SERPINA4 (serpin family A member 4)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 5267
Gene name Serpin family A member 4
Gene symbol SERPINA4
Synonyms (NCBI Gene)
KALKLSTKSTPI-4PI4kallistatin
Chromosome 14
Chromosome location 14q32.13
miRNA miRNA information provided by mirtarbase database.
394
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (394)
miRTarBase ID miRNA Experiments Reference
MIRT609249 hsa-miR-141-5p HITS-CLIP 23824327
MIRT609246 hsa-miR-5088-3p HITS-CLIP 23824327
MIRT609245 hsa-miR-1237-3p HITS-CLIP 23824327
MIRT609244 hsa-miR-4287 HITS-CLIP 23824327
MIRT609243 hsa-miR-4685-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (13)
GO ID Ontology Definition Evidence Reference
GO:0004867 Function Serine-type endopeptidase inhibitor activity IBA
GO:0004867 Function Serine-type endopeptidase inhibitor activity IEA
GO:0004867 Function Serine-type endopeptidase inhibitor activity TAS 1334488
GO:0005515 Function Protein binding IPI 28514442, 33961781
GO:0005576 Component Extracellular region HDA 27068509
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
147935 8948 ENSG00000100665
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P29622
Protein name Kallistatin (Kallikrein inhibitor) (Peptidase inhibitor 4) (PI-4) (Serpin A4)
Protein function Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of
PDB 6F02
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00079 Serpin 53 → 424 Serpin (serine protease inhibitor) Domain
Tissue specificity TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.
Sequence
Sequence length 427
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Platelet degranulation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Gastric cancer Uncertain significance rs191488393 RCV005931182
Show/Hide Text Mining Associations (25)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Inhibit 32712615
Acute Kidney Injury Associate 28270177
Amyotrophic Lateral Sclerosis Associate 37646115
Angina Stable Inhibit 32712615
Aortic Aneurysm Abdominal Associate 22163325
Atherosclerosis Associate 32712615
Breast Neoplasms Inhibit 23666756
Breast Neoplasms Associate 26790955
Carcinoma Hepatocellular Associate 31322260
Cell Transformation Neoplastic Associate 26790955