Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	51659
Gene name	GINS complex subunit 2
Gene symbol	GINS2
Synonyms (NCBI Gene)	HSPC037PSF2Pfs2
Chromosome	16
Chromosome location	16q24.1
Summary	The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extract

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016400	hsa-miR-193b-3p	Microarray	20304954
MIRT040250	hsa-miR-615-3p	CLASH	23622248
MIRT677709	hsa-miR-625-3p	HITS-CLIP	23824327
MIRT677708	hsa-miR-22-3p	HITS-CLIP	23824327
MIRT677707	hsa-miR-1295b-3p	HITS-CLIP	23824327
MIRT677706	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT677705	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677704	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677703	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677702	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677701	hsa-miR-1976	HITS-CLIP	23824327
MIRT677700	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677699	hsa-miR-4279	HITS-CLIP	23824327
MIRT668141	hsa-miR-142-3p	HITS-CLIP	23824327
MIRT668140	hsa-miR-548ac	HITS-CLIP	23824327
MIRT668139	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT668138	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT668137	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT668136	hsa-miR-548z	HITS-CLIP	23824327
MIRT668135	hsa-miR-3200-3p	HITS-CLIP	23824327
MIRT668134	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT668133	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT668132	hsa-miR-3591-5p	HITS-CLIP	23824327
MIRT496520	hsa-miR-3929	PAR-CLIP	22291592
MIRT496519	hsa-miR-4419b	PAR-CLIP	22291592
MIRT496518	hsa-miR-4478	PAR-CLIP	22291592
MIRT496517	hsa-miR-6849-3p	PAR-CLIP	22291592
MIRT496516	hsa-miR-3190-5p	PAR-CLIP	22291592
MIRT496515	hsa-miR-198	PAR-CLIP	22291592
MIRT496514	hsa-miR-6512-3p	PAR-CLIP	22291592
MIRT496513	hsa-miR-6720-5p	PAR-CLIP	22291592
MIRT677709	hsa-miR-625-3p	HITS-CLIP	23824327
MIRT677708	hsa-miR-22-3p	HITS-CLIP	23824327
MIRT677707	hsa-miR-1295b-3p	HITS-CLIP	23824327
MIRT677706	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT677705	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677704	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677703	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677702	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677701	hsa-miR-1976	HITS-CLIP	23824327
MIRT677700	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677699	hsa-miR-4279	HITS-CLIP	23824327
MIRT668141	hsa-miR-142-3p	HITS-CLIP	23824327
MIRT668140	hsa-miR-548ac	HITS-CLIP	23824327
MIRT668139	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT668138	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT668137	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT668136	hsa-miR-548z	HITS-CLIP	23824327
MIRT668135	hsa-miR-3200-3p	HITS-CLIP	23824327
MIRT668134	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT668133	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT668132	hsa-miR-3591-5p	HITS-CLIP	23824327
MIRT496520	hsa-miR-3929	PAR-CLIP	22291592
MIRT496519	hsa-miR-4419b	PAR-CLIP	22291592
MIRT496518	hsa-miR-4478	PAR-CLIP	22291592
MIRT496517	hsa-miR-6849-3p	PAR-CLIP	22291592
MIRT496516	hsa-miR-3190-5p	PAR-CLIP	22291592
MIRT496515	hsa-miR-198	PAR-CLIP	22291592
MIRT496514	hsa-miR-6512-3p	PAR-CLIP	22291592
MIRT496513	hsa-miR-6720-5p	PAR-CLIP	22291592
MIRT1019196	hsa-miR-1286	CLIP-seq
MIRT1019197	hsa-miR-135a	CLIP-seq
MIRT1019198	hsa-miR-135b	CLIP-seq
MIRT1019199	hsa-miR-2115	CLIP-seq
MIRT1019200	hsa-miR-3185	CLIP-seq
MIRT1019201	hsa-miR-3190	CLIP-seq
MIRT1019202	hsa-miR-3194-3p	CLIP-seq
MIRT1019203	hsa-miR-4491	CLIP-seq
MIRT1019204	hsa-miR-4657	CLIP-seq
MIRT1019205	hsa-miR-4709-3p	CLIP-seq
MIRT1019206	hsa-miR-4722-5p	CLIP-seq
MIRT1019207	hsa-miR-4768-3p	CLIP-seq
MIRT1019208	hsa-miR-576-3p	CLIP-seq
MIRT1019209	hsa-miR-595	CLIP-seq
MIRT1019210	hsa-miR-760	CLIP-seq
MIRT2001803	hsa-miR-1185	CLIP-seq
MIRT2001804	hsa-miR-1237	CLIP-seq
MIRT2001805	hsa-miR-1248	CLIP-seq
MIRT1019196	hsa-miR-1286	CLIP-seq
MIRT2001806	hsa-miR-1321	CLIP-seq
MIRT1019197	hsa-miR-135a	CLIP-seq
MIRT1019198	hsa-miR-135b	CLIP-seq
MIRT1019199	hsa-miR-2115	CLIP-seq
MIRT2001807	hsa-miR-3119	CLIP-seq
MIRT2001808	hsa-miR-3125	CLIP-seq
MIRT2001809	hsa-miR-3157-5p	CLIP-seq
MIRT2001810	hsa-miR-3158-3p	CLIP-seq
MIRT2001811	hsa-miR-3162-5p	CLIP-seq
MIRT1019202	hsa-miR-3194-3p	CLIP-seq
MIRT2001812	hsa-miR-3679-5p	CLIP-seq
MIRT2001813	hsa-miR-3916	CLIP-seq
MIRT2001814	hsa-miR-4310	CLIP-seq
MIRT2001815	hsa-miR-4420	CLIP-seq
MIRT2001816	hsa-miR-4677-3p	CLIP-seq
MIRT2001817	hsa-miR-4679	CLIP-seq
MIRT2001818	hsa-miR-4690-3p	CLIP-seq
MIRT2001819	hsa-miR-4699-3p	CLIP-seq
MIRT1019206	hsa-miR-4722-5p	CLIP-seq
MIRT2001820	hsa-miR-4724-5p	CLIP-seq
MIRT2001821	hsa-miR-4739	CLIP-seq
MIRT2001822	hsa-miR-4756-5p	CLIP-seq
MIRT1019207	hsa-miR-4768-3p	CLIP-seq
MIRT2001823	hsa-miR-4769-3p	CLIP-seq
MIRT2001824	hsa-miR-4777-5p	CLIP-seq
MIRT2001825	hsa-miR-4799-5p	CLIP-seq
MIRT2001826	hsa-miR-518d-5p	CLIP-seq
MIRT2001827	hsa-miR-519b-5p	CLIP-seq
MIRT2001828	hsa-miR-519c-5p	CLIP-seq
MIRT2001829	hsa-miR-520c-5p	CLIP-seq
MIRT2001830	hsa-miR-526a	CLIP-seq
MIRT1019209	hsa-miR-595	CLIP-seq
MIRT1019210	hsa-miR-760	CLIP-seq
MIRT2001831	hsa-miR-767-5p	CLIP-seq
MIRT2001832	hsa-miR-877	CLIP-seq
MIRT2001833	hsa-miR-942	CLIP-seq
MIRT2234850	hsa-miR-1200	CLIP-seq
MIRT1019202	hsa-miR-3194-3p	CLIP-seq
MIRT2234851	hsa-miR-339-3p	CLIP-seq
MIRT2234852	hsa-miR-3691-5p	CLIP-seq
MIRT2234853	hsa-miR-4324	CLIP-seq
MIRT2234854	hsa-miR-4711-5p	CLIP-seq
MIRT2234855	hsa-miR-4752	CLIP-seq
MIRT2234856	hsa-miR-544b	CLIP-seq
MIRT1019210	hsa-miR-760	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000727	Process	Double-strand break repair via break-induced replication	IBA
GO:0000811	Component	GINS complex	IBA
GO:0000811	Component	GINS complex	IEA
GO:0000811	Component	GINS complex	IPI	17417653
GO:0005515	Function	Protein binding	IPI	16189514, 17525332, 22540012, 24299456, 25416956, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	22474384
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	17467990
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006260	Process	DNA replication	IDA	22474384
GO:0006260	Process	DNA replication	IEA
GO:0006260	Process	DNA replication	NAS	17467990
GO:0071162	Component	CMG complex	IEA
GO:0071162	Component	CMG complex	IPI	22474384
GO:0071162	Component	CMG complex	ISS

MIM	HGNC	e!Ensembl
610609	24575	ENSG00000131153

Q9Y248

Protein name

DNA replication complex GINS protein PSF2 (GINS complex subunit 2)

Protein function

Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653). GINS complex is a core component of CDC45-MCM-GINS (CM

PDB

2E9X , 2EHO , 2Q9Q , 6XTX , 6XTY , 7PFO , 7PLO , 8B9D , 8OK2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05916	Sld5	42 → 153	GINS complex protein	Family

Sequence

MDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFNPGLPVEVPLWLAINLKQRQKCRL
LPPEWMDVEKLEKMRDHERKEETFTPMPSPYYMELTKLLLNHASDNIPKADEIRTLVKDM
WDTRIAKLRVSADSFVRQQEAHAKLDNLTLMEINTSGTFLTQALNHMYKLRTNLQPLEST
QSQDF

Sequence length

185

Interactions

View interactions

	Reactome
			Unwinding of DNA

GINS2 (GINS complex subunit 2)