PHKG1 (phosphorylase kinase catalytic subunit gamma 1)

Gene

• Entrez ID: 5260
• Gene name: Phosphorylase kinase catalytic subunit gamma 1
• Gene symbol: PHKG1
• Synonyms (NCBI Gene): PHKG
• Chromosome: 7
• Chromosome location: 7p11.2
• Summary: This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT643299	hsa-miR-4780	HITS-CLIP	23824327
MIRT643298	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT643297	hsa-miR-1292-5p	HITS-CLIP	23824327
MIRT643296	hsa-miR-4471	HITS-CLIP	23824327
MIRT643295	hsa-miR-8059	HITS-CLIP	23824327
MIRT643294	hsa-miR-623	HITS-CLIP	23824327
MIRT643293	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT643292	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT643291	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT643290	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT643299	hsa-miR-4780	HITS-CLIP	23824327
MIRT643298	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT643297	hsa-miR-1292-5p	HITS-CLIP	23824327
MIRT643296	hsa-miR-4471	HITS-CLIP	23824327
MIRT643295	hsa-miR-8059	HITS-CLIP	23824327
MIRT643294	hsa-miR-623	HITS-CLIP	23824327
MIRT643293	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT643292	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT643291	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT643290	hsa-miR-5006-3p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004689	Function	Phosphorylase kinase activity	IBA
GO:0004689	Function	Phosphorylase kinase activity	IEA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005964	Component	Phosphorylase kinase complex	IBA
GO:0005964	Component	Phosphorylase kinase complex	IEA
GO:0005975	Process	Carbohydrate metabolic process	NAS	2297530
GO:0005977	Process	Glycogen metabolic process	IBA
GO:0005977	Process	Glycogen metabolic process	IEA
GO:0007165	Process	Signal transduction	IBA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019899	Function	Enzyme binding	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: 172470
• HGNC: 8930
• e!Ensembl: ENSG00000164776

Protein

• UniProt ID: Q16816
• Protein name: Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26)
• Protein function: Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI
• PDB: 8JFK, 8JFL, 8XY7, 8XYA, 8XYB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	20 → 288	Protein kinase domain	Domain

• Sequence:

  MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFS
  PEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKV
  TLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGER
  LREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLR
  MIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFS
  PRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVK
  KGQQQNRAALFENTPKAVLLSLAEEDY

• Sequence length: 387

Pathways

KEGG:

Calcium signaling pathway
Insulin signaling pathway
Glucagon signaling pathway

Reactome:

Glycogen breakdown (glycogenolysis)