p	PAR-CLIP	23446348
MIRT499410	hsa-miR-6875-5p	PAR-CLIP	23446348
MIRT499409	hsa-let-7a-5p	PAR-CLIP	23446348
MIRT499408	hsa-let-7b-5p	PAR-CLIP	23446348
MIRT499407	hsa-let-7c-5p	PAR-CLIP	23446348
MIRT499406	hsa-let-7d-5p	PAR-CLIP	23446348
MIRT499405	hsa-let-7e-5p	PAR-CLIP	23446348
MIRT499404	hsa-let-7f-5p	PAR-CLIP	23446348
MIRT499403	hsa-let-7g-5p	PAR-CLIP	23446348
MIRT499402	hsa-let-7i-5p	PAR-CLIP	23446348
MIRT499401	hsa-miR-4458	PAR-CLIP	23446348
MIRT499400	hsa-miR-4500	PAR-CLIP	23446348
MIRT499399	hsa-miR-98-5p	PAR-CLIP	23446348
MIRT499398	hsa-miR-202-3p	PAR-CLIP	23446348
MIRT499397	hsa-miR-5589-3p	PAR-CLIP	23446348
MIRT499395	hsa-miR-3202	PAR-CLIP	23446348
MIRT499394	hsa-miR-1249-5p	PAR-CLIP	23446348
MIRT499393	hsa-miR-6797-5p	PAR-CLIP	23446348
MIRT499390	hsa-miR-149-3p	PAR-CLIP	23446348
MIRT499389	hsa-miR-4728-5p	PAR-CLIP	23446348
MIRT499388	hsa-miR-6785-5p	PAR-CLIP	23446348
MIRT499387	hsa-miR-6883-5p	PAR-CLIP	23446348
MIRT499381	hsa-miR-4710	PAR-CLIP	23446348
MIRT499380	hsa-miR-8065	PAR-CLIP	23446348
MIRT499378	hsa-miR-1294	PAR-CLIP	23446348
MIRT499376	hsa-miR-425-3p	PAR-CLIP	23446348
MIRT499375	hsa-miR-6771-5p	PAR-CLIP	23446348
MIRT499428	hsa-miR-6732-3p	PAR-CLIP	24398324
MIRT499427	hsa-miR-5683	PAR-CLIP	24398324
MIRT499426	hsa-miR-4802-3p	PAR-CLIP	24398324
MIRT499425	hsa-miR-504-5p	PAR-CLIP	24398324
MIRT499424	hsa-miR-383-5p	PAR-CLIP	24398324
MIRT499423	hsa-miR-6858-3p	PAR-CLIP	24398324
MIRT499422	hsa-miR-4676-5p	PAR-CLIP	24398324
MIRT499421	hsa-miR-575	PAR-CLIP	24398324
MIRT499420	hsa-miR-4476	PAR-CLIP	24398324
MIRT499419	hsa-miR-6876-5p	PAR-CLIP	24398324
MIRT499418	hsa-miR-6890-5p	PAR-CLIP	24398324
MIRT499417	hsa-miR-4717-3p	PAR-CLIP	24398324
MIRT499416	hsa-miR-1288-5p	PAR-CLIP	24398324
MIRT499415	hsa-miR-1224-3p	PAR-CLIP	24398324
MIRT499414	hsa-miR-1249-3p	PAR-CLIP	24398324
MIRT499413	hsa-miR-6746-5p	PAR-CLIP	24398324
MIRT499412	hsa-miR-3179	PAR-CLIP	24398324
MIRT499411	hsa-miR-3126-5p	PAR-CLIP	24398324
MIRT499410	hsa-miR-6875-5p	PAR-CLIP	24398324
MIRT499409	hsa-let-7a-5p	PAR-CLIP	24398324
MIRT499408	hsa-let-7b-5p	PAR-CLIP	24398324
MIRT499407	hsa-let-7c-5p	PAR-CLIP	24398324
MIRT499406	hsa-let-7d-5p	PAR-CLIP	24398324
MIRT499405	hsa-let-7e-5p	PAR-CLIP	24398324
MIRT499404	hsa-let-7f-5p	PAR-CLIP	24398324
MIRT499403	hsa-let-7g-5p	PAR-CLIP	24398324
MIRT499402	hsa-let-7i-5p	PAR-CLIP	24398324
MIRT499401	hsa-miR-4458	PAR-CLIP	24398324
MIRT499400	hsa-miR-4500	PAR-CLIP	24398324
MIRT499399	hsa-miR-98-5p	PAR-CLIP	24398324
MIRT499398	hsa-miR-202-3p	PAR-CLIP	24398324
MIRT499397	hsa-miR-5589-3p	PAR-CLIP	24398324
MIRT499396	hsa-miR-3194-5p	PAR-CLIP	24398324
MIRT499395	hsa-miR-3202	PAR-CLIP	24398324
MIRT499394	hsa-miR-1249-5p	PAR-CLIP	24398324
MIRT499393	hsa-miR-6797-5p	PAR-CLIP	24398324
MIRT499392	hsa-miR-6717-5p	PAR-CLIP	24398324
MIRT499391	hsa-miR-8053	PAR-CLIP	24398324
MIRT499390	hsa-miR-149-3p	PAR-CLIP	24398324
MIRT499389	hsa-miR-4728-5p	PAR-CLIP	24398324
MIRT499388	hsa-miR-6785-5p	PAR-CLIP	24398324
MIRT499387	hsa-miR-6883-5p	PAR-CLIP	24398324
MIRT499386	hsa-miR-342-5p	PAR-CLIP	24398324
MIRT499385	hsa-miR-4664-5p	PAR-CLIP	24398324
MIRT499384	hsa-miR-4651	PAR-CLIP	24398324
MIRT499383	hsa-miR-608	PAR-CLIP	24398324
MIRT499382	hsa-miR-6747-5p	PAR-CLIP	24398324
MIRT499381	hsa-miR-4710	PAR-CLIP	24398324
MIRT499380	hsa-miR-8065	PAR-CLIP	24398324
MIRT499379	hsa-miR-542-3p	PAR-CLIP	24398324
MIRT499378	hsa-miR-1294	PAR-CLIP	24398324
MIRT499377	hsa-miR-6726-3p	PAR-CLIP	24398324
MIRT499376	hsa-miR-425-3p	PAR-CLIP	24398324
MIRT499375	hsa-miR-6771-5p	PAR-CLIP	24398324
MIRT499374	hsa-miR-6737-5p	PAR-CLIP	24398324
MIRT499373	hsa-miR-6812-5p	PAR-CLIP	24398324
MIRT499372	hsa-miR-6819-5p	PAR-CLIP	24398324
MIRT2297703	hsa-miR-4643	CLIP-seq

126

Show/Hide all (126)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001775	Process	Cell activation	IEA
GO:0001775	Process	Cell activation	ISS
GO:0001784	Function	Phosphotyrosine residue binding	IPI	20624904
GO:0001878	Process	Response to yeast	IEA
GO:0001878	Process	Response to yeast	ISS
GO:0002092	Process	Positive regulation of receptor internalization	IEA
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	IEA
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	ISS
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002224	Process	Toll-like receptor signaling pathway	IEA
GO:0002224	Process	Toll-like receptor signaling pathway	ISS
GO:0002281	Process	Macrophage activation involved in immune response	IEA
GO:0002281	Process	Macrophage activation involved in immune response	ISS
GO:0002316	Process	Follicular B cell differentiation	IEA
GO:0002732	Process	Positive regulation of dendritic cell cytokine production	IEA
GO:0002732	Process	Positive regulation of dendritic cell cytokine production	ISS
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IBA
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IDA	11606584, 12181444
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IEA
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IMP	32514138
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	TAS
GO:0004629	Function	Phospholipase C activity	TAS
GO:0005515	Function	Protein binding	IPI	15644415, 16273093, 24642916, 24658140, 24728074, 25241761, 25814554, 31980649, 33961781, 35512704
GO:0005737	Component	Cytoplasm	IDA	11331309
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	11331309, 11606584
GO:0005886	Component	Plasma membrane	IDA	11606584
GO:0005886	Component	Plasma membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006661	Process	Phosphatidylinositol biosynthetic process	IDA	11606584, 12181444
GO:0007165	Process	Signal transduction	IEA
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0009395	Process	Phospholipid catabolic process	IEA
GO:0010468	Process	Regulation of gene expression	IEA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0010628	Process	Positive regulation of gene expression	IMP	32514138
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0010634	Process	Positive regulation of epithelial cell migration	IBA
GO:0012501	Process	Programmed cell death	IEA
GO:0016020	Component	Membrane	IEA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016055	Process	Wnt signaling pathway	TAS	18784435
GO:0016787	Function	Hydrolase activity	IEA
GO:0019216	Process	Regulation of lipid metabolic process	IMP	32514138
GO:0019722	Process	Calcium-mediated signaling	IEA
GO:0019722	Process	Calcium-mediated signaling	IMP	11606584
GO:0019722	Process	Calcium-mediated signaling	NAS	11043765
GO:0019901	Function	Protein kinase binding	IPI	11606584
GO:0030168	Process	Platelet activation	TAS
GO:0030183	Process	B cell differentiation	IEA
GO:0030183	Process	B cell differentiation	ISS
GO:0031663	Process	Lipopolysaccharide-mediated signaling pathway	IMP	32514138
GO:0032481	Process	Positive regulation of type I interferon production	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0032587	Component	Ruffle membrane	IBA
GO:0032587	Component	Ruffle membrane	IDA	11331309
GO:0032587	Component	Ruffle membrane	IEA
GO:0032733	Process	Positive regulation of interleukin-10 production	IEA
GO:0032733	Process	Positive regulation of interleukin-10 production	ISS
GO:0032735	Process	Positive regulation of interleukin-12 production	IEA
GO:0032735	Process	Positive regulation of interleukin-12 production	ISS
GO:0032743	Process	Positive regulation of interleukin-2 production	IEA
GO:0032743	Process	Positive regulation of interleukin-2 production	ISS
GO:0032747	Process	Positive regulation of interleukin-23 production	IEA
GO:0032747	Process	Positive regulation of interleukin-23 production	ISS
GO:0032755	Process	Positive regulation of interleukin-6 production	IEA
GO:0032755	Process	Positive regulation of interleukin-6 production	ISS
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IEA
GO:0032760	Process	Positive regulation of tumor necrosis factor production	ISS
GO:0032959	Process	Inositol trisphosphate biosynthetic process	IEA
GO:0035556	Process	Intracellular signal transduction	IDA	11606584, 14656219
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0035556	Process	Intracellular signal transduction	IMP	32514138
GO:0035556	Process	Intracellular signal transduction	ISS
GO:0038095	Process	Fc-epsilon receptor signaling pathway	IEA
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0042113	Process	B cell activation	IDA	30107486
GO:0043069	Process	Negative regulation of programmed cell death	IEA
GO:0043122	Process	Regulation of canonical NF-kappaB signal transduction	IEA
GO:0043122	Process	Regulation of canonical NF-kappaB signal transduction	ISS
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	ISS
GO:0043410	Process	Positive regulation of MAPK cascade	IEA
GO:0043410	Process	Positive regulation of MAPK cascade	ISS
GO:0045121	Component	Membrane raft	IEA
GO:0045121	Component	Membrane raft	ISS
GO:0046488	Process	Phosphatidylinositol metabolic process	IBA
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	23555801
GO:0048678	Process	Response to axon injury	IMP	32514138
GO:0050850	Process	Positive regulation of calcium-mediated signaling	IEA
GO:0050850	Process	Positive regulation of calcium-mediated signaling	ISS
GO:0050851	Process	Antigen receptor-mediated signaling pathway	IEA
GO:0050852	Process	T cell receptor signaling pathway	IEA
GO:0050852	Process	T cell receptor signaling pathway	ISS
GO:0050853	Process	B cell receptor signaling pathway	IDA	15509800
GO:0050853	Process	B cell receptor signaling pathway	IEA
GO:0050853	Process	B cell receptor signaling pathway	IMP	11606584
GO:0050853	Process	B cell receptor signaling pathway	ISS
GO:0050853	Process	B cell receptor signaling pathway	TAS	23555801
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IBA
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IDA	11606584
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IEA
GO:0051282	Process	Regulation of sequestering of calcium ion	IEA
GO:0060100	Process	Positive regulation of phagocytosis, engulfment	IMP	32514138
GO:0060907	Process	Positive regulation of macrophage cytokine production	IEA
GO:0060907	Process	Positive regulation of macrophage cytokine production	ISS
GO:0061760	Process	Antifungal innate immune response	IEA
GO:0061760	Process	Antifungal innate immune response	ISS
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070884	Process	Regulation of calcineurin-NFAT signaling cascade	IEA
GO:0070884	Process	Regulation of calcineurin-NFAT signaling cascade	ISS
GO:0071277	Process	Cellular response to calcium ion	IMP	11606584
GO:0071396	Process	Cellular response to lipid	IMP	32514138
GO:0097110	Function	Scaffold protein binding	IPI	11606584, 23555801
GO:0097708	Component	Intracellular vesicle	IDA	11331309
GO:0140031	Function	Phosphorylation-dependent protein binding	IEA
GO:0150078	Process	Positive regulation of neuroinflammatory response	IMP	32514138
GO:1900227	Process	Positive regulation of NLRP3 inflammasome complex assembly	IMP	32514138
GO:1902533	Process	Positive regulation of intracellular signal transduction	ISS
GO:1902808	Process	Positive regulation of cell cycle G1/S phase transition	ISS
GO:1903428	Process	Positive regulation of reactive oxygen species biosynthetic process	IEA
GO:1903428	Process	Positive regulation of reactive oxygen species biosynthetic process	ISS
GO:1990782	Function	Protein tyrosine kinase binding	IPI	32514138
GO:1990858	Process	Cellular response to lectin	IEA
GO:1990858	Process	Cellular response to lectin	ISS

MIM	HGNC	e!Ensembl
600220	9066	ENSG00000197943

P16885

Protein name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)

Protein function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. {ECO:

PDB

2K2J , 2W2W , 2W2X , 8JQG , 8JQH , 8JQI , 8T7C

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00388	PI-PLC-X	314 → 457	Phosphatidylinositol-specific phospholipase C, X domain	Family
PF00017	SH2	532 → 617	SH2 domain	Domain
PF00017	SH2	646 → 720	SH2 domain	Domain
PF00018	SH3_1	775 → 821	SH3 domain	Domain
PF00387	PI-PLC-Y	930 → 1042	Phosphatidylinositol-specific phospholipase C, Y domain	Family
PF00168	C2	1061 → 1168	C2 domain	Domain

Sequence

MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA
FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSN
SKFYS

Sequence length

1265

Interactions

View interactions

	KEGG		Reactome
	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Ras signaling pathway Calcium signaling pathway Chemokine signaling pathway NF-kappa B signaling pathway HIF-1 signaling pathway Phosphatidylinositol signaling system Phospholipase D signaling pathway Axon guidance VEGF signaling pathway Osteoclast differentiation Platelet activation Neutrophil extracellular trap formation C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Neurotrophin signaling pathway Inflammatory mediator regulation of TRP channels Thyroid hormone signaling pathway AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Vibrio cholerae infection Epithelial cell signaling in Helicobacter pylori infection Shigellosis Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Glioma Non-small cell lung cancer Hepatocellular carcinoma		GPVI-mediated activation cascade Toll Like Receptor 4 (TLR4) Cascade Synthesis of IP3 and IP4 in the cytosol Generation of second messenger molecules Role of phospholipids in phagocytosis DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) signaling Dectin-2 family FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

1661

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation	Likely pathogenic; Pathogenic	rs2143682648, rs2143705605, rs397514562	RCV001650513 RCV002260534 RCV000032898
Familial cold autoinflammatory syndrome 3	Likely pathogenic; Pathogenic	rs753618006, rs746749620, rs1381167403	RCV001824263 RCV002305070 RCV001227511

Show/Hide Unknown Diseases (17)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign; Conflicting classifications of pathogenicity	rs16956026, rs61755444	RCV005918097 RCV005901728
Adrenocortical carcinoma, hereditary	Benign	rs115583707	RCV005896923
Cervical cancer	Likely benign; Benign	rs200892679, rs74856898	RCV005926279 RCV005910742
Clonal Cytopenia of Undetermined Significance	Likely benign	rs377753289	RCV003152739
Colon adenocarcinoma	Benign; Likely benign	rs142825971, rs117077093	RCV005900968 RCV005907865
Familial cancer of breast	Benign; Likely benign	rs142825971	RCV005900967
Familial cold autoinflammatory syndrome	Likely benign	rs373933998	RCV002466690
Gastric cancer	Uncertain significance; Benign; Likely benign	rs769466948, rs115583707, rs185307548	RCV005922830 RCV005896924 RCV005913347
Hepatocellular carcinoma	Benign	rs115583707	RCV005896922
Lung cancer	Benign; Likely benign	rs16956026, rs117077093	RCV005918101 RCV005907867
Malignant tumor of esophagus	Benign	rs16956026, rs74856898	RCV005918098 RCV005910741
Nonpapillary renal cell carcinoma	Likely benign	rs1143686	RCV005912662
Ovarian serous cystadenocarcinoma	Benign	rs16956026	RCV005918100
PLCG2-related disorder	Likely benign; Uncertain significance; Benign; Conflicting classifications of pathogenicity	rs780081424, rs554237118, rs767695750, rs763556693, rs190840748, rs755617580, rs1910869594, rs1314680723, rs746020068, rs1333994781, rs750926701, rs1187780050, rs1909975248, rs147501175, rs1386427506 View all (38 more)	RCV003900622 RCV003911203 RCV003923687 RCV003898871 RCV003412041 RCV003404708 RCV003397332 RCV003408438 RCV004741643 RCV003894162 RCV003901642 RCV003901929 RCV003944092 RCV003976987 RCV003983682 RCV003925507 RCV003925508 RCV003935497 RCV003953171 RCV003918060 RCV004742553 RCV003980264 RCV003928106 RCV003965384 RCV003945648 RCV003980265 RCV003980266 RCV003928105 RCV003953170 RCV003892559 RCV003420255 RCV004742627 RCV003947963 RCV003955528 RCV003413644 RCV003411758 RCV003918278 RCV003948001 RCV003943092 RCV003970751 RCV003953342 RCV003948286 RCV003957958 RCV004742676 RCV003968326 RCV003923311 RCV003978046 RCV004743215 RCV004743253 RCV003953460 RCV003413894 RCV004743270 RCV003414004
Recurrent fever	Uncertain significance	rs750799204	RCV001599197
Sarcoma	Benign	rs16956026	RCV005918099
Thyroid cancer, nonmedullary, 1	Likely benign; Benign	rs1143686, rs117077093	RCV005912663 RCV005907866

Show/Hide Text Mining Associations (75)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
AA amyloidosis	Associate	32166339, 32894242
Achondroplasia and Swiss type agammaglobulinemia	Inhibit	9778529
Adenocarcinoma	Associate	32509861
Adjustment Disorders	Associate	31853824
Agammaglobulinemia	Associate	32671674
Alzheimer Disease	Associate	28714976, 30258121, 30326945, 31131421, 32166339, 32894242, 33092647, 33239300, 34099642, 34615897, 35895133, 36530083, 36933698, 40528303
Alzheimer Disease	Inhibit	33092647
Amyotrophic Lateral Sclerosis	Associate	31131421
Anovulation	Associate	40287692
Aortic Aneurysm Abdominal	Associate	25993291
Arthritis Psoriatic	Associate	36113963
Asthma	Associate	32186396
Autism Spectrum Disorder	Associate	35773312
Autoimmune Diseases	Associate	22236196, 36933698
Blood Platelet Disorders	Associate	20525309, 29436605, 31163690, 31889510
Breast Neoplasms	Associate	24080446
Burkitt Lymphoma	Associate	28465297
Carcinoma Basal Cell	Stimulate	36253891
Carcinoma Non Small Cell Lung	Associate	32965722, 37074454
Carcinoma Non Small Cell Lung	Stimulate	37031207
Carcinoma Renal Cell	Associate	35276058, 36530957
Clinical Deterioration	Associate	37314786
Cognition Disorders	Associate	32166339, 36530083, 36933698
Common Variable Immunodeficiency	Associate	31853824, 32047491, 33859323
Cryopyrin Associated Periodic Syndromes	Associate	22236196, 25760457, 30619256
Cutis Laxa	Associate	30619256
Dementia	Associate	31131421
Diabetes Mellitus Type 1	Associate	22344559
Disease Progression	Associate	37314786, 37955424
Frontotemporal Dementia	Associate	31131421
Gastrointestinal Stromal Tumors	Associate	37616163
Genetic Diseases Inborn	Associate	36113963
Genetic Predisposition to Disease	Associate	30508305
Graves Ophthalmopathy	Stimulate	37989267
Hemolytic Uremic Syndrome	Associate	36033826
Hereditary Autoinflammatory Diseases	Associate	23000145, 25418813, 32671674, 33042144, 36113963
Hodgkin Disease	Associate	12881301, 28791394
Humoral Hypercalcemia Of Malignancy	Associate	32671674
Immunologic Deficiency Syndromes	Associate	22236196, 23000145, 32671674
Inflammation	Associate	23000145, 31853824, 31889510, 36070248, 38061598
Inflammatory Bowel Diseases	Associate	36113963
Laryngeal Neoplasms	Associate	36033826
Leukemia Lymphocytic Chronic B Cell	Associate	15728130, 24489640, 24869598, 28049639, 28212557, 28418267, 29122990, 29259203, 30508305, 31243043, 34778802, 36567979, 36696464, 37227160, 37314786, 37523714, 38055246 View all (2 more)
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	23719297
Leukemia Prolymphocytic	Associate	28049639
Lewy Body Disease	Associate	30326945, 31131421, 33092647
Lung Neoplasms	Associate	37031207
Lupus Erythematosus Systemic	Associate	36180106
Lymphoma Follicular	Associate	36994552
Lymphoma T Cell	Associate	36567979
Macular Degeneration	Associate	31560769, 32631374
Meningococcal Infections	Associate	36033826
Mental Disorders	Associate	35773312
Multiple System Atrophy	Associate	30326945
Myelodysplastic Syndromes	Associate	30787430
Myoclonic dystonia	Associate	35773312
Neoplasm Metastasis	Associate	37031207
Neoplasms	Associate	12881301, 31889510, 32047491, 33725976, 36933698
Nephrotic Syndrome	Associate	25349203
Neurodegenerative Diseases	Associate	30326945, 31131421, 38061598
Obesity	Associate	30658193
Ovarian Neoplasms	Associate	35120576
Pediatric acute onset neuropsychiatric syndrome	Associate	35773312
Polycystic Ovary Syndrome	Associate	33224973, 37226082, 40287692
Sarcoma	Associate	33725976
Skin Manifestations	Associate	25760457
Small Cell Lung Carcinoma	Associate	34653364
Spondylitis Ankylosing	Associate	38223749
Stomach Neoplasms	Associate	14606067
Supranuclear Palsy Progressive	Associate	30326945, 33092647
Tauopathies	Associate	30326945
Thyroiditis Autoimmune	Associate	22236196
Urticaria	Associate	23000145
Venous Thromboembolism	Associate	31420334, 37537391
Waldenstrom Macroglobulinemia	Associate	30402490

PLCG2 (phospholipase C gamma 2)