Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51735
Gene name Gene Name - the full gene name approved by the HGNC.	Rap guanine nucleotide exchange factor 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RAPGEF6
Synonyms (NCBI Gene) Gene synonyms aliases	KIA001LB, PDZ-GEF2, PDZGEF2, RA-GEF-2, RAGEF2
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q31.1

Show/Hide all(264)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030847	hsa-miR-21-5p	Microarray	18591254
MIRT036590	hsa-miR-940	CLASH	23622248
MIRT720726	hsa-miR-4698	HITS-CLIP	19536157
MIRT720725	hsa-miR-6736-3p	HITS-CLIP	19536157
MIRT720724	hsa-miR-4267	HITS-CLIP	19536157
MIRT720723	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT720722	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT720721	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT720720	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT720719	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT720718	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT720717	hsa-miR-4268	HITS-CLIP	19536157
MIRT720716	hsa-miR-188-3p	HITS-CLIP	19536157
MIRT720715	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT720714	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT720713	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT720712	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT726784	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT726783	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT720726	hsa-miR-4698	HITS-CLIP	19536157
MIRT720725	hsa-miR-6736-3p	HITS-CLIP	19536157
MIRT720724	hsa-miR-4267	HITS-CLIP	19536157
MIRT720723	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT720722	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT720721	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT720720	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT720719	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT720718	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT720717	hsa-miR-4268	HITS-CLIP	19536157
MIRT720716	hsa-miR-188-3p	HITS-CLIP	19536157
MIRT720715	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT720714	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT720713	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT720712	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT1290906	hsa-miR-1270	CLIP-seq
MIRT1290907	hsa-miR-1273e	CLIP-seq
MIRT1290908	hsa-miR-1286	CLIP-seq
MIRT1290909	hsa-miR-130a	CLIP-seq
MIRT1290910	hsa-miR-130b	CLIP-seq
MIRT1290911	hsa-miR-1324	CLIP-seq
MIRT1290912	hsa-miR-135a	CLIP-seq
MIRT1290913	hsa-miR-135b	CLIP-seq
MIRT1290914	hsa-miR-142-5p	CLIP-seq
MIRT1290915	hsa-miR-1470	CLIP-seq
MIRT1290916	hsa-miR-205	CLIP-seq
MIRT1290917	hsa-miR-219-2-3p	CLIP-seq
MIRT1290918	hsa-miR-2355-3p	CLIP-seq
MIRT1290919	hsa-miR-2964a-3p	CLIP-seq
MIRT1290920	hsa-miR-301a	CLIP-seq
MIRT1290921	hsa-miR-301b	CLIP-seq
MIRT1290922	hsa-miR-3119	CLIP-seq
MIRT1290923	hsa-miR-3140-3p	CLIP-seq
MIRT1290924	hsa-miR-3153	CLIP-seq
MIRT1290925	hsa-miR-3157-5p	CLIP-seq
MIRT1290926	hsa-miR-3163	CLIP-seq
MIRT1290927	hsa-miR-3166	CLIP-seq
MIRT1290928	hsa-miR-3173-3p	CLIP-seq
MIRT1290929	hsa-miR-340	CLIP-seq
MIRT1290930	hsa-miR-3614-5p	CLIP-seq
MIRT1290931	hsa-miR-365	CLIP-seq
MIRT1290932	hsa-miR-3666	CLIP-seq
MIRT1290933	hsa-miR-3940-5p	CLIP-seq
MIRT1290934	hsa-miR-3978	CLIP-seq
MIRT1290935	hsa-miR-4282	CLIP-seq
MIRT1290936	hsa-miR-4295	CLIP-seq
MIRT1290937	hsa-miR-4424	CLIP-seq
MIRT1290938	hsa-miR-4469	CLIP-seq
MIRT1290939	hsa-miR-4477a	CLIP-seq
MIRT1290940	hsa-miR-4507	CLIP-seq
MIRT1290941	hsa-miR-454	CLIP-seq
MIRT1290942	hsa-miR-4646-3p	CLIP-seq
MIRT1290943	hsa-miR-4667-3p	CLIP-seq
MIRT1290944	hsa-miR-4671-3p	CLIP-seq
MIRT1290945	hsa-miR-4683	CLIP-seq
MIRT1290946	hsa-miR-4690-3p	CLIP-seq
MIRT1290947	hsa-miR-4694-3p	CLIP-seq
MIRT1290948	hsa-miR-4695-5p	CLIP-seq
MIRT1290949	hsa-miR-4700-3p	CLIP-seq
MIRT1290950	hsa-miR-4712-3p	CLIP-seq
MIRT1290951	hsa-miR-4717-5p	CLIP-seq
MIRT1290952	hsa-miR-4722-5p	CLIP-seq
MIRT1290953	hsa-miR-5095	CLIP-seq
MIRT1290954	hsa-miR-513a-3p	CLIP-seq
MIRT1290955	hsa-miR-548l	CLIP-seq
MIRT1290956	hsa-miR-548n	CLIP-seq
MIRT1290957	hsa-miR-569	CLIP-seq
MIRT1290958	hsa-miR-587	CLIP-seq
MIRT1290959	hsa-miR-606	CLIP-seq
MIRT1290960	hsa-miR-620	CLIP-seq
MIRT1290961	hsa-miR-676	CLIP-seq
MIRT1290962	hsa-miR-7	CLIP-seq
MIRT1290963	hsa-miR-922	CLIP-seq
MIRT1290964	hsa-miR-103a	CLIP-seq
MIRT1290965	hsa-miR-107	CLIP-seq
MIRT1290966	hsa-miR-1180	CLIP-seq
MIRT1290967	hsa-miR-1245b-5p	CLIP-seq
MIRT1290968	hsa-miR-1271	CLIP-seq
MIRT1290969	hsa-miR-182	CLIP-seq
MIRT1290970	hsa-miR-185	CLIP-seq
MIRT1290971	hsa-miR-19a	CLIP-seq
MIRT1290972	hsa-miR-19b	CLIP-seq
MIRT1290973	hsa-miR-224	CLIP-seq
MIRT1290974	hsa-miR-23a	CLIP-seq
MIRT1290975	hsa-miR-23b	CLIP-seq
MIRT1290976	hsa-miR-23c	CLIP-seq
MIRT1290977	hsa-miR-2682	CLIP-seq
MIRT1290978	hsa-miR-3142	CLIP-seq
MIRT1290979	hsa-miR-3145-3p	CLIP-seq
MIRT1290925	hsa-miR-3157-5p	CLIP-seq
MIRT1290980	hsa-miR-3192	CLIP-seq
MIRT1290981	hsa-miR-3664-5p	CLIP-seq
MIRT1290982	hsa-miR-3714	CLIP-seq
MIRT1290983	hsa-miR-3935	CLIP-seq
MIRT1290984	hsa-miR-4306	CLIP-seq
MIRT1290985	hsa-miR-4463	CLIP-seq
MIRT1290986	hsa-miR-4470	CLIP-seq
MIRT1290939	hsa-miR-4477a	CLIP-seq
MIRT1290987	hsa-miR-4477b	CLIP-seq
MIRT1290988	hsa-miR-449c	CLIP-seq
MIRT1290989	hsa-miR-4644	CLIP-seq
MIRT1290990	hsa-miR-4645-5p	CLIP-seq
MIRT1290991	hsa-miR-4673	CLIP-seq
MIRT1290992	hsa-miR-4696	CLIP-seq
MIRT1290993	hsa-miR-4699-3p	CLIP-seq
MIRT1290994	hsa-miR-4704-5p	CLIP-seq
MIRT1290995	hsa-miR-4774-5p	CLIP-seq
MIRT1290996	hsa-miR-4796-3p	CLIP-seq
MIRT1290997	hsa-miR-507	CLIP-seq
MIRT1290998	hsa-miR-518a-5p	CLIP-seq
MIRT1290999	hsa-miR-520g	CLIP-seq
MIRT1291000	hsa-miR-520h	CLIP-seq
MIRT1291001	hsa-miR-527	CLIP-seq
MIRT1291002	hsa-miR-548aa	CLIP-seq
MIRT1291003	hsa-miR-557	CLIP-seq
MIRT1291004	hsa-miR-561	CLIP-seq
MIRT1291005	hsa-miR-661	CLIP-seq
MIRT1291006	hsa-miR-935	CLIP-seq
MIRT1291007	hsa-miR-96	CLIP-seq
MIRT1290939	hsa-miR-4477a	CLIP-seq
MIRT1291008	hsa-miR-4775	CLIP-seq
MIRT1291009	hsa-miR-590-3p	CLIP-seq
MIRT1290964	hsa-miR-103a	CLIP-seq
MIRT1290965	hsa-miR-107	CLIP-seq
MIRT1291010	hsa-miR-1205	CLIP-seq
MIRT1290968	hsa-miR-1271	CLIP-seq
MIRT1291011	hsa-miR-1276	CLIP-seq
MIRT1290909	hsa-miR-130a	CLIP-seq
MIRT1290910	hsa-miR-130b	CLIP-seq
MIRT1290911	hsa-miR-1324	CLIP-seq
MIRT1290912	hsa-miR-135a	CLIP-seq
MIRT1290913	hsa-miR-135b	CLIP-seq
MIRT1290915	hsa-miR-1470	CLIP-seq
MIRT1290969	hsa-miR-182	CLIP-seq
MIRT1291012	hsa-miR-1909	CLIP-seq
MIRT1291013	hsa-miR-2467-5p	CLIP-seq
MIRT1290920	hsa-miR-301a	CLIP-seq
MIRT1290921	hsa-miR-301b	CLIP-seq
MIRT1290922	hsa-miR-3119	CLIP-seq
MIRT1291014	hsa-miR-3132	CLIP-seq
MIRT1291015	hsa-miR-3148	CLIP-seq
MIRT1291016	hsa-miR-3149	CLIP-seq
MIRT1290924	hsa-miR-3153	CLIP-seq
MIRT1291017	hsa-miR-3188	CLIP-seq
MIRT1291018	hsa-miR-3607-3p	CLIP-seq
MIRT1291019	hsa-miR-3617	CLIP-seq
MIRT1291020	hsa-miR-3652	CLIP-seq
MIRT1291021	hsa-miR-3658	CLIP-seq
MIRT1290932	hsa-miR-3666	CLIP-seq
MIRT1291022	hsa-miR-3686	CLIP-seq
MIRT1291023	hsa-miR-3691-3p	CLIP-seq
MIRT1291024	hsa-miR-3921	CLIP-seq
MIRT1291025	hsa-miR-3975	CLIP-seq
MIRT1291026	hsa-miR-4263	CLIP-seq
MIRT1290936	hsa-miR-4295	CLIP-seq
MIRT1291027	hsa-miR-4311	CLIP-seq
MIRT1291028	hsa-miR-4325	CLIP-seq
MIRT1291029	hsa-miR-4422	CLIP-seq
MIRT1291030	hsa-miR-4430	CLIP-seq
MIRT1290938	hsa-miR-4469	CLIP-seq
MIRT1290986	hsa-miR-4470	CLIP-seq
MIRT1290987	hsa-miR-4477b	CLIP-seq
MIRT1290941	hsa-miR-454	CLIP-seq
MIRT1291031	hsa-miR-4639-3p	CLIP-seq
MIRT1291032	hsa-miR-4652-3p	CLIP-seq
MIRT1291033	hsa-miR-4653-5p	CLIP-seq
MIRT1290943	hsa-miR-4667-3p	CLIP-seq
MIRT1291034	hsa-miR-4668-5p	CLIP-seq
MIRT1290944	hsa-miR-4671-3p	CLIP-seq
MIRT1291035	hsa-miR-4682	CLIP-seq
MIRT1291036	hsa-miR-4714-5p	CLIP-seq
MIRT1291037	hsa-miR-4795-3p	CLIP-seq
MIRT1291038	hsa-miR-4797-5p	CLIP-seq
MIRT1291039	hsa-miR-4799-5p	CLIP-seq
MIRT1291040	hsa-miR-485-5p	CLIP-seq
MIRT1290997	hsa-miR-507	CLIP-seq
MIRT1291041	hsa-miR-511	CLIP-seq
MIRT1290955	hsa-miR-548l	CLIP-seq
MIRT1290956	hsa-miR-548n	CLIP-seq
MIRT1291003	hsa-miR-557	CLIP-seq
MIRT1291004	hsa-miR-561	CLIP-seq
MIRT1291042	hsa-miR-568	CLIP-seq
MIRT1290957	hsa-miR-569	CLIP-seq
MIRT1291043	hsa-miR-576-5p	CLIP-seq
MIRT1291044	hsa-miR-583	CLIP-seq
MIRT1291009	hsa-miR-590-3p	CLIP-seq
MIRT1290959	hsa-miR-606	CLIP-seq
MIRT1291045	hsa-miR-641	CLIP-seq
MIRT1291046	hsa-miR-660	CLIP-seq
MIRT1291047	hsa-miR-875-3p	CLIP-seq
MIRT1291007	hsa-miR-96	CLIP-seq
MIRT2086527	hsa-miR-217	CLIP-seq
MIRT1290982	hsa-miR-3714	CLIP-seq
MIRT1291041	hsa-miR-511	CLIP-seq
MIRT2086528	hsa-miR-3671	CLIP-seq
MIRT1291009	hsa-miR-590-3p	CLIP-seq
MIRT1290982	hsa-miR-3714	CLIP-seq
MIRT1290922	hsa-miR-3119	CLIP-seq
MIRT1290982	hsa-miR-3714	CLIP-seq
MIRT2432443	hsa-miR-129-5p	CLIP-seq
MIRT1290922	hsa-miR-3119	CLIP-seq
MIRT2607981	hsa-miR-10a	CLIP-seq
MIRT2607982	hsa-miR-10b	CLIP-seq
MIRT2607983	hsa-miR-1252	CLIP-seq
MIRT2607984	hsa-miR-155	CLIP-seq
MIRT2607985	hsa-miR-214	CLIP-seq
MIRT2607986	hsa-miR-221	CLIP-seq
MIRT2607987	hsa-miR-222	CLIP-seq
MIRT2607988	hsa-miR-33a	CLIP-seq
MIRT2607989	hsa-miR-33b	CLIP-seq
MIRT2607990	hsa-miR-3591-3p	CLIP-seq
MIRT2607991	hsa-miR-3619-5p	CLIP-seq
MIRT2607992	hsa-miR-3688-5p	CLIP-seq
MIRT2607993	hsa-miR-3692	CLIP-seq
MIRT2607994	hsa-miR-3907	CLIP-seq
MIRT2607995	hsa-miR-4297	CLIP-seq
MIRT1290987	hsa-miR-4477b	CLIP-seq
MIRT2607996	hsa-miR-4530	CLIP-seq
MIRT2607997	hsa-miR-4728-3p	CLIP-seq
MIRT2607998	hsa-miR-4786-5p	CLIP-seq
MIRT2607999	hsa-miR-548ag	CLIP-seq
MIRT2608000	hsa-miR-548ai	CLIP-seq
MIRT2608001	hsa-miR-548v	CLIP-seq
MIRT2608002	hsa-miR-579	CLIP-seq
MIRT2608003	hsa-miR-634	CLIP-seq
MIRT2608004	hsa-miR-657	CLIP-seq
MIRT2608005	hsa-miR-761	CLIP-seq
MIRT2608006	hsa-miR-769-5p	CLIP-seq
MIRT2608007	hsa-miR-885-3p	CLIP-seq
MIRT2607983	hsa-miR-1252	CLIP-seq
MIRT2607984	hsa-miR-155	CLIP-seq
MIRT2607986	hsa-miR-221	CLIP-seq
MIRT2607987	hsa-miR-222	CLIP-seq
MIRT1290973	hsa-miR-224	CLIP-seq
MIRT2607988	hsa-miR-33a	CLIP-seq
MIRT2607989	hsa-miR-33b	CLIP-seq
MIRT2607994	hsa-miR-3907	CLIP-seq
MIRT1290983	hsa-miR-3935	CLIP-seq
MIRT1290987	hsa-miR-4477b	CLIP-seq
MIRT2607997	hsa-miR-4728-3p	CLIP-seq
MIRT2607998	hsa-miR-4786-5p	CLIP-seq
MIRT2607999	hsa-miR-548ag	CLIP-seq
MIRT2608000	hsa-miR-548ai	CLIP-seq
MIRT2608001	hsa-miR-548v	CLIP-seq
MIRT2608006	hsa-miR-769-5p	CLIP-seq

Show/Hide all(29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	11524421
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	12095257, 14698303, 17240990, 23434281
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IDA	22797597
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	11524421
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0007265	Process	Ras protein signal transduction	IBA
GO:0007265	Process	Ras protein signal transduction	NAS	11524421
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IBA
GO:0016324	Component	Apical plasma membrane	IDA	22797597
GO:0016324	Component	Apical plasma membrane	IEA
GO:0030033	Process	Microvillus assembly	IEA
GO:0030139	Component	Endocytic vesicle	IBA
GO:0030139	Component	Endocytic vesicle	IDA	22797597
GO:0030742	Function	GTP-dependent protein binding	IDA	11524421
GO:0031267	Function	Small GTPase binding	IDA	11524421
GO:0043087	Process	Regulation of GTPase activity	NAS	11524421
GO:0070300	Function	Phosphatidic acid binding	IDA	22797597
GO:0070300	Function	Phosphatidic acid binding	IEA
GO:0072659	Process	Protein localization to plasma membrane	IEA
GO:0090557	Process	Establishment of endothelial intestinal barrier	IMP	23885123
GO:1903698	Process	Positive regulation of microvillus assembly	IGI	22797597

MIM	HGNC	e!Ensembl
610499	20655	ENSG00000158987

Protein

UniProt ID

Q8TEU7

Protein name

Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)

Protein function

Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.

PDB

2D93 , 3LNY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00027	cNMP_binding	300 → 382	Cyclic nucleotide-binding domain	Domain
PF00618	RasGEF_N	415 → 502	RasGEF N-terminal motif	Domain
PF00595	PDZ	530 → 609	PDZ domain	Domain
PF00788	RA	749 → 835	Ras association (RalGDS/AF-6) domain	Domain
PF00617	RasGEF	863 → 1041	RasGEF domain	Family

Tissue specificity

TISSUE SPECIFICITY: Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11524421}.

Sequence

MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSG
NQVLFCSETIARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVEN
AKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTENPH
PQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEI
DRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEV
VEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVR
TKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKAT
PERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLL
WVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRES
PLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRN
NTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKG
SKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMP
IPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHA
VHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLC
SDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHL
KRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLA
SVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDM
TFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLD
VQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGT
LTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKD
PALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDN
LSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHS
QHGPGWTLLKPSLIKCLAVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLP
NPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKSWTSSSSLS
DTYEPNYGTVKQRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDR
YREPPPTPPGYLGISLADLKEGPHTHLKPPDYSVAVQRSKMMHNSLSRLPPASLSSNLVA
CVPSKIVTQPQRHNLQPFHPKLGDVTDADSEADENEQVSAV

Sequence length

1601

Interactions

View interactions

	KEGG
	Rap1 signaling pathway Tight junction

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma	N/A	N/A	GWAS

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Salivary Duct Calculi	Associate	34176176

RAPGEF6 (Rap guanine nucleotide exchange factor 6)