PLAU (plasminogen activator, urokinase)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5328
Gene name Gene Name - the full gene name approved by the HGNC.
Plasminogen activator, urokinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PLAU
Synonyms (NCBI Gene) Gene synonyms aliases
ATF, BDPLT5, QPD, UPA, URK, u-PA
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(81)
miRTarBase ID miRNA Experiments Reference
MIRT004291 hsa-miR-23b-3p Luciferase reporter assay, qRT-PCR, Western blot 19490101
MIRT004291 hsa-miR-23b-3p Luciferase reporter assay, qRT-PCR, Western blot 19490101
MIRT004413 hsa-miR-193b-3p Western blot, Luciferase reporter assay 19701247
MIRT004291 hsa-miR-23b-3p qRT-PCR, Western blot 21242962
MIRT024290 hsa-miR-215-5p Microarray 19074876
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(19)
Transcription factor Regulation Reference
ATF2 Unknown 10454570
ATF4 Activation 18829529
CREB1 Unknown 11776974
EGR1 Activation 21283769
ETS1 Unknown 10211993;11556732
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(56)
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0004252 Function Serine-type endopeptidase activity IBA
GO:0004252 Function Serine-type endopeptidase activity IEA
GO:0004252 Function Serine-type endopeptidase activity TAS
GO:0005515 Function Protein binding IPI 3501295, 7904248, 10340997, 14696115, 18376415, 22449964, 25168896, 32296183, 32814053, 33961781
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
191840 9052 ENSG00000122861
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P00749
Protein name Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]
Protein function Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
PDB 1C5W , 1C5X , 1C5Y , 1C5Z , 1EJN , 1F5K , 1F5L , 1F92 , 1FV9 , 1GI7 , 1GI8 , 1GI9 , 1GJ7 , 1GJ8 , 1GJ9 , 1GJA , 1GJB , 1GJC , 1GJD , 1KDU , 1LMW , 1O3P , 1O5A , 1O5B , 1O5C , 1OWD , 1OWE , 1OWH , 1OWI , 1OWJ , 1OWK , 1SC8 , 1SQA , 1SQO , 1SQT , 1U6Q , 1URK , 1VJ9 , 1VJA , 1W0Z , 1W10 , 1W11 , 1W12 , 1W13 , 1W14 , 2FD6 , 2I9A , 2I9B , 2NWN , 2O8T , 2O8U
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00051 Kringle 70 → 151 Kringle domain Domain
PF00089 Trypsin 179 → 419 Trypsin Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the prostate gland and prostate cancers. {ECO:0000269|PubMed:15988036}.
Sequence
Sequence length 431
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  NF-kappa B signaling pathway
Complement and coagulation cascades
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Prostate cancer 		  Neutrophil degranulation
Dissolution of Fibrin Clot
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (4)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Crohn Disease Crohn's disease N/A N/A GWAS
Hirschsprung Disease Hirschsprung disease, susceptibility to, 1 N/A N/A ClinVar
Inflammatory Bowel Disease Inflammatory bowel disease N/A N/A GWAS
Quebec Platelet Disorder quebec platelet disorder N/A N/A ClinVar
Show/Hide Text Mining Associations (203)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 11399944, 1310252, 17264880, 21829465, 36928883
Adenocarcinoma of Lung Associate 28454121
Adenoma Associate 20496126, 30175151, 9006343
Allan Herndon Dudley syndrome Stimulate 18076013
Alzheimer Disease Associate 18076107
Ameloblastoma Inhibit 36507758
Angioedemas Hereditary Inhibit 11050091
Aortic Aneurysm Associate 35952493
Aortic Aneurysm Abdominal Associate 35952493, 7552526, 7615837, 9013920
Aortic Dissection Associate 9013920