VIT (vitrin)

Gene

• Entrez ID: 5212
• Gene name: Vitrin
• Gene symbol: VIT
• Synonyms (NCBI Gene): VIT1
• Chromosome: 2
• Chromosome location: 2p22.2
• Summary: This gene encodes an extracellular matrix (ECM) protein. The protein may be associated with cell adhesion and migration. High levels of expression of the protein in specific parts of the brain suggest its likely role in neural development. [provided by Re

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022689	hsa-miR-124-3p	Microarray	18668037
MIRT1485080	hsa-miR-4663	CLIP-seq
MIRT1485081	hsa-miR-4738-3p	CLIP-seq
MIRT1485082	hsa-miR-4797-5p	CLIP-seq
MIRT1485083	hsa-miR-628-5p	CLIP-seq
MIRT1485084	hsa-miR-138	CLIP-seq
MIRT1485085	hsa-miR-15a	CLIP-seq
MIRT1485086	hsa-miR-15b	CLIP-seq
MIRT1485087	hsa-miR-16	CLIP-seq
MIRT1485088	hsa-miR-195	CLIP-seq
MIRT1485089	hsa-miR-3168	CLIP-seq
MIRT1485090	hsa-miR-424	CLIP-seq
MIRT1485091	hsa-miR-4422	CLIP-seq
MIRT1485080	hsa-miR-4663	CLIP-seq
MIRT1485092	hsa-miR-4729	CLIP-seq
MIRT1485081	hsa-miR-4738-3p	CLIP-seq
MIRT1485082	hsa-miR-4797-5p	CLIP-seq
MIRT1485093	hsa-miR-497	CLIP-seq
MIRT1485094	hsa-miR-570	CLIP-seq
MIRT1485083	hsa-miR-628-5p	CLIP-seq
MIRT1485095	hsa-miR-935	CLIP-seq
MIRT2145939	hsa-miR-323-3p	CLIP-seq
MIRT2145940	hsa-miR-4753-3p	CLIP-seq
MIRT1485080	hsa-miR-4663	CLIP-seq
MIRT1485081	hsa-miR-4738-3p	CLIP-seq
MIRT1485082	hsa-miR-4797-5p	CLIP-seq
MIRT1485083	hsa-miR-628-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005539	Function	Glycosaminoglycan binding	IEA
GO:0005614	Component	Interstitial matrix	IBA	21873635
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IBA	21873635
GO:0021510	Process	Spinal cord development	ISS
GO:0030198	Process	Extracellular matrix organization	IBA	21873635
GO:0062023	Component	Collagen-containing extracellular matrix	IBA	21873635

Other IDs

• MIM: 617693
• HGNC: 12697
• e!Ensembl: ENSG00000205221

Protein

• UniProt ID: Q6UXI7
• Protein name: Vitrin
• Protein function: Promotes matrix assembly and cell adhesiveness. Plays a role in spinal cord formation by regulating the proliferation and differentiation of neural stem cells.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03815	LCCL	38 → 133	LCCL domain	Domain
  PF00092	VWA	293 → 472	von Willebrand factor type A domain	Domain
  PF00092	VWA	495 → 663	von Willebrand factor type A domain	Domain

• Sequence:

  MRTVVLTMKASVIEMFLVLLVTGVHSNKETAKKIKRPKFTVPQINCDVKAGKIIDPEFIV
  KCPAGCQDPKYHVYGTDVYASYSSVCGAAVHSGVLDNSGGKILVRKVAGQSGYKGSYSNG
  VQSLSLPRWRESFIVLESKPKKGVTYPSALTYSSSKSPAAQAGETTKAYQRPPIPGTTAQ
  PVTLMQLLAVTVAVATPTTLPRPSPSAASTTSIPRPQSVGHRSQEMDLWSTATYTSSQNR
  PRADPGIQRQDPSGAAFQKPVGADVSLGLVPKEELSTQSLEPVSLGDPNCKIDLSFLIDG
  STSIGKRRFRIQKQLLADVAQALDIGPAGPLMGVVQYGDNPATHFNLKTHTNSRDLKTAI
  EKITQRGGLSNVGRAISFVTKNFFSKANGNRSGAPNVVVVMVDGWPTDKVEEASRLARES
  GINIFFITIEGAAENEKQYVVEPNFANKAVCRTNGFYSLHVQSWFGLHKTLQPLVKRVCD
  TDRLACSKTCLNSADIGFVIDGSSSVGTGNFRTVLQFVTNLTKEFEISDTDTRIGAVQYT
  YEQRLEFGFDKYSSKPDILNAIKRVGYWSGGTSTGAAINFALEQLFKKSKPNKRKLMILI
  TDGRSYDDVRIPAMAAHLKGVITYAIGVAWAAQEELEVIATHPARDHSFFVDEFDNLHQY
  VPRIIQNICTEFNSQPRN

• Sequence length: 678

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Metabolic Syndrome	Metabolic Syndrome			GWAS
Hypertrophic cardiomyopathy	Hypertrophic cardiomyopathy			GWAS
Oligodendroglioma	Oligodendroglioma			GWAS
Leprosy	Leprosy			GWAS
Schizophrenia	Schizophrenia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Alveolar capillary dysplasia	Associate	38029923
Osteoarthritis	Associate	25575966