Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5173
Gene name	Prodynorphin
Gene symbol	PDYN
Synonyms (NCBI Gene)	ADCAPENKBSCA23
Chromosome	20
Chromosome location	20p13
Summary	The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid rec

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miRTarBase ID	miRNA	Experiments	Reference
MIRT608780	hsa-miR-548av-3p	HITS-CLIP	24906430
MIRT608779	hsa-miR-93-3p	HITS-CLIP	24906430
MIRT608778	hsa-miR-6743-3p	HITS-CLIP	24906430
MIRT608777	hsa-miR-8075	HITS-CLIP	24906430
MIRT608776	hsa-miR-6882-3p	HITS-CLIP	24906430
MIRT1223948	hsa-miR-2110	CLIP-seq
MIRT1223949	hsa-miR-3151	CLIP-seq
MIRT1223950	hsa-miR-3202	CLIP-seq
MIRT1223951	hsa-miR-4265	CLIP-seq
MIRT1223952	hsa-miR-4271	CLIP-seq
MIRT1223953	hsa-miR-4296	CLIP-seq
MIRT1223954	hsa-miR-4322	CLIP-seq
MIRT1223955	hsa-miR-4447	CLIP-seq
MIRT1223956	hsa-miR-4472	CLIP-seq
MIRT1223957	hsa-miR-4475	CLIP-seq
MIRT1223958	hsa-miR-4725-3p	CLIP-seq
MIRT1223959	hsa-miR-4747-5p	CLIP-seq
MIRT1223960	hsa-miR-491-5p	CLIP-seq
MIRT1223961	hsa-miR-1976	CLIP-seq
MIRT1223962	hsa-miR-3690	CLIP-seq
MIRT1223963	hsa-miR-4254	CLIP-seq
MIRT1223964	hsa-miR-711	CLIP-seq
MIRT2065272	hsa-miR-1261	CLIP-seq
MIRT2065273	hsa-miR-3145-3p	CLIP-seq
MIRT2065274	hsa-miR-3201	CLIP-seq
MIRT2065275	hsa-miR-3684	CLIP-seq
MIRT2065276	hsa-miR-376a	CLIP-seq
MIRT2065277	hsa-miR-376b	CLIP-seq
MIRT2065278	hsa-miR-378g	CLIP-seq
MIRT2065279	hsa-miR-3913-3p	CLIP-seq
MIRT2065280	hsa-miR-3929	CLIP-seq
MIRT2065281	hsa-miR-4419b	CLIP-seq
MIRT2065282	hsa-miR-4478	CLIP-seq
MIRT2065283	hsa-miR-4505	CLIP-seq
MIRT2065284	hsa-miR-4520a-3p	CLIP-seq
MIRT2065285	hsa-miR-4520b-3p	CLIP-seq
MIRT2065286	hsa-miR-4529-3p	CLIP-seq
MIRT2065287	hsa-miR-4791	CLIP-seq
MIRT2065288	hsa-miR-4803	CLIP-seq
MIRT2065289	hsa-miR-532-3p	CLIP-seq
MIRT2065290	hsa-miR-539	CLIP-seq
MIRT2065291	hsa-miR-662	CLIP-seq
MIRT2065275	hsa-miR-3684	CLIP-seq
MIRT2065276	hsa-miR-376a	CLIP-seq
MIRT2065277	hsa-miR-376b	CLIP-seq
MIRT2065272	hsa-miR-1261	CLIP-seq
MIRT2065273	hsa-miR-3145-3p	CLIP-seq
MIRT2065274	hsa-miR-3201	CLIP-seq
MIRT2065278	hsa-miR-378g	CLIP-seq
MIRT2065280	hsa-miR-3929	CLIP-seq
MIRT2065281	hsa-miR-4419b	CLIP-seq
MIRT2065282	hsa-miR-4478	CLIP-seq
MIRT2065283	hsa-miR-4505	CLIP-seq
MIRT2065287	hsa-miR-4791	CLIP-seq
MIRT2456195	hsa-miR-197	CLIP-seq
MIRT2456196	hsa-miR-3977	CLIP-seq
MIRT2456197	hsa-miR-4277	CLIP-seq
MIRT2456198	hsa-miR-4522	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001515	Function	Opioid peptide activity	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	9047294
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007218	Process	Neuropeptide signaling pathway	IEA
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0007600	Process	Sensory perception	IBA
GO:0030425	Component	Dendrite	IBA
GO:0031628	Function	Opioid receptor binding	IBA
GO:0043025	Component	Neuronal cell body	IBA
GO:0043679	Component	Axon terminus	IBA
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IDA	10098940
GO:0098992	Component	Neuronal dense core vesicle	IDA	10098940

MIM	HGNC	e!Ensembl
131340	8820	ENSG00000101327

P01213

Protein name

Proenkephalin-B (Beta-neoendorphin-dynorphin) (Preprodynorphin) [Cleaved into: Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin (Big Dyn); Dynorphin A(1-17) (Dyn-A17) (Dynorphin A); Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; Rimorphin (Dynor

Protein function

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). ; Dynorphin peptides differenti

PDB

2N2F , 7Y1F , 8F7W , 8VJU , 8VJV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01160	Opiods_neuropep	21 → 67	Vertebrate endogenous opioids neuropeptide	Family

Sequence

MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWE
RCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKEN
TLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLR
KYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRS
QEDPNAYSGELFDA

Sequence length

254

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Hormone signaling Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Cocaine addiction Amphetamine addiction Alcoholism		Opioid Signalling G-protein activation Peptide ligand-binding receptors G alpha (i) signalling events

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Spinocerebellar ataxia type 23	Pathogenic; Likely pathogenic	rs267606939, rs201486601	RCV000018095 RCV000018097

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Autosomal dominant cerebellar ataxia	Uncertain significance; Likely benign; Benign	rs886056533, rs188187030, rs745377265, rs775379753, rs187098720, rs574928545, rs886056538, rs572674195, rs1997794	RCV000269910 RCV000333444 RCV000368252 RCV000388020 RCV000382262 RCV000269505 RCV000329214 RCV000300116 RCV000273681
Cholangiocarcinoma	Benign	rs1418035	RCV005918079
PDYN-related disorder	Benign; Likely benign	rs59191035, rs77727400	RCV003905304 RCV003928823

Show/Hide Text Mining Associations (23)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alcoholism	Associate	29925858
Alzheimer Disease	Associate	33878365
Ataxia	Associate	21035104
Bipolar Disorder	Inhibit	28830794
Brain Diseases	Associate	25220237
Carcinoma Renal Cell	Associate	21035104
Epilepsy	Associate	10646497, 19437412
Epilepsy Temporal Lobe	Associate	19437412
Frontotemporal Dementia	Associate	32576262
Gait Ataxia	Associate	21035104
HIV Infections	Associate	23392455
HIV Infections	Inhibit	24405578
Lewy Body Disease	Associate	32552841
Mental Disorders	Associate	25220237
Mood Disorders	Associate	10646497
Neuroblastoma	Associate	11094064
Neurodegenerative Diseases	Associate	21035104
Neurotoxicity Syndromes	Associate	21035104
Opioid Related Disorders	Associate	30936032
Pain	Associate	18507845, 38128761, 9819380
Spinocerebellar Ataxia 11	Associate	19089525
Spinocerebellar ataxia 23	Associate	19089525, 21035104
Substance Related Disorders	Associate	10646497

PDYN (prodynorphin)