PLA2G2A (phospholipase A2 group IIA)

Gene Gene information from NCBI Gene database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 5320
Gene name Phospholipase A2 group IIA
Gene symbol PLA2G2A
Synonyms (NCBI Gene)
MOM1PLA2PLA2BPLA2LPLA2SPLAS1sPLA2
Chromosome 1
Chromosome location 1p36.13
Summary The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, whi
SNPs SNP information provided by dbSNP.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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SNP ID Visualize variation Clinical significance Consequence
rs587776800 CA>- Pathogenic Coding sequence variant, frameshift variant
miRNA miRNA information provided by mirtarbase database.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT1238582 hsa-miR-1293 CLIP-seq
MIRT1238583 hsa-miR-3065-3p CLIP-seq
MIRT1238584 hsa-miR-4291 CLIP-seq
MIRT1238585 hsa-miR-4483 CLIP-seq
MIRT1238582 hsa-miR-1293 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
NFKB1 Unknown 11899260
RELA Unknown 11899260
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0003824 Function Catalytic activity IEA
GO:0004623 Function Phospholipase A2 activity IDA 17069818
GO:0004623 Function Phospholipase A2 activity IEA
GO:0005509 Function Calcium ion binding IBA
GO:0005509 Function Calcium ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
172411 9031 ENSG00000188257
Protein Protein information from UniProt database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P14555
Protein name Phospholipase A2, membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Non-pancreatic secretory phospholipase A2) (NPS-PLA2) (Phosphatidylcholine 2-acylhydrolase 2A)
Protein function Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (PubMed:10455175, PubMed:10681567, PubMed:2925633). Hy
PDB 1AYP , 1BBC , 1DB4 , 1DB5 , 1DCY , 1J1A , 1KQU , 1KVO , 1N28 , 1N29 , 1POD , 1POE , 3U8B , 3U8D , 3U8H , 3U8I , 5G3N
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00068 Phospholip_A2_1 22 → 130 Phospholipase A2 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in various tissues including heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, prostate, ovary, colon and small intestine. Not detected in lymphoid organs and brain (PubMed:10455175, PubMed:10681567). Expressed
Sequence
Sequence length 144
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Ras signaling pathway
Vascular smooth muscle contraction
Pancreatic secretion
Fat digestion and absorption 		  Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Antimicrobial peptides
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial colorectal cancer Pathogenic rs587776800 RCV000014605
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
PLA2G2A-related disorder Benign; Likely benign rs34568801, rs2236771, rs4744, rs779631054, rs11573162 RCV003921875
RCV003979707
RCV003973869
RCV003981346
RCV003983245
Show/Hide Text Mining Associations (65)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 8598867
Adenocarcinoma Associate 18212756, 20176206
Alzheimer Disease Stimulate 22832605
Arthritis Rheumatoid Associate 18089561
Astrocytoma Associate 20639215
Atherosclerosis Associate 11351047, 11786516, 12386144, 18264128, 22494626
Autoimmune Diseases Associate 12829607
Blood Platelet Disorders Associate 18396070
Carcinogenesis Associate 24641411, 26715269
Carcinoma Hepatocellular Associate 15527765, 28077172