Gene Gene information from NCBI Gene database.
Entrez ID 5170
Gene name 3-phosphoinositide dependent protein kinase 1
Gene symbol PDPK1
Synonyms (NCBI Gene)
PDK1PDPK2PDPK2PPRO0461
Chromosome 16
Chromosome location 16p13.3
miRNA miRNA information provided by mirtarbase database.
1001
miRTarBase ID miRNA Experiments Reference
MIRT021308 hsa-miR-125a-5p Sequencing 20371350
MIRT021893 hsa-miR-128-3p Microarray 17612493
MIRT025610 hsa-miR-10a-5p Sequencing 20371350
MIRT030439 hsa-miR-24-3p Microarray 19748357
MIRT051003 hsa-miR-17-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
66
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003323 Process Type B pancreatic cell development IEA
GO:0004672 Function Protein kinase activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0004674 Function Protein serine/threonine kinase activity IDA 9094314, 9368760
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605213 8816 ENSG00000140992
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15530
Protein name 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1)
Protein function Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:1
PDB 1H1W , 1OKY , 1OKZ , 1UU3 , 1UU7 , 1UU8 , 1UU9 , 1UVR , 1W1D , 1W1G , 1W1H , 1Z5M , 2BIY , 2PE0 , 2PE1 , 2PE2 , 2R7B , 2VKI , 2XCH , 2XCK , 3H9O , 3HRC , 3HRF , 3ION , 3IOP , 3NAX , 3NAY , 3NUN , 3NUS , 3NUU , 3NUY , 3ORX , 3ORZ , 3OTU , 3PWY , 3QC4 , 3QCQ , 3QCS , 3QCX , 3QCY , 3QD0 , 3QD3 , 3QD4 , 3RCJ , 3RWP , 3RWQ , 3SC1 , 4A06 , 4A07 , 4AW0 , 4AW1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 82 342 Protein kinase domain Domain
PF14593 PH_3 446 548 PH domain Domain
Tissue specificity TISSUE SPECIFICITY: Appears to be expressed ubiquitously. The Tyr-9 phosphorylated form is markedly increased in diseased tissue compared with normal tissue from lung, liver, colon and breast. {ECO:0000269|PubMed:18024423}.
Sequence
Sequence length 556
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Platinum drug resistance
PPAR signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Axon guidance
Focal adhesion
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Thyroid hormone signaling pathway
Insulin resistance
Aldosterone-regulated sodium reabsorption
Toxoplasmosis
Proteoglycans in cancer
Chemical carcinogenesis - reactive oxygen species
Endometrial cancer
Prostate cancer
Non-small cell lung cancer
Choline metabolism in cancer
Lipid and atherosclerosis
  GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Downstream TCR signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated NF-kB activation
Integrin signaling
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases activate PKNs
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Estrogen-stimulated signaling through PRKCZ
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
PDPK1-related disorder Likely benign rs141143951, rs201375554, rs747477279 RCV003909271
RCV003944236
RCV003946866
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Amebiasis Associate 28765971
Breast Neoplasms Associate 24739482, 39201344
Carcinogenesis Stimulate 24739482
Carcinoma Hepatocellular Associate 36447138
Carcinoma Non Small Cell Lung Associate 23867003, 28840963
Chromosome Deletion Associate 30245510
Colorectal Neoplasms Associate 12000750, 20197379, 31160710
Developmental Disabilities Associate 30245510
Epilepsy Associate 30245510
Esophageal Neoplasms Associate 30178844