Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5270
Gene name Gene Name - the full gene name approved by the HGNC.	Serpin family E member 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SERPINE2
Synonyms (NCBI Gene) Gene synonyms aliases	GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q36.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for ch

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001419	hsa-miR-16-5p	pSILAC	18668040
MIRT028560	hsa-miR-30a-5p	Proteomics	18668040
MIRT001419	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT044124	hsa-miR-30e-3p	CLASH	23622248
MIRT1338896	hsa-miR-3163	CLIP-seq
MIRT1338897	hsa-miR-410	CLIP-seq
MIRT1338898	hsa-miR-4528	CLIP-seq
MIRT1338899	hsa-miR-586	CLIP-seq
MIRT1553544	hsa-miR-1244	CLIP-seq
MIRT1553545	hsa-miR-1275	CLIP-seq
MIRT1553546	hsa-miR-1299	CLIP-seq
MIRT1553547	hsa-miR-132	CLIP-seq
MIRT1553548	hsa-miR-186	CLIP-seq
MIRT1553549	hsa-miR-194	CLIP-seq
MIRT1553550	hsa-miR-199a-3p	CLIP-seq
MIRT1553551	hsa-miR-199b-3p	CLIP-seq
MIRT1553552	hsa-miR-2052	CLIP-seq
MIRT1553553	hsa-miR-2053	CLIP-seq
MIRT1553554	hsa-miR-212	CLIP-seq
MIRT1553555	hsa-miR-296-3p	CLIP-seq
MIRT1553556	hsa-miR-3065-5p	CLIP-seq
MIRT1553557	hsa-miR-3120-3p	CLIP-seq
MIRT1553558	hsa-miR-3129-5p	CLIP-seq
MIRT1553559	hsa-miR-3133	CLIP-seq
MIRT1553560	hsa-miR-3182	CLIP-seq
MIRT1553561	hsa-miR-3545-3p	CLIP-seq
MIRT1553562	hsa-miR-3591-5p	CLIP-seq
MIRT1553563	hsa-miR-3606	CLIP-seq
MIRT1553564	hsa-miR-3654	CLIP-seq
MIRT1553565	hsa-miR-3920	CLIP-seq
MIRT1553566	hsa-miR-3973	CLIP-seq
MIRT1553567	hsa-miR-3975	CLIP-seq
MIRT1338897	hsa-miR-410	CLIP-seq
MIRT1553568	hsa-miR-4269	CLIP-seq
MIRT1553569	hsa-miR-4326	CLIP-seq
MIRT1553570	hsa-miR-4433	CLIP-seq
MIRT1553571	hsa-miR-4443	CLIP-seq
MIRT1553572	hsa-miR-4511	CLIP-seq
MIRT1553573	hsa-miR-451b	CLIP-seq
MIRT1553574	hsa-miR-4525	CLIP-seq
MIRT1338898	hsa-miR-4528	CLIP-seq
MIRT1553575	hsa-miR-4539	CLIP-seq
MIRT1553576	hsa-miR-4638-3p	CLIP-seq
MIRT1553577	hsa-miR-4652-3p	CLIP-seq
MIRT1553578	hsa-miR-4659a-3p	CLIP-seq
MIRT1553579	hsa-miR-4659b-3p	CLIP-seq
MIRT1553580	hsa-miR-4665-5p	CLIP-seq
MIRT1553581	hsa-miR-4668-5p	CLIP-seq
MIRT1553582	hsa-miR-4696	CLIP-seq
MIRT1553583	hsa-miR-4716-3p	CLIP-seq
MIRT1553584	hsa-miR-4723-5p	CLIP-seq
MIRT1553585	hsa-miR-4766-5p	CLIP-seq
MIRT1553586	hsa-miR-5096	CLIP-seq
MIRT1553587	hsa-miR-513a-3p	CLIP-seq
MIRT1553588	hsa-miR-542-3p	CLIP-seq
MIRT1553589	hsa-miR-545	CLIP-seq
MIRT1553590	hsa-miR-548an	CLIP-seq
MIRT1553591	hsa-miR-548b-3p	CLIP-seq
MIRT1553592	hsa-miR-548p	CLIP-seq
MIRT1553593	hsa-miR-583	CLIP-seq
MIRT1338899	hsa-miR-586	CLIP-seq
MIRT1553594	hsa-miR-590-3p	CLIP-seq
MIRT1553595	hsa-miR-625	CLIP-seq
MIRT1553596	hsa-miR-671-5p	CLIP-seq
MIRT1553597	hsa-miR-875-3p	CLIP-seq
MIRT1553598	hsa-miR-921	CLIP-seq
MIRT1553599	hsa-miR-924	CLIP-seq
MIRT1553600	hsa-miR-936	CLIP-seq
MIRT2433032	hsa-miR-1200	CLIP-seq
MIRT1553544	hsa-miR-1244	CLIP-seq
MIRT1553545	hsa-miR-1275	CLIP-seq
MIRT2433033	hsa-miR-1286	CLIP-seq
MIRT2433034	hsa-miR-1298	CLIP-seq
MIRT1553546	hsa-miR-1299	CLIP-seq
MIRT1553547	hsa-miR-132	CLIP-seq
MIRT1553548	hsa-miR-186	CLIP-seq
MIRT1553549	hsa-miR-194	CLIP-seq
MIRT1553550	hsa-miR-199a-3p	CLIP-seq
MIRT1553551	hsa-miR-199b-3p	CLIP-seq
MIRT1553552	hsa-miR-2052	CLIP-seq
MIRT1553553	hsa-miR-2053	CLIP-seq
MIRT1553554	hsa-miR-212	CLIP-seq
MIRT1553555	hsa-miR-296-3p	CLIP-seq
MIRT1553556	hsa-miR-3065-5p	CLIP-seq
MIRT1553557	hsa-miR-3120-3p	CLIP-seq
MIRT1553558	hsa-miR-3129-5p	CLIP-seq
MIRT1553559	hsa-miR-3133	CLIP-seq
MIRT2433035	hsa-miR-3140-5p	CLIP-seq
MIRT1338896	hsa-miR-3163	CLIP-seq
MIRT1553560	hsa-miR-3182	CLIP-seq
MIRT1553561	hsa-miR-3545-3p	CLIP-seq
MIRT1553565	hsa-miR-3920	CLIP-seq
MIRT1338897	hsa-miR-410	CLIP-seq
MIRT2433036	hsa-miR-421	CLIP-seq
MIRT2433037	hsa-miR-4294	CLIP-seq
MIRT1553569	hsa-miR-4326	CLIP-seq
MIRT1553571	hsa-miR-4443	CLIP-seq
MIRT1553572	hsa-miR-4511	CLIP-seq
MIRT1553573	hsa-miR-451b	CLIP-seq
MIRT1553574	hsa-miR-4525	CLIP-seq
MIRT1338898	hsa-miR-4528	CLIP-seq
MIRT1553575	hsa-miR-4539	CLIP-seq
MIRT1553578	hsa-miR-4659a-3p	CLIP-seq
MIRT1553579	hsa-miR-4659b-3p	CLIP-seq
MIRT1553580	hsa-miR-4665-5p	CLIP-seq
MIRT1553581	hsa-miR-4668-5p	CLIP-seq
MIRT1553582	hsa-miR-4696	CLIP-seq
MIRT2433038	hsa-miR-4709-5p	CLIP-seq
MIRT1553583	hsa-miR-4716-3p	CLIP-seq
MIRT2433039	hsa-miR-4722-5p	CLIP-seq
MIRT1553584	hsa-miR-4723-5p	CLIP-seq
MIRT1553585	hsa-miR-4766-5p	CLIP-seq
MIRT2433040	hsa-miR-4775	CLIP-seq
MIRT1553587	hsa-miR-513a-3p	CLIP-seq
MIRT1553590	hsa-miR-548an	CLIP-seq
MIRT1553591	hsa-miR-548b-3p	CLIP-seq
MIRT1338899	hsa-miR-586	CLIP-seq
MIRT1553594	hsa-miR-590-3p	CLIP-seq
MIRT1553595	hsa-miR-625	CLIP-seq
MIRT2433041	hsa-miR-664	CLIP-seq
MIRT1553596	hsa-miR-671-5p	CLIP-seq
MIRT1553597	hsa-miR-875-3p	CLIP-seq
MIRT2433042	hsa-miR-888	CLIP-seq
MIRT1553599	hsa-miR-924	CLIP-seq
MIRT1553600	hsa-miR-936	CLIP-seq
MIRT1553544	hsa-miR-1244	CLIP-seq
MIRT2433034	hsa-miR-1298	CLIP-seq
MIRT1553546	hsa-miR-1299	CLIP-seq
MIRT1553547	hsa-miR-132	CLIP-seq
MIRT2440156	hsa-miR-1470	CLIP-seq
MIRT1553548	hsa-miR-186	CLIP-seq
MIRT1553549	hsa-miR-194	CLIP-seq
MIRT1553550	hsa-miR-199a-3p	CLIP-seq
MIRT1553551	hsa-miR-199b-3p	CLIP-seq
MIRT1553553	hsa-miR-2053	CLIP-seq
MIRT1553554	hsa-miR-212	CLIP-seq
MIRT1553555	hsa-miR-296-3p	CLIP-seq
MIRT1553557	hsa-miR-3120-3p	CLIP-seq
MIRT1553558	hsa-miR-3129-5p	CLIP-seq
MIRT1553559	hsa-miR-3133	CLIP-seq
MIRT1338896	hsa-miR-3163	CLIP-seq
MIRT1553560	hsa-miR-3182	CLIP-seq
MIRT2440157	hsa-miR-323b-3p	CLIP-seq
MIRT1553562	hsa-miR-3591-5p	CLIP-seq
MIRT1553563	hsa-miR-3606	CLIP-seq
MIRT2440158	hsa-miR-370	CLIP-seq
MIRT1553565	hsa-miR-3920	CLIP-seq
MIRT1338897	hsa-miR-410	CLIP-seq
MIRT2433036	hsa-miR-421	CLIP-seq
MIRT2440159	hsa-miR-4255	CLIP-seq
MIRT1553569	hsa-miR-4326	CLIP-seq
MIRT1553570	hsa-miR-4433	CLIP-seq
MIRT2440160	hsa-miR-4446-5p	CLIP-seq
MIRT1553572	hsa-miR-4511	CLIP-seq
MIRT1553573	hsa-miR-451b	CLIP-seq
MIRT1338898	hsa-miR-4528	CLIP-seq
MIRT1553578	hsa-miR-4659a-3p	CLIP-seq
MIRT1553579	hsa-miR-4659b-3p	CLIP-seq
MIRT2440161	hsa-miR-4667-3p	CLIP-seq
MIRT1553582	hsa-miR-4696	CLIP-seq
MIRT2433038	hsa-miR-4709-5p	CLIP-seq
MIRT2440162	hsa-miR-4755-5p	CLIP-seq
MIRT1553585	hsa-miR-4766-5p	CLIP-seq
MIRT2440163	hsa-miR-4773	CLIP-seq
MIRT2440164	hsa-miR-4793-5p	CLIP-seq
MIRT2440165	hsa-miR-4797-3p	CLIP-seq
MIRT1553587	hsa-miR-513a-3p	CLIP-seq
MIRT1553591	hsa-miR-548b-3p	CLIP-seq
MIRT1338899	hsa-miR-586	CLIP-seq
MIRT1553594	hsa-miR-590-3p	CLIP-seq
MIRT2440166	hsa-miR-642a	CLIP-seq
MIRT2433041	hsa-miR-664	CLIP-seq
MIRT1553596	hsa-miR-671-5p	CLIP-seq
MIRT1553597	hsa-miR-875-3p	CLIP-seq
MIRT2440167	hsa-miR-875-5p	CLIP-seq
MIRT1553598	hsa-miR-921	CLIP-seq
MIRT1553600	hsa-miR-936	CLIP-seq
MIRT1553557	hsa-miR-3120-3p	CLIP-seq
MIRT1553560	hsa-miR-3182	CLIP-seq
MIRT1553565	hsa-miR-3920	CLIP-seq
MIRT1553570	hsa-miR-4433	CLIP-seq
MIRT1553573	hsa-miR-451b	CLIP-seq
MIRT1553578	hsa-miR-4659a-3p	CLIP-seq
MIRT1553579	hsa-miR-4659b-3p	CLIP-seq
MIRT1553582	hsa-miR-4696	CLIP-seq
MIRT1553585	hsa-miR-4766-5p	CLIP-seq
MIRT1553587	hsa-miR-513a-3p	CLIP-seq
MIRT2433032	hsa-miR-1200	CLIP-seq
MIRT1553544	hsa-miR-1244	CLIP-seq
MIRT2433034	hsa-miR-1298	CLIP-seq
MIRT1553546	hsa-miR-1299	CLIP-seq
MIRT1553547	hsa-miR-132	CLIP-seq
MIRT1553548	hsa-miR-186	CLIP-seq
MIRT1553549	hsa-miR-194	CLIP-seq
MIRT1553550	hsa-miR-199a-3p	CLIP-seq
MIRT1553551	hsa-miR-199b-3p	CLIP-seq
MIRT1553552	hsa-miR-2052	CLIP-seq
MIRT1553553	hsa-miR-2053	CLIP-seq
MIRT1553554	hsa-miR-212	CLIP-seq
MIRT1553555	hsa-miR-296-3p	CLIP-seq
MIRT1553556	hsa-miR-3065-5p	CLIP-seq
MIRT1553557	hsa-miR-3120-3p	CLIP-seq
MIRT1553558	hsa-miR-3129-5p	CLIP-seq
MIRT1553559	hsa-miR-3133	CLIP-seq
MIRT2433035	hsa-miR-3140-5p	CLIP-seq
MIRT1338896	hsa-miR-3163	CLIP-seq
MIRT1553560	hsa-miR-3182	CLIP-seq
MIRT1553561	hsa-miR-3545-3p	CLIP-seq
MIRT1553562	hsa-miR-3591-5p	CLIP-seq
MIRT1553563	hsa-miR-3606	CLIP-seq
MIRT1553564	hsa-miR-3654	CLIP-seq
MIRT1553565	hsa-miR-3920	CLIP-seq
MIRT1553567	hsa-miR-3975	CLIP-seq
MIRT1338897	hsa-miR-410	CLIP-seq
MIRT2433036	hsa-miR-421	CLIP-seq
MIRT2440159	hsa-miR-4255	CLIP-seq
MIRT1553569	hsa-miR-4326	CLIP-seq
MIRT1553570	hsa-miR-4433	CLIP-seq
MIRT1553572	hsa-miR-4511	CLIP-seq
MIRT1553573	hsa-miR-451b	CLIP-seq
MIRT1338898	hsa-miR-4528	CLIP-seq
MIRT1553575	hsa-miR-4539	CLIP-seq
MIRT1553576	hsa-miR-4638-3p	CLIP-seq
MIRT1553578	hsa-miR-4659a-3p	CLIP-seq
MIRT1553579	hsa-miR-4659b-3p	CLIP-seq
MIRT1553582	hsa-miR-4696	CLIP-seq
MIRT2433038	hsa-miR-4709-5p	CLIP-seq
MIRT1553585	hsa-miR-4766-5p	CLIP-seq
MIRT2440165	hsa-miR-4797-3p	CLIP-seq
MIRT1553586	hsa-miR-5096	CLIP-seq
MIRT1553587	hsa-miR-513a-3p	CLIP-seq
MIRT1553589	hsa-miR-545	CLIP-seq
MIRT1553591	hsa-miR-548b-3p	CLIP-seq
MIRT1553593	hsa-miR-583	CLIP-seq
MIRT1338899	hsa-miR-586	CLIP-seq
MIRT1553594	hsa-miR-590-3p	CLIP-seq
MIRT2433041	hsa-miR-664	CLIP-seq
MIRT1553596	hsa-miR-671-5p	CLIP-seq
MIRT1553597	hsa-miR-875-3p	CLIP-seq
MIRT2433042	hsa-miR-888	CLIP-seq
MIRT1553598	hsa-miR-921	CLIP-seq
MIRT1553600	hsa-miR-936	CLIP-seq
MIRT2433032	hsa-miR-1200	CLIP-seq
MIRT1553544	hsa-miR-1244	CLIP-seq
MIRT1553545	hsa-miR-1275	CLIP-seq
MIRT2433034	hsa-miR-1298	CLIP-seq
MIRT1553546	hsa-miR-1299	CLIP-seq
MIRT1553547	hsa-miR-132	CLIP-seq
MIRT2440156	hsa-miR-1470	CLIP-seq
MIRT1553548	hsa-miR-186	CLIP-seq
MIRT1553549	hsa-miR-194	CLIP-seq
MIRT1553550	hsa-miR-199a-3p	CLIP-seq
MIRT1553551	hsa-miR-199b-3p	CLIP-seq
MIRT1553553	hsa-miR-2053	CLIP-seq
MIRT1553554	hsa-miR-212	CLIP-seq
MIRT1553555	hsa-miR-296-3p	CLIP-seq
MIRT1553556	hsa-miR-3065-5p	CLIP-seq
MIRT1553557	hsa-miR-3120-3p	CLIP-seq
MIRT1553558	hsa-miR-3129-5p	CLIP-seq
MIRT1553559	hsa-miR-3133	CLIP-seq
MIRT2433035	hsa-miR-3140-5p	CLIP-seq
MIRT1338896	hsa-miR-3163	CLIP-seq
MIRT1553560	hsa-miR-3182	CLIP-seq
MIRT2440157	hsa-miR-323b-3p	CLIP-seq
MIRT1553561	hsa-miR-3545-3p	CLIP-seq
MIRT1553562	hsa-miR-3591-5p	CLIP-seq
MIRT1553563	hsa-miR-3606	CLIP-seq
MIRT1553564	hsa-miR-3654	CLIP-seq
MIRT2440158	hsa-miR-370	CLIP-seq
MIRT1553565	hsa-miR-3920	CLIP-seq
MIRT1553567	hsa-miR-3975	CLIP-seq
MIRT1338897	hsa-miR-410	CLIP-seq
MIRT2433036	hsa-miR-421	CLIP-seq
MIRT2440159	hsa-miR-4255	CLIP-seq
MIRT1553569	hsa-miR-4326	CLIP-seq
MIRT1553570	hsa-miR-4433	CLIP-seq
MIRT1553571	hsa-miR-4443	CLIP-seq
MIRT2440160	hsa-miR-4446-5p	CLIP-seq
MIRT1553573	hsa-miR-451b	CLIP-seq
MIRT1553574	hsa-miR-4525	CLIP-seq
MIRT1338898	hsa-miR-4528	CLIP-seq
MIRT1553575	hsa-miR-4539	CLIP-seq
MIRT1553576	hsa-miR-4638-3p	CLIP-seq
MIRT1553578	hsa-miR-4659a-3p	CLIP-seq
MIRT1553579	hsa-miR-4659b-3p	CLIP-seq
MIRT1553580	hsa-miR-4665-5p	CLIP-seq
MIRT2440161	hsa-miR-4667-3p	CLIP-seq
MIRT1553582	hsa-miR-4696	CLIP-seq
MIRT2433038	hsa-miR-4709-5p	CLIP-seq
MIRT1553583	hsa-miR-4716-3p	CLIP-seq
MIRT1553584	hsa-miR-4723-5p	CLIP-seq
MIRT2440162	hsa-miR-4755-5p	CLIP-seq
MIRT1553585	hsa-miR-4766-5p	CLIP-seq
MIRT2440164	hsa-miR-4793-5p	CLIP-seq
MIRT2440165	hsa-miR-4797-3p	CLIP-seq
MIRT1553586	hsa-miR-5096	CLIP-seq
MIRT1553587	hsa-miR-513a-3p	CLIP-seq
MIRT1553589	hsa-miR-545	CLIP-seq
MIRT1553593	hsa-miR-583	CLIP-seq
MIRT1338899	hsa-miR-586	CLIP-seq
MIRT1553594	hsa-miR-590-3p	CLIP-seq
MIRT1553595	hsa-miR-625	CLIP-seq
MIRT2440166	hsa-miR-642a	CLIP-seq
MIRT2433041	hsa-miR-664	CLIP-seq
MIRT1553596	hsa-miR-671-5p	CLIP-seq
MIRT1553597	hsa-miR-875-3p	CLIP-seq
MIRT2440167	hsa-miR-875-5p	CLIP-seq
MIRT2433042	hsa-miR-888	CLIP-seq
MIRT1553598	hsa-miR-921	CLIP-seq
MIRT1553600	hsa-miR-936	CLIP-seq

Show/Hide all(44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IBA	21873635
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IDA	3997857, 19249338, 19855083
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IMP	19855083
GO:0005102	Function	Signaling receptor binding	IPI	17379830
GO:0005515	Function	Protein binding	IPI	3279057, 19911255, 25416956
GO:0005539	Function	Glycosaminoglycan binding	IDA	19855083
GO:0005576	Component	Extracellular region	IDA	3997857, 19855083
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005829	Component	Cytosol	IDA	19855083
GO:0007596	Process	Blood coagulation	TAS
GO:0008201	Function	Heparin binding	IDA	1939253, 3997857
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0010757	Process	Negative regulation of plasminogen activation	IMP	19855083
GO:0010766	Process	Negative regulation of sodium ion transport	IEA
GO:0010951	Process	Negative regulation of endopeptidase activity	IBA	21873635
GO:0010955	Process	Negative regulation of protein processing	IC	19855083
GO:0014067	Process	Negative regulation of phosphatidylinositol 3-kinase signaling	IEA
GO:0021683	Process	Cerebellar granular layer morphogenesis	IEA
GO:0030195	Process	Negative regulation of blood coagulation	IC	19855083
GO:0030195	Process	Negative regulation of blood coagulation	IDA	17379830
GO:0030308	Process	Negative regulation of cell growth	IEA
GO:0030334	Process	Regulation of cell migration	NAS	2877744
GO:0031091	Component	Platelet alpha granule	IDA	19855083
GO:0031091	Component	Platelet alpha granule	IMP	19855083
GO:0031232	Component	Extrinsic component of external side of plasma membrane	IDA	19855083
GO:0031594	Component	Neuromuscular junction	ISS	2037625
GO:0032940	Process	Secretion by cell	IEA
GO:0033363	Process	Secretory granule organization	IEA
GO:0042177	Process	Negative regulation of protein catabolic process	IEA
GO:0042628	Process	Mating plug formation	IEA
GO:0045861	Process	Negative regulation of proteolysis	IDA	3997857, 17379830
GO:0045879	Process	Negative regulation of smoothened signaling pathway	IEA
GO:0048505	Process	Regulation of timing of cell differentiation	IEA
GO:0048711	Process	Positive regulation of astrocyte differentiation	IDA	1691280
GO:0050974	Process	Detection of mechanical stimulus involved in sensory perception	IEA
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IEA
GO:0060291	Process	Long-term synaptic potentiation	IEA
GO:0060384	Process	Innervation	IEA
GO:0061108	Process	Seminal vesicle epithelium development	IEA
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	28327460
GO:0062023	Component	Collagen-containing extracellular matrix	IDA	3279057
GO:0090331	Process	Negative regulation of platelet aggregation	ISS	19855083
GO:1903561	Component	Extracellular vesicle	HDA	24769233

MIM	HGNC	e!Ensembl
177010	8951	ENSG00000135919

Protein

UniProt ID

P07093

Protein name

Glia-derived nexin (GDN) (Peptidase inhibitor 7) (PI-7) (Protease nexin 1) (PN-1) (Protease nexin I) (Serpin E2)

Protein function

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

PDB

4DY0 , 4DY7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00079	Serpin	31 → 398	Serpin (serine protease inhibitor)	Domain

Sequence

MNWHLPLFLLASVTLPSICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIAS
VLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNAS
EIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTR
LVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYN
FIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVA
QTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTA
ILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP

Sequence length

398

Interactions

View interactions

	KEGG		Reactome
	Complement and coagulation cascades		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Dissolution of Fibrin Clot

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)

Show/Hide Text Mining Associations (47)

Disease Name	Relationship Type	References
Associations from Text Mining
AA amyloidosis	Associate	23592924
Adenocarcinoma	Associate	36505099
Adenocarcinoma of Lung	Associate	33317533, 34648881
alpha 1 Antitrypsin Deficiency	Associate	22145704
Asthma	Associate	21436250, 30206357
Astrocytoma	Associate	11939722
Blood Coagulation Disorders	Associate	28677735
Carcinogenesis	Associate	28453461, 33317533
Carcinoma Non Small Cell Lung	Associate	34648881
Carcinoma Renal Cell	Associate	36646679
Colorectal Neoplasms	Stimulate	19555470
Coronary Artery Disease	Associate	31679650
Diabetes Mellitus Type 2	Associate	31679650, 35948367
Diabetic Neuropathies	Associate	28677735
Drug Hypersensitivity	Associate	30206357
Emphysema	Associate	21067581, 22145704
Endometrial Neoplasms	Associate	28453461
Esophageal Squamous Cell Carcinoma	Associate	36011368
Fibrosis	Associate	26503507
Glioblastoma	Associate	39938577
Glucosephosphate Dehydrogenase Deficiency	Associate	28453461
Heart Failure	Associate	35942730
Hepatoblastoma	Associate	36505099
Hypoxia	Associate	19017876
Idiopathic Interstitial Pneumonias	Associate	26503507
Idiopathic Pulmonary Fibrosis	Stimulate	25199049
Inflammation	Associate	34516487
Intervertebral Disc Degeneration	Associate	27460424
Lead Poisoning Nervous System	Associate	33094798
Lung Neoplasms	Associate	34648881
Neoplasm Metastasis	Associate	32844403, 36646679
Neoplasm Metastasis	Stimulate	36505099
Neoplasms	Associate	28255192, 28453461, 29716922, 36505099, 36646679
Neoplasms	Inhibit	31199037
Neurodegenerative Diseases	Associate	11925594
Obesity	Associate	28125591
Osteoarthritis	Associate	25853553
Osteoarthritis	Inhibit	33094798
Osteopetrosis	Inhibit	24336069
Pulmonary Disease Chronic Obstructive	Associate	19017876, 19949669, 20525719, 21067581, 21401569, 21436250, 22028159, 22145704, 22976395, 27193053, 32099002
Pulmonary Disease Chronic Obstructive	Inhibit	23886569
Pulmonary Emphysema	Associate	21067581
Squamous Cell Carcinoma of Head and Neck	Associate	26318431
Stomach Neoplasms	Associate	25400735, 31199037
Thyroid Cancer Papillary	Stimulate	28255192
Urinary Bladder Neoplasms	Associate	40481075
Venous Thromboembolism	Associate	37537391

SERPINE2 (serpin family E member 2)