Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	53353
Gene name Gene Name - the full gene name approved by the HGNC.	LDL receptor related protein 1B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LRP1B
Synonyms (NCBI Gene) Gene synonyms aliases	LRP-1B, LRP-DIT, LRPDIT
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q22.1-q22.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reporte

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016828	hsa-miR-335-5p	Microarray	18185580
MIRT020555	hsa-miR-155-5p	Other	20584899
MIRT028914	hsa-miR-26b-5p	Microarray	19088304
MIRT053461	hsa-miR-200c-3p	Microarray	23807165
MIRT713286	hsa-miR-5692a	HITS-CLIP	19536157
MIRT713285	hsa-miR-106b-3p	HITS-CLIP	19536157
MIRT713286	hsa-miR-5692a	HITS-CLIP	19536157
MIRT713285	hsa-miR-106b-3p	HITS-CLIP	19536157
MIRT1117869	hsa-miR-103a	CLIP-seq
MIRT1117870	hsa-miR-106a	CLIP-seq
MIRT1117871	hsa-miR-106b	CLIP-seq
MIRT1117872	hsa-miR-107	CLIP-seq
MIRT1117873	hsa-miR-1323	CLIP-seq
MIRT1117874	hsa-miR-15a	CLIP-seq
MIRT1117875	hsa-miR-15b	CLIP-seq
MIRT1117876	hsa-miR-16	CLIP-seq
MIRT1117877	hsa-miR-17	CLIP-seq
MIRT1117878	hsa-miR-195	CLIP-seq
MIRT1117879	hsa-miR-20a	CLIP-seq
MIRT1117880	hsa-miR-20b	CLIP-seq
MIRT1117881	hsa-miR-214	CLIP-seq
MIRT1117882	hsa-miR-2467-3p	CLIP-seq
MIRT1117883	hsa-miR-25	CLIP-seq
MIRT1117884	hsa-miR-3074-3p	CLIP-seq
MIRT1117885	hsa-miR-3117-5p	CLIP-seq
MIRT1117886	hsa-miR-3125	CLIP-seq
MIRT1117887	hsa-miR-3143	CLIP-seq
MIRT1117888	hsa-miR-3148	CLIP-seq
MIRT1117889	hsa-miR-32	CLIP-seq
MIRT1117890	hsa-miR-3613-5p	CLIP-seq
MIRT1117891	hsa-miR-3614-3p	CLIP-seq
MIRT1117892	hsa-miR-3619-5p	CLIP-seq
MIRT1117893	hsa-miR-363	CLIP-seq
MIRT1117894	hsa-miR-367	CLIP-seq
MIRT1117895	hsa-miR-3678-3p	CLIP-seq
MIRT1117896	hsa-miR-3688-3p	CLIP-seq
MIRT1117897	hsa-miR-3916	CLIP-seq
MIRT1117898	hsa-miR-3923	CLIP-seq
MIRT1117899	hsa-miR-3928	CLIP-seq
MIRT1117900	hsa-miR-424	CLIP-seq
MIRT1117901	hsa-miR-425	CLIP-seq
MIRT1117902	hsa-miR-4279	CLIP-seq
MIRT1117903	hsa-miR-4290	CLIP-seq
MIRT1117904	hsa-miR-4291	CLIP-seq
MIRT1117905	hsa-miR-4310	CLIP-seq
MIRT1117906	hsa-miR-4325	CLIP-seq
MIRT1117907	hsa-miR-4517	CLIP-seq
MIRT1117908	hsa-miR-4687-5p	CLIP-seq
MIRT1117909	hsa-miR-4699-5p	CLIP-seq
MIRT1117910	hsa-miR-4709-3p	CLIP-seq
MIRT1117911	hsa-miR-4742-3p	CLIP-seq
MIRT1117912	hsa-miR-4756-3p	CLIP-seq
MIRT1117913	hsa-miR-495	CLIP-seq
MIRT1117914	hsa-miR-497	CLIP-seq
MIRT1117915	hsa-miR-498	CLIP-seq
MIRT1117916	hsa-miR-519a	CLIP-seq
MIRT1117917	hsa-miR-519b-3p	CLIP-seq
MIRT1117918	hsa-miR-519c-3p	CLIP-seq
MIRT1117919	hsa-miR-519d	CLIP-seq
MIRT1117920	hsa-miR-543	CLIP-seq
MIRT1117921	hsa-miR-548o	CLIP-seq
MIRT1117922	hsa-miR-548p	CLIP-seq
MIRT1117923	hsa-miR-548t	CLIP-seq
MIRT1117924	hsa-miR-577	CLIP-seq
MIRT1117925	hsa-miR-592	CLIP-seq
MIRT1117926	hsa-miR-597	CLIP-seq
MIRT1117927	hsa-miR-761	CLIP-seq
MIRT1117928	hsa-miR-922	CLIP-seq
MIRT1117929	hsa-miR-92a	CLIP-seq
MIRT1117930	hsa-miR-92b	CLIP-seq
MIRT1117931	hsa-miR-93	CLIP-seq
MIRT1117883	hsa-miR-25	CLIP-seq
MIRT1117889	hsa-miR-32	CLIP-seq
MIRT1117893	hsa-miR-363	CLIP-seq
MIRT1117894	hsa-miR-367	CLIP-seq
MIRT1117898	hsa-miR-3923	CLIP-seq
MIRT1117906	hsa-miR-4325	CLIP-seq
MIRT1117915	hsa-miR-498	CLIP-seq
MIRT1117922	hsa-miR-548p	CLIP-seq
MIRT1117929	hsa-miR-92a	CLIP-seq
MIRT1117930	hsa-miR-92b	CLIP-seq
MIRT1117883	hsa-miR-25	CLIP-seq
MIRT1117889	hsa-miR-32	CLIP-seq
MIRT1117893	hsa-miR-363	CLIP-seq
MIRT1117894	hsa-miR-367	CLIP-seq
MIRT1117898	hsa-miR-3923	CLIP-seq
MIRT1117906	hsa-miR-4325	CLIP-seq
MIRT2033345	hsa-miR-4704-3p	CLIP-seq
MIRT1117915	hsa-miR-498	CLIP-seq
MIRT2033346	hsa-miR-548n	CLIP-seq
MIRT1117922	hsa-miR-548p	CLIP-seq
MIRT1117923	hsa-miR-548t	CLIP-seq
MIRT1117929	hsa-miR-92a	CLIP-seq
MIRT1117930	hsa-miR-92b	CLIP-seq
MIRT2263680	hsa-miR-1283	CLIP-seq
MIRT2263681	hsa-miR-2116	CLIP-seq
MIRT1117883	hsa-miR-25	CLIP-seq
MIRT1117889	hsa-miR-32	CLIP-seq
MIRT2263682	hsa-miR-3202	CLIP-seq
MIRT2263683	hsa-miR-361-5p	CLIP-seq
MIRT1117893	hsa-miR-363	CLIP-seq
MIRT1117894	hsa-miR-367	CLIP-seq
MIRT1117898	hsa-miR-3923	CLIP-seq
MIRT2263684	hsa-miR-4273	CLIP-seq
MIRT2263685	hsa-miR-4277	CLIP-seq
MIRT1117906	hsa-miR-4325	CLIP-seq
MIRT2263686	hsa-miR-4493	CLIP-seq
MIRT2263687	hsa-miR-4533	CLIP-seq
MIRT2263688	hsa-miR-4659a-3p	CLIP-seq
MIRT2263689	hsa-miR-4659b-3p	CLIP-seq
MIRT2263690	hsa-miR-4677-5p	CLIP-seq
MIRT2033345	hsa-miR-4704-3p	CLIP-seq
MIRT2263691	hsa-miR-4796-5p	CLIP-seq
MIRT1117915	hsa-miR-498	CLIP-seq
MIRT2263692	hsa-miR-548c-3p	CLIP-seq
MIRT2033346	hsa-miR-548n	CLIP-seq
MIRT1117922	hsa-miR-548p	CLIP-seq
MIRT1117923	hsa-miR-548t	CLIP-seq
MIRT2263693	hsa-miR-890	CLIP-seq
MIRT1117929	hsa-miR-92a	CLIP-seq
MIRT1117930	hsa-miR-92b	CLIP-seq
MIRT1117883	hsa-miR-25	CLIP-seq
MIRT1117889	hsa-miR-32	CLIP-seq
MIRT1117893	hsa-miR-363	CLIP-seq
MIRT1117894	hsa-miR-367	CLIP-seq
MIRT1117898	hsa-miR-3923	CLIP-seq
MIRT1117906	hsa-miR-4325	CLIP-seq
MIRT1117915	hsa-miR-498	CLIP-seq
MIRT1117922	hsa-miR-548p	CLIP-seq
MIRT1117929	hsa-miR-92a	CLIP-seq
MIRT1117930	hsa-miR-92b	CLIP-seq
MIRT2563023	hsa-miR-452	CLIP-seq
MIRT2563024	hsa-miR-4676-3p	CLIP-seq
MIRT2563025	hsa-miR-548a-5p	CLIP-seq
MIRT2563026	hsa-miR-548ab	CLIP-seq
MIRT2563027	hsa-miR-548ak	CLIP-seq
MIRT2563028	hsa-miR-548b-5p	CLIP-seq
MIRT2563029	hsa-miR-548c-5p	CLIP-seq
MIRT2563030	hsa-miR-548d-5p	CLIP-seq
MIRT2563031	hsa-miR-548h	CLIP-seq
MIRT2563032	hsa-miR-548i	CLIP-seq
MIRT2563033	hsa-miR-548j	CLIP-seq
MIRT2033346	hsa-miR-548n	CLIP-seq
MIRT2563034	hsa-miR-548w	CLIP-seq
MIRT2563035	hsa-miR-548y	CLIP-seq
MIRT2563036	hsa-miR-559	CLIP-seq
MIRT2563023	hsa-miR-452	CLIP-seq
MIRT2563024	hsa-miR-4676-3p	CLIP-seq
MIRT2563025	hsa-miR-548a-5p	CLIP-seq
MIRT2563026	hsa-miR-548ab	CLIP-seq
MIRT2563027	hsa-miR-548ak	CLIP-seq
MIRT2563028	hsa-miR-548b-5p	CLIP-seq
MIRT2563029	hsa-miR-548c-5p	CLIP-seq
MIRT2563030	hsa-miR-548d-5p	CLIP-seq
MIRT2563031	hsa-miR-548h	CLIP-seq
MIRT2563032	hsa-miR-548i	CLIP-seq
MIRT2563033	hsa-miR-548j	CLIP-seq
MIRT2033346	hsa-miR-548n	CLIP-seq
MIRT2563034	hsa-miR-548w	CLIP-seq
MIRT2563035	hsa-miR-548y	CLIP-seq
MIRT2563036	hsa-miR-559	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005041	Function	Low-density lipoprotein particle receptor activity	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005886	Component	Plasma membrane	IBA
GO:0006897	Process	Endocytosis	IEA
GO:0006898	Process	Receptor-mediated endocytosis	IEA
GO:0006898	Process	Receptor-mediated endocytosis	TAS	10766186
GO:0015031	Process	Protein transport	TAS	10766186
GO:0016020	Component	Membrane	IEA
GO:0043235	Component	Receptor complex	IBA
GO:0043235	Component	Receptor complex	IDA	23382219

MIM	HGNC	e!Ensembl
608766	6693	ENSG00000168702

Protein

UniProt ID

Q9NZR2

Protein name

Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT)

Protein function

Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00057	Ldl_recept_a	30 → 69	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	75 → 113	Low-density lipoprotein receptor domain class A	Repeat
PF07645	EGF_CA	155 → 193	Calcium-binding EGF domain	Domain
PF00058	Ldl_recept_b	295 → 335	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	568 → 608	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	611 → 654	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	657 → 704	Low-density lipoprotein receptor repeat class B	Repeat
PF14670	FXa_inhibition	798 → 833		Domain
PF00057	Ldl_recept_a	843 → 881	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	884 → 922	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	925 → 962	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	965 → 1002	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	1004 → 1042	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	1051 → 1088	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	1093 → 1131	Low-density lipoprotein receptor domain class A	Repeat
PF14670	FXa_inhibition	1176 → 1212		Domain
PF00058	Ldl_recept_b	1347 → 1387	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	1390 → 1434	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	1618 → 1658	Low-density lipoprotein receptor repeat class B	Repeat
PF14670	FXa_inhibition	1838 → 1874		Domain
PF00058	Ldl_recept_b	1965 → 2005	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	2008 → 2049	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	2330 → 2372	Low-density lipoprotein receptor repeat class B	Repeat
PF00057	Ldl_recept_a	2508 → 2547	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2550 → 2586	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2589 → 2625	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2641 → 2674	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2680 → 2716	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2718 → 2756	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2759 → 2799	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2803 → 2840	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2843 → 2884	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	2889 → 2925	Low-density lipoprotein receptor domain class A	Repeat
PF12662	cEGF	2948 → 2971	Complement Clr-like EGF-like	Domain
PF16472	DUF5050	3007 → 3241	Domain of unknown function (DUF5050)	Domain
PF14670	FXa_inhibition	3277 → 3313		Domain
PF00057	Ldl_recept_a	3315 → 3352	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3355 → 3391	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3394 → 3431	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3434 → 3471	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3474 → 3510	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3513 → 3549	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3551 → 3587	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3592 → 3628	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3630 → 3667	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3672 → 3710	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	3760 → 3796	Low-density lipoprotein receptor domain class A	Repeat
PF07645	EGF_CA	3844 → 3880	Calcium-binding EGF domain	Domain
PF00058	Ldl_recept_b	4039 → 4080	Low-density lipoprotein receptor repeat class B	Repeat
PF00008	EGF	4253 → 4283	EGF-like domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain. {ECO:0000269|PubMed:11384978}.

Sequence

MSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPD
DSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNC
QQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSC
VEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDF
IYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFV
DHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMN
RTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGIT
VFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPY
GMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDL
NTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDN
VEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMY
WTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIE
KVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPP
LFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEA
LPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIP
KRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMA
SCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIP
GHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCE
DGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK
HPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCP
EGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEA
FIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSES
GGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHP
RAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIV
WTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTG
QNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLM
KLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERL
YWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARL
DGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSI
DYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQL
GTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCM
CTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAE
NDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVA
RLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIA
WPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSD
RAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLY
RGNSRRTCACAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRY
FKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAW
DTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQ
HPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVI
VKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDT
NSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGN
GECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDN
SDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKT
TGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWI
CDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAIT
CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPK
QFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPL
NPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQ
DCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQ
PDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWI
DSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLY
PTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALT
IDYVNRRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRA
HKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCAC
PTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPG
RFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQD
DCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHE
FQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDC
ADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYI
CASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVD
GSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRP
HRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQ
CDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNR
QCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILG
FIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQAN
SGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTR
LLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDY
FSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRV
QKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGK
YLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNG
GTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRC
QYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFC
NCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHIS
TRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEV
DHDHNDGGLLDPGFMIDPTKARYIGGGPSAFKLPHTAPPIYLNSDLKGPLTAGPTNYSNP
VYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA

Sequence length

4599

Interactions

View interactions

Show/Hide Unknown Diseases (13)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma (childhood onset)	N/A	N/A	GWAS
Cataract	Cataract	N/A	N/A	GWAS
Glaucoma	Glaucoma	N/A	N/A	GWAS
Glioblastoma	Glioblastoma	N/A	N/A	GWAS
Hypertension	Hypertension	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Keratoconus	Keratoconus	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Motion Sickness	Motion sickness	N/A	N/A	GWAS
Renal Carcinoma	Renal cell carcinoma	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS
Takayasu Arteritis	Takayasu arteritis	N/A	N/A	GWAS
Uveal Melanoma	Uveal melanoma	N/A	N/A	GWAS

Show/Hide Text Mining Associations (68)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	30121391, 30720096, 33500480, 34152098
Adenocarcinoma of Lung	Associate	18948947, 28522810, 35069585, 38166691
Adrenocortical Carcinoma	Associate	25078331, 34410225
Alzheimer Disease	Associate	26621834, 36951251
Anodontia	Associate	31270961
Biliary Tract Neoplasms	Associate	33754015
Breast Neoplasms	Associate	33653800
Carcinogenesis	Associate	16918994, 35069585
Carcinoma	Associate	37115272
Carcinoma Basal Cell	Associate	33928395
Carcinoma Hepatocellular	Associate	34386813, 35150083, 35389768, 35651292, 35777027, 36153509
Carcinoma Intraductal Noninfiltrating	Associate	26718977
Carcinoma Merkel Cell	Associate	36736454
Carcinoma Non Small Cell Lung	Inhibit	11031110
Carcinoma Non Small Cell Lung	Associate	33629637, 34603481, 36282125, 37525904
Carcinoma Pancreatic Ductal	Associate	33255265, 34313325
Carcinoma Renal Cell	Inhibit	23521319
Carcinosarcoma	Associate	32209061
Cardiovascular Diseases	Associate	23420841
Colorectal Neoplasms	Associate	29575536, 33836681, 36520636, 37394872, 37992266
Diabetes Mellitus Type 1	Associate	22069270
Endometrial Neoplasms	Associate	39686583
Esophageal Neoplasms	Associate	28548104
Esophageal Squamous Cell Carcinoma	Inhibit	16918994
Glioblastoma	Associate	19435819, 34875133, 37511044
Glioma	Associate	16247447, 37511044
Hemihyperplasia Isolated	Associate	12004004
Keratoconus	Associate	33729517
Kidney Neoplasms	Associate	23521319
Laryngeal Neoplasms	Associate	35911687
Leukemia Lymphoma Adult T Cell	Associate	33562071
Leukemia Myeloid Acute	Associate	32011516, 38019014
Lung Diseases	Associate	33653800
Lung Neoplasms	Associate	28522810, 33200540
Lymphatic Metastasis	Associate	34152098, 39686583
Lymphoma	Associate	37657032
Lymphoma Follicular	Associate	30802265
Lymphoma Mantle Cell	Associate	37605345
Lymphoma Non Hodgkin	Associate	37742945
Lymphoma Primary Cutaneous Anaplastic Large Cell	Associate	34382383
Melanoma	Associate	33653800
Microsatellite Instability	Associate	31270961, 33653800
Multiple Myeloma	Associate	29895955
Neoplasm Metastasis	Associate	33255265, 37394872, 39673828
Neoplasms	Inhibit	11031110, 12004004, 17227771, 18948947, 20073072, 34689147, 36823311, 37742945
Neoplasms	Associate	23521319, 28548104, 29575536, 30703342, 30720096, 31312661, 32209061, 33432021, 33629637, 33653800, 33754015, 33810183, 33933102, 33994859, 34382383 View all (20 more)
Neoplastic Cells Circulating	Associate	29565466
Obesity	Associate	30755693
Ovarian Neoplasms	Associate	33432021, 34689147, 36721777, 37525498, 37742945
Pancreatic Neoplasms	Associate	25945796
Pdgfrb Associated Chronic Eosinophilic Leukemia	Associate	32011516
Pre Eclampsia	Associate	23420841
Prostatic Neoplasms	Associate	30877185, 31270961, 33115829, 33214693
Prostatitis	Associate	33653800
Pulmonary Disease Chronic Obstructive	Stimulate	28522810
Pulmonary Disease Chronic Obstructive	Associate	35860812
Red Cell Aplasia Pure	Associate	29767669
Rhabdomyosarcoma Embryonal	Associate	39379998
Sarcoma	Associate	33653800
Sarcopenia	Associate	36573383
Small Cell Lung Carcinoma	Associate	31199602, 35596192
Squamous Cell Carcinoma of Head and Neck	Associate	16918994, 33994859, 37340028, 37373553
Stomach Neoplasms	Associate	31312661, 32034058, 33511732, 33827485, 33900127, 33933102, 34551773, 34603481, 36823311
Stomach Neoplasms	Inhibit	36606427
Thyroid Neoplasms	Associate	36916542, 40184130
Urethral Neoplasms	Associate	12004004
Urinary Bladder Neoplasms	Associate	35841413
Uterine Cervical Neoplasms	Associate	17504382, 33994859, 36333792

LRP1B (LDL receptor related protein 1B)