Gene Gene information from NCBI Gene database.
Entrez ID 5272
Gene name Serpin family B member 9
Gene symbol SERPINB9
Synonyms (NCBI Gene)
CAP-3CAP3PI-9PI9
Chromosome 6
Chromosome location 6p25.2
Summary This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression
miRNA miRNA information provided by mirtarbase database.
582
miRTarBase ID miRNA Experiments Reference
MIRT006182 hsa-miR-29a-3p Luciferase reporter assayMicroarrayNorthern blotqRT-PCRWestern blot 21880628
MIRT006182 hsa-miR-29a-3p Luciferase reporter assayMicroarrayNorthern blotqRT-PCRWestern blot 21880628
MIRT006182 hsa-miR-29a-3p Luciferase reporter assayMicroarrayNorthern blotqRT-PCRWestern blot 21880628
MIRT006182 hsa-miR-29a-3p Luciferase reporter assayMicroarrayNorthern blotqRT-PCRWestern blot 21880628
MIRT006182 hsa-miR-29a-3p Luciferase reporter assayMicroarrayNorthern blotqRT-PCRWestern blot 21880628
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
ESR1 Unknown 11682627
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IPI 16267761
GO:0002448 Process Mast cell mediated immunity IEP 15739160
GO:0004867 Function Serine-type endopeptidase inhibitor activity IBA
GO:0004867 Function Serine-type endopeptidase inhibitor activity IDA 8910377, 11485349
GO:0004867 Function Serine-type endopeptidase inhibitor activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601799 8955 ENSG00000170542
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P50453
Protein name Serpin B9 (Cytoplasmic antiproteinase 3) (CAP-3) (CAP3) (Peptidase inhibitor 9) (PI-9)
Protein function Granzyme B inhibitor.
PDB 8ZCR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00079 Serpin 6 376 Serpin (serine protease inhibitor) Domain
Sequence
Sequence length 376
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Amoebiasis  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CHLORACNE CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
VITILIGO GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Associate 19055699
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Associate 38092781
★☆☆☆☆
Found in Text Mining only
Amyloidosis Associate 29967939
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm Abdominal Associate 25993294
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 17490628, 25048347
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Associate 31059128
★☆☆☆☆
Found in Text Mining only
Enteropathy Associated T Cell Lymphoma Associate 11756176
★☆☆☆☆
Found in Text Mining only
GATA2 Deficiency Associate 11756176
★☆☆☆☆
Found in Text Mining only
Hereditary Autoinflammatory Diseases Associate 26992230
★☆☆☆☆
Found in Text Mining only
HIV Infections Associate 24445365
★☆☆☆☆
Found in Text Mining only