PGA5 (pepsinogen A5)

Gene Gene information from NCBI Gene database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID 5222
Gene name Pepsinogen A5
Gene symbol PGA5
Synonyms (NCBI Gene)
Pg5
Chromosome 11
Chromosome location 11q12.2
Summary This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the act
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene Transcription factors Gene ontology Other IDs Protein Pathways
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Transcription factor Regulation Reference
SOX2 Activation 17136346
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene Transcription factors Gene ontology Other IDs Protein Pathways
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GO ID Ontology Definition Evidence Reference
GO:0004190 Function Aspartic-type endopeptidase activity IBA
GO:0004190 Function Aspartic-type endopeptidase activity IEA
GO:0005576 Component Extracellular region IEA
GO:0006508 Process Proteolysis IBA
GO:0006508 Process Proteolysis IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene Transcription factors Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
169730 8887 ENSG00000256713
Protein Protein information from UniProt database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P0DJD9
Protein name Pepsin A-5 (EC 3.4.23.1) (Pepsinogen-5)
Protein function Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07966 A1_Propeptide 17 → 45 A1 Propeptide Motif
PF00026 Asp 75 → 387 Eukaryotic aspartyl protease Family
Sequence
Sequence length 388
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Transcription factors Gene ontology Other IDs Protein Pathways
  KEGG  Reactome
  Protein digestion and absorption   Surfactant metabolism