Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51728
Gene name Gene Name - the full gene name approved by the HGNC.
RNA polymerase III subunit K
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
POLR3K
Synonyms (NCBI Gene) Gene synonyms aliases
C11, C11-RNP3, HLD21, My010, RPC10, RPC11, RPC12.5
Disease Acronyms (UniProt) Disease acronyms from UniProt database
HLD21
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT041912 hsa-miR-484 CLASH 23622248
MIRT664512 hsa-miR-4524b-3p HITS-CLIP 23824327
MIRT664511 hsa-miR-3929 HITS-CLIP 23824327
MIRT664510 hsa-miR-4419b HITS-CLIP 23824327
MIRT664509 hsa-miR-4478 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0003899 Function DNA-directed 5'-3' RNA polymerase activity IBA 21873635
GO:0005515 Function Protein binding IPI 32296183
GO:0005654 Component Nucleoplasm TAS
GO:0005666 Component RNA polymerase III complex IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606007 14121 ENSG00000161980
Protein
UniProt ID Q9Y2Y1
Protein name DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerase III subunit K) (RNA polymerase III 12.5 kDa subunit) (RPC12.5) (RNA polymerase III subunit C11) (HsC11p) (RPC11) (hRPC11)
Protein function Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:30584594, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:3367478
PDB 7A6H , 7AE1 , 7AE3 , 7AEA , 7AST , 7D58 , 7D59 , 7DN3 , 7DU2 , 7FJI , 7FJJ , 8ITY , 8IUE , 8IUH , 9FSO , 9FSP , 9FSQ , 9FSR , 9FSS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02150 RNA_POL_M_15KD 2 37 RNA polymerases M/15 Kd subunit Domain
PF01096 TFIIS_C 67 107 Transcription factor S-II (TFIIS) Domain
Sequence
Sequence length 108
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  RNA polymerase
Cytosolic DNA-sensing pathway
  Cytosolic sensors of pathogen-associated DNA
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
21364753
Unknown
Disease term Disease name Evidence References Source
Leukodystrophy leukodystrophy, hypomyelinating, 21 GenCC
Associations from Text Mining
Disease Name Relationship Type References
Anemia hypochromic microcytic Associate 32720864
Anodontia Associate 33005949
Elejalde Disease Associate 31089205
Hypogonadism Associate 33005949
Influenza Human Inhibit 33096707
Leukodystrophy Metachromatic Associate 33005949, 40176224, 40225923
Pelizaeus Merzbacher like disease autosomal recessive 2 Associate 40176224
RNA Virus Infections Associate 31438894
Stomach Neoplasms Associate 35036435
Uterine Cervical Neoplasms Associate 16803519