Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5335
Gene name	Phospholipase C gamma 1
Gene symbol	PLCG1
Synonyms (NCBI Gene)	IDAANCKAP3PLC-IIPLC1PLC148PLCgamma1
Chromosome	20
Chromosome location	20q12
Summary	The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction

283

Show/Hide all (283)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025369	hsa-miR-34a-5p	Proteomics	21566225
MIRT025369	hsa-miR-34a-5p	Proteomics	21566225
MIRT049488	hsa-miR-92a-3p	CLASH	23622248
MIRT037381	hsa-miR-744-3p	CLASH	23622248
MIRT035779	hsa-miR-1914-3p	CLASH	23622248
MIRT654999	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT654998	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT654997	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT654996	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT654995	hsa-miR-1298-5p	HITS-CLIP	23824327
MIRT654994	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT654993	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT654992	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT654991	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT654990	hsa-miR-6777-5p	HITS-CLIP	23824327
MIRT501596	hsa-miR-200c-3p	PAR-CLIP	24398324
MIRT501595	hsa-miR-429	PAR-CLIP	24398324
MIRT501594	hsa-miR-200b-3p	PAR-CLIP	24398324
MIRT501593	hsa-miR-369-3p	PAR-CLIP	24398324
MIRT501592	hsa-miR-5692a	PAR-CLIP	24398324
MIRT501590	hsa-miR-8084	PAR-CLIP	24398324
MIRT501591	hsa-miR-3143	PAR-CLIP	24398324
MIRT501589	hsa-miR-3672	PAR-CLIP	24398324
MIRT501588	hsa-miR-6864-3p	PAR-CLIP	24398324
MIRT501587	hsa-miR-302c-5p	PAR-CLIP	24398324
MIRT501586	hsa-miR-552-5p	PAR-CLIP	24398324
MIRT448578	hsa-miR-3606-3p	PAR-CLIP	22100165
MIRT448577	hsa-miR-513a-3p	PAR-CLIP	22100165
MIRT448576	hsa-miR-513c-3p	PAR-CLIP	22100165
MIRT448575	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT448574	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT448573	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT448572	hsa-miR-6885-3p	PAR-CLIP	22100165
MIRT448571	hsa-miR-4635	PAR-CLIP	22100165
MIRT448570	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT448569	hsa-miR-766-5p	PAR-CLIP	22100165
MIRT448568	hsa-miR-7154-3p	PAR-CLIP	22100165
MIRT448567	hsa-miR-765	PAR-CLIP	22100165
MIRT448565	hsa-miR-6894-5p	PAR-CLIP	22100165
MIRT448566	hsa-miR-516b-5p	PAR-CLIP	22100165
MIRT448563	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT448564	hsa-miR-573	PAR-CLIP	22100165
MIRT448578	hsa-miR-3606-3p	PAR-CLIP	22100165
MIRT448577	hsa-miR-513a-3p	PAR-CLIP	22100165
MIRT448576	hsa-miR-513c-3p	PAR-CLIP	22100165
MIRT448575	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT448574	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT448573	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT448572	hsa-miR-6885-3p	PAR-CLIP	22100165
MIRT448571	hsa-miR-4635	PAR-CLIP	22100165
MIRT448570	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT448569	hsa-miR-766-5p	PAR-CLIP	22100165
MIRT448568	hsa-miR-7154-3p	PAR-CLIP	22100165
MIRT448567	hsa-miR-765	PAR-CLIP	22100165
MIRT448565	hsa-miR-6894-5p	PAR-CLIP	22100165
MIRT448566	hsa-miR-516b-5p	PAR-CLIP	22100165
MIRT448563	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT448564	hsa-miR-573	PAR-CLIP	22100165
MIRT448578	hsa-miR-3606-3p	PAR-CLIP	26701625
MIRT448577	hsa-miR-513a-3p	PAR-CLIP	26701625
MIRT448576	hsa-miR-513c-3p	PAR-CLIP	26701625
MIRT654999	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT654998	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT654997	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT654996	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT654995	hsa-miR-1298-5p	HITS-CLIP	23824327
MIRT654994	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT654993	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT654992	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT654991	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT654990	hsa-miR-6777-5p	HITS-CLIP	23824327
MIRT501596	hsa-miR-200c-3p	PAR-CLIP	24398324
MIRT501595	hsa-miR-429	PAR-CLIP	24398324
MIRT501594	hsa-miR-200b-3p	PAR-CLIP	24398324
MIRT501593	hsa-miR-369-3p	PAR-CLIP	24398324
MIRT501592	hsa-miR-5692a	PAR-CLIP	24398324
MIRT501590	hsa-miR-8084	PAR-CLIP	24398324
MIRT501591	hsa-miR-3143	PAR-CLIP	24398324
MIRT501589	hsa-miR-3672	PAR-CLIP	24398324
MIRT501588	hsa-miR-6864-3p	PAR-CLIP	24398324
MIRT501587	hsa-miR-302c-5p	PAR-CLIP	24398324
MIRT501586	hsa-miR-552-5p	PAR-CLIP	24398324
MIRT448578	hsa-miR-3606-3p	PAR-CLIP	22100165
MIRT448577	hsa-miR-513a-3p	PAR-CLIP	22100165
MIRT448576	hsa-miR-513c-3p	PAR-CLIP	22100165
MIRT448575	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT448574	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT448573	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT448572	hsa-miR-6885-3p	PAR-CLIP	22100165
MIRT448571	hsa-miR-4635	PAR-CLIP	22100165
MIRT448570	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT448569	hsa-miR-766-5p	PAR-CLIP	22100165
MIRT448568	hsa-miR-7154-3p	PAR-CLIP	22100165
MIRT448567	hsa-miR-765	PAR-CLIP	22100165
MIRT448565	hsa-miR-6894-5p	PAR-CLIP	22100165
MIRT448566	hsa-miR-516b-5p	PAR-CLIP	22100165
MIRT448563	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT448564	hsa-miR-573	PAR-CLIP	22100165
MIRT448578	hsa-miR-3606-3p	PAR-CLIP	22100165
MIRT448577	hsa-miR-513a-3p	PAR-CLIP	22100165
MIRT448576	hsa-miR-513c-3p	PAR-CLIP	22100165
MIRT448575	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT448574	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT448573	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT448572	hsa-miR-6885-3p	PAR-CLIP	22100165
MIRT448571	hsa-miR-4635	PAR-CLIP	22100165
MIRT448570	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT448569	hsa-miR-766-5p	PAR-CLIP	22100165
MIRT448568	hsa-miR-7154-3p	PAR-CLIP	22100165
MIRT448567	hsa-miR-765	PAR-CLIP	22100165
MIRT448565	hsa-miR-6894-5p	PAR-CLIP	22100165
MIRT448566	hsa-miR-516b-5p	PAR-CLIP	22100165
MIRT448563	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT448564	hsa-miR-573	PAR-CLIP	22100165
MIRT1239898	hsa-miR-103a	CLIP-seq
MIRT1239899	hsa-miR-107	CLIP-seq
MIRT1239900	hsa-miR-1184	CLIP-seq
MIRT1239901	hsa-miR-1207-5p	CLIP-seq
MIRT1239902	hsa-miR-1273g	CLIP-seq
MIRT1239903	hsa-miR-129-5p	CLIP-seq
MIRT1239904	hsa-miR-139-3p	CLIP-seq
MIRT1239905	hsa-miR-200b	CLIP-seq
MIRT1239906	hsa-miR-200c	CLIP-seq
MIRT1239907	hsa-miR-205	CLIP-seq
MIRT1239908	hsa-miR-218	CLIP-seq
MIRT1239909	hsa-miR-2392	CLIP-seq
MIRT1239910	hsa-miR-3127-5p	CLIP-seq
MIRT1239911	hsa-miR-3136-3p	CLIP-seq
MIRT1239912	hsa-miR-3150b-3p	CLIP-seq
MIRT1239913	hsa-miR-3152-5p	CLIP-seq
MIRT1239914	hsa-miR-3162-3p	CLIP-seq
MIRT1239915	hsa-miR-3183	CLIP-seq
MIRT1239916	hsa-miR-3202	CLIP-seq
MIRT1239917	hsa-miR-320a	CLIP-seq
MIRT1239918	hsa-miR-320b	CLIP-seq
MIRT1239919	hsa-miR-320c	CLIP-seq
MIRT1239920	hsa-miR-320d	CLIP-seq
MIRT1239921	hsa-miR-338-5p	CLIP-seq
MIRT1239922	hsa-miR-3612	CLIP-seq
MIRT1239923	hsa-miR-3622b-5p	CLIP-seq
MIRT1239924	hsa-miR-3657	CLIP-seq
MIRT1239925	hsa-miR-3909	CLIP-seq
MIRT1239926	hsa-miR-3918	CLIP-seq
MIRT1239927	hsa-miR-3925-3p	CLIP-seq
MIRT1239928	hsa-miR-4253	CLIP-seq
MIRT1239929	hsa-miR-4269	CLIP-seq
MIRT1239930	hsa-miR-4297	CLIP-seq
MIRT1239931	hsa-miR-4426	CLIP-seq
MIRT1239932	hsa-miR-4429	CLIP-seq
MIRT1239933	hsa-miR-4436b-3p	CLIP-seq
MIRT1239934	hsa-miR-4443	CLIP-seq
MIRT1239935	hsa-miR-4446-5p	CLIP-seq
MIRT1239936	hsa-miR-4459	CLIP-seq
MIRT1239937	hsa-miR-4461	CLIP-seq
MIRT1239938	hsa-miR-4487	CLIP-seq
MIRT1239939	hsa-miR-4514	CLIP-seq
MIRT1239940	hsa-miR-4533	CLIP-seq
MIRT1239941	hsa-miR-455-5p	CLIP-seq
MIRT1239942	hsa-miR-4640-5p	CLIP-seq
MIRT1239943	hsa-miR-4647	CLIP-seq
MIRT1239944	hsa-miR-4661-3p	CLIP-seq
MIRT1239945	hsa-miR-4662b	CLIP-seq
MIRT1239946	hsa-miR-4665-3p	CLIP-seq
MIRT1239947	hsa-miR-4669	CLIP-seq
MIRT1239948	hsa-miR-4689	CLIP-seq
MIRT1239949	hsa-miR-4692	CLIP-seq
MIRT1239950	hsa-miR-4710	CLIP-seq
MIRT1239951	hsa-miR-4722-5p	CLIP-seq
MIRT1239952	hsa-miR-4723-3p	CLIP-seq
MIRT1239953	hsa-miR-4726-5p	CLIP-seq
MIRT1239954	hsa-miR-4731-5p	CLIP-seq
MIRT1239955	hsa-miR-4742-5p	CLIP-seq
MIRT1239956	hsa-miR-4755-5p	CLIP-seq
MIRT1239957	hsa-miR-4758-3p	CLIP-seq
MIRT1239958	hsa-miR-4763-3p	CLIP-seq
MIRT1239959	hsa-miR-4774-3p	CLIP-seq
MIRT1239960	hsa-miR-4784	CLIP-seq
MIRT1239961	hsa-miR-4802-5p	CLIP-seq
MIRT1239962	hsa-miR-486-3p	CLIP-seq
MIRT1239963	hsa-miR-515-5p	CLIP-seq
MIRT1239964	hsa-miR-650	CLIP-seq
MIRT1239965	hsa-miR-766	CLIP-seq
MIRT1239966	hsa-miR-938	CLIP-seq
MIRT1239967	hsa-miR-940	CLIP-seq
MIRT1239904	hsa-miR-139-3p	CLIP-seq
MIRT1239912	hsa-miR-3150b-3p	CLIP-seq
MIRT1239921	hsa-miR-338-5p	CLIP-seq
MIRT1239936	hsa-miR-4459	CLIP-seq
MIRT1239937	hsa-miR-4461	CLIP-seq
MIRT1239948	hsa-miR-4689	CLIP-seq
MIRT1239951	hsa-miR-4722-5p	CLIP-seq
MIRT1239960	hsa-miR-4784	CLIP-seq
MIRT1239898	hsa-miR-103a	CLIP-seq
MIRT1239899	hsa-miR-107	CLIP-seq
MIRT2070571	hsa-miR-1179	CLIP-seq
MIRT1239900	hsa-miR-1184	CLIP-seq
MIRT2070572	hsa-miR-1287	CLIP-seq
MIRT1239909	hsa-miR-2392	CLIP-seq
MIRT2070573	hsa-miR-3065-3p	CLIP-seq
MIRT2070574	hsa-miR-3120-5p	CLIP-seq
MIRT2070575	hsa-miR-3135b	CLIP-seq
MIRT2070576	hsa-miR-4420	CLIP-seq
MIRT2070577	hsa-miR-4505	CLIP-seq
MIRT2070578	hsa-miR-4645-5p	CLIP-seq
MIRT2070579	hsa-miR-4652-3p	CLIP-seq
MIRT2070580	hsa-miR-4673	CLIP-seq
MIRT2070581	hsa-miR-4778-3p	CLIP-seq
MIRT2070582	hsa-miR-627	CLIP-seq
MIRT2070583	hsa-miR-924	CLIP-seq
MIRT1239898	hsa-miR-103a	CLIP-seq
MIRT1239899	hsa-miR-107	CLIP-seq
MIRT1239900	hsa-miR-1184	CLIP-seq
MIRT2297667	hsa-miR-1227	CLIP-seq
MIRT2297668	hsa-miR-1289	CLIP-seq
MIRT1239904	hsa-miR-139-3p	CLIP-seq
MIRT2297669	hsa-miR-147	CLIP-seq
MIRT2297670	hsa-miR-1827	CLIP-seq
MIRT2297671	hsa-miR-1914	CLIP-seq
MIRT2297672	hsa-miR-1976	CLIP-seq
MIRT2297673	hsa-miR-199a-3p	CLIP-seq
MIRT2297674	hsa-miR-199b-3p	CLIP-seq
MIRT1239905	hsa-miR-200b	CLIP-seq
MIRT1239906	hsa-miR-200c	CLIP-seq
MIRT2297675	hsa-miR-223	CLIP-seq
MIRT1239909	hsa-miR-2392	CLIP-seq
MIRT2297676	hsa-miR-3064-5p	CLIP-seq
MIRT2297677	hsa-miR-3129-5p	CLIP-seq
MIRT1239911	hsa-miR-3136-3p	CLIP-seq
MIRT2297678	hsa-miR-3189-3p	CLIP-seq
MIRT2297679	hsa-miR-3198	CLIP-seq
MIRT2297680	hsa-miR-331-3p	CLIP-seq
MIRT1239922	hsa-miR-3612	CLIP-seq
MIRT2297681	hsa-miR-3616-3p	CLIP-seq
MIRT1239923	hsa-miR-3622b-5p	CLIP-seq
MIRT1239925	hsa-miR-3909	CLIP-seq
MIRT2297682	hsa-miR-3926	CLIP-seq
MIRT2297683	hsa-miR-4252	CLIP-seq
MIRT1239928	hsa-miR-4253	CLIP-seq
MIRT2297684	hsa-miR-4294	CLIP-seq
MIRT2297685	hsa-miR-4309	CLIP-seq
MIRT2297686	hsa-miR-432	CLIP-seq
MIRT1239933	hsa-miR-4436b-3p	CLIP-seq
MIRT1239934	hsa-miR-4443	CLIP-seq
MIRT2297687	hsa-miR-4448	CLIP-seq
MIRT2297688	hsa-miR-4464	CLIP-seq
MIRT2297689	hsa-miR-4697-3p	CLIP-seq
MIRT1239950	hsa-miR-4710	CLIP-seq
MIRT1239954	hsa-miR-4731-5p	CLIP-seq
MIRT2297690	hsa-miR-4748	CLIP-seq
MIRT2070581	hsa-miR-4778-3p	CLIP-seq
MIRT1239961	hsa-miR-4802-5p	CLIP-seq
MIRT1239962	hsa-miR-486-3p	CLIP-seq
MIRT2297691	hsa-miR-548ac	CLIP-seq
MIRT2297692	hsa-miR-548ae	CLIP-seq
MIRT2297693	hsa-miR-548aj	CLIP-seq
MIRT2297694	hsa-miR-548am	CLIP-seq
MIRT2297695	hsa-miR-548d-3p	CLIP-seq
MIRT2297696	hsa-miR-548p	CLIP-seq
MIRT2297697	hsa-miR-548x	CLIP-seq
MIRT2297698	hsa-miR-548z	CLIP-seq
MIRT2297699	hsa-miR-599	CLIP-seq
MIRT2070582	hsa-miR-627	CLIP-seq
MIRT1239964	hsa-miR-650	CLIP-seq
MIRT2297700	hsa-miR-892b	CLIP-seq
MIRT2297701	hsa-miR-922	CLIP-seq
MIRT2070583	hsa-miR-924	CLIP-seq
MIRT2297702	hsa-miR-936	CLIP-seq
MIRT1239912	hsa-miR-3150b-3p	CLIP-seq
MIRT1239914	hsa-miR-3162-3p	CLIP-seq
MIRT1239915	hsa-miR-3183	CLIP-seq
MIRT1239921	hsa-miR-338-5p	CLIP-seq
MIRT2297683	hsa-miR-4252	CLIP-seq
MIRT2595176	hsa-miR-4279	CLIP-seq
MIRT1239935	hsa-miR-4446-5p	CLIP-seq
MIRT1239936	hsa-miR-4459	CLIP-seq
MIRT2595177	hsa-miR-4639-3p	CLIP-seq
MIRT1239948	hsa-miR-4689	CLIP-seq
MIRT1239950	hsa-miR-4710	CLIP-seq
MIRT1239951	hsa-miR-4722-5p	CLIP-seq
MIRT1239952	hsa-miR-4723-3p	CLIP-seq
MIRT1239956	hsa-miR-4755-5p	CLIP-seq
MIRT1239960	hsa-miR-4784	CLIP-seq
MIRT1239963	hsa-miR-515-5p	CLIP-seq

Show/Hide all (63)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	IDA	17229814
GO:0001726	Component	Ruffle	IEA
GO:0002862	Process	Negative regulation of inflammatory response to antigenic stimulus	TAS
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IBA
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IDA	2550068
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IEA
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	TAS
GO:0004629	Function	Phospholipase C activity	IDA	20510673
GO:0004629	Function	Phospholipase C activity	IMP	37422272
GO:0004629	Function	Phospholipase C activity	TAS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005168	Function	Neurotrophin TRKA receptor binding	IPI	15488758
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	1396585, 1656221, 7537096, 7537265, 7693694, 7993895, 8321198, 8384556, 8627166, 8657103, 8892607, 9020117, 9045636, 9489702, 9593725, 9697839, 10811803, 10873601, 11796522, 11896612, 14568990, 14570588, 14722116, 15641795, 15929943, 16273093, 16525023, 16921170, 16938345, 17229814, 1
GO:0005737	Component	Cytoplasm	IDA	15702972
GO:0005829	Component	Cytosol	IDA	2550068
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	20510673
GO:0005886	Component	Plasma membrane	IDA	2550068, 22454520
GO:0005886	Component	Plasma membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IMP	22454520
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	ISS
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0008180	Component	COP9 signalosome	IDA	22561606
GO:0009395	Process	Phospholipid catabolic process	IEA
GO:0010634	Process	Positive regulation of epithelial cell migration	IBA
GO:0010634	Process	Positive regulation of epithelial cell migration	IMP	17229814
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016477	Process	Cell migration	IMP	22454520
GO:0016787	Function	Hydrolase activity	IEA
GO:0019722	Process	Calcium-mediated signaling	IEA
GO:0019722	Process	Calcium-mediated signaling	IMP	22454520
GO:0019901	Function	Protein kinase binding	IPI	22454520
GO:0030027	Component	Lamellipodium	IDA	17229814
GO:0030027	Component	Lamellipodium	IEA
GO:0032587	Component	Ruffle membrane	IBA
GO:0032587	Component	Ruffle membrane	IDA	11331309
GO:0032587	Component	Ruffle membrane	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0038095	Process	Fc-epsilon receptor signaling pathway	IEA
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0042995	Component	Cell projection	IDA	22454520
GO:0042995	Component	Cell projection	IEA
GO:0043536	Process	Positive regulation of blood vessel endothelial cell migration	IDA	20011604
GO:0045766	Process	Positive regulation of angiogenesis	IDA	20011604
GO:0046488	Process	Phosphatidylinositol metabolic process	IBA
GO:0046488	Process	Phosphatidylinositol metabolic process	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA
GO:0050429	Function	Calcium-dependent phospholipase C activity	ISS
GO:0050851	Process	Antigen receptor-mediated signaling pathway	IEA
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IBA
GO:0051281	Process	Positive regulation of release of sequestered calcium ion into cytosol	IMP	22454520
GO:0051282	Process	Regulation of sequestering of calcium ion	IEA
GO:0071364	Process	Cellular response to epidermal growth factor stimulus	IDA	17229814
GO:0071364	Process	Cellular response to epidermal growth factor stimulus	IMP	22454520
GO:0120548	Function	Phosphatidylinositol phospholipase C activity	IEA
GO:1905564	Process	Positive regulation of vascular endothelial cell proliferation	IMP	27464494
GO:2000353	Process	Positive regulation of endothelial cell apoptotic process	IMP	27464494

MIM	HGNC	e!Ensembl
172420	9065	ENSG00000124181

P19174

Protein name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)

Protein function

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediate

PDB

1HSQ , 2HSP , 4EY0 , 4FBN , 7NXE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00388	PI-PLC-X	322 → 465	Phosphatidylinositol-specific phospholipase C, X domain	Family
PF00017	SH2	550 → 639	SH2 domain	Domain
PF00017	SH2	668 → 741	SH2 domain	Domain
PF00018	SH3_1	797 → 843	SH3 domain	Domain
PF00387	PI-PLC-Y	953 → 1068	Phosphatidylinositol-specific phospholipase C, Y domain	Family
PF00168	C2	1088 → 1193	C2 domain	Domain

Sequence

MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDF
RISQEHLADHFDSRERRAPRRTRVNGDNRL

Sequence length

1290

Interactions

View interactions

	KEGG		Reactome
	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway Chemokine signaling pathway NF-kappa B signaling pathway HIF-1 signaling pathway Phosphatidylinositol signaling system Phospholipase D signaling pathway Axon guidance VEGF signaling pathway Neutrophil extracellular trap formation Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Neurotrophin signaling pathway Inflammatory mediator regulation of TRP channels Thyroid hormone signaling pathway AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Parkinson disease Pathways of neurodegeneration - multiple diseases Vibrio cholerae infection Epithelial cell signaling in Helicobacter pylori infection Shigellosis Yersinia infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Glioma Non-small cell lung cancer Hepatocellular carcinoma Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis		ISG15 antiviral mechanism Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Synthesis of IP3 and IP4 in the cytosol Downstream signal transduction Generation of second messenger molecules Role of phospholipids in phagocytosis PECAM1 interactions EGFR interacts with phospholipase C-gamma DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization VEGFR2 mediated cell proliferation Constitutive Signaling by EGFRvIII Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 point mutants in cancer RET signaling Activated NTRK2 signals through PLCG1 Activated NTRK3 signals through PLCG1 FCGR3A-mediated IL10 synthesis Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Immune dysregulation, autoimmunity, and autoinflammation	Pathogenic	rs2515585150	RCV003330117

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Hereditary breast ovarian cancer syndrome	Uncertain significance	rs761555687	RCV001374521
PLCG1-related disorder	Uncertain significance	rs2515561074, rs2515563874	RCV003894186 RCV003944548

Show/Hide Text Mining Associations (68)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	25308733
Adenocarcinoma of Lung	Associate	34869771, 35421944
Aortic Aneurysm Abdominal	Associate	25993291
Arthritis Rheumatoid	Associate	37008939
Ataxia Telangiectasia	Associate	9083089
Blood Platelet Disorders	Associate	31889510
Breast Neoplasms	Associate	14710234, 23320987, 28112359, 31323325, 31362705
Calcinosis Cutis	Associate	31362705
Carcinogenesis	Associate	29049217, 31049933
Carcinoma Hepatocellular	Associate	26290635, 35242200, 35535333, 36920176
Carcinoma Ovarian Epithelial	Associate	24740199
Carcinoma Renal Cell	Associate	24576174
Carcinoma Squamous Cell	Associate	20510673, 20621058, 26464646
Chronobiology Disorders	Associate	22022282
Colorectal Neoplasms	Associate	27562229, 29693170
COVID 19	Associate	37426642
Diabetes Mellitus	Associate	37460827
Diabetes Mellitus Type 2	Associate	1639386, 37538791, 38034011, 8094595
Drug Related Side Effects and Adverse Reactions	Associate	36480602
Ectodermal Dysplasia	Associate	37873683
Fetal Death	Associate	25257609
Fetal Growth Retardation	Associate	25257609
Fetal Hypoxia	Associate	25257609
Glioblastoma	Associate	21649900, 25943352
Glioma	Associate	20506511
Graves Ophthalmopathy	Stimulate	37989267
Hemangioma capillary infantile	Associate	36181115
Hemangiosarcoma	Associate	24633157, 26440310, 26474454
Hernia Inguinal	Associate	31910207
Hypothalamic hamartomas	Associate	25307426
Hypoxia Brain	Stimulate	20395290
Inflammation	Associate	29693170, 29950425, 31889510, 37426642
Ischemia	Associate	25257609
Leukemia	Inhibit	7828717
Leukemia Lymphocytic Chronic B Cell	Associate	36177050
Leukemia Lymphoma Adult T Cell	Associate	29794791, 30032036, 33426772, 34793541, 36442790
Lupus Erythematosus Systemic	Associate	37426642
Lymphatic Metastasis	Associate	25308733
Lymphatic Metastasis	Stimulate	26464646
Lymphoma T Cell	Associate	27369867, 28148900, 31049933, 34793541, 36442790
Lymphoma T Cell Cutaneous	Associate	25140833, 26269406, 29794791, 31049933, 34793541
Lymphoma T Cell Peripheral	Associate	34793541, 35895386
Lymphoproliferative Disorders	Associate	12766168
Mason Type Diabetes	Associate	1639386
Metabolic Syndrome	Associate	22022282, 27827461
Multiple Sclerosis	Associate	23469041
Mycosis Fungoides	Associate	29794791
Myelodysplastic Syndromes	Inhibit	31755660
Myotonic Dystrophy	Associate	32323808
Neoplasm Metastasis	Associate	14710234, 25308733, 31362705
Neoplasms	Associate	14710234, 20506511, 22454520, 25308733, 25435355, 26269406, 26464646, 26474454, 27121473, 29115528, 29794791, 31298409, 31362705, 31889510, 33577785, 36480602 View all (1 more)
Non alcoholic Fatty Liver Disease	Associate	23931760
Obesity	Associate	22022282
Osteoarthritis	Associate	25073093, 26247939
Osteoporosis	Associate	37335694
Ovarian Neoplasms	Associate	31298409
Pancreatic Neoplasms	Associate	29049217, 35677632, 35682857
Periodontitis	Associate	35844512
Pre Eclampsia	Stimulate	25257609
Pulmonary Disease Chronic Obstructive	Inhibit	37194062
Sarcoidosis	Associate	22984568
Sepsis	Inhibit	36250055
Severe combined immunodeficiency due to adenosine deaminase deficiency	Associate	1639386
Sezary Syndrome	Associate	26269406, 26551670, 27121473
Shock Septic	Inhibit	36250055
Squamous Cell Carcinoma of Head and Neck	Associate	18594017, 20395290, 26464646, 33466212
Stomach Neoplasms	Associate	25308733, 27039174, 32679742, 37863665
Uveomeningoencephalitic Syndrome	Associate	35003060

PLCG1 (phospholipase C gamma 1)