MSRB1 (methionine sulfoxide reductase B1)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51734
Gene name Gene Name - the full gene name approved by the HGNC.
Methionine sulfoxide reductase B1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MSRB1
Synonyms (NCBI Gene) Gene synonyms aliases
HSPC270, SELENOR, SELENOX, SELR, SELX, SEPX1, SepR
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methi
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(27)
miRTarBase ID miRNA Experiments Reference
MIRT045669 hsa-miR-149-5p CLASH 23622248
MIRT656122 hsa-miR-3145-5p HITS-CLIP 23824327
MIRT656120 hsa-miR-6793-3p HITS-CLIP 23824327
MIRT656121 hsa-miR-937-5p HITS-CLIP 23824327
MIRT656119 hsa-miR-627-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(13)
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding ISS
GO:0005515 Function Protein binding IPI 23805218, 28579431, 32296183
GO:0005575 Component Cellular_component ND
GO:0005634 Component Nucleus IEA
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
606216 14133 ENSG00000198736
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9NZV6
Protein name Methionine-R-sulfoxide reductase B1 (MsrB1) (EC 1.8.4.12) (EC 1.8.4.14) (Selenoprotein X) (SelX)
Protein function Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-tra
PDB 3MAO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01641 SelR 5 → 105 SelR domain Family
Sequence
Sequence length 116
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Protein repair
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)		 18081029
Show/Hide Text Mining Associations (10)
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 23805218, 36497178
Breast Neoplasms Associate 17519015
Carcinoma Hepatocellular Associate 34719306
Colorectal Neoplasms Associate 25541970, 34719306
Dermatitis Atopic Associate 36497178
Osteoarthritis Associate 37033956
Osteosarcoma Associate 34719306
Rectal Neoplasms Associate 25541970
Respiratory Distress Syndrome Associate 37336980
Sepsis Associate 37336980