Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	5201
Gene name	Prefoldin subunit 1
Gene symbol	PFDN1
Synonyms (NCBI Gene)	PDFPFD1
Chromosome	5
Chromosome location	5q31.3
Summary	This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023289	hsa-miR-122-5p	Microarray	17612493
MIRT023736	hsa-miR-1-3p	Proteomics	18668040
MIRT1226113	hsa-miR-3202	CLIP-seq
MIRT1226114	hsa-miR-361-3p	CLIP-seq
MIRT1226115	hsa-miR-4476	CLIP-seq
MIRT1226116	hsa-miR-4502	CLIP-seq
MIRT1226117	hsa-miR-760	CLIP-seq
MIRT2066081	hsa-miR-217	CLIP-seq
MIRT2066082	hsa-miR-3120-5p	CLIP-seq
MIRT2066083	hsa-miR-3182	CLIP-seq
MIRT2066084	hsa-miR-3618	CLIP-seq
MIRT2066085	hsa-miR-3675-5p	CLIP-seq
MIRT2066086	hsa-miR-4418	CLIP-seq
MIRT2066087	hsa-miR-4446-3p	CLIP-seq
MIRT2066088	hsa-miR-4492	CLIP-seq
MIRT2066089	hsa-miR-4498	CLIP-seq
MIRT2066090	hsa-miR-4505	CLIP-seq
MIRT2066091	hsa-miR-4646-5p	CLIP-seq
MIRT2066092	hsa-miR-4685-5p	CLIP-seq
MIRT2066093	hsa-miR-4747-5p	CLIP-seq
MIRT2066094	hsa-miR-509-3-5p	CLIP-seq
MIRT2066095	hsa-miR-509-5p	CLIP-seq
MIRT2066096	hsa-miR-762	CLIP-seq
MIRT2066097	hsa-miR-934	CLIP-seq
MIRT2293730	hsa-miR-1	CLIP-seq
MIRT2293731	hsa-miR-1207-5p	CLIP-seq
MIRT2293732	hsa-miR-1267	CLIP-seq
MIRT2293733	hsa-miR-206	CLIP-seq
MIRT2293734	hsa-miR-24	CLIP-seq
MIRT2293735	hsa-miR-3153	CLIP-seq
MIRT2293736	hsa-miR-3159	CLIP-seq
MIRT2293737	hsa-miR-3545-3p	CLIP-seq
MIRT2293738	hsa-miR-3664-3p	CLIP-seq
MIRT2293739	hsa-miR-3673	CLIP-seq
MIRT2066085	hsa-miR-3675-5p	CLIP-seq
MIRT2293740	hsa-miR-3714	CLIP-seq
MIRT2293741	hsa-miR-4283	CLIP-seq
MIRT2293742	hsa-miR-4434	CLIP-seq
MIRT2293743	hsa-miR-4437	CLIP-seq
MIRT2066087	hsa-miR-4446-3p	CLIP-seq
MIRT2293744	hsa-miR-4489	CLIP-seq
MIRT2066088	hsa-miR-4492	CLIP-seq
MIRT2066089	hsa-miR-4498	CLIP-seq
MIRT2066090	hsa-miR-4505	CLIP-seq
MIRT2293745	hsa-miR-4516	CLIP-seq
MIRT2293746	hsa-miR-452	CLIP-seq
MIRT2066091	hsa-miR-4646-5p	CLIP-seq
MIRT2293747	hsa-miR-4676-3p	CLIP-seq
MIRT2066092	hsa-miR-4685-5p	CLIP-seq
MIRT2293748	hsa-miR-4693-5p	CLIP-seq
MIRT2066093	hsa-miR-4747-5p	CLIP-seq
MIRT2293749	hsa-miR-4763-3p	CLIP-seq
MIRT2293750	hsa-miR-613	CLIP-seq
MIRT2293751	hsa-miR-653	CLIP-seq
MIRT2066096	hsa-miR-762	CLIP-seq
MIRT2293752	hsa-miR-940	CLIP-seq
MIRT2066092	hsa-miR-4685-5p	CLIP-seq
MIRT2591759	hsa-miR-1207-3p	CLIP-seq
MIRT2591760	hsa-miR-1229	CLIP-seq
MIRT2591761	hsa-miR-1253	CLIP-seq
MIRT2591762	hsa-miR-1288	CLIP-seq
MIRT2591763	hsa-miR-1302	CLIP-seq
MIRT2591764	hsa-miR-1343	CLIP-seq
MIRT2591765	hsa-miR-146b-3p	CLIP-seq
MIRT2591766	hsa-miR-149	CLIP-seq
MIRT2591767	hsa-miR-1538	CLIP-seq
MIRT2591768	hsa-miR-1976	CLIP-seq
MIRT2591769	hsa-miR-2116	CLIP-seq
MIRT2066081	hsa-miR-217	CLIP-seq
MIRT2591770	hsa-miR-3064-5p	CLIP-seq
MIRT2066082	hsa-miR-3120-5p	CLIP-seq
MIRT2591771	hsa-miR-3135	CLIP-seq
MIRT2591772	hsa-miR-3157-3p	CLIP-seq
MIRT2591773	hsa-miR-3173-5p	CLIP-seq
MIRT2066083	hsa-miR-3182	CLIP-seq
MIRT2591774	hsa-miR-3183	CLIP-seq
MIRT2591775	hsa-miR-3192	CLIP-seq
MIRT2591776	hsa-miR-3199	CLIP-seq
MIRT1226113	hsa-miR-3202	CLIP-seq
MIRT2591777	hsa-miR-337-3p	CLIP-seq
MIRT2591778	hsa-miR-3616-3p	CLIP-seq
MIRT2066084	hsa-miR-3618	CLIP-seq
MIRT2591779	hsa-miR-3620	CLIP-seq
MIRT2591780	hsa-miR-3652	CLIP-seq
MIRT2591781	hsa-miR-3681	CLIP-seq
MIRT2591782	hsa-miR-3922-5p	CLIP-seq
MIRT2591783	hsa-miR-3978	CLIP-seq
MIRT2591784	hsa-miR-4252	CLIP-seq
MIRT2591785	hsa-miR-4269	CLIP-seq
MIRT2591786	hsa-miR-4298	CLIP-seq
MIRT2591787	hsa-miR-4311	CLIP-seq
MIRT2066086	hsa-miR-4418	CLIP-seq
MIRT2591788	hsa-miR-4420	CLIP-seq
MIRT2591789	hsa-miR-4430	CLIP-seq
MIRT1226115	hsa-miR-4476	CLIP-seq
MIRT2591790	hsa-miR-4481	CLIP-seq
MIRT2066090	hsa-miR-4505	CLIP-seq
MIRT2591791	hsa-miR-4514	CLIP-seq
MIRT2591792	hsa-miR-4524	CLIP-seq
MIRT2591793	hsa-miR-4527	CLIP-seq
MIRT2591794	hsa-miR-4648	CLIP-seq
MIRT2591795	hsa-miR-4652-3p	CLIP-seq
MIRT2591796	hsa-miR-4659a-3p	CLIP-seq
MIRT2591797	hsa-miR-4659b-3p	CLIP-seq
MIRT2591798	hsa-miR-4663	CLIP-seq
MIRT2591799	hsa-miR-4668-5p	CLIP-seq
MIRT2591800	hsa-miR-4677-5p	CLIP-seq
MIRT2066092	hsa-miR-4685-5p	CLIP-seq
MIRT2591801	hsa-miR-4692	CLIP-seq
MIRT2591802	hsa-miR-4700-3p	CLIP-seq
MIRT2591803	hsa-miR-4708-3p	CLIP-seq
MIRT2591804	hsa-miR-4723-3p	CLIP-seq
MIRT2591805	hsa-miR-4742-5p	CLIP-seq
MIRT2591806	hsa-miR-4745-3p	CLIP-seq
MIRT2591807	hsa-miR-4745-5p	CLIP-seq
MIRT2591808	hsa-miR-4747-3p	CLIP-seq
MIRT2591809	hsa-miR-4778-5p	CLIP-seq
MIRT2591810	hsa-miR-4794	CLIP-seq
MIRT2066094	hsa-miR-509-3-5p	CLIP-seq
MIRT2066095	hsa-miR-509-5p	CLIP-seq
MIRT2591811	hsa-miR-516a-3p	CLIP-seq
MIRT2591812	hsa-miR-548aa	CLIP-seq
MIRT2591813	hsa-miR-548m	CLIP-seq
MIRT2591814	hsa-miR-642a	CLIP-seq
MIRT2591815	hsa-miR-759	CLIP-seq
MIRT2591816	hsa-miR-767-3p	CLIP-seq
MIRT2591817	hsa-miR-874	CLIP-seq
MIRT2066097	hsa-miR-934	CLIP-seq
MIRT2591759	hsa-miR-1207-3p	CLIP-seq
MIRT2591760	hsa-miR-1229	CLIP-seq
MIRT2591761	hsa-miR-1253	CLIP-seq
MIRT2591762	hsa-miR-1288	CLIP-seq
MIRT2591763	hsa-miR-1302	CLIP-seq
MIRT2591764	hsa-miR-1343	CLIP-seq
MIRT2591765	hsa-miR-146b-3p	CLIP-seq
MIRT2591766	hsa-miR-149	CLIP-seq
MIRT2591767	hsa-miR-1538	CLIP-seq
MIRT2591768	hsa-miR-1976	CLIP-seq
MIRT2591769	hsa-miR-2116	CLIP-seq
MIRT2066081	hsa-miR-217	CLIP-seq
MIRT2591770	hsa-miR-3064-5p	CLIP-seq
MIRT2066082	hsa-miR-3120-5p	CLIP-seq
MIRT2591771	hsa-miR-3135	CLIP-seq
MIRT2591772	hsa-miR-3157-3p	CLIP-seq
MIRT2591773	hsa-miR-3173-5p	CLIP-seq
MIRT2066083	hsa-miR-3182	CLIP-seq
MIRT2591774	hsa-miR-3183	CLIP-seq
MIRT2591775	hsa-miR-3192	CLIP-seq
MIRT2591776	hsa-miR-3199	CLIP-seq
MIRT1226113	hsa-miR-3202	CLIP-seq
MIRT2591777	hsa-miR-337-3p	CLIP-seq
MIRT2591778	hsa-miR-3616-3p	CLIP-seq
MIRT2066084	hsa-miR-3618	CLIP-seq
MIRT2591779	hsa-miR-3620	CLIP-seq
MIRT2591780	hsa-miR-3652	CLIP-seq
MIRT2591781	hsa-miR-3681	CLIP-seq
MIRT2591782	hsa-miR-3922-5p	CLIP-seq
MIRT2591783	hsa-miR-3978	CLIP-seq
MIRT2591784	hsa-miR-4252	CLIP-seq
MIRT2591785	hsa-miR-4269	CLIP-seq
MIRT2591786	hsa-miR-4298	CLIP-seq
MIRT2591787	hsa-miR-4311	CLIP-seq
MIRT2066086	hsa-miR-4418	CLIP-seq
MIRT2591788	hsa-miR-4420	CLIP-seq
MIRT2591789	hsa-miR-4430	CLIP-seq
MIRT1226115	hsa-miR-4476	CLIP-seq
MIRT2591790	hsa-miR-4481	CLIP-seq
MIRT2066090	hsa-miR-4505	CLIP-seq
MIRT2591791	hsa-miR-4514	CLIP-seq
MIRT2591792	hsa-miR-4524	CLIP-seq
MIRT2591793	hsa-miR-4527	CLIP-seq
MIRT2591794	hsa-miR-4648	CLIP-seq
MIRT2591795	hsa-miR-4652-3p	CLIP-seq
MIRT2591796	hsa-miR-4659a-3p	CLIP-seq
MIRT2591797	hsa-miR-4659b-3p	CLIP-seq
MIRT2591798	hsa-miR-4663	CLIP-seq
MIRT2591799	hsa-miR-4668-5p	CLIP-seq
MIRT2591800	hsa-miR-4677-5p	CLIP-seq
MIRT2066092	hsa-miR-4685-5p	CLIP-seq
MIRT2591801	hsa-miR-4692	CLIP-seq
MIRT2591802	hsa-miR-4700-3p	CLIP-seq
MIRT2591803	hsa-miR-4708-3p	CLIP-seq
MIRT2591804	hsa-miR-4723-3p	CLIP-seq
MIRT2591805	hsa-miR-4742-5p	CLIP-seq
MIRT2591806	hsa-miR-4745-3p	CLIP-seq
MIRT2591807	hsa-miR-4745-5p	CLIP-seq
MIRT2591808	hsa-miR-4747-3p	CLIP-seq
MIRT2591809	hsa-miR-4778-5p	CLIP-seq
MIRT2591810	hsa-miR-4794	CLIP-seq
MIRT2066094	hsa-miR-509-3-5p	CLIP-seq
MIRT2066095	hsa-miR-509-5p	CLIP-seq
MIRT2591811	hsa-miR-516a-3p	CLIP-seq
MIRT2591812	hsa-miR-548aa	CLIP-seq
MIRT2591813	hsa-miR-548m	CLIP-seq
MIRT2591814	hsa-miR-642a	CLIP-seq
MIRT2591815	hsa-miR-759	CLIP-seq
MIRT2591816	hsa-miR-767-3p	CLIP-seq
MIRT2591817	hsa-miR-874	CLIP-seq
MIRT2066097	hsa-miR-934	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IDA	23614719
GO:0005515	Function	Protein binding	IPI	16169070, 16876117, 21900206, 28514442, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	IDA	30955883
GO:0006457	Process	Protein folding	IEA
GO:0006457	Process	Protein folding	NAS	32699605
GO:0016272	Component	Prefoldin complex	IDA	23614719, 30955883
GO:0016272	Component	Prefoldin complex	IEA
GO:0016272	Component	Prefoldin complex	NAS	32699605
GO:0032991	Component	Protein-containing complex	IEA
GO:0044183	Function	Protein folding chaperone	IBA
GO:0044183	Function	Protein folding chaperone	IPI	16876117
GO:0051082	Function	Unfolded protein binding	IBA
GO:0051082	Function	Unfolded protein binding	IDA	30955883
GO:0051082	Function	Unfolded protein binding	IEA
GO:1905907	Process	Negative regulation of amyloid fibril formation	IDA	23614719

MIM	HGNC	e!Ensembl
604897	8866	ENSG00000113068

O60925

Protein name

Prefoldin subunit 1

Protein function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

PDB

6NR8 , 6NR9 , 6NRB , 6NRC , 6NRD , 7WU7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01920	Prefoldin_2	14 → 119	Prefoldin subunit	Coiled-coil

Sequence

MAAPVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLNRTKKHAHLTDTEIMTLVDETNM
YEGVGRMFILQSKEAIHSQLLEKQKIAEEKIKELEQKKSYLERSVKEAEDNIREMLMARR
AQ

Sequence length

122

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	35217267	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Associate	21052085	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	31957800	★★★★★ ★☆☆☆☆ Found in Text Mining only

PFDN1 (prefoldin subunit 1)