PLAU (plasminogen activator, urokinase)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 5328
Gene name Plasminogen activator, urokinase
Gene symbol PLAU
Synonyms (NCBI Gene)
ATFBDPLT5QPDUPAURKu-PA
Chromosome 10
Chromosome location 10q22.2
Summary This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically
miRNA miRNA information provided by mirtarbase database.
81
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT004291 hsa-miR-23b-3p Luciferase reporter assayqRT-PCRWestern blot 19490101
MIRT004291 hsa-miR-23b-3p Luciferase reporter assayqRT-PCRWestern blot 19490101
MIRT004413 hsa-miR-193b-3p Western blotLuciferase reporter assay 19701247
MIRT004291 hsa-miR-23b-3p qRT-PCRWestern blot 21242962
MIRT024290 hsa-miR-215-5p Microarray 19074876
Transcription factors Transcription factors information provided by TRRUST V2 database.
19
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
ATF2 Unknown 10454570
ATF4 Activation 18829529
CREB1 Unknown 11776974
EGR1 Activation 21283769
ETS1 Unknown 10211993;11556732
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
56
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0004252 Function Serine-type endopeptidase activity IBA
GO:0004252 Function Serine-type endopeptidase activity IEA
GO:0004252 Function Serine-type endopeptidase activity TAS
GO:0005515 Function Protein binding IPI 3501295, 7904248, 10340997, 14696115, 18376415, 22449964, 25168896, 32296183, 32814053, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
191840 9052 ENSG00000122861
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P00749
Protein name Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]
Protein function Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
PDB 1C5W , 1C5X , 1C5Y , 1C5Z , 1EJN , 1F5K , 1F5L , 1F92 , 1FV9 , 1GI7 , 1GI8 , 1GI9 , 1GJ7 , 1GJ8 , 1GJ9 , 1GJA , 1GJB , 1GJC , 1GJD , 1KDU , 1LMW , 1O3P , 1O5A , 1O5B , 1O5C , 1OWD , 1OWE , 1OWH , 1OWI , 1OWJ , 1OWK , 1SC8 , 1SQA , 1SQO , 1SQT , 1U6Q , 1URK , 1VJ9 , 1VJA , 1W0Z , 1W10 , 1W11 , 1W12 , 1W13 , 1W14 , 2FD6 , 2I9A , 2I9B , 2NWN , 2O8T , 2O8U
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00051 Kringle 70 → 151 Kringle domain Domain
PF00089 Trypsin 179 → 419 Trypsin Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the prostate gland and prostate cancers. {ECO:0000269|PubMed:15988036}.
Sequence
Sequence length 431
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  NF-kappa B signaling pathway
Complement and coagulation cascades
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Prostate cancer 		  Neutrophil degranulation
Dissolution of Fibrin Clot
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
100
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (17)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs2227567 RCV005891847
Alzheimer disease type 1 Conflicting classifications of pathogenicity rs371106595 RCV005396932
Alzheimer disease, late-onset, susceptibility to Benign rs2227564 RCV000013052
Cervical cancer Benign rs2227567 RCV005891849
Show/Hide Text Mining Associations (203)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 11399944, 1310252, 17264880, 21829465, 36928883
Adenocarcinoma of Lung Associate 28454121
Adenoma Associate 20496126, 30175151, 9006343
Allan Herndon Dudley syndrome Stimulate 18076013
Alzheimer Disease Associate 18076107
Ameloblastoma Inhibit 36507758
Angioedemas Hereditary Inhibit 11050091
Aortic Aneurysm Associate 35952493
Aortic Aneurysm Abdominal Associate 35952493, 7552526, 7615837, 9013920
Aortic Dissection Associate 9013920