Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5198
Gene name	Phosphoribosylformylglycinamidine synthase
Gene symbol	PFAS
Synonyms (NCBI Gene)	FGAMSFGAR-ATFGARATGATD8PURL
Chromosome	17
Chromosome location	17p13.1
Summary	Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encode

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miRTarBase ID	miRNA	Experiments	Reference
MIRT051541	hsa-let-7e-5p	CLASH	23622248
MIRT050032	hsa-miR-27a-3p	CLASH	23622248
MIRT048843	hsa-miR-93-5p	CLASH	23622248
MIRT048110	hsa-miR-197-3p	CLASH	23622248
MIRT047554	hsa-miR-10a-5p	CLASH	23622248
MIRT047471	hsa-miR-10b-5p	CLASH	23622248
MIRT043096	hsa-miR-324-5p	CLASH	23622248
MIRT038636	hsa-miR-125a-3p	CLASH	23622248
MIRT038233	hsa-miR-330-5p	CLASH	23622248
MIRT458905	hsa-miR-4695-5p	HITS-CLIP	23706177
MIRT458904	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT458903	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT458899	hsa-miR-4257	HITS-CLIP	23706177
MIRT458898	hsa-miR-4459	HITS-CLIP	23706177
MIRT458897	hsa-miR-194-3p	HITS-CLIP	23706177
MIRT458895	hsa-miR-6840-3p	HITS-CLIP	23706177
MIRT517890	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT517889	hsa-miR-6086	HITS-CLIP	23706177
MIRT458892	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT458890	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT458889	hsa-miR-3612	HITS-CLIP	23706177
MIRT458888	hsa-miR-650	HITS-CLIP	23706177
MIRT458887	hsa-miR-6877-5p	HITS-CLIP	23706177
MIRT458886	hsa-miR-6781-5p	HITS-CLIP	23706177
MIRT458885	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT458883	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT458906	hsa-miR-122-3p	PAR-CLIP	23446348
MIRT458905	hsa-miR-4695-5p	PAR-CLIP	23446348
MIRT458904	hsa-miR-1910-3p	PAR-CLIP	23446348
MIRT458903	hsa-miR-6511a-5p	PAR-CLIP	23446348
MIRT458899	hsa-miR-4257	PAR-CLIP	23446348
MIRT458898	hsa-miR-4459	PAR-CLIP	23446348
MIRT458897	hsa-miR-194-3p	PAR-CLIP	23446348
MIRT458896	hsa-miR-665	PAR-CLIP	23446348
MIRT458895	hsa-miR-6840-3p	PAR-CLIP	23446348
MIRT458893	hsa-miR-1827	PAR-CLIP	23446348
MIRT517890	hsa-miR-377-5p	PAR-CLIP	23446348
MIRT517889	hsa-miR-6086	PAR-CLIP	23446348
MIRT458892	hsa-miR-2467-3p	PAR-CLIP	23446348
MIRT458890	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT458889	hsa-miR-3612	PAR-CLIP	23446348
MIRT458888	hsa-miR-650	PAR-CLIP	23446348
MIRT458887	hsa-miR-6877-5p	PAR-CLIP	23446348
MIRT458886	hsa-miR-6781-5p	PAR-CLIP	23446348
MIRT458885	hsa-miR-455-3p	PAR-CLIP	23446348
MIRT458883	hsa-miR-6516-5p	PAR-CLIP	23446348
MIRT458907	hsa-miR-302f	PAR-CLIP	23592263
MIRT458906	hsa-miR-122-3p	PAR-CLIP	23592263
MIRT458905	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT458904	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT458903	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT458902	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT458901	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT458900	hsa-miR-940	PAR-CLIP	23592263
MIRT458899	hsa-miR-4257	PAR-CLIP	23592263
MIRT458898	hsa-miR-4459	PAR-CLIP	23592263
MIRT458897	hsa-miR-194-3p	PAR-CLIP	23592263
MIRT458896	hsa-miR-665	PAR-CLIP	23592263
MIRT458895	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT458894	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT458893	hsa-miR-1827	PAR-CLIP	23592263
MIRT458892	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT458891	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT458890	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT458889	hsa-miR-3612	PAR-CLIP	23592263
MIRT458888	hsa-miR-650	PAR-CLIP	23592263
MIRT458887	hsa-miR-6877-5p	PAR-CLIP	23592263
MIRT458886	hsa-miR-6781-5p	PAR-CLIP	23592263
MIRT458885	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT458884	hsa-miR-1273e	PAR-CLIP	23592263
MIRT458883	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT458882	hsa-miR-132-3p	PAR-CLIP	23592263
MIRT458881	hsa-miR-212-3p	PAR-CLIP	23592263
MIRT458880	hsa-miR-4530	PAR-CLIP	23592263
MIRT458879	hsa-miR-338-3p	PAR-CLIP	23592263
MIRT458878	hsa-miR-4509	PAR-CLIP	23592263
MIRT458877	hsa-miR-6512-3p	PAR-CLIP	23592263
MIRT458876	hsa-miR-6720-5p	PAR-CLIP	23592263
MIRT289905	hsa-miR-4709-3p	PAR-CLIP	23592263
MIRT458893	hsa-miR-1827	PAR-CLIP	27292025
MIRT458904	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT458897	hsa-miR-194-3p	PAR-CLIP	27292025
MIRT458892	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT458889	hsa-miR-3612	PAR-CLIP	27292025
MIRT458899	hsa-miR-4257	PAR-CLIP	27292025
MIRT458898	hsa-miR-4459	PAR-CLIP	27292025
MIRT458885	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT458905	hsa-miR-4695-5p	PAR-CLIP	27292025
MIRT458890	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT458888	hsa-miR-650	PAR-CLIP	27292025
MIRT458903	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT458883	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT458896	hsa-miR-665	PAR-CLIP	27292025
MIRT458886	hsa-miR-6781-5p	PAR-CLIP	27292025
MIRT458895	hsa-miR-6840-3p	PAR-CLIP	27292025
MIRT458887	hsa-miR-6877-5p	PAR-CLIP	27292025
MIRT458905	hsa-miR-4695-5p	HITS-CLIP	23706177
MIRT458904	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT458903	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT458899	hsa-miR-4257	HITS-CLIP	23706177
MIRT458898	hsa-miR-4459	HITS-CLIP	23706177
MIRT458897	hsa-miR-194-3p	HITS-CLIP	23706177
MIRT458895	hsa-miR-6840-3p	HITS-CLIP	23706177
MIRT517890	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT517889	hsa-miR-6086	HITS-CLIP	23706177
MIRT458892	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT458890	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT458889	hsa-miR-3612	HITS-CLIP	23706177
MIRT458888	hsa-miR-650	HITS-CLIP	23706177
MIRT458887	hsa-miR-6877-5p	HITS-CLIP	23706177
MIRT458886	hsa-miR-6781-5p	HITS-CLIP	23706177
MIRT458885	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT458883	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT458906	hsa-miR-122-3p	PAR-CLIP	23446348
MIRT458905	hsa-miR-4695-5p	PAR-CLIP	23446348
MIRT458904	hsa-miR-1910-3p	PAR-CLIP	23446348
MIRT458903	hsa-miR-6511a-5p	PAR-CLIP	23446348
MIRT458899	hsa-miR-4257	PAR-CLIP	23446348
MIRT458898	hsa-miR-4459	PAR-CLIP	23446348
MIRT458897	hsa-miR-194-3p	PAR-CLIP	23446348
MIRT458896	hsa-miR-665	PAR-CLIP	23446348
MIRT458895	hsa-miR-6840-3p	PAR-CLIP	23446348
MIRT458893	hsa-miR-1827	PAR-CLIP	23446348
MIRT517890	hsa-miR-377-5p	PAR-CLIP	23446348
MIRT517889	hsa-miR-6086	PAR-CLIP	23446348
MIRT458892	hsa-miR-2467-3p	PAR-CLIP	23446348
MIRT458890	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT458889	hsa-miR-3612	PAR-CLIP	23446348
MIRT458888	hsa-miR-650	PAR-CLIP	23446348
MIRT458887	hsa-miR-6877-5p	PAR-CLIP	23446348
MIRT458886	hsa-miR-6781-5p	PAR-CLIP	23446348
MIRT458885	hsa-miR-455-3p	PAR-CLIP	23446348
MIRT458883	hsa-miR-6516-5p	PAR-CLIP	23446348
MIRT458907	hsa-miR-302f	PAR-CLIP	23592263
MIRT458906	hsa-miR-122-3p	PAR-CLIP	23592263
MIRT458905	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT458904	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT458903	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT458902	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT458901	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT458900	hsa-miR-940	PAR-CLIP	23592263
MIRT458899	hsa-miR-4257	PAR-CLIP	23592263
MIRT458898	hsa-miR-4459	PAR-CLIP	23592263
MIRT458897	hsa-miR-194-3p	PAR-CLIP	23592263
MIRT458896	hsa-miR-665	PAR-CLIP	23592263
MIRT458895	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT458894	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT458893	hsa-miR-1827	PAR-CLIP	23592263
MIRT458892	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT458891	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT458890	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT458889	hsa-miR-3612	PAR-CLIP	23592263
MIRT458888	hsa-miR-650	PAR-CLIP	23592263
MIRT458887	hsa-miR-6877-5p	PAR-CLIP	23592263
MIRT458886	hsa-miR-6781-5p	PAR-CLIP	23592263
MIRT458885	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT458884	hsa-miR-1273e	PAR-CLIP	23592263
MIRT458883	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT458882	hsa-miR-132-3p	PAR-CLIP	23592263
MIRT458881	hsa-miR-212-3p	PAR-CLIP	23592263
MIRT458880	hsa-miR-4530	PAR-CLIP	23592263
MIRT458879	hsa-miR-338-3p	PAR-CLIP	23592263
MIRT458878	hsa-miR-4509	PAR-CLIP	23592263
MIRT458877	hsa-miR-6512-3p	PAR-CLIP	23592263
MIRT458876	hsa-miR-6720-5p	PAR-CLIP	23592263
MIRT289905	hsa-miR-4709-3p	PAR-CLIP	23592263
MIRT1226065	hsa-miR-1245b-3p	CLIP-seq
MIRT1226066	hsa-miR-1258	CLIP-seq
MIRT1226067	hsa-miR-132	CLIP-seq
MIRT1226068	hsa-miR-146a	CLIP-seq
MIRT1226069	hsa-miR-146b-5p	CLIP-seq
MIRT1226070	hsa-miR-212	CLIP-seq
MIRT1226071	hsa-miR-2278	CLIP-seq
MIRT1226072	hsa-miR-3065-5p	CLIP-seq
MIRT1226073	hsa-miR-3121-3p	CLIP-seq
MIRT1226074	hsa-miR-3122	CLIP-seq
MIRT1226075	hsa-miR-3129-3p	CLIP-seq
MIRT1226076	hsa-miR-3180-5p	CLIP-seq
MIRT1226077	hsa-miR-3192	CLIP-seq
MIRT1226078	hsa-miR-323-5p	CLIP-seq
MIRT1226079	hsa-miR-34b	CLIP-seq
MIRT1226080	hsa-miR-3614-5p	CLIP-seq
MIRT1226081	hsa-miR-3647-3p	CLIP-seq
MIRT1226082	hsa-miR-3650	CLIP-seq
MIRT1226083	hsa-miR-3672	CLIP-seq
MIRT1226084	hsa-miR-3689a-3p	CLIP-seq
MIRT1226085	hsa-miR-3689c	CLIP-seq
MIRT1226086	hsa-miR-3913-5p	CLIP-seq
MIRT1226087	hsa-miR-3929	CLIP-seq
MIRT1226088	hsa-miR-4266	CLIP-seq
MIRT1226089	hsa-miR-4277	CLIP-seq
MIRT1226090	hsa-miR-4419b	CLIP-seq
MIRT1226091	hsa-miR-4455	CLIP-seq
MIRT1226092	hsa-miR-4468	CLIP-seq
MIRT1226093	hsa-miR-4478	CLIP-seq
MIRT1226094	hsa-miR-4672	CLIP-seq
MIRT1226095	hsa-miR-4709-5p	CLIP-seq
MIRT1226096	hsa-miR-4728-5p	CLIP-seq
MIRT1226097	hsa-miR-4786-5p	CLIP-seq
MIRT1226098	hsa-miR-4789-5p	CLIP-seq
MIRT1226099	hsa-miR-4795-3p	CLIP-seq
MIRT1226100	hsa-miR-485-5p	CLIP-seq
MIRT1226101	hsa-miR-486-5p	CLIP-seq
MIRT1226102	hsa-miR-520a-5p	CLIP-seq
MIRT1226103	hsa-miR-525-5p	CLIP-seq
MIRT1226104	hsa-miR-550a	CLIP-seq
MIRT1226105	hsa-miR-561	CLIP-seq
MIRT1226106	hsa-miR-589	CLIP-seq
MIRT1226107	hsa-miR-595	CLIP-seq
MIRT1226108	hsa-miR-609	CLIP-seq
MIRT1226109	hsa-miR-610	CLIP-seq
MIRT1226110	hsa-miR-661	CLIP-seq
MIRT1226111	hsa-miR-769-5p	CLIP-seq
MIRT1226112	hsa-miR-876-3p	CLIP-seq
MIRT2066046	hsa-miR-1224-3p	CLIP-seq
MIRT1226065	hsa-miR-1245b-3p	CLIP-seq
MIRT2066047	hsa-miR-1252	CLIP-seq
MIRT2066048	hsa-miR-1260	CLIP-seq
MIRT2066049	hsa-miR-1260b	CLIP-seq
MIRT2066050	hsa-miR-1262	CLIP-seq
MIRT2066051	hsa-miR-1280	CLIP-seq
MIRT2066052	hsa-miR-142-3p	CLIP-seq
MIRT1226068	hsa-miR-146a	CLIP-seq
MIRT1226069	hsa-miR-146b-5p	CLIP-seq
MIRT2066053	hsa-miR-214	CLIP-seq
MIRT2066054	hsa-miR-3145-5p	CLIP-seq
MIRT1226076	hsa-miR-3180-5p	CLIP-seq
MIRT1226078	hsa-miR-323-5p	CLIP-seq
MIRT2066055	hsa-miR-335	CLIP-seq
MIRT2066056	hsa-miR-3591-5p	CLIP-seq
MIRT2066057	hsa-miR-3619-5p	CLIP-seq
MIRT1226081	hsa-miR-3647-3p	CLIP-seq
MIRT1226082	hsa-miR-3650	CLIP-seq
MIRT1226083	hsa-miR-3672	CLIP-seq
MIRT2066058	hsa-miR-3675-3p	CLIP-seq
MIRT2066059	hsa-miR-3677-5p	CLIP-seq
MIRT1226089	hsa-miR-4277	CLIP-seq
MIRT2066060	hsa-miR-4280	CLIP-seq
MIRT2066061	hsa-miR-4291	CLIP-seq
MIRT1226091	hsa-miR-4455	CLIP-seq
MIRT2066062	hsa-miR-4514	CLIP-seq
MIRT2066063	hsa-miR-4680-3p	CLIP-seq
MIRT2066064	hsa-miR-4684-5p	CLIP-seq
MIRT2066065	hsa-miR-4690-5p	CLIP-seq
MIRT2066066	hsa-miR-4691-3p	CLIP-seq
MIRT2066067	hsa-miR-4692	CLIP-seq
MIRT2066068	hsa-miR-4701-3p	CLIP-seq
MIRT2066069	hsa-miR-4723-5p	CLIP-seq
MIRT1226096	hsa-miR-4728-5p	CLIP-seq
MIRT2066070	hsa-miR-4797-5p	CLIP-seq
MIRT1226101	hsa-miR-486-5p	CLIP-seq
MIRT2066071	hsa-miR-508-5p	CLIP-seq
MIRT1226102	hsa-miR-520a-5p	CLIP-seq
MIRT1226103	hsa-miR-525-5p	CLIP-seq
MIRT2066072	hsa-miR-532-3p	CLIP-seq
MIRT2066073	hsa-miR-539	CLIP-seq
MIRT2066074	hsa-miR-542-3p	CLIP-seq
MIRT2066075	hsa-miR-548c-3p	CLIP-seq
MIRT1226104	hsa-miR-550a	CLIP-seq
MIRT1226105	hsa-miR-561	CLIP-seq
MIRT1226106	hsa-miR-589	CLIP-seq
MIRT2066076	hsa-miR-590-3p	CLIP-seq
MIRT1226108	hsa-miR-609	CLIP-seq
MIRT1226110	hsa-miR-661	CLIP-seq
MIRT2066077	hsa-miR-759	CLIP-seq
MIRT2066078	hsa-miR-761	CLIP-seq
MIRT2066079	hsa-miR-766	CLIP-seq
MIRT1226112	hsa-miR-876-3p	CLIP-seq
MIRT2066080	hsa-miR-922	CLIP-seq
MIRT2066046	hsa-miR-1224-3p	CLIP-seq
MIRT1226066	hsa-miR-1258	CLIP-seq
MIRT2293725	hsa-miR-3121-5p	CLIP-seq
MIRT1226074	hsa-miR-3122	CLIP-seq
MIRT2293726	hsa-miR-3184	CLIP-seq
MIRT1226079	hsa-miR-34b	CLIP-seq
MIRT1226080	hsa-miR-3614-5p	CLIP-seq
MIRT1226081	hsa-miR-3647-3p	CLIP-seq
MIRT1226083	hsa-miR-3672	CLIP-seq
MIRT1226084	hsa-miR-3689a-3p	CLIP-seq
MIRT1226085	hsa-miR-3689c	CLIP-seq
MIRT1226086	hsa-miR-3913-5p	CLIP-seq
MIRT2293727	hsa-miR-423-5p	CLIP-seq
MIRT1226088	hsa-miR-4266	CLIP-seq
MIRT2293728	hsa-miR-4489	CLIP-seq
MIRT1226096	hsa-miR-4728-5p	CLIP-seq
MIRT1226097	hsa-miR-4786-5p	CLIP-seq
MIRT2293729	hsa-miR-628-5p	CLIP-seq
MIRT1226110	hsa-miR-661	CLIP-seq
MIRT1226111	hsa-miR-769-5p	CLIP-seq
MIRT1226098	hsa-miR-4789-5p	CLIP-seq
MIRT1226110	hsa-miR-661	CLIP-seq
MIRT2066058	hsa-miR-3675-3p	CLIP-seq
MIRT1226091	hsa-miR-4455	CLIP-seq
MIRT2066064	hsa-miR-4684-5p	CLIP-seq
MIRT2066075	hsa-miR-548c-3p	CLIP-seq
MIRT1226108	hsa-miR-609	CLIP-seq
MIRT2066046	hsa-miR-1224-3p	CLIP-seq
MIRT1226066	hsa-miR-1258	CLIP-seq
MIRT2591746	hsa-miR-125a-5p	CLIP-seq
MIRT2591747	hsa-miR-125b	CLIP-seq
MIRT2066048	hsa-miR-1260	CLIP-seq
MIRT2066049	hsa-miR-1260b	CLIP-seq
MIRT2066050	hsa-miR-1262	CLIP-seq
MIRT2066051	hsa-miR-1280	CLIP-seq
MIRT1226074	hsa-miR-3122	CLIP-seq
MIRT2066054	hsa-miR-3145-5p	CLIP-seq
MIRT1226077	hsa-miR-3192	CLIP-seq
MIRT1226078	hsa-miR-323-5p	CLIP-seq
MIRT1226079	hsa-miR-34b	CLIP-seq
MIRT1226080	hsa-miR-3614-5p	CLIP-seq
MIRT1226081	hsa-miR-3647-3p	CLIP-seq
MIRT1226082	hsa-miR-3650	CLIP-seq
MIRT1226083	hsa-miR-3672	CLIP-seq
MIRT2066058	hsa-miR-3675-3p	CLIP-seq
MIRT1226084	hsa-miR-3689a-3p	CLIP-seq
MIRT1226085	hsa-miR-3689c	CLIP-seq
MIRT2591748	hsa-miR-377	CLIP-seq
MIRT1226086	hsa-miR-3913-5p	CLIP-seq
MIRT2591749	hsa-miR-3941	CLIP-seq
MIRT1226088	hsa-miR-4266	CLIP-seq
MIRT2591750	hsa-miR-4319	CLIP-seq
MIRT1226091	hsa-miR-4455	CLIP-seq
MIRT2591751	hsa-miR-4643	CLIP-seq
MIRT2591752	hsa-miR-4645-3p	CLIP-seq
MIRT2591753	hsa-miR-466	CLIP-seq
MIRT1226094	hsa-miR-4672	CLIP-seq
MIRT2066064	hsa-miR-4684-5p	CLIP-seq
MIRT2066068	hsa-miR-4701-3p	CLIP-seq
MIRT1226096	hsa-miR-4728-5p	CLIP-seq
MIRT2591754	hsa-miR-4732-3p	CLIP-seq
MIRT1226097	hsa-miR-4786-5p	CLIP-seq
MIRT2591755	hsa-miR-4789-3p	CLIP-seq
MIRT1226098	hsa-miR-4789-5p	CLIP-seq
MIRT1226099	hsa-miR-4795-3p	CLIP-seq
MIRT1226101	hsa-miR-486-5p	CLIP-seq
MIRT2066071	hsa-miR-508-5p	CLIP-seq
MIRT2591756	hsa-miR-520f	CLIP-seq
MIRT2066074	hsa-miR-542-3p	CLIP-seq
MIRT2591757	hsa-miR-544b	CLIP-seq
MIRT2066075	hsa-miR-548c-3p	CLIP-seq
MIRT1226104	hsa-miR-550a	CLIP-seq
MIRT1226107	hsa-miR-595	CLIP-seq
MIRT1226108	hsa-miR-609	CLIP-seq
MIRT1226109	hsa-miR-610	CLIP-seq
MIRT1226110	hsa-miR-661	CLIP-seq
MIRT2591758	hsa-miR-670	CLIP-seq
MIRT2066079	hsa-miR-766	CLIP-seq
MIRT1226111	hsa-miR-769-5p	CLIP-seq
MIRT1226112	hsa-miR-876-3p	CLIP-seq
MIRT2066046	hsa-miR-1224-3p	CLIP-seq
MIRT1226066	hsa-miR-1258	CLIP-seq
MIRT2591746	hsa-miR-125a-5p	CLIP-seq
MIRT2591747	hsa-miR-125b	CLIP-seq
MIRT2066048	hsa-miR-1260	CLIP-seq
MIRT2066049	hsa-miR-1260b	CLIP-seq
MIRT2066051	hsa-miR-1280	CLIP-seq
MIRT1226071	hsa-miR-2278	CLIP-seq
MIRT1226073	hsa-miR-3121-3p	CLIP-seq
MIRT1226074	hsa-miR-3122	CLIP-seq
MIRT1226077	hsa-miR-3192	CLIP-seq
MIRT1226078	hsa-miR-323-5p	CLIP-seq
MIRT1226079	hsa-miR-34b	CLIP-seq
MIRT1226080	hsa-miR-3614-5p	CLIP-seq
MIRT1226081	hsa-miR-3647-3p	CLIP-seq
MIRT1226082	hsa-miR-3650	CLIP-seq
MIRT1226083	hsa-miR-3672	CLIP-seq
MIRT2066058	hsa-miR-3675-3p	CLIP-seq
MIRT1226084	hsa-miR-3689a-3p	CLIP-seq
MIRT1226085	hsa-miR-3689c	CLIP-seq
MIRT2591748	hsa-miR-377	CLIP-seq
MIRT1226086	hsa-miR-3913-5p	CLIP-seq
MIRT2591749	hsa-miR-3941	CLIP-seq
MIRT1226088	hsa-miR-4266	CLIP-seq
MIRT2591750	hsa-miR-4319	CLIP-seq
MIRT1226091	hsa-miR-4455	CLIP-seq
MIRT1226092	hsa-miR-4468	CLIP-seq
MIRT2687676	hsa-miR-450b-5p	CLIP-seq
MIRT2591751	hsa-miR-4643	CLIP-seq
MIRT2591752	hsa-miR-4645-3p	CLIP-seq
MIRT2591753	hsa-miR-466	CLIP-seq
MIRT1226094	hsa-miR-4672	CLIP-seq
MIRT2066064	hsa-miR-4684-5p	CLIP-seq
MIRT1226096	hsa-miR-4728-5p	CLIP-seq
MIRT2591754	hsa-miR-4732-3p	CLIP-seq
MIRT1226097	hsa-miR-4786-5p	CLIP-seq
MIRT2591755	hsa-miR-4789-3p	CLIP-seq
MIRT1226098	hsa-miR-4789-5p	CLIP-seq
MIRT1226099	hsa-miR-4795-3p	CLIP-seq
MIRT2591756	hsa-miR-520f	CLIP-seq
MIRT2066074	hsa-miR-542-3p	CLIP-seq
MIRT2591757	hsa-miR-544b	CLIP-seq
MIRT2066075	hsa-miR-548c-3p	CLIP-seq
MIRT1226107	hsa-miR-595	CLIP-seq
MIRT1226108	hsa-miR-609	CLIP-seq
MIRT1226109	hsa-miR-610	CLIP-seq
MIRT1226110	hsa-miR-661	CLIP-seq
MIRT2591758	hsa-miR-670	CLIP-seq
MIRT1226111	hsa-miR-769-5p	CLIP-seq
MIRT1226112	hsa-miR-876-3p	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004642	Function	Phosphoribosylformylglycinamidine synthase activity	IBA
GO:0004642	Function	Phosphoribosylformylglycinamidine synthase activity	IDA	10548741, 27590927
GO:0004642	Function	Phosphoribosylformylglycinamidine synthase activity	IEA
GO:0004642	Function	Phosphoribosylformylglycinamidine synthase activity	TAS
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006164	Process	Purine nucleotide biosynthetic process	IBA
GO:0006164	Process	Purine nucleotide biosynthetic process	IEA
GO:0006177	Process	GMP biosynthetic process	IDA	27590927
GO:0006189	Process	'de novo' IMP biosynthetic process	IDA	27590927
GO:0006189	Process	'de novo' IMP biosynthetic process	IEA
GO:0006189	Process	'de novo' IMP biosynthetic process	NAS	10548741
GO:0006541	Process	Glutamine metabolic process	IEA
GO:0009168	Process	Purine ribonucleoside monophosphate biosynthetic process	TAS
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0044208	Process	'de novo' AMP biosynthetic process	IDA	27590927
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0097065	Process	Anterior head development	IEA
GO:0097294	Process	'de novo' XMP biosynthetic process	IDA	27590927

MIM	HGNC	e!Ensembl
602133	8863	ENSG00000178921

O15067

Protein name

Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotran

Protein function

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and gluta

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18076	FGAR-AT_N	39 → 160	Formylglycinamide ribonucleotide amidotransferase N-terminal	Domain
PF18072	FGAR-AT_linker	184 → 232	Formylglycinamide ribonucleotide amidotransferase linker domain	Domain
PF02769	AIRS_C	444 → 603	AIR synthase related protein, C-terminal domain	Domain
PF02769	AIRS_C	848 → 991	AIR synthase related protein, C-terminal domain	Domain
PF13507	GATase_5	1062 → 1333		Domain

Sequence

MSPVLHFYVRPSGHEGAAPGHTRRKLQGKLPELQGVETELCYNVNWTAEALPSAEETKKL
MWLFGCPLLLDDVARESWLLPGSNDLLLEVGPRLNFSTPTSTNIVSVCRATGLGPVDRVE
TTRRYRLSFAHPPSAEVEAIALATLHDRMTEQHFPHPIQSFSPESMPEPLNGPINILGEG
RLALEKANQELGLALDSWDLDFYTKRFQELQRNPSTVEAFDLAQSNSEHSRHWFFKGQLH
VDGQKLVHSLFESIMSTQESSNPNNVLKFCDNSSAIQGKEVRFLRPEDPTRPSRFQQQQG
LRHVVFTAETHNFPTGVCPFSGATTGTGGRIRDVQCTGRGAHVVAGTAGYCFGNLHIPGY
NLPWEDPSFQYPGNFARPLEVAIEASNGASDYGNKFGEPVLAGFARSLGLQLPDGQRREW
IKPIMFSGGIGSMEADHISKEAPEPGMEVVKVGGPVYRIGVGGGAASSVQVQGDNTSDLD
FGAVQRGDPEMEQKMNRVIRACVEAPKGNPICSLHDQGAGGNGNVLKELSDPAGAIIYTS
RFQLGDPTLNALEIWGAEYQESNALLLRSPNRDFLTHVSARERCPACFVGTITGDRRIVL
VDDRECPVRRNGQGDAPPTPLPTPVDLELEWVLGKMPRKEFFLQRKPPMLQPLALPPGLS
VHQALERVLRLPAVASKRYLTNKVDRSVGGLVAQQQCVGPLQTPLADVAVVALSHEELIG
AATALGEQPVKSLLDPKVAARLAVAEALTNLVFALVTDLRDVKCSGNWMWAAKLPGEGAA
LADACEAMVAVMAALGVAVDGGKDSLSMAARVGTETVRAPGSLVISAYAVCPDITATVTP
DLKHPEGRGHLLYVALSPGQHRLGGTALAQCFSQLGEHPPDLDLPENLVRAFSITQGLLK
DRLLCSGHDVSDGGLVTCLLEMAFAGNCGLQVDVPVPRVDVLSVLFAEEPGLVLEVQEPD
LAQVLKRYRDAGLHCLELGHTGEAGPHAMVRVSVNGAVVLEEPVGELRALWEETSFQLDR
LQAEPRCVAEEERGLRERMGPSYCLPPTFPKASVPREPGGPSPRVAILREEGSNGDREMA
DAFHLAGFEVWDVTMQDLCSGAIGLDTFRGVAFVGGFSYADVLGSAKGWAAAVTFHPRAG
AELRRFRKRPDTFSLGVCNGCQLLALLGWVGGDPNEDAAEMGPDSQPARPGLLLRHNLSG
RYESRWASVRVGPGPALMLRGMEGAVLPVWSAHGEGYVAFSSPELQAQIEARGLAPLHWA
DDDGNPTEQYPLNPNGSPGGVAGICSCDGRHLAVMPHPERAVRPWQWAWRPPPFDTLTTS
PWLQLFINARNWTLEGSC

Sequence length

1338

Interactions

View interactions

	KEGG		Reactome
	Purine metabolism Metabolic pathways		Purine ribonucleoside monophosphate biosynthesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CEREBRORETINAL MICROANGIOPATHY WITH CALCIFICATIONS AND CYSTS 1	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DYSKERATOSIS CONGENITA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLOMERULONEPHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Graves Ophthalmopathy	Associate	37884559	★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Associate	37228185	★★★★★ ★☆☆☆☆ Found in Text Mining only

PFAS (phosphoribosylformylglycinamidine synthase)