PALS2 (protein associated with LIN7 2, MAGUK p55 family member)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51678
Gene name Gene Name - the full gene name approved by the HGNC.
Protein associated with LIN7 2, MAGUK p55 family member
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PALS2
Synonyms (NCBI Gene) Gene synonyms aliases
MPP6, VAM-1, VAM1, p55T
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p15.3
Summary Summary of gene provided in NCBI Entrez Gene.
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling protei
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(9)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 11311936, 24366813, 28514442, 32296183, 33961781
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0005911 Component Cell-cell junction IBA
GO:0016020 Component Membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
606959 18167 ENSG00000105926
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Q9NZW5
Protein name Protein PALS2 (MAGUK p55 subfamily member 6) (Membrane protein, palmitoylated 6) (Veli-associated MAGUK 1) (VAM-1)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02828 L27 1 → 54 L27 domain Domain
PF02828 L27 57 → 109 L27 domain Domain
PF00595 PDZ 131 → 206 PDZ domain Domain
PF07653 SH3_2 219 → 282 Variant SH3 domain Domain
PF00625 Guanylate_kin 337 → 527 Guanylate kinase Domain
Tissue specificity TISSUE SPECIFICITY: Abundant in testis, brain, and kidney with lower levels detectable in other tissues.
Sequence
Sequence length 540
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (5)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Bipolar Disorder Bipolar disorder N/A N/A GWAS
Gout Gout N/A N/A GWAS
Neuroticism Neuroticism N/A N/A GWAS
Schizophrenia Schizophrenia N/A N/A GWAS