Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51663
Gene name Gene Name - the full gene name approved by the HGNC.
Zinc finger RNA binding protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ZFR
Synonyms (NCBI Gene) Gene synonyms aliases
SPG71, ZFR1
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes an RNA-binding protein characterized by its DZF (domain associated with zinc fingers) domain. The encoded protein may play a role in the nucleocytoplasmic shuttling of another RNA-binding protein, Staufen homolog 2, in neurons. Expressio
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025344 hsa-miR-34a-5p Proteomics 21566225
MIRT041922 hsa-miR-484 CLASH 23622248
MIRT686247 hsa-miR-5700 HITS-CLIP 23313552
MIRT686246 hsa-miR-3120-3p HITS-CLIP 23313552
MIRT686245 hsa-miR-545-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003725 Function Double-stranded RNA binding IBA 21873635
GO:0003727 Function Single-stranded RNA binding IBA 21873635
GO:0005515 Function Protein binding IPI 20195357
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
615635 17277 ENSG00000056097
Protein
UniProt ID Q96KR1
Protein name Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog)
Protein function Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12874 zf-met 331 355 Domain
PF12874 zf-met 382 406 Domain
PF12874 zf-met 582 606 Domain
PF07528 DZF 790 1038 DZF domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in lung, liver, lymphocytes, heart, pancreas, placenta, brain and kidney. {ECO:0000269|PubMed:11574164}.
Sequence
MIPICPVVSFTYVPSRLGEDAKMATGNYFGFTHSGAAAAAAAAQYSQQPASGVAYSHPTT
VASYTVHQAPVAAHTVTAAYAPAAATVAVARPAPVAVAAAATAAAYGGYPTAHTATDYGY
TQRQQEAPPPPPPATTQNYQDSYSYVRSTAPAVAYDSKQYYQQPTATAAAVAAAAQPQPS
VAETYYQTAPKAGYSQGATQYTQAQQTRQVTAIKPATPSPATTTFSIYPVSSTVQPVAAA
ATVVPSYTQSATYSTTAVTYSGTSYSGYEAAVYSAASSYYQQQQQQQKQAAAAAAAAAAT
AAWTGTTFTKKAPFQNKQLKPKQPPKPPQIHYCDVCKISCAGPQTYKEHLEGQKHKKKEA
ALKASQNTSSSNSSTRGTQNQLRCELCDVSCTGADAYAAHIRGAKHQKVVKLHTKLGKPI
PSTEPNVVSQATSSTAVSASKPTASPSSIAANNCTVNTSSVATSSMKGLTTTGNSSLNST
SNTKVSAVPTNMAAKKTSTPKINFVGGNKLQSTGNKAEDIKGTECVKSTPVTSAVQIPEV
KQDTVSEPVTPASLAALQSDVQPVGHDYVEEVRNDEGKVIRFHCKLCECSFNDPNAKEMH
LKGRRH
RLQYKKKVNPDLQVEVKPSIRARKIQEEKMRKQMQKEEYWRRREEEERWRMEMR
RYEEDMYWRRMEEEQHHWDDRRRMPDGGYPHGPPGPLGLLGVRPGMPPQPQGPAPLRRPD
SSDDRYVMTKHATIYPTEEELQAVQKIVSITERALKLVSDSLSEHEKNKNKEGDDKKEGG
KDRALKGVLRVGVLAKGLLLRGDRNVNLVLLCSEKPSKTLLSRIAENLPKQLAVISPEKY
DIKCAVSEAAIILNSCVEPKMQVTITLTSPIIREENMREGDVTSGMVKDPPDVLDRQKCL
DALAALRHAKWFQARANGLQSCVIIIRILRDLCQRVPTWSDFPSWAMELLVEKAISSASS
PQSPGDALRRVFECISSGIILKGSPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALRL
LAFRQIHKVLGMDPLPQM
SQRFNIHNNRKRRRDSDGVDGFEAEGKKDKKDYDNF
Sequence length 1074
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Developmental delay Global developmental delay rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291
View all (32 more)
Mental retardation Mild Mental Retardation rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315
View all (1024 more)
Spastic paraplegia Autosomal recessive spastic paraplegia type 71 rs118204049, rs121918262, rs104894490, rs119476046, rs281865117, rs281865118, rs137853017, rs72554620, rs121908610, rs121908611, rs121908613, rs116171274, rs121434442, rs121434443, rs137852520
View all (368 more)
Unknown
Disease term Disease name Evidence References Source
Spastic Paraplegia hereditary spastic paraplegia, autosomal recessive spastic paraplegia type 71 GenCC
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 33090396
Carcinoma Non Small Cell Lung Associate 31407591
Neoplasms Associate 31407591
Neoplasms Stimulate 33090396
Uterine Cervical Neoplasms Associate 35127342