PDYN (prodynorphin)

Gene

• Entrez ID: 5173
• Gene name: Prodynorphin
• Gene symbol: PDYN
• Synonyms (NCBI Gene): ADCA, PENKB, SCA23
• Disease Acronyms (UniProt): SCA23
• Chromosome: 20
• Chromosome location: 20p13
• Summary: The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid rec

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT608780	hsa-miR-548av-3p	HITS-CLIP	24906430
MIRT608779	hsa-miR-93-3p	HITS-CLIP	24906430
MIRT608778	hsa-miR-6743-3p	HITS-CLIP	24906430
MIRT608777	hsa-miR-8075	HITS-CLIP	24906430
MIRT608776	hsa-miR-6882-3p	HITS-CLIP	24906430
MIRT1223948	hsa-miR-2110	CLIP-seq
MIRT1223949	hsa-miR-3151	CLIP-seq
MIRT1223950	hsa-miR-3202	CLIP-seq
MIRT1223951	hsa-miR-4265	CLIP-seq
MIRT1223952	hsa-miR-4271	CLIP-seq
MIRT1223953	hsa-miR-4296	CLIP-seq
MIRT1223954	hsa-miR-4322	CLIP-seq
MIRT1223955	hsa-miR-4447	CLIP-seq
MIRT1223956	hsa-miR-4472	CLIP-seq
MIRT1223957	hsa-miR-4475	CLIP-seq
MIRT1223958	hsa-miR-4725-3p	CLIP-seq
MIRT1223959	hsa-miR-4747-5p	CLIP-seq
MIRT1223960	hsa-miR-491-5p	CLIP-seq
MIRT1223961	hsa-miR-1976	CLIP-seq
MIRT1223962	hsa-miR-3690	CLIP-seq
MIRT1223963	hsa-miR-4254	CLIP-seq
MIRT1223964	hsa-miR-711	CLIP-seq
MIRT2065272	hsa-miR-1261	CLIP-seq
MIRT2065273	hsa-miR-3145-3p	CLIP-seq
MIRT2065274	hsa-miR-3201	CLIP-seq
MIRT2065275	hsa-miR-3684	CLIP-seq
MIRT2065276	hsa-miR-376a	CLIP-seq
MIRT2065277	hsa-miR-376b	CLIP-seq
MIRT2065278	hsa-miR-378g	CLIP-seq
MIRT2065279	hsa-miR-3913-3p	CLIP-seq
MIRT2065280	hsa-miR-3929	CLIP-seq
MIRT2065281	hsa-miR-4419b	CLIP-seq
MIRT2065282	hsa-miR-4478	CLIP-seq
MIRT2065283	hsa-miR-4505	CLIP-seq
MIRT2065284	hsa-miR-4520a-3p	CLIP-seq
MIRT2065285	hsa-miR-4520b-3p	CLIP-seq
MIRT2065286	hsa-miR-4529-3p	CLIP-seq
MIRT2065287	hsa-miR-4791	CLIP-seq
MIRT2065288	hsa-miR-4803	CLIP-seq
MIRT2065289	hsa-miR-532-3p	CLIP-seq
MIRT2065290	hsa-miR-539	CLIP-seq
MIRT2065291	hsa-miR-662	CLIP-seq
MIRT2065275	hsa-miR-3684	CLIP-seq
MIRT2065276	hsa-miR-376a	CLIP-seq
MIRT2065277	hsa-miR-376b	CLIP-seq
MIRT2065272	hsa-miR-1261	CLIP-seq
MIRT2065273	hsa-miR-3145-3p	CLIP-seq
MIRT2065274	hsa-miR-3201	CLIP-seq
MIRT2065278	hsa-miR-378g	CLIP-seq
MIRT2065280	hsa-miR-3929	CLIP-seq
MIRT2065281	hsa-miR-4419b	CLIP-seq
MIRT2065282	hsa-miR-4478	CLIP-seq
MIRT2065283	hsa-miR-4505	CLIP-seq
MIRT2065287	hsa-miR-4791	CLIP-seq
MIRT2456195	hsa-miR-197	CLIP-seq
MIRT2456196	hsa-miR-3977	CLIP-seq
MIRT2456197	hsa-miR-4277	CLIP-seq
MIRT2456198	hsa-miR-4522	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001515	Function	Opioid peptide activity	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	9047294
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007218	Process	Neuropeptide signaling pathway	IBA	21873635
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0007600	Process	Sensory perception	IBA	21873635
GO:0030425	Component	Dendrite	IBA	21873635
GO:0031628	Function	Opioid receptor binding	IBA	21873635
GO:0043025	Component	Neuronal cell body	IBA	21873635
GO:0043679	Component	Axon terminus	IBA	21873635

Other IDs

• MIM: 131340
• HGNC: 8820
• e!Ensembl: ENSG00000101327

Protein

• UniProt ID: P01213
• Protein name: Proenkephalin-B (Beta-neoendorphin-dynorphin) (Preprodynorphin) [Cleaved into: Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin (Big Dyn); Dynorphin A(1-17) (Dyn-A17) (Dynorphin A); Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; Rimorphin (Dynor
• Protein function: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). ; Dynorphin peptides differenti
• PDB: 2N2F, 7Y1F, 8F7W, 8VJU, 8VJV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01160	Opiods_neuropep	21 → 67	Vertebrate endogenous opioids neuropeptide	Family

• Sequence:

  MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWE
  RCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKEN
  TLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLR
  KYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRS
  QEDPNAYSGELFDA

• Sequence length: 254

Pathways

KEGG:

Neuroactive ligand-receptor interaction
Hormone signaling
Spinocerebellar ataxia
Pathways of neurodegeneration - multiple diseases
Cocaine addiction
Amphetamine addiction
Alcoholism

Reactome:

Opioid Signalling
G-protein activation
Peptide ligand-binding receptors
G alpha (i) signalling events

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Cerebellar ataxia	Progressive cerebellar ataxia	rs28936415, rs199476133, rs540331226, rs797046006, rs863224069, rs138358708, rs1057519429, rs750959420, rs1568440440, rs1597846084, rs759460806, rs761486324, rs1240335250, rs1596489887
Cholestasis	Cholestasis	rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039	16919318
Parkinson disease	Parkinsonian Disorders, Autosomal Dominant Juvenile Parkinson Disease, PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE	rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121918104, rs1589451049, rs104893877, rs104893878, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106	9930741
Polyneuropathy	Polyneuropathy	rs1597597437
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	11576758, 12207142, 15301734
Seizure	Complex partial seizures, Generalized seizures, Visual seizure, Tonic - clonic seizures, Single Seizure	rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061, rs121912707, rs118192249, rs118192251, rs118192217, rs118192218, rs118192219, rs118192222, rs118192226, rs118192228, rs118192234, rs118192236, rs118192235, rs118192241, rs118192242, rs118192185, rs118192188, rs118192245, rs118192246, rs118192186, rs118192194, rs118192197, rs118192199, rs118192201, rs118192202, rs118192203, rs118192204, rs118192205, rs118192206, rs118192208, rs118192211, rs118192216, rs118192239, rs387906684, rs387906686, rs387906687, rs1596893185, rs387907126, rs387907281, rs397515405, rs587778771, rs730882067, rs730882073, rs397514579, rs397514582, rs587776976, rs398122394, rs121918784, rs121918751, rs121918735, rs398123588, rs587780450, rs61749751, rs587777620, rs727503974, rs730882124, rs794726710, rs794726697, rs794726799, rs794727444, rs794727740, rs796053166, rs794726825, rs796052676, rs796053219, rs796053220, rs796053228, rs796052653, rs759584387, rs796052650, rs796052641, rs796052626, rs796052623, rs796052663, rs796052615, rs796052802, rs797044999, rs797045047, rs797045942, rs797045941, rs118192212, rs797044938, rs777257591, rs864321712, rs879255652, rs886039268, rs886039517, rs886039529, rs199497486, rs886039496, rs886039903, rs886041300, rs769827124, rs886041339, rs886041591, rs587783092, rs1555850151, rs1057516123, rs1057516121, rs1057516115, rs1057516111, rs1057516106, rs1057516105, rs756921902, rs1057516089, rs1057516087, rs1057516080, rs1057516076, rs1060499544, rs1555850512, rs1057517919, rs118192231, rs1057520413, rs1060503101, rs1064796294, rs1064794981, rs1064794632, rs1064797245, rs1131691830, rs1131692231, rs1131691936, rs1554626549, rs1553579225, rs1553531385, rs121918736, rs1554898088, rs1553579282, rs763353895, rs1553463119, rs1554093891, rs77838305, rs1555408401, rs1554627439, rs1554097873, rs1555850403, rs1064794719, rs1315483224, rs1567134495, rs770187706, rs1057518555, rs1576983339, rs1574192005, rs1459374430, rs1586800133, rs1574641522, rs1572096837, rs1572630269, rs1574554892, rs1574556643, rs1574571769, rs1574641605, rs1574697769, rs1574716524, rs1574746733, rs1574746935, rs1574752700, rs1574754680, rs863225030, rs1601545088, rs1600714727, rs1371059392, rs1600767259, rs1339542565, rs1600785769, rs2065899210, rs1600732174, rs1162306056, rs879255709, rs1900111672, rs2066910297, rs1554122080, rs796052941, rs1600789325, rs2082695884, rs1737677036, rs1737495759, rs868389022, rs1737685202, rs1737672350, rs762737130	1675896
Spinocerebellar ataxia	SPINOCEREBELLAR ATAXIA 23, Spinocerebellar ataxia type 23	rs80356538, rs80356539, rs56144125, rs28937887, rs80356544, rs80356540, rs80356542, rs1941485201, rs121918306, rs151344520, rs151344519, rs151344521, rs151344523, rs151344512, rs193922926, rs104894393, rs587776685, rs121908216, rs121908215, rs121908217, rs121909326, rs121918511, rs121918512, rs121918513, rs121918514, rs121918515, rs121918516, rs121918517, rs121918518, rs1555808841, rs104894699, rs104894700, rs121912425, rs121913123, rs267606939, rs201486601, rs387906679, rs151344514, rs151344515, rs151344517, rs387907033, rs387907089, rs794726680, rs761213683, rs794726681, rs1555779353, rs151344513, rs151344518, rs151344522, rs397514535, rs397514536, rs318240735, rs386134171, rs386134158, rs386134159, rs386134160, rs386134161, rs386134162, rs386134163, rs386134164, rs386134165, rs386134166, rs386134168, rs386134170, rs386134169, rs146859515, rs373728971, rs397515475, rs397515476, rs587777052, rs121908247, rs121908200, rs398122959, rs587777127, rs587777128, rs587777235, rs587777340, rs587777341, rs587777342, rs587777344, rs587777345, rs587777346, rs587777347, rs587780326, rs587777670, rs587777671, rs606231451, rs606231452, rs540331226, rs144272231, rs690016544, rs727502823, rs372250159, rs793888526, rs876657385, rs869320748, rs876657386, rs786205229, rs876657387, rs774694340, rs786205867, rs794727411, rs797044955, rs797044872, rs797045634, rs797045240, rs765592794, rs797045900, rs748445058, rs863223919, rs765987297, rs863224882, rs753611141, rs869025292, rs869025293, rs755221106, rs869312685, rs751181600, rs886037832, rs875989881, rs372245668, rs879255601, rs876657414, rs752281590, rs879253883, rs1114167316, rs879255651, rs879255653, rs879255654, rs886039392, rs540839115, rs886039762, rs201128942, rs886041279, rs531656357, rs1057519453, rs1057519454, rs573267388, rs1057519561, rs200277996, rs1064795856, rs749320057, rs750331613, rs1131692265, rs761564262, rs1555768154, rs1210764379, rs758937084, rs1555475283, rs1555475375, rs760424025, rs1555806333, rs1554308513, rs1554274719, rs1554317158, rs201920319, rs1553724533, rs1554985851, rs768831597, rs1554986345, rs1555755878, rs1554902760, rs368143665, rs1555370787, rs1322796318, rs1553756062, rs772345347, rs149905705, rs1555475794, rs760752847, rs1555781806, rs1555738369, rs1554986337, rs1184563885, rs1553758021, rs1559718601, rs1206950481, rs1568523843, rs748984540, rs1557539450, rs1557541619, rs771145682, rs1564808324, rs1567283195, rs752352896, rs1557794465, rs547792505, rs193922929, rs1571636501, rs1571636508, rs1571939827, rs1571939905, rs1559603328, rs1562374476, rs1599651549, rs1590020571, rs1598832526, rs1575415900, rs779142717, rs781016340, rs1366090807, rs1579319300, rs1311909367, rs1589625941, rs749656742, rs1317590341, rs1599943097, rs1590955348, rs749679347, rs1590911156, rs1395191127, rs1405576707, rs541484241, rs1598820860, rs1598832568, rs1589611043, rs758809498, rs754446573	21035104, 23471613, 23108490, 21712028

Unknown
Disease term	Disease name	Evidence	References	Source
Mental depression	Mental Depression, Depressive disorder, Unipolar Depression, Major Depressive Disorder		23101464, 23904614, 24231353, 24816773, 23293139, 11576758, 19116947, 11803449	ClinVar
Spinocerebellar Ataxia	spinocerebellar ataxia type 23			GenCC

Associations from Text Mining
Disease Name	Relationship Type	References
Alcoholism	Associate	29925858
Alzheimer Disease	Associate	33878365
Ataxia	Associate	21035104
Bipolar Disorder	Inhibit	28830794
Brain Diseases	Associate	25220237
Carcinoma Renal Cell	Associate	21035104
Epilepsy	Associate	10646497, 19437412
Epilepsy Temporal Lobe	Associate	19437412
Frontotemporal Dementia	Associate	32576262
Gait Ataxia	Associate	21035104
HIV Infections	Associate	23392455
HIV Infections	Inhibit	24405578
Lewy Body Disease	Associate	32552841
Mental Disorders	Associate	25220237
Mood Disorders	Associate	10646497
Neuroblastoma	Associate	11094064
Neurodegenerative Diseases	Associate	21035104
Neurotoxicity Syndromes	Associate	21035104
Opioid Related Disorders	Associate	30936032
Pain	Associate	18507845, 38128761, 9819380
Spinocerebellar Ataxia 11	Associate	19089525
Spinocerebellar ataxia 23	Associate	19089525, 21035104
Substance Related Disorders	Associate	10646497