PGA5 (pepsinogen A5)

Gene
Gene Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5222
Gene name Gene Name - the full gene name approved by the HGNC.
Pepsinogen A5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PGA5
Synonyms (NCBI Gene) Gene synonyms aliases
Pg5
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q12.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the act
Transcription factors
Gene Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all(1)
Transcription factor Regulation Reference
SOX2 Activation 17136346
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all(6)
GO ID Ontology Definition Evidence Reference
GO:0004190 Function Aspartic-type endopeptidase activity IEA
GO:0006508 Process Proteolysis IEA
GO:0007586 Process Digestion IEA
GO:0044267 Process Cellular protein metabolic process TAS
GO:0070062 Component Extracellular exosome HDA 23533145
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Transcription factors Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
169730 8887 ENSG00000256713
Protein
Gene Transcription factors Gene ontology Other IDs Protein Pathways
UniProt ID P0DJD9
Protein name Pepsin A-5 (EC 3.4.23.1) (Pepsinogen-5)
Protein function Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07966 A1_Propeptide 17 → 45 A1 Propeptide Motif
PF00026 Asp 75 → 387 Eukaryotic aspartyl protease Family
Sequence
Sequence length 388
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Transcription factors Gene ontology Other IDs Protein Pathways
  KEGG   Reactome
  Protein digestion and absorption   Surfactant metabolism