Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5328
Gene name Gene Name - the full gene name approved by the HGNC.
Plasminogen activator, urokinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PLAU
Synonyms (NCBI Gene) Gene synonyms aliases
ATF, BDPLT5, QPD, UPA, URK, u-PA
Disease Acronyms (UniProt) Disease acronyms from UniProt database
QPD
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004291 hsa-miR-23b-3p Luciferase reporter assay, qRT-PCR, Western blot 19490101
MIRT004291 hsa-miR-23b-3p Luciferase reporter assay, qRT-PCR, Western blot 19490101
MIRT004413 hsa-miR-193b-3p Western blot, Luciferase reporter assay 19701247
MIRT004291 hsa-miR-23b-3p qRT-PCR, Western blot 21242962
MIRT024290 hsa-miR-215-5p Microarray 19074876
Transcription factors
Transcription factor Regulation Reference
ATF2 Unknown 10454570
ATF4 Activation 18829529
CREB1 Unknown 11776974
EGR1 Activation 21283769
ETS1 Unknown 10211993;11556732
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0004252 Function Serine-type endopeptidase activity IBA 21873635
GO:0004252 Function Serine-type endopeptidase activity TAS
GO:0005515 Function Protein binding IPI 3501295, 7904248, 10340997, 14696115, 18376415, 32296183, 32814053
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
191840 9052 ENSG00000122861
Protein
UniProt ID P00749
Protein name Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]
Protein function Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
PDB 1C5W , 1C5X , 1C5Y , 1C5Z , 1EJN , 1F5K , 1F5L , 1F92 , 1FV9 , 1GI7 , 1GI8 , 1GI9 , 1GJ7 , 1GJ8 , 1GJ9 , 1GJA , 1GJB , 1GJC , 1GJD , 1KDU , 1LMW , 1O3P , 1O5A , 1O5B , 1O5C , 1OWD , 1OWE , 1OWH , 1OWI , 1OWJ , 1OWK , 1SC8 , 1SQA , 1SQO , 1SQT , 1U6Q , 1URK , 1VJ9 , 1VJA , 1W0Z , 1W10 , 1W11 , 1W12 , 1W13 , 1W14 , 2FD6 , 2I9A , 2I9B , 2NWN , 2O8T , 2O8U
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00051 Kringle 70 151 Kringle domain Domain
PF00089 Trypsin 179 419 Trypsin Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the prostate gland and prostate cancers. {ECO:0000269|PubMed:15988036}.
Sequence
Sequence length 431
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  NF-kappa B signaling pathway
Complement and coagulation cascades
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Prostate cancer
  Neutrophil degranulation
Dissolution of Fibrin Clot
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Adenocarcinoma Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular rs121913530, rs886039394, rs121913474 10467400
Alzheimer disease Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039
View all (65 more)
Carcinoma Carcinoma, Cribriform, Carcinoma, Granular Cell rs121912654, rs555607708, rs786202962, rs1564055259 10467400
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
16367923
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 21912604 ClinVar
Cerebral infarction Cerebral Infarction 15502123, 12133459, 16773802 ClinVar
Coronary heart disease Coronary heart disease 1730212, 9181759 ClinVar
Crohn disease Crohn Disease 26192919, 28067908, 26974007 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 11399944, 1310252, 17264880, 21829465, 36928883
Adenocarcinoma of Lung Associate 28454121
Adenoma Associate 20496126, 30175151, 9006343
Allan Herndon Dudley syndrome Stimulate 18076013
Alzheimer Disease Associate 18076107
Ameloblastoma Inhibit 36507758
Angioedemas Hereditary Inhibit 11050091
Aortic Aneurysm Associate 35952493
Aortic Aneurysm Abdominal Associate 35952493, 7552526, 7615837, 9013920
Aortic Dissection Associate 9013920