Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5316
Gene name Gene Name - the full gene name approved by the HGNC.
PBX/knotted 1 homeobox 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PKNOX1
Synonyms (NCBI Gene) Gene synonyms aliases
PREP1, pkonx1c
Chromosome Chromosome number
21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
21q22.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT030936 hsa-miR-21-5p Microarray 18591254
MIRT037993 hsa-miR-500a-5p CLASH 23622248
MIRT724123 hsa-miR-6768-5p HITS-CLIP 19536157
MIRT724122 hsa-miR-6808-5p HITS-CLIP 19536157
MIRT724121 hsa-miR-6893-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0001525 Process Angiogenesis IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602100 9022 ENSG00000160199
Protein
UniProt ID P55347
Protein name Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1)
Protein function Activates transcription in the presence of PBX1A and HOXA1.
PDB 1X2N
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16493 Meis_PKNOX_N 80 165 N-terminal of Homeobox Meis and PKNOX1 Family
PF05920 Homeobox_KN 277 316 Homeobox KN domain Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Isoform 2 is expressed in all examined tissues except in bone marrow. {ECO:0000269|PubMed:15468914, ECO:0000269|PubMed:9143494}.
Sequence
MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYR
HPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVK
AIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPG
SPYSPVQSQQIQSAI
TGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQ
LQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTN
LTLLQVNNWFINARRR
ILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPS
ELTMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEEDAGALA
PAHISGLVLENSDSLQ
Sequence length 436
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Associations from Text Mining
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 22347417
AIDS Dementia Complex Associate 22347417
Breast Neoplasms Associate 40625743
Carcinoma Hepatocellular Associate 40625743
Carcinoma Non Small Cell Lung Associate 40625743
Dementia Associate 22347417
Fibular hypoplasia and complex brachydactyly Associate 40625743
Leukemia Associate 22185299
Multiple Myeloma Associate 27060151
Neoplasm Metastasis Associate 40625743