Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5168
Gene name Gene Name - the full gene name approved by the HGNC.	Ectonucleotide pyrophosphatase/phosphodiesterase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ENPP2
Synonyms (NCBI Gene) Gene synonyms aliases	ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8q24.12
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5` end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evoke

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miRTarBase ID	miRNA	Experiments	Reference
MIRT537688	hsa-miR-29a-3p	PAR-CLIP	22012620
MIRT537687	hsa-miR-29b-3p	PAR-CLIP	22012620
MIRT537686	hsa-miR-29c-3p	PAR-CLIP	22012620
MIRT537685	hsa-miR-107	PAR-CLIP	22012620
MIRT537684	hsa-miR-103a-3p	PAR-CLIP	22012620
MIRT537683	hsa-miR-4762-5p	PAR-CLIP	22012620
MIRT537682	hsa-miR-3065-3p	PAR-CLIP	22012620
MIRT537681	hsa-miR-3158-5p	PAR-CLIP	22012620
MIRT537680	hsa-miR-1184	PAR-CLIP	22012620
MIRT537679	hsa-miR-1205	PAR-CLIP	22012620
MIRT537678	hsa-miR-17-3p	PAR-CLIP	22012620
MIRT537677	hsa-miR-767-5p	PAR-CLIP	22012620
MIRT537688	hsa-miR-29a-3p	PAR-CLIP	22012620
MIRT537687	hsa-miR-29b-3p	PAR-CLIP	22012620
MIRT537686	hsa-miR-29c-3p	PAR-CLIP	22012620
MIRT537685	hsa-miR-107	PAR-CLIP	22012620
MIRT537684	hsa-miR-103a-3p	PAR-CLIP	22012620
MIRT537683	hsa-miR-4762-5p	PAR-CLIP	22012620
MIRT537682	hsa-miR-3065-3p	PAR-CLIP	22012620
MIRT537681	hsa-miR-3158-5p	PAR-CLIP	22012620
MIRT537680	hsa-miR-1184	PAR-CLIP	22012620
MIRT537679	hsa-miR-1205	PAR-CLIP	22012620
MIRT537678	hsa-miR-17-3p	PAR-CLIP	22012620
MIRT537677	hsa-miR-767-5p	PAR-CLIP	22012620
MIRT964016	hsa-miR-4484	CLIP-seq
MIRT964017	hsa-miR-520d-5p	CLIP-seq
MIRT964018	hsa-miR-524-5p	CLIP-seq
MIRT964019	hsa-miR-548an	CLIP-seq
MIRT964020	hsa-miR-891b	CLIP-seq
MIRT2448862	hsa-miR-1263	CLIP-seq
MIRT2448863	hsa-miR-3159	CLIP-seq
MIRT2448864	hsa-miR-4700-3p	CLIP-seq
MIRT2524041	hsa-miR-101	CLIP-seq
MIRT2524042	hsa-miR-103a	CLIP-seq
MIRT2524043	hsa-miR-1238	CLIP-seq
MIRT2524044	hsa-miR-144	CLIP-seq
MIRT2524045	hsa-miR-2115	CLIP-seq
MIRT2524046	hsa-miR-29a	CLIP-seq
MIRT2524047	hsa-miR-29b	CLIP-seq
MIRT2524048	hsa-miR-29c	CLIP-seq
MIRT2524049	hsa-miR-300	CLIP-seq
MIRT2524050	hsa-miR-3120-3p	CLIP-seq
MIRT2524051	hsa-miR-3143	CLIP-seq
MIRT2524052	hsa-miR-3148	CLIP-seq
MIRT2524053	hsa-miR-3161	CLIP-seq
MIRT2524054	hsa-miR-3163	CLIP-seq
MIRT2524055	hsa-miR-338-5p	CLIP-seq
MIRT2524056	hsa-miR-33a	CLIP-seq
MIRT2524057	hsa-miR-33b	CLIP-seq
MIRT2524058	hsa-miR-3647-3p	CLIP-seq
MIRT2524059	hsa-miR-3671	CLIP-seq
MIRT2524060	hsa-miR-3688-5p	CLIP-seq
MIRT2524061	hsa-miR-381	CLIP-seq
MIRT2524062	hsa-miR-3978	CLIP-seq
MIRT2524063	hsa-miR-4302	CLIP-seq
MIRT2524064	hsa-miR-4432	CLIP-seq
MIRT2524065	hsa-miR-4436b-5p	CLIP-seq
MIRT964016	hsa-miR-4484	CLIP-seq
MIRT2524066	hsa-miR-4666-3p	CLIP-seq
MIRT2448864	hsa-miR-4700-3p	CLIP-seq
MIRT2524067	hsa-miR-4759	CLIP-seq
MIRT2524068	hsa-miR-499-5p	CLIP-seq
MIRT964017	hsa-miR-520d-5p	CLIP-seq
MIRT964018	hsa-miR-524-5p	CLIP-seq
MIRT2524069	hsa-miR-543	CLIP-seq
MIRT2524070	hsa-miR-545	CLIP-seq
MIRT2524071	hsa-miR-548ac	CLIP-seq
MIRT2524072	hsa-miR-548ae	CLIP-seq
MIRT2524073	hsa-miR-548aj	CLIP-seq
MIRT2524074	hsa-miR-548am	CLIP-seq
MIRT964019	hsa-miR-548an	CLIP-seq
MIRT2524075	hsa-miR-548c-3p	CLIP-seq
MIRT2524076	hsa-miR-548d-3p	CLIP-seq
MIRT2524077	hsa-miR-548x	CLIP-seq
MIRT2524078	hsa-miR-548z	CLIP-seq
MIRT2524079	hsa-miR-587	CLIP-seq
MIRT2524080	hsa-miR-607	CLIP-seq
MIRT2524081	hsa-miR-889	CLIP-seq
MIRT964020	hsa-miR-891b	CLIP-seq
MIRT2524041	hsa-miR-101	CLIP-seq
MIRT2524042	hsa-miR-103a	CLIP-seq
MIRT2524043	hsa-miR-1238	CLIP-seq
MIRT2680071	hsa-miR-132	CLIP-seq
MIRT2524044	hsa-miR-144	CLIP-seq
MIRT2524045	hsa-miR-2115	CLIP-seq
MIRT2680072	hsa-miR-212	CLIP-seq
MIRT2680073	hsa-miR-299-5p	CLIP-seq
MIRT2524046	hsa-miR-29a	CLIP-seq
MIRT2524047	hsa-miR-29b	CLIP-seq
MIRT2524048	hsa-miR-29c	CLIP-seq
MIRT2524049	hsa-miR-300	CLIP-seq
MIRT2524050	hsa-miR-3120-3p	CLIP-seq
MIRT2524051	hsa-miR-3143	CLIP-seq
MIRT2524052	hsa-miR-3148	CLIP-seq
MIRT2524054	hsa-miR-3163	CLIP-seq
MIRT2524055	hsa-miR-338-5p	CLIP-seq
MIRT2524056	hsa-miR-33a	CLIP-seq
MIRT2524057	hsa-miR-33b	CLIP-seq
MIRT2524058	hsa-miR-3647-3p	CLIP-seq
MIRT2680074	hsa-miR-3658	CLIP-seq
MIRT2524059	hsa-miR-3671	CLIP-seq
MIRT2524060	hsa-miR-3688-5p	CLIP-seq
MIRT2524061	hsa-miR-381	CLIP-seq
MIRT2524062	hsa-miR-3978	CLIP-seq
MIRT2524063	hsa-miR-4302	CLIP-seq
MIRT2680075	hsa-miR-4307	CLIP-seq
MIRT2524065	hsa-miR-4436b-5p	CLIP-seq
MIRT964016	hsa-miR-4484	CLIP-seq
MIRT2524066	hsa-miR-4666-3p	CLIP-seq
MIRT2448864	hsa-miR-4700-3p	CLIP-seq
MIRT2524067	hsa-miR-4759	CLIP-seq
MIRT2680076	hsa-miR-4795-3p	CLIP-seq
MIRT2680077	hsa-miR-509-3p	CLIP-seq
MIRT964017	hsa-miR-520d-5p	CLIP-seq
MIRT964018	hsa-miR-524-5p	CLIP-seq
MIRT2524069	hsa-miR-543	CLIP-seq
MIRT2524070	hsa-miR-545	CLIP-seq
MIRT2680078	hsa-miR-548a-3p	CLIP-seq
MIRT2524071	hsa-miR-548ac	CLIP-seq
MIRT2524072	hsa-miR-548ae	CLIP-seq
MIRT2524073	hsa-miR-548aj	CLIP-seq
MIRT2524074	hsa-miR-548am	CLIP-seq
MIRT964019	hsa-miR-548an	CLIP-seq
MIRT2524075	hsa-miR-548c-3p	CLIP-seq
MIRT2524076	hsa-miR-548d-3p	CLIP-seq
MIRT2680079	hsa-miR-548e	CLIP-seq
MIRT2680080	hsa-miR-548f	CLIP-seq
MIRT2524077	hsa-miR-548x	CLIP-seq
MIRT2524078	hsa-miR-548z	CLIP-seq
MIRT2680081	hsa-miR-556-3p	CLIP-seq
MIRT2524079	hsa-miR-587	CLIP-seq
MIRT2524080	hsa-miR-607	CLIP-seq
MIRT2524081	hsa-miR-889	CLIP-seq
MIRT964020	hsa-miR-891b	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
NFATC2	Unknown	22986745

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0004528	Function	Phosphodiesterase I activity	IBA	21873635
GO:0004551	Function	Nucleotide diphosphatase activity	IEA
GO:0004622	Function	Lysophospholipase activity	IBA	21873635
GO:0004622	Function	Lysophospholipase activity	IDA	12354767, 14500380, 15280042, 21240271, 21393252, 26371182
GO:0005044	Function	Scavenger receptor activity	IEA
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005509	Function	Calcium ion binding	IDA	26371182
GO:0005509	Function	Calcium ion binding	ISS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	15280042, 26371182
GO:0005615	Component	Extracellular space	ISS
GO:0005886	Component	Plasma membrane	TAS	8579579
GO:0006897	Process	Endocytosis	IEA
GO:0006935	Process	Chemotaxis	NAS	7982964
GO:0006955	Process	Immune response	IEA
GO:0008134	Function	Transcription factor binding	TAS	8586446
GO:0008270	Function	Zinc ion binding	IBA	21873635
GO:0008270	Function	Zinc ion binding	IDA	26371182
GO:0008270	Function	Zinc ion binding	ISS
GO:0009395	Process	Phospholipid catabolic process	IDA	15280042, 26371182
GO:0010634	Process	Positive regulation of epithelial cell migration	IGI	18054784
GO:0010634	Process	Positive regulation of epithelial cell migration	IMP	18054784
GO:0016787	Function	Hydrolase activity	TAS	7982964
GO:0030149	Process	Sphingolipid catabolic process	IDA	14500380
GO:0030247	Function	Polysaccharide binding	IEA
GO:0030334	Process	Regulation of cell migration	IDA	1733949
GO:0034638	Process	Phosphatidylcholine catabolic process	IBA	21873635
GO:0034638	Process	Phosphatidylcholine catabolic process	IDA	21240271
GO:0045765	Process	Regulation of angiogenesis	IEA
GO:0047391	Function	Alkylglycerophosphoethanolamine phosphodiesterase activity	IBA	21873635
GO:0048870	Process	Cell motility	TAS	1733949
GO:0050731	Process	Positive regulation of peptidyl-tyrosine phosphorylation	IDA	18054784
GO:0090305	Process	Nucleic acid phosphodiester bond hydrolysis	IEA
GO:2000394	Process	Positive regulation of lamellipodium morphogenesis	IGI	18054784

MIM	HGNC	e!Ensembl
601060	3357	ENSG00000136960

Protein

UniProt ID

Q13822

Protein name

Autotaxin (EC 3.1.4.39) (EC 3.1.4.4) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2) (E-NPP 2) (Extracellular lysophospholipase D) (LysoPLD)

Protein function

Secreted lysophospholipase D that hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:12354767, PubMed:14500380, PubMed:15769751, PubMed:26371182, PubMed:27754931). Its major

PDB

4ZG6 , 4ZG7 , 4ZG9 , 4ZGA , 5KXA , 5M7M , 5MHP , 8C3O , 8C3P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01033	Somatomedin_B	57 → 97	Somatomedin B domain	Family
PF01033	Somatomedin_B	101 → 141	Somatomedin B domain	Family
PF01663	Phosphodiest	166 → 478	Type I phosphodiesterase / nucleotide pyrophosphatase	Family
PF01223	Endonuclease_NS	602 → 845	DNA/RNA non-specific endonuclease	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in blood plasma (at protein level) (PubMed:12176993, PubMed:26371182). Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma,

Sequence

MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCK
GRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHC
SEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDA
TFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHER
PSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQH
FKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNK
VNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYG
RPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVS
PSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVL
VKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQ
PADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFR
KTSRSYPEILTLKTYLHTYESEI

Sequence length

863

Interactions

View interactions

	KEGG		Reactome
	Ether lipid metabolism Metabolic pathways		Vitamin B5 (pantothenate) metabolism

ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2)