Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51728
Gene name	RNA polymerase III subunit K
Gene symbol	POLR3K
Synonyms (NCBI Gene)	C11C11-RNP3HLD21My010RPC10RPC11RPC12.5
Chromosome	16
Chromosome location	16p13.3
Summary	This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the

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Show/Hide all (258)

miRTarBase ID	miRNA	Experiments	Reference
MIRT041912	hsa-miR-484	CLASH	23622248
MIRT664512	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT664511	hsa-miR-3929	HITS-CLIP	23824327
MIRT664510	hsa-miR-4419b	HITS-CLIP	23824327
MIRT664509	hsa-miR-4478	HITS-CLIP	23824327
MIRT664508	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT664507	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT664506	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT664505	hsa-miR-4780	HITS-CLIP	23824327
MIRT664504	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT664503	hsa-miR-4329	HITS-CLIP	23824327
MIRT664502	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT664501	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT664500	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT664499	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT664498	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT664497	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT664496	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT664495	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT664494	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT664493	hsa-miR-623	HITS-CLIP	23824327
MIRT664492	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT664491	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT664490	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT664489	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT664488	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT664487	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT664486	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT664485	hsa-miR-3689c	HITS-CLIP	23824327
MIRT664484	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT664483	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT664482	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT637749	hsa-miR-4704-5p	HITS-CLIP	23824327
MIRT637748	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT637747	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT637746	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT637745	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT637744	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT637743	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT637742	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT637741	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT637740	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT637739	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT637738	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT637737	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT637736	hsa-miR-760	HITS-CLIP	23824327
MIRT637735	hsa-miR-8057	HITS-CLIP	23824327
MIRT285702	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT531137	hsa-miR-5692a	PAR-CLIP	21572407
MIRT531135	hsa-miR-3163	PAR-CLIP	21572407
MIRT542286	hsa-miR-3120-5p	PAR-CLIP	21572407
MIRT234132	hsa-miR-302a-5p	PAR-CLIP	21572407
MIRT542280	hsa-miR-200c-5p	PAR-CLIP	21572407
MIRT542278	hsa-miR-550a-3p	PAR-CLIP	21572407
MIRT542275	hsa-miR-6888-3p	PAR-CLIP	21572407
MIRT542292	hsa-miR-4432	PAR-CLIP	21572407
MIRT542291	hsa-miR-3664-5p	PAR-CLIP	21572407
MIRT542290	hsa-miR-589-3p	PAR-CLIP	21572407
MIRT542289	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT542288	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT542287	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT542285	hsa-miR-4486	PAR-CLIP	21572407
MIRT542286	hsa-miR-3120-5p	PAR-CLIP	21572407
MIRT542284	hsa-miR-4522	PAR-CLIP	21572407
MIRT542283	hsa-miR-661	PAR-CLIP	21572407
MIRT542282	hsa-miR-1273a	PAR-CLIP	21572407
MIRT542281	hsa-miR-4649-5p	PAR-CLIP	21572407
MIRT542279	hsa-miR-6729-5p	PAR-CLIP	21572407
MIRT542280	hsa-miR-200c-5p	PAR-CLIP	21572407
MIRT542278	hsa-miR-550a-3p	PAR-CLIP	21572407
MIRT542276	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT542277	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT542275	hsa-miR-6888-3p	PAR-CLIP	21572407
MIRT531137	hsa-miR-5692a	PAR-CLIP	22012620
MIRT531136	hsa-miR-3121-3p	PAR-CLIP	22012620
MIRT531135	hsa-miR-3163	PAR-CLIP	22012620
MIRT234132	hsa-miR-302a-5p	PAR-CLIP	22012620
MIRT542282	hsa-miR-1273a	PAR-CLIP	27292025
MIRT542280	hsa-miR-200c-5p	PAR-CLIP	27292025
MIRT542286	hsa-miR-3120-5p	PAR-CLIP	27292025
MIRT542291	hsa-miR-3664-5p	PAR-CLIP	27292025
MIRT542292	hsa-miR-4432	PAR-CLIP	27292025
MIRT542285	hsa-miR-4486	PAR-CLIP	27292025
MIRT542284	hsa-miR-4522	PAR-CLIP	27292025
MIRT542281	hsa-miR-4649-5p	PAR-CLIP	27292025
MIRT542278	hsa-miR-550a-3p	PAR-CLIP	27292025
MIRT542290	hsa-miR-589-3p	PAR-CLIP	27292025
MIRT542276	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT542283	hsa-miR-661	PAR-CLIP	27292025
MIRT542277	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT542279	hsa-miR-6729-5p	PAR-CLIP	27292025
MIRT542289	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT542275	hsa-miR-6888-3p	PAR-CLIP	27292025
MIRT542287	hsa-miR-766-3p	PAR-CLIP	27292025
MIRT542288	hsa-miR-939-3p	PAR-CLIP	27292025
MIRT664512	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT664511	hsa-miR-3929	HITS-CLIP	23824327
MIRT664510	hsa-miR-4419b	HITS-CLIP	23824327
MIRT664509	hsa-miR-4478	HITS-CLIP	23824327
MIRT664508	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT664507	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT664506	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT664505	hsa-miR-4780	HITS-CLIP	23824327
MIRT664504	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT664503	hsa-miR-4329	HITS-CLIP	23824327
MIRT664502	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT664501	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT664500	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT664499	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT664498	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT664497	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT664496	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT664495	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT664494	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT664493	hsa-miR-623	HITS-CLIP	23824327
MIRT664492	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT664491	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT664490	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT664489	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT664488	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT664487	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT664486	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT664485	hsa-miR-3689c	HITS-CLIP	23824327
MIRT664484	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT664483	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT664482	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT637749	hsa-miR-4704-5p	HITS-CLIP	23824327
MIRT637748	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT637747	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT637746	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT637745	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT637744	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT637743	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT637742	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT637741	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT637740	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT637739	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT637738	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT637737	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT637736	hsa-miR-760	HITS-CLIP	23824327
MIRT637735	hsa-miR-8057	HITS-CLIP	23824327
MIRT285702	hsa-miR-3692-3p	HITS-CLIP	23824327
MIRT531137	hsa-miR-5692a	PAR-CLIP	21572407
MIRT531135	hsa-miR-3163	PAR-CLIP	21572407
MIRT542286	hsa-miR-3120-5p	PAR-CLIP	21572407
MIRT234132	hsa-miR-302a-5p	PAR-CLIP	21572407
MIRT542280	hsa-miR-200c-5p	PAR-CLIP	21572407
MIRT542278	hsa-miR-550a-3p	PAR-CLIP	21572407
MIRT542275	hsa-miR-6888-3p	PAR-CLIP	21572407
MIRT542292	hsa-miR-4432	PAR-CLIP	21572407
MIRT542291	hsa-miR-3664-5p	PAR-CLIP	21572407
MIRT542290	hsa-miR-589-3p	PAR-CLIP	21572407
MIRT542289	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT542288	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT542287	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT542285	hsa-miR-4486	PAR-CLIP	21572407
MIRT542286	hsa-miR-3120-5p	PAR-CLIP	21572407
MIRT542284	hsa-miR-4522	PAR-CLIP	21572407
MIRT542283	hsa-miR-661	PAR-CLIP	21572407
MIRT542282	hsa-miR-1273a	PAR-CLIP	21572407
MIRT542281	hsa-miR-4649-5p	PAR-CLIP	21572407
MIRT542279	hsa-miR-6729-5p	PAR-CLIP	21572407
MIRT542280	hsa-miR-200c-5p	PAR-CLIP	21572407
MIRT542278	hsa-miR-550a-3p	PAR-CLIP	21572407
MIRT542276	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT542277	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT542275	hsa-miR-6888-3p	PAR-CLIP	21572407
MIRT531137	hsa-miR-5692a	PAR-CLIP	22012620
MIRT531136	hsa-miR-3121-3p	PAR-CLIP	22012620
MIRT531135	hsa-miR-3163	PAR-CLIP	22012620
MIRT234132	hsa-miR-302a-5p	PAR-CLIP	22012620
MIRT1249390	hsa-miR-1	CLIP-seq
MIRT1249391	hsa-miR-101	CLIP-seq
MIRT1249392	hsa-miR-106a	CLIP-seq
MIRT1249393	hsa-miR-106b	CLIP-seq
MIRT1249394	hsa-miR-1197	CLIP-seq
MIRT1249395	hsa-miR-1254	CLIP-seq
MIRT1249396	hsa-miR-132	CLIP-seq
MIRT1249397	hsa-miR-142-5p	CLIP-seq
MIRT1249398	hsa-miR-17	CLIP-seq
MIRT1249399	hsa-miR-181a	CLIP-seq
MIRT1249400	hsa-miR-181b	CLIP-seq
MIRT1249401	hsa-miR-181c	CLIP-seq
MIRT1249402	hsa-miR-181d	CLIP-seq
MIRT1249403	hsa-miR-186	CLIP-seq
MIRT1249404	hsa-miR-194	CLIP-seq
MIRT1249405	hsa-miR-206	CLIP-seq
MIRT1249406	hsa-miR-20a	CLIP-seq
MIRT1249407	hsa-miR-20b	CLIP-seq
MIRT1249408	hsa-miR-212	CLIP-seq
MIRT1249409	hsa-miR-2909	CLIP-seq
MIRT1249410	hsa-miR-3116	CLIP-seq
MIRT1249411	hsa-miR-3117-3p	CLIP-seq
MIRT1249412	hsa-miR-3162-5p	CLIP-seq
MIRT1249413	hsa-miR-3169	CLIP-seq
MIRT1249414	hsa-miR-3190	CLIP-seq
MIRT1249415	hsa-miR-3609	CLIP-seq
MIRT1249416	hsa-miR-3620	CLIP-seq
MIRT1249417	hsa-miR-3664-3p	CLIP-seq
MIRT1249418	hsa-miR-3667-5p	CLIP-seq
MIRT1249419	hsa-miR-3941	CLIP-seq
MIRT1249420	hsa-miR-4262	CLIP-seq
MIRT1249421	hsa-miR-4279	CLIP-seq
MIRT1249422	hsa-miR-4286	CLIP-seq
MIRT1249423	hsa-miR-433	CLIP-seq
MIRT1249424	hsa-miR-4436a	CLIP-seq
MIRT1249425	hsa-miR-466	CLIP-seq
MIRT1249426	hsa-miR-4672	CLIP-seq
MIRT1249427	hsa-miR-4717-5p	CLIP-seq
MIRT1249428	hsa-miR-4759	CLIP-seq
MIRT1249429	hsa-miR-4796-3p	CLIP-seq
MIRT1249430	hsa-miR-505	CLIP-seq
MIRT1249431	hsa-miR-519d	CLIP-seq
MIRT1249432	hsa-miR-520d-5p	CLIP-seq
MIRT1249433	hsa-miR-524-5p	CLIP-seq
MIRT1249434	hsa-miR-548ae	CLIP-seq
MIRT1249435	hsa-miR-548ah	CLIP-seq
MIRT1249436	hsa-miR-548aj	CLIP-seq
MIRT1249437	hsa-miR-548am	CLIP-seq
MIRT1249438	hsa-miR-548p	CLIP-seq
MIRT1249439	hsa-miR-548x	CLIP-seq
MIRT1249440	hsa-miR-613	CLIP-seq
MIRT1249441	hsa-miR-617	CLIP-seq
MIRT1249442	hsa-miR-7	CLIP-seq
MIRT1249443	hsa-miR-802	CLIP-seq
MIRT1249444	hsa-miR-93	CLIP-seq
MIRT1249390	hsa-miR-1	CLIP-seq
MIRT1249394	hsa-miR-1197	CLIP-seq
MIRT1249405	hsa-miR-206	CLIP-seq
MIRT1249417	hsa-miR-3664-3p	CLIP-seq
MIRT1249418	hsa-miR-3667-5p	CLIP-seq
MIRT1249424	hsa-miR-4436a	CLIP-seq
MIRT2073690	hsa-miR-4475	CLIP-seq
MIRT1249430	hsa-miR-505	CLIP-seq
MIRT2073691	hsa-miR-509-3p	CLIP-seq
MIRT1249432	hsa-miR-520d-5p	CLIP-seq
MIRT1249433	hsa-miR-524-5p	CLIP-seq
MIRT1249438	hsa-miR-548p	CLIP-seq
MIRT1249440	hsa-miR-613	CLIP-seq
MIRT2300636	hsa-miR-1202	CLIP-seq
MIRT2300637	hsa-miR-3126-5p	CLIP-seq
MIRT2300638	hsa-miR-3194-5p	CLIP-seq
MIRT2300639	hsa-miR-3972	CLIP-seq
MIRT2300640	hsa-miR-603	CLIP-seq
MIRT1249394	hsa-miR-1197	CLIP-seq
MIRT2597481	hsa-miR-149	CLIP-seq
MIRT1249417	hsa-miR-3664-3p	CLIP-seq
MIRT1249418	hsa-miR-3667-5p	CLIP-seq
MIRT2597482	hsa-miR-3692	CLIP-seq
MIRT2597483	hsa-miR-412	CLIP-seq
MIRT1249424	hsa-miR-4436a	CLIP-seq
MIRT2597484	hsa-miR-4640-3p	CLIP-seq
MIRT1249438	hsa-miR-548p	CLIP-seq
MIRT2597481	hsa-miR-149	CLIP-seq
MIRT2597482	hsa-miR-3692	CLIP-seq
MIRT2597483	hsa-miR-412	CLIP-seq
MIRT2597484	hsa-miR-4640-3p	CLIP-seq
MIRT1249438	hsa-miR-548p	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000428	Component	DNA-directed RNA polymerase complex	IEA
GO:0002376	Process	Immune system process	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003899	Function	DNA-directed RNA polymerase activity	IEA
GO:0003899	Function	DNA-directed RNA polymerase activity	TAS	9869639
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005666	Component	RNA polymerase III complex	IDA	33335104, 34675218
GO:0005666	Component	RNA polymerase III complex	IEA
GO:0005666	Component	RNA polymerase III complex	TAS	9869639
GO:0005829	Component	Cytosol	TAS
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006383	Process	Transcription by RNA polymerase III	IEA
GO:0006383	Process	Transcription by RNA polymerase III	TAS	9869639
GO:0008270	Function	Zinc ion binding	IDA	34675218
GO:0008270	Function	Zinc ion binding	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051607	Process	Defense response to virus	IEA

MIM	HGNC	e!Ensembl
606007	14121	ENSG00000161980

Q9Y2Y1

Protein name

DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerase III subunit K) (RNA polymerase III 12.5 kDa subunit) (RPC12.5) (RNA polymerase III subunit C11) (HsC11p) (RPC11) (hRPC11)

Protein function

Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:30584594, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:3367478

PDB

7A6H , 7AE1 , 7AE3 , 7AEA , 7AST , 7D58 , 7D59 , 7DN3 , 7DU2 , 7FJI , 7FJJ , 8ITY , 8IUE , 8IUH , 9FSO , 9FSP , 9FSQ , 9FSR , 9FSS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02150	RNA_POL_M_15KD	2 → 37	RNA polymerases M/15 Kd subunit	Domain
PF01096	TFIIS_C	67 → 107	Transcription factor S-II (TFIIS)	Domain

Sequence

MLLFCPGCGNGLIVEEGQRCHRFSCNTCPYVHNITRKVTNRKYPKLKEVDDVLGGAAAWE
NVDSTAESCPKCEHPRAYFMQLQTRSADEPMTTFYKCCNAQCGHRWRD

Sequence length

108

Interactions

View interactions

	KEGG		Reactome
	RNA polymerase Cytosolic DNA-sensing pathway		Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Leukodystrophy, hypomyelinating, 21	Pathogenic	rs1432006875, rs1288202550	RCV001376157 RCV003329479

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Anemia hypochromic microcytic	Associate	32720864
Anodontia	Associate	33005949
Elejalde Disease	Associate	31089205
Hypogonadism	Associate	33005949
Influenza Human	Inhibit	33096707
Leukodystrophy Metachromatic	Associate	33005949, 40176224, 40225923
Pelizaeus Merzbacher like disease autosomal recessive 2	Associate	40176224
RNA Virus Infections	Associate	31438894
Stomach Neoplasms	Associate	35036435
Uterine Cervical Neoplasms	Associate	16803519

POLR3K (RNA polymerase III subunit K)