PKM (pyruvate kinase M1/2)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5315
Gene name Gene Name - the full gene name approved by the HGNC.
Pyruvate kinase M1/2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PKM
Synonyms (NCBI Gene) Gene synonyms aliases
CTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1, p58
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q23
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyro
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(149)
miRTarBase ID miRNA Experiments Reference
MIRT001816 hsa-miR-133a-3p Immunohistochemistry 18464261
MIRT001815 hsa-miR-133b Immunohistochemistry 18464261
MIRT005520 hsa-miR-326 Luciferase reporter assay, qRT-PCR, Western blot 20667897
MIRT005520 hsa-miR-326 Luciferase reporter assay, qRT-PCR, Western blot 20667897
MIRT005520 hsa-miR-326 Luciferase reporter assay, qRT-PCR, Western blot 20667897
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
ZBTB7A Repression 25184678
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(49)
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IEA
GO:0001666 Process Response to hypoxia IEA
GO:0001889 Process Liver development IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0003729 Function MRNA binding ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
179050 9021 ENSG00000067225
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P14618
Protein name Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein
Protein function Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active te
PDB 1T5A , 1ZJH , 3BJF , 3BJT , 3G2G , 3GQY , 3GR4 , 3H6O , 3ME3 , 3SRD , 3SRF , 3SRH , 3U2Z , 4B2D , 4FXF , 4FXJ , 4G1N , 4JPG , 4QG6 , 4QG8 , 4QG9 , 4QGC , 4RPP , 4WJ8 , 4YJ5 , 5X0I , 5X1V , 5X1W , 6B6U , 6GG3 , 6GG4 , 6GG5 , 6GG6 , 6JFB , 6NU1 , 6NU5 , 6NUB , 6TTF , 6TTH , 6TTI , 6TTQ , 6V74 , 6V75 , 6V76 , 6WP3 , 6WP4 , 6WP5 , 6WP6 , 7L21 , 8G2E , 8HGF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00224 PK 42 → 395 Pyruvate kinase, barrel domain Family
PF02887 PK_C 410 → 528 Pyruvate kinase, alpha/beta domain Domain
Tissue specificity TISSUE SPECIFICITY: [Isoform M2]: Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells. {ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823}.; TISSUE SPECIFICITY: [Isoform M1
Sequence
Sequence length 531
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Glycolysis / Gluconeogenesis
Pyruvate metabolism
Metabolic pathways
Carbon metabolism
Biosynthesis of amino acids
Glucagon signaling pathway
Type II diabetes mellitus
Human papillomavirus infection
Viral carcinogenesis
Central carbon metabolism in cancer 		  Neutrophil degranulation
Glycolysis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Carcinoma Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 16316942
Osteoporosis Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis rs72658152, rs72667023, rs587776916, rs72656370, rs768615287 18924182
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Show/Hide Text Mining Associations (127)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 22087286
Adenocarcinoma Stimulate 27150162
Adenocarcinoma of Lung Associate 26501265, 28489603, 30925904, 32716147, 34285141, 35924724, 37880717, 38097666, 38224012
Alzheimer Disease Associate 30578620, 35987203, 37454217
Anemia Aplastic Associate 29636835
Anophthalmia with pulmonary hypoplasia Associate 32633891
Arthritis Rheumatoid Associate 35256696, 36059477
beta Thalassemia Associate 40085946
Brain Neoplasms Associate 32372141
Breast Neoplasms Inhibit 22874552