Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5170
Gene name Gene Name - the full gene name approved by the HGNC.
3-phosphoinositide dependent protein kinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PDPK1
Synonyms (NCBI Gene) Gene synonyms aliases
PDK1, PDPK2, PDPK2P, PRO0461
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p13.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021308 hsa-miR-125a-5p Sequencing 20371350
MIRT021893 hsa-miR-128-3p Microarray 17612493
MIRT025610 hsa-miR-10a-5p Sequencing 20371350
MIRT030439 hsa-miR-24-3p Microarray 19748357
MIRT051003 hsa-miR-17-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002223 Process Stimulatory C-type lectin receptor signaling pathway TAS
GO:0003323 Process Type B pancreatic cell development IEA
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 9368760
GO:0004674 Function Protein serine/threonine kinase activity TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605213 8816 ENSG00000140992
Protein
UniProt ID O15530
Protein name 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1)
Protein function Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:1
PDB 1H1W , 1OKY , 1OKZ , 1UU3 , 1UU7 , 1UU8 , 1UU9 , 1UVR , 1W1D , 1W1G , 1W1H , 1Z5M , 2BIY , 2PE0 , 2PE1 , 2PE2 , 2R7B , 2VKI , 2XCH , 2XCK , 3H9O , 3HRC , 3HRF , 3ION , 3IOP , 3NAX , 3NAY , 3NUN , 3NUS , 3NUU , 3NUY , 3ORX , 3ORZ , 3OTU , 3PWY , 3QC4 , 3QCQ , 3QCS , 3QCX , 3QCY , 3QD0 , 3QD3 , 3QD4 , 3RCJ , 3RWP , 3RWQ , 3SC1 , 4A06 , 4A07 , 4AW0 , 4AW1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 82 342 Protein kinase domain Domain
PF14593 PH_3 446 548 PH domain Domain
Tissue specificity TISSUE SPECIFICITY: Appears to be expressed ubiquitously. The Tyr-9 phosphorylated form is markedly increased in diseased tissue compared with normal tissue from lung, liver, colon and breast. {ECO:0000269|PubMed:18024423}.
Sequence
Sequence length 556
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Platinum drug resistance
PPAR signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Axon guidance
Focal adhesion
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Thyroid hormone signaling pathway
Insulin resistance
Aldosterone-regulated sodium reabsorption
Toxoplasmosis
Proteoglycans in cancer
Chemical carcinogenesis - reactive oxygen species
Endometrial cancer
Prostate cancer
Non-small cell lung cancer
Choline metabolism in cancer
Lipid and atherosclerosis
  GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Downstream TCR signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated NF-kB activation
Integrin signaling
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases activate PKNs
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Estrogen-stimulated signaling through PRKCZ
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast adenocarcinoma Breast adenocarcinoma rs28934874, rs112445441, rs121913279, rs121913286, rs104886003, rs121434592
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
24739482
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
24739482
Diffuse lymphoma Diffuse Large B-Cell Lymphoma rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291 21173233
Unknown
Disease term Disease name Evidence References Source
Congestive heart failure Congestive heart failure 19429709 ClinVar
Heart failure Heart failure, Left-Sided Heart Failure, Heart Failure, Right-Sided 19429709 ClinVar
Myocardial infarction Myocardial Failure 19429709 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Amebiasis Associate 28765971
Breast Neoplasms Associate 24739482, 39201344
Carcinogenesis Stimulate 24739482
Carcinoma Hepatocellular Associate 36447138
Carcinoma Non Small Cell Lung Associate 23867003, 28840963
Chromosome Deletion Associate 30245510
Colorectal Neoplasms Associate 12000750, 20197379, 31160710
Developmental Disabilities Associate 30245510
Epilepsy Associate 30245510
Esophageal Neoplasms Associate 30178844