PGD (phosphogluconate dehydrogenase)

Gene

• Entrez ID: 5226
• Gene name: Phosphogluconate dehydrogenase
• Gene symbol: PGD
• Synonyms (NCBI Gene): 6PGD
• Chromosome: 1
• Chromosome location: 1p36.22
• Summary: 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-p

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023542	hsa-miR-1-3p	Proteomics	18668040
MIRT051576	hsa-let-7e-5p	CLASH	23622248
MIRT047325	hsa-miR-181a-5p	CLASH	23622248
MIRT046414	hsa-miR-15b-5p	CLASH	23622248
MIRT042801	hsa-miR-339-5p	CLASH	23622248
MIRT042195	hsa-miR-484	CLASH	23622248
MIRT437466	hsa-miR-206	Luciferase reporter assay, Quantitative proteomic approach, Western blot	23921124
MIRT023542	hsa-miR-1-3p	Luciferase reporter assay, Quantitative proteomic approach, Western blot	23921124
MIRT711502	hsa-miR-548av-3p	HITS-CLIP	19536157
MIRT711501	hsa-miR-548g-3p	HITS-CLIP	19536157
MIRT711500	hsa-miR-892a	HITS-CLIP	19536157
MIRT711499	hsa-miR-4768-3p	HITS-CLIP	19536157
MIRT711498	hsa-miR-4459	HITS-CLIP	19536157
MIRT711497	hsa-miR-4433a-3p	HITS-CLIP	19536157
MIRT711496	hsa-miR-3664-3p	HITS-CLIP	19536157
MIRT711495	hsa-miR-6740-3p	HITS-CLIP	19536157
MIRT711494	hsa-miR-4711-3p	HITS-CLIP	19536157
MIRT711493	hsa-miR-6867-5p	HITS-CLIP	19536157
MIRT711492	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT726967	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT046414	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726966	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726965	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT711502	hsa-miR-548av-3p	HITS-CLIP	19536157
MIRT711501	hsa-miR-548g-3p	HITS-CLIP	19536157
MIRT711500	hsa-miR-892a	HITS-CLIP	19536157
MIRT711499	hsa-miR-4768-3p	HITS-CLIP	19536157
MIRT711498	hsa-miR-4459	HITS-CLIP	19536157
MIRT711497	hsa-miR-4433a-3p	HITS-CLIP	19536157
MIRT711496	hsa-miR-3664-3p	HITS-CLIP	19536157
MIRT711495	hsa-miR-6740-3p	HITS-CLIP	19536157
MIRT711494	hsa-miR-4711-3p	HITS-CLIP	19536157
MIRT711493	hsa-miR-6867-5p	HITS-CLIP	19536157
MIRT711492	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT1227294	hsa-miR-1	CLIP-seq
MIRT1227295	hsa-miR-103a	CLIP-seq
MIRT1227296	hsa-miR-107	CLIP-seq
MIRT1227297	hsa-miR-1260	CLIP-seq
MIRT1227298	hsa-miR-1260b	CLIP-seq
MIRT1227299	hsa-miR-1273f	CLIP-seq
MIRT1227300	hsa-miR-15a	CLIP-seq
MIRT1227301	hsa-miR-15b	CLIP-seq
MIRT1227302	hsa-miR-16	CLIP-seq
MIRT1227303	hsa-miR-1827	CLIP-seq
MIRT1227304	hsa-miR-188-3p	CLIP-seq
MIRT1227305	hsa-miR-195	CLIP-seq
MIRT1227306	hsa-miR-2467-3p	CLIP-seq
MIRT1227307	hsa-miR-3156-3p	CLIP-seq
MIRT1227308	hsa-miR-3171	CLIP-seq
MIRT1227309	hsa-miR-3186-3p	CLIP-seq
MIRT1227310	hsa-miR-3190	CLIP-seq
MIRT1227311	hsa-miR-342-3p	CLIP-seq
MIRT1227312	hsa-miR-34a	CLIP-seq
MIRT1227313	hsa-miR-34c-5p	CLIP-seq
MIRT1227314	hsa-miR-3616-3p	CLIP-seq
MIRT1227315	hsa-miR-3622b-5p	CLIP-seq
MIRT1227316	hsa-miR-3663-5p	CLIP-seq
MIRT1227317	hsa-miR-3673	CLIP-seq
MIRT1227318	hsa-miR-424	CLIP-seq
MIRT1227319	hsa-miR-4252	CLIP-seq
MIRT1227320	hsa-miR-4253	CLIP-seq
MIRT1227321	hsa-miR-4294	CLIP-seq
MIRT1227322	hsa-miR-4301	CLIP-seq
MIRT1227323	hsa-miR-4428	CLIP-seq
MIRT1227324	hsa-miR-4433	CLIP-seq
MIRT1227325	hsa-miR-4436b-3p	CLIP-seq
MIRT1227326	hsa-miR-4461	CLIP-seq
MIRT1227327	hsa-miR-4468	CLIP-seq
MIRT1227328	hsa-miR-449a	CLIP-seq
MIRT1227329	hsa-miR-449b	CLIP-seq
MIRT1227330	hsa-miR-4502	CLIP-seq
MIRT1227331	hsa-miR-4527	CLIP-seq
MIRT1227332	hsa-miR-4639-3p	CLIP-seq
MIRT1227333	hsa-miR-4640-5p	CLIP-seq
MIRT1227334	hsa-miR-4659a-5p	CLIP-seq
MIRT1227335	hsa-miR-4659b-5p	CLIP-seq
MIRT1227336	hsa-miR-4660	CLIP-seq
MIRT1227337	hsa-miR-4717-3p	CLIP-seq
MIRT1227338	hsa-miR-4724-5p	CLIP-seq
MIRT1227339	hsa-miR-4726-5p	CLIP-seq
MIRT1227340	hsa-miR-4761-3p	CLIP-seq
MIRT1227341	hsa-miR-4786-3p	CLIP-seq
MIRT1227342	hsa-miR-4802-3p	CLIP-seq
MIRT1227343	hsa-miR-497	CLIP-seq
MIRT1227344	hsa-miR-520d-5p	CLIP-seq
MIRT1227345	hsa-miR-524-5p	CLIP-seq
MIRT1227346	hsa-miR-542-3p	CLIP-seq
MIRT1227347	hsa-miR-548a-3p	CLIP-seq
MIRT1227348	hsa-miR-548ae	CLIP-seq
MIRT1227349	hsa-miR-548aj	CLIP-seq
MIRT1227350	hsa-miR-548am	CLIP-seq
MIRT1227351	hsa-miR-548e	CLIP-seq
MIRT1227352	hsa-miR-548f	CLIP-seq
MIRT1227353	hsa-miR-548g	CLIP-seq
MIRT1227354	hsa-miR-548x	CLIP-seq
MIRT1227355	hsa-miR-600	CLIP-seq
MIRT1227356	hsa-miR-602	CLIP-seq
MIRT1227357	hsa-miR-613	CLIP-seq
MIRT1227358	hsa-miR-622	CLIP-seq
MIRT1227359	hsa-miR-646	CLIP-seq
MIRT1227360	hsa-miR-671-5p	CLIP-seq
MIRT1227361	hsa-miR-760	CLIP-seq
MIRT1227295	hsa-miR-103a	CLIP-seq
MIRT1227296	hsa-miR-107	CLIP-seq
MIRT1227300	hsa-miR-15a	CLIP-seq
MIRT1227301	hsa-miR-15b	CLIP-seq
MIRT1227302	hsa-miR-16	CLIP-seq
MIRT1227305	hsa-miR-195	CLIP-seq
MIRT1227310	hsa-miR-3190	CLIP-seq
MIRT1227311	hsa-miR-342-3p	CLIP-seq
MIRT1227316	hsa-miR-3663-5p	CLIP-seq
MIRT1227318	hsa-miR-424	CLIP-seq
MIRT1227331	hsa-miR-4527	CLIP-seq
MIRT1227343	hsa-miR-497	CLIP-seq
MIRT1227344	hsa-miR-520d-5p	CLIP-seq
MIRT1227345	hsa-miR-524-5p	CLIP-seq
MIRT1227346	hsa-miR-542-3p	CLIP-seq
MIRT1227361	hsa-miR-760	CLIP-seq
MIRT2294130	hsa-miR-1226	CLIP-seq
MIRT1227297	hsa-miR-1260	CLIP-seq
MIRT1227298	hsa-miR-1260b	CLIP-seq
MIRT1227299	hsa-miR-1273f	CLIP-seq
MIRT1227304	hsa-miR-188-3p	CLIP-seq
MIRT2294131	hsa-miR-3120-5p	CLIP-seq
MIRT1227307	hsa-miR-3156-3p	CLIP-seq
MIRT1227308	hsa-miR-3171	CLIP-seq
MIRT1227309	hsa-miR-3186-3p	CLIP-seq
MIRT2294132	hsa-miR-346	CLIP-seq
MIRT2294133	hsa-miR-3667-3p	CLIP-seq
MIRT1227319	hsa-miR-4252	CLIP-seq
MIRT2294134	hsa-miR-4288	CLIP-seq
MIRT1227322	hsa-miR-4301	CLIP-seq
MIRT2294135	hsa-miR-4421	CLIP-seq
MIRT1227326	hsa-miR-4461	CLIP-seq
MIRT1227330	hsa-miR-4502	CLIP-seq
MIRT2294136	hsa-miR-4520a-5p	CLIP-seq
MIRT2294137	hsa-miR-4520b-5p	CLIP-seq
MIRT1227332	hsa-miR-4639-3p	CLIP-seq
MIRT1227341	hsa-miR-4786-3p	CLIP-seq
MIRT1227356	hsa-miR-602	CLIP-seq
MIRT1227358	hsa-miR-622	CLIP-seq
MIRT2294138	hsa-miR-632	CLIP-seq
MIRT2294139	hsa-miR-634	CLIP-seq
MIRT1227360	hsa-miR-671-5p	CLIP-seq
MIRT2294140	hsa-miR-933	CLIP-seq
MIRT2392444	hsa-miR-3157-5p	CLIP-seq
MIRT1227311	hsa-miR-342-3p	CLIP-seq
MIRT1227361	hsa-miR-760	CLIP-seq
MIRT1227297	hsa-miR-1260	CLIP-seq
MIRT1227298	hsa-miR-1260b	CLIP-seq
MIRT1227299	hsa-miR-1273f	CLIP-seq
MIRT2592102	hsa-miR-145	CLIP-seq
MIRT1227304	hsa-miR-188-3p	CLIP-seq
MIRT2592103	hsa-miR-1910	CLIP-seq
MIRT1227306	hsa-miR-2467-3p	CLIP-seq
MIRT1227307	hsa-miR-3156-3p	CLIP-seq
MIRT1227311	hsa-miR-342-3p	CLIP-seq
MIRT1227314	hsa-miR-3616-3p	CLIP-seq
MIRT1227315	hsa-miR-3622b-5p	CLIP-seq
MIRT2592104	hsa-miR-383	CLIP-seq
MIRT1227320	hsa-miR-4253	CLIP-seq
MIRT2592105	hsa-miR-4257	CLIP-seq
MIRT1227322	hsa-miR-4301	CLIP-seq
MIRT1227323	hsa-miR-4428	CLIP-seq
MIRT1227325	hsa-miR-4436b-3p	CLIP-seq
MIRT1227327	hsa-miR-4468	CLIP-seq
MIRT2592106	hsa-miR-455-3p	CLIP-seq
MIRT1227332	hsa-miR-4639-3p	CLIP-seq
MIRT1227336	hsa-miR-4660	CLIP-seq
MIRT1227340	hsa-miR-4761-3p	CLIP-seq
MIRT2592107	hsa-miR-4772-5p	CLIP-seq
MIRT2592108	hsa-miR-4797-5p	CLIP-seq
MIRT1227344	hsa-miR-520d-5p	CLIP-seq
MIRT1227345	hsa-miR-524-5p	CLIP-seq
MIRT1227353	hsa-miR-548g	CLIP-seq
MIRT1227359	hsa-miR-646	CLIP-seq
MIRT2592109	hsa-miR-759	CLIP-seq
MIRT1227361	hsa-miR-760	CLIP-seq
MIRT2294140	hsa-miR-933	CLIP-seq
MIRT1227297	hsa-miR-1260	CLIP-seq
MIRT1227298	hsa-miR-1260b	CLIP-seq
MIRT1227299	hsa-miR-1273f	CLIP-seq
MIRT2592102	hsa-miR-145	CLIP-seq
MIRT1227304	hsa-miR-188-3p	CLIP-seq
MIRT2592103	hsa-miR-1910	CLIP-seq
MIRT1227306	hsa-miR-2467-3p	CLIP-seq
MIRT1227307	hsa-miR-3156-3p	CLIP-seq
MIRT1227311	hsa-miR-342-3p	CLIP-seq
MIRT1227314	hsa-miR-3616-3p	CLIP-seq
MIRT1227315	hsa-miR-3622b-5p	CLIP-seq
MIRT2592104	hsa-miR-383	CLIP-seq
MIRT1227320	hsa-miR-4253	CLIP-seq
MIRT2592105	hsa-miR-4257	CLIP-seq
MIRT1227322	hsa-miR-4301	CLIP-seq
MIRT1227323	hsa-miR-4428	CLIP-seq
MIRT1227325	hsa-miR-4436b-3p	CLIP-seq
MIRT1227327	hsa-miR-4468	CLIP-seq
MIRT2592106	hsa-miR-455-3p	CLIP-seq
MIRT1227332	hsa-miR-4639-3p	CLIP-seq
MIRT1227336	hsa-miR-4660	CLIP-seq
MIRT1227340	hsa-miR-4761-3p	CLIP-seq
MIRT2592107	hsa-miR-4772-5p	CLIP-seq
MIRT2592108	hsa-miR-4797-5p	CLIP-seq
MIRT1227344	hsa-miR-520d-5p	CLIP-seq
MIRT1227345	hsa-miR-524-5p	CLIP-seq
MIRT1227359	hsa-miR-646	CLIP-seq
MIRT2592109	hsa-miR-759	CLIP-seq
MIRT1227361	hsa-miR-760	CLIP-seq
MIRT2294140	hsa-miR-933	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004616	Function	Phosphogluconate dehydrogenase (decarboxylating) activity	IBA
GO:0004616	Function	Phosphogluconate dehydrogenase (decarboxylating) activity	IEA
GO:0004616	Function	Phosphogluconate dehydrogenase (decarboxylating) activity	ISS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006098	Process	Pentose-phosphate shunt	IEA
GO:0006098	Process	Pentose-phosphate shunt	ISS
GO:0006739	Process	NADP+ metabolic process	IEA
GO:0006740	Process	NADPH regeneration	IEA
GO:0009051	Process	Pentose-phosphate shunt, oxidative branch	IBA
GO:0009051	Process	Pentose-phosphate shunt, oxidative branch	IDA	3858849
GO:0009051	Process	Pentose-phosphate shunt, oxidative branch	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0019322	Process	Pentose biosynthetic process	IEA
GO:0019521	Process	D-gluconate metabolic process	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0031406	Function	Carboxylic acid binding	IEA
GO:0050661	Function	NADP binding	IBA
GO:0050661	Function	NADP binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145

Other IDs

• MIM: 172200
• HGNC: 8891
• e!Ensembl: ENSG00000142657

Protein

• UniProt ID: P52209
• Protein name: 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)
• Protein function: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
• PDB: 2JKV, 4GWG, 4GWK, 5UQ9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03446	NAD_binding_2	5 → 175	NAD binding domain of 6-phosphogluconate dehydrogenase	Domain
  PF00393	6PGD	180 → 469	6-phosphogluconate dehydrogenase, C-terminal domain	Domain

• Sequence:

  MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKE
  MVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKG
  ILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAG
  HFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANIL
  KFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQA
  SKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIAL
  MWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPM
  PCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSS
  YNA

• Sequence length: 483

Pathways

KEGG:

Pentose phosphate pathway
Glutathione metabolism
Metabolic pathways
Carbon metabolism

Reactome:

Pentose phosphate pathway