Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5218
Gene name Gene Name - the full gene name approved by the HGNC.
Cyclin dependent kinase 14
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CDK14
Synonyms (NCBI Gene) Gene synonyms aliases
PFTAIRE1, PFTK1
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q21.13
Summary Summary of gene provided in NCBI Entrez Gene.
PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003763 hsa-miR-1-3p Microarray 15685193
MIRT003763 hsa-miR-1-3p Microarray 15685193
MIRT024450 hsa-miR-215-5p Microarray 19074876
MIRT026414 hsa-miR-192-5p Microarray 19074876
MIRT029296 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000083 Process Regulation of transcription involved in G1/S transition of mitotic cell cycle IBA 21873635
GO:0000086 Process G2/M transition of mitotic cell cycle IDA 20059949
GO:0000308 Component Cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA 19524571, 20059949
GO:0004693 Function Cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0004693 Function Cyclin-dependent protein serine/threonine kinase activity IMP 19524571, 20059949
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610679 8883 ENSG00000058091
Protein
UniProt ID O94921
Protein name Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1)
Protein function Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylatio
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 135 419 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected. {ECO:0000269|PubMed:11313143}.
Sequence
Sequence length 469
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Transcriptional misregulation in cancer  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Common variable immunodeficiency Common Variable Immunodeficiency rs72553883, rs121908379, rs104894650, rs587776775, rs398122863, rs398122864, rs397514332, rs397514331, rs727502786, rs727502787, rs72553882, rs869320688, rs869320689, rs869320754, rs773694113
View all (35 more)
21497890
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 27458099
Breast Neoplasms Associate 26488471
Carcinoma Hepatocellular Associate 26488471
Carcinoma Non Small Cell Lung Stimulate 27458099, 34637340
Carcinoma Pancreatic Ductal Associate 30915884, 33635431
Carcinoma Renal Cell Associate 26406598
Colorectal Neoplasms Associate 27458094, 32737302
Coronary Disease Associate 21829389
Esophageal Neoplasms Stimulate 22333595
Esophageal Squamous Cell Carcinoma Associate 22333595