Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51807
Gene name Gene Name - the full gene name approved by the HGNC.	Tubulin alpha 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TUBA8
Synonyms (NCBI Gene) Gene synonyms aliases	CDCBM8, MACTHC2, TUBAL2
Disease Acronyms (UniProt) Disease acronyms from UniProt database	MACTHC2
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q11.21
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the alpha tubulin protein family. Alpha tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene are associated with polymicrogyria

Show/Hide all(3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs2234333	A>G,T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs138073466	A>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs878853254	GTTGCTTCCCTCTC>-	Pathogenic	Intron variant

Show/Hide all(30)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018195	hsa-miR-335-5p	Microarray	18185580
MIRT019370	hsa-miR-148b-3p	Microarray	17612493
MIRT1463010	hsa-miR-124	CLIP-seq
MIRT1463011	hsa-miR-1343	CLIP-seq
MIRT1463012	hsa-miR-3714	CLIP-seq
MIRT1463013	hsa-miR-3910	CLIP-seq
MIRT1463014	hsa-miR-506	CLIP-seq
MIRT1463015	hsa-miR-555	CLIP-seq
MIRT1463016	hsa-miR-940	CLIP-seq
MIRT2360015	hsa-miR-1184	CLIP-seq
MIRT2360016	hsa-miR-1587	CLIP-seq
MIRT2360017	hsa-miR-320a	CLIP-seq
MIRT2360018	hsa-miR-320b	CLIP-seq
MIRT2360019	hsa-miR-320c	CLIP-seq
MIRT2360020	hsa-miR-320d	CLIP-seq
MIRT2360021	hsa-miR-3591-5p	CLIP-seq
MIRT2360022	hsa-miR-3606	CLIP-seq
MIRT2360023	hsa-miR-3659	CLIP-seq
MIRT2360024	hsa-miR-378g	CLIP-seq
MIRT2360025	hsa-miR-4255	CLIP-seq
MIRT2360026	hsa-miR-4429	CLIP-seq
MIRT2360027	hsa-miR-4492	CLIP-seq
MIRT2360028	hsa-miR-4498	CLIP-seq
MIRT2360029	hsa-miR-4656	CLIP-seq
MIRT2360030	hsa-miR-4675	CLIP-seq
MIRT2360031	hsa-miR-4738-3p	CLIP-seq
MIRT2360032	hsa-miR-4741	CLIP-seq
MIRT2360033	hsa-miR-642b	CLIP-seq
MIRT2360034	hsa-miR-762	CLIP-seq
MIRT2360035	hsa-miR-921	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IBA	21873635
GO:0000278	Process	Mitotic cell cycle	IBA	21873635
GO:0003924	Function	GTPase activity	IEA
GO:0005200	Function	Structural constituent of cytoskeleton	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005525	Function	GTP binding	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005874	Component	Microtubule	IBA	21873635
GO:0015630	Component	Microtubule cytoskeleton	IDA

MIM	HGNC	e!Ensembl
605742	12410	ENSG00000183785

Protein

UniProt ID

Q9NY65

Protein name

Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain]

Protein function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule en

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00091	Tubulin	3 → 214	Tubulin/FtsZ family, GTPase domain	Domain
PF03953	Tubulin_C	263 → 393	Tubulin C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Preferentially expressed in heart, skeletal muscle and testis. Expressed at low levels in the developing brain. Expressed in megakaryocytes and platelets (PubMed:34704371). {ECO:0000269|PubMed:20466094, ECO:0000269|PubMed:34704371}.

Sequence

MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFDAQASKINDDDSFTTFFSETGNGK
HVPRAVMIDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLD
RIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNS
QMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGTDSFEEENEGEEF

Sequence length

449

Interactions

View interactions

	KEGG		Reactome
	Phagosome Apoptosis Tight junction Gap junction Motor proteins Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection		Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Recycling pathway of L1 Cilium Assembly RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin HCMV Early Events Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins

Show/Hide Causal Diseases (8)

Disease term	Disease name	dbSNP ID	References
Causal
Agenesis of corpus callosum	Agenesis of corpus callosum	rs754914260, rs1057519053, rs1057519056, rs1057519054, rs1057519055, rs1057519057, rs1384496494, rs1599017933
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557 View all (6 more)	29892015, 30061737
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291 View all (32 more)
Microcephaly	Microcephaly	rs397704721, rs267607176, rs267607177, rs397704725, rs267606717, rs267606718, rs199422202, rs121434311, rs199422203, rs199422126, rs387906274, rs121434305, rs199422125, rs199422135, rs189678019 View all (280 more)
Hypotonia	Neonatal Hypotonia	rs141138948, rs397517172, rs869312824, rs1583169151
Polymicrogyria	Polymicrogyria	rs1558010146, rs1558003446, rs1575508937
Seizure	Tonic - clonic seizures	rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061 View all (179 more)
West syndrome	West Syndrome	rs267606715, rs267608421, rs727503974, rs786205598, rs794727152, rs796053134, rs796053162, rs1057517854, rs267608618, rs1555952078, rs1555954752, rs749975104

Show/Hide Unknown Diseases (4)

Disease term	Disease name	References	Source
Unknown
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	29892015, 30061737	ClinVar
Polymicrogyria with optic nerve hypoplasia	Polymicrogyria With Optic Nerve Hypoplasia, Polymicrogyria with optic nerve hypoplasia	19896110, 28007376	ClinVar
Polymicrogyria With Optic Nerve Hypoplasia	polymicrogyria with optic nerve hypoplasia		GenCC
Atrial Fibrillation	Atrial Fibrillation		GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining
Bipolar Disorder	Associate	16380905
Femur Head Necrosis	Associate	35126370
Genetic Diseases Inborn	Associate	34704371
Heart Septal Defects Ventricular	Associate	19268070
Iliotibial Band Syndrome	Associate	34704371
Lissencephaly	Associate	19896110
Neurologic Manifestations	Associate	22591407
Optic Nerve Hypoplasia	Associate	19896110
Polymicrogyria	Associate	19896110
Spondylitis Ankylosing	Associate	35126370

TUBA8 (tubulin alpha 8)