Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51747
Gene name Gene Name - the full gene name approved by the HGNC.
LUC7 like 3 pre-mRNA splicing factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LUC7L3
Synonyms (NCBI Gene) Gene synonyms aliases
CRA, CREAP-1, CROP, LUC7A, OA48-18, hLuc7A
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.33
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020883 hsa-miR-155-5p Proteomics 18668040
MIRT045993 hsa-miR-125b-5p CLASH 23622248
MIRT041706 hsa-miR-484 CLASH 23622248
MIRT040591 hsa-miR-92b-3p CLASH 23622248
MIRT449190 hsa-miR-15a-5p PAR-CLIP 22100165
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003729 Function MRNA binding IBA
GO:0003729 Function MRNA binding IEA
GO:0003729 Function MRNA binding IMP 10631324
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609434 24309 ENSG00000108848
Protein
UniProt ID O95232
Protein name Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1)
Protein function Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03194 LUC7 3 295 LUC7 N_terminus Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Highest levels in heart, brain, pancreas, thymus, ovary, small intestine and peripheral blood leukocytes, as well as cerebellum, putamen and pituitary gland. Lowest levels in lung, liver and kidney. Also expressed in
Sequence
Sequence length 432
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 32497068
Carcinoma Renal Cell Associate 24899691
Death Sudden Associate 21859973
Head and Neck Neoplasms Associate 22986368
Heart Failure Associate 21859973, 22939879
Hypoxia Stimulate 22939879
Nasopharyngeal Carcinoma Associate 22986368
Neoplasms Associate 22986368, 34001978
Prostatic Neoplasms Associate 37143720