Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5300
Gene name Gene Name - the full gene name approved by the HGNC.
Peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PIN1
Synonyms (NCBI Gene) Gene synonyms aliases
DOD, UBL5
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-ph
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT043127 hsa-miR-324-5p CLASH 23622248
MIRT042314 hsa-miR-484 CLASH 23622248
MIRT437915 hsa-miR-200c-3p Flow, Luciferase reporter assay, qRT-PCR, Western blot 24786790
MIRT437915 hsa-miR-200c-3p Flow, Luciferase reporter assay, qRT-PCR, Western blot 24786790
MIRT438291 hsa-miR-200b-3p Luciferase reporter assay 24072701
Transcription factors
Transcription factor Regulation Reference
E2F1 Unknown 20376080
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000413 Process Protein peptidyl-prolyl isomerization TAS 11533658
GO:0001666 Process Response to hypoxia IDA 25576397
GO:0001932 Process Regulation of protein phosphorylation IDA 24964035
GO:0001934 Process Positive regulation of protein phosphorylation IGI 19638580
GO:0003755 Function Peptidyl-prolyl cis-trans isomerase activity EXP 20956805
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601052 8988 ENSG00000127445
Protein
UniProt ID Q13526
Protein name Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1)
Protein function Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphoryl
PDB 1F8A , 1I6C , 1I8G , 1I8H , 1NMV , 1NMW , 1PIN , 1ZCN , 2F21 , 2ITK , 2KBU , 2KCF , 2LB3 , 2M8I , 2M8J , 2M9E , 2M9F , 2M9I , 2M9J , 2N1O , 2Q5A , 2RUC , 2RUD , 2RUQ , 2RUR , 2XP3 , 2XP4 , 2XP5 , 2XP6 , 2XP7 , 2XP8 , 2XP9 , 2XPA , 2XPB , 2ZQS , 2ZQT , 2ZQU , 2ZQV , 2ZR4 , 2ZR5 , 2ZR6 , 3I6C , 3IK8 , 3IKD , 3IKG , 3JYJ , 3KAB , 3KAC , 3KAD , 3KAF , 3KAG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00397 WW 7 37 WW domain Domain
PF00639 Rotamase 59 163 PPIC-type PPIASE domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in immune cells in the lung (at protein level) (PubMed:29686383). The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells. {ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:2
Sequence
Sequence length 163
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Viral life cycle - HIV-1
RIG-I-like receptor signaling pathway
  ISG15 antiviral mechanism
RHO GTPases Activate NADPH Oxidases
Regulation of TP53 Activity through Phosphorylation
PI5P Regulates TP53 Acetylation
Negative regulators of DDX58/IFIH1 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
19671742, 19681904
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
19671742, 19681904
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
19681904, 19671742
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 26752745
Adrenal Insufficiency Associate 23096908
Aging Premature Associate 20580132
Alzheimer Disease Associate 11432833, 16384626, 17482359, 19909517, 20580132, 22184106, 23697802, 29775635, 38554950
Alzheimer Disease Stimulate 21243369
Anophthalmia with pulmonary hypoplasia Stimulate 32347623
Asthma Associate 28125291
Atherosclerosis Associate 29545340
Blood Coagulation Disorders Associate 29545340
Breast Neoplasms Stimulate 11432833, 12101225, 15111319