Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	5168
Gene name	Ectonucleotide pyrophosphatase/phosphodiesterase 2
Gene symbol	ENPP2
Synonyms (NCBI Gene)	ATXATX-XAUTOTAXINLysoPLDNPP2PD-IALPHAPDNP2
Chromosome	8
Chromosome location	8q24.12
Summary	The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5` end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evoke

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miRTarBase ID	miRNA	Experiments	Reference
MIRT537688	hsa-miR-29a-3p	PAR-CLIP	22012620
MIRT537687	hsa-miR-29b-3p	PAR-CLIP	22012620
MIRT537686	hsa-miR-29c-3p	PAR-CLIP	22012620
MIRT537685	hsa-miR-107	PAR-CLIP	22012620
MIRT537684	hsa-miR-103a-3p	PAR-CLIP	22012620
MIRT537683	hsa-miR-4762-5p	PAR-CLIP	22012620
MIRT537682	hsa-miR-3065-3p	PAR-CLIP	22012620
MIRT537681	hsa-miR-3158-5p	PAR-CLIP	22012620
MIRT537680	hsa-miR-1184	PAR-CLIP	22012620
MIRT537679	hsa-miR-1205	PAR-CLIP	22012620
MIRT537678	hsa-miR-17-3p	PAR-CLIP	22012620
MIRT537677	hsa-miR-767-5p	PAR-CLIP	22012620
MIRT537688	hsa-miR-29a-3p	PAR-CLIP	22012620
MIRT537687	hsa-miR-29b-3p	PAR-CLIP	22012620
MIRT537686	hsa-miR-29c-3p	PAR-CLIP	22012620
MIRT537685	hsa-miR-107	PAR-CLIP	22012620
MIRT537684	hsa-miR-103a-3p	PAR-CLIP	22012620
MIRT537683	hsa-miR-4762-5p	PAR-CLIP	22012620
MIRT537682	hsa-miR-3065-3p	PAR-CLIP	22012620
MIRT537681	hsa-miR-3158-5p	PAR-CLIP	22012620
MIRT537680	hsa-miR-1184	PAR-CLIP	22012620
MIRT537679	hsa-miR-1205	PAR-CLIP	22012620
MIRT537678	hsa-miR-17-3p	PAR-CLIP	22012620
MIRT537677	hsa-miR-767-5p	PAR-CLIP	22012620
MIRT964016	hsa-miR-4484	CLIP-seq
MIRT964017	hsa-miR-520d-5p	CLIP-seq
MIRT964018	hsa-miR-524-5p	CLIP-seq
MIRT964019	hsa-miR-548an	CLIP-seq
MIRT964020	hsa-miR-891b	CLIP-seq
MIRT2448862	hsa-miR-1263	CLIP-seq
MIRT2448863	hsa-miR-3159	CLIP-seq
MIRT2448864	hsa-miR-4700-3p	CLIP-seq
MIRT2524041	hsa-miR-101	CLIP-seq
MIRT2524042	hsa-miR-103a	CLIP-seq
MIRT2524043	hsa-miR-1238	CLIP-seq
MIRT2524044	hsa-miR-144	CLIP-seq
MIRT2524045	hsa-miR-2115	CLIP-seq
MIRT2524046	hsa-miR-29a	CLIP-seq
MIRT2524047	hsa-miR-29b	CLIP-seq
MIRT2524048	hsa-miR-29c	CLIP-seq
MIRT2524049	hsa-miR-300	CLIP-seq
MIRT2524050	hsa-miR-3120-3p	CLIP-seq
MIRT2524051	hsa-miR-3143	CLIP-seq
MIRT2524052	hsa-miR-3148	CLIP-seq
MIRT2524053	hsa-miR-3161	CLIP-seq
MIRT2524054	hsa-miR-3163	CLIP-seq
MIRT2524055	hsa-miR-338-5p	CLIP-seq
MIRT2524056	hsa-miR-33a	CLIP-seq
MIRT2524057	hsa-miR-33b	CLIP-seq
MIRT2524058	hsa-miR-3647-3p	CLIP-seq
MIRT2524059	hsa-miR-3671	CLIP-seq
MIRT2524060	hsa-miR-3688-5p	CLIP-seq
MIRT2524061	hsa-miR-381	CLIP-seq
MIRT2524062	hsa-miR-3978	CLIP-seq
MIRT2524063	hsa-miR-4302	CLIP-seq
MIRT2524064	hsa-miR-4432	CLIP-seq
MIRT2524065	hsa-miR-4436b-5p	CLIP-seq
MIRT964016	hsa-miR-4484	CLIP-seq
MIRT2524066	hsa-miR-4666-3p	CLIP-seq
MIRT2448864	hsa-miR-4700-3p	CLIP-seq
MIRT2524067	hsa-miR-4759	CLIP-seq
MIRT2524068	hsa-miR-499-5p	CLIP-seq
MIRT964017	hsa-miR-520d-5p	CLIP-seq
MIRT964018	hsa-miR-524-5p	CLIP-seq
MIRT2524069	hsa-miR-543	CLIP-seq
MIRT2524070	hsa-miR-545	CLIP-seq
MIRT2524071	hsa-miR-548ac	CLIP-seq
MIRT2524072	hsa-miR-548ae	CLIP-seq
MIRT2524073	hsa-miR-548aj	CLIP-seq
MIRT2524074	hsa-miR-548am	CLIP-seq
MIRT964019	hsa-miR-548an	CLIP-seq
MIRT2524075	hsa-miR-548c-3p	CLIP-seq
MIRT2524076	hsa-miR-548d-3p	CLIP-seq
MIRT2524077	hsa-miR-548x	CLIP-seq
MIRT2524078	hsa-miR-548z	CLIP-seq
MIRT2524079	hsa-miR-587	CLIP-seq
MIRT2524080	hsa-miR-607	CLIP-seq
MIRT2524081	hsa-miR-889	CLIP-seq
MIRT964020	hsa-miR-891b	CLIP-seq
MIRT2524041	hsa-miR-101	CLIP-seq
MIRT2524042	hsa-miR-103a	CLIP-seq
MIRT2524043	hsa-miR-1238	CLIP-seq
MIRT2680071	hsa-miR-132	CLIP-seq
MIRT2524044	hsa-miR-144	CLIP-seq
MIRT2524045	hsa-miR-2115	CLIP-seq
MIRT2680072	hsa-miR-212	CLIP-seq
MIRT2680073	hsa-miR-299-5p	CLIP-seq
MIRT2524046	hsa-miR-29a	CLIP-seq
MIRT2524047	hsa-miR-29b	CLIP-seq
MIRT2524048	hsa-miR-29c	CLIP-seq
MIRT2524049	hsa-miR-300	CLIP-seq
MIRT2524050	hsa-miR-3120-3p	CLIP-seq
MIRT2524051	hsa-miR-3143	CLIP-seq
MIRT2524052	hsa-miR-3148	CLIP-seq
MIRT2524054	hsa-miR-3163	CLIP-seq
MIRT2524055	hsa-miR-338-5p	CLIP-seq
MIRT2524056	hsa-miR-33a	CLIP-seq
MIRT2524057	hsa-miR-33b	CLIP-seq
MIRT2524058	hsa-miR-3647-3p	CLIP-seq
MIRT2680074	hsa-miR-3658	CLIP-seq
MIRT2524059	hsa-miR-3671	CLIP-seq
MIRT2524060	hsa-miR-3688-5p	CLIP-seq
MIRT2524061	hsa-miR-381	CLIP-seq
MIRT2524062	hsa-miR-3978	CLIP-seq
MIRT2524063	hsa-miR-4302	CLIP-seq
MIRT2680075	hsa-miR-4307	CLIP-seq
MIRT2524065	hsa-miR-4436b-5p	CLIP-seq
MIRT964016	hsa-miR-4484	CLIP-seq
MIRT2524066	hsa-miR-4666-3p	CLIP-seq
MIRT2448864	hsa-miR-4700-3p	CLIP-seq
MIRT2524067	hsa-miR-4759	CLIP-seq
MIRT2680076	hsa-miR-4795-3p	CLIP-seq
MIRT2680077	hsa-miR-509-3p	CLIP-seq
MIRT964017	hsa-miR-520d-5p	CLIP-seq
MIRT964018	hsa-miR-524-5p	CLIP-seq
MIRT2524069	hsa-miR-543	CLIP-seq
MIRT2524070	hsa-miR-545	CLIP-seq
MIRT2680078	hsa-miR-548a-3p	CLIP-seq
MIRT2524071	hsa-miR-548ac	CLIP-seq
MIRT2524072	hsa-miR-548ae	CLIP-seq
MIRT2524073	hsa-miR-548aj	CLIP-seq
MIRT2524074	hsa-miR-548am	CLIP-seq
MIRT964019	hsa-miR-548an	CLIP-seq
MIRT2524075	hsa-miR-548c-3p	CLIP-seq
MIRT2524076	hsa-miR-548d-3p	CLIP-seq
MIRT2680079	hsa-miR-548e	CLIP-seq
MIRT2680080	hsa-miR-548f	CLIP-seq
MIRT2524077	hsa-miR-548x	CLIP-seq
MIRT2524078	hsa-miR-548z	CLIP-seq
MIRT2680081	hsa-miR-556-3p	CLIP-seq
MIRT2524079	hsa-miR-587	CLIP-seq
MIRT2524080	hsa-miR-607	CLIP-seq
MIRT2524081	hsa-miR-889	CLIP-seq
MIRT964020	hsa-miR-891b	CLIP-seq

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Transcription factor	Regulation	Reference
NFATC2	Unknown	22986745

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0004528	Function	Phosphodiesterase I activity	IBA
GO:0004528	Function	Phosphodiesterase I activity	TAS	7982964
GO:0004622	Function	Phosphatidylcholine lysophospholipase activity	IBA
GO:0004622	Function	Phosphatidylcholine lysophospholipase activity	IDA	12354767, 14500380, 15280042, 21240271, 21393252, 26371182
GO:0004622	Function	Phosphatidylcholine lysophospholipase activity	IEA
GO:0004630	Function	Phospholipase D activity	IEA
GO:0005044	Function	Scavenger receptor activity	IEA
GO:0005509	Function	Calcium ion binding	IDA	26371182
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	ISS
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	15280042, 26371182
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	ISS
GO:0005886	Component	Plasma membrane	TAS	8579579
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006644	Process	Phospholipid metabolic process	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0006935	Process	Chemotaxis	NAS	7982964
GO:0006955	Process	Immune response	IEA
GO:0008270	Function	Zinc ion binding	IDA	26371182
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	ISS
GO:0009395	Process	Phospholipid catabolic process	IDA	15280042, 26371182
GO:0010634	Process	Positive regulation of epithelial cell migration	IGI	18054784
GO:0010634	Process	Positive regulation of epithelial cell migration	IMP	18054784
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016787	Function	Hydrolase activity	TAS	7982964
GO:0030149	Process	Sphingolipid catabolic process	IDA	14500380
GO:0030247	Function	Polysaccharide binding	IEA
GO:0030334	Process	Regulation of cell migration	IDA	1733949
GO:0034638	Process	Phosphatidylcholine catabolic process	IBA
GO:0034638	Process	Phosphatidylcholine catabolic process	IDA	21240271
GO:0034638	Process	Phosphatidylcholine catabolic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0047391	Function	Alkylglycerophosphoethanolamine phosphodiesterase activity	IBA
GO:0047391	Function	Alkylglycerophosphoethanolamine phosphodiesterase activity	IEA
GO:0048870	Process	Cell motility	TAS	1733949
GO:0050731	Process	Positive regulation of peptidyl-tyrosine phosphorylation	IDA	18054784
GO:2000394	Process	Positive regulation of lamellipodium morphogenesis	IGI	18054784

MIM	HGNC	e!Ensembl
601060	3357	ENSG00000136960

Q13822

Protein name

Autotaxin (EC 3.1.4.39) (EC 3.1.4.4) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2) (E-NPP 2) (Extracellular lysophospholipase D) (LysoPLD)

Protein function

Secreted lysophospholipase D that hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:12354767, PubMed:14500380, PubMed:15769751, PubMed:26371182, PubMed:27754931). Its major

PDB

4ZG6 , 4ZG7 , 4ZG9 , 4ZGA , 5KXA , 5M7M , 5MHP , 8C3O , 8C3P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01033	Somatomedin_B	57 → 97	Somatomedin B domain	Family
PF01033	Somatomedin_B	101 → 141	Somatomedin B domain	Family
PF01663	Phosphodiest	166 → 478	Type I phosphodiesterase / nucleotide pyrophosphatase	Family
PF01223	Endonuclease_NS	602 → 845	DNA/RNA non-specific endonuclease	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in blood plasma (at protein level) (PubMed:12176993, PubMed:26371182). Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma,

Sequence

MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCK
GRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHC
SEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDA
TFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHER
PSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQH
FKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNK
VNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYG
RPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVS
PSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVL
VKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQ
PADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFR
KTSRSYPEILTLKTYLHTYESEI

Sequence length

863

Interactions

View interactions

	KEGG		Reactome
	Ether lipid metabolism Metabolic pathways		Vitamin B5 (pantothenate) metabolism

ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2)