Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51659
Gene name Gene Name - the full gene name approved by the HGNC.	GINS complex subunit 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GINS2
Synonyms (NCBI Gene) Gene synonyms aliases	HSPC037, PSF2, Pfs2
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16q24.1
Summary Summary of gene provided in NCBI Entrez Gene.	The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extract

Show/Hide all(124)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016400	hsa-miR-193b-3p	Microarray	20304954
MIRT040250	hsa-miR-615-3p	CLASH	23622248
MIRT677709	hsa-miR-625-3p	HITS-CLIP	23824327
MIRT677708	hsa-miR-22-3p	HITS-CLIP	23824327
MIRT677707	hsa-miR-1295b-3p	HITS-CLIP	23824327
MIRT677706	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT677705	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677704	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677703	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677702	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677701	hsa-miR-1976	HITS-CLIP	23824327
MIRT677700	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677699	hsa-miR-4279	HITS-CLIP	23824327
MIRT668141	hsa-miR-142-3p	HITS-CLIP	23824327
MIRT668140	hsa-miR-548ac	HITS-CLIP	23824327
MIRT668139	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT668138	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT668137	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT668136	hsa-miR-548z	HITS-CLIP	23824327
MIRT668135	hsa-miR-3200-3p	HITS-CLIP	23824327
MIRT668134	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT668133	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT668132	hsa-miR-3591-5p	HITS-CLIP	23824327
MIRT496520	hsa-miR-3929	PAR-CLIP	22291592
MIRT496519	hsa-miR-4419b	PAR-CLIP	22291592
MIRT496518	hsa-miR-4478	PAR-CLIP	22291592
MIRT496517	hsa-miR-6849-3p	PAR-CLIP	22291592
MIRT496516	hsa-miR-3190-5p	PAR-CLIP	22291592
MIRT496515	hsa-miR-198	PAR-CLIP	22291592
MIRT496514	hsa-miR-6512-3p	PAR-CLIP	22291592
MIRT496513	hsa-miR-6720-5p	PAR-CLIP	22291592
MIRT677709	hsa-miR-625-3p	HITS-CLIP	23824327
MIRT677708	hsa-miR-22-3p	HITS-CLIP	23824327
MIRT677707	hsa-miR-1295b-3p	HITS-CLIP	23824327
MIRT677706	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT677705	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677704	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677703	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677702	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677701	hsa-miR-1976	HITS-CLIP	23824327
MIRT677700	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677699	hsa-miR-4279	HITS-CLIP	23824327
MIRT668141	hsa-miR-142-3p	HITS-CLIP	23824327
MIRT668140	hsa-miR-548ac	HITS-CLIP	23824327
MIRT668139	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT668138	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT668137	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT668136	hsa-miR-548z	HITS-CLIP	23824327
MIRT668135	hsa-miR-3200-3p	HITS-CLIP	23824327
MIRT668134	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT668133	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT668132	hsa-miR-3591-5p	HITS-CLIP	23824327
MIRT496520	hsa-miR-3929	PAR-CLIP	22291592
MIRT496519	hsa-miR-4419b	PAR-CLIP	22291592
MIRT496518	hsa-miR-4478	PAR-CLIP	22291592
MIRT496517	hsa-miR-6849-3p	PAR-CLIP	22291592
MIRT496516	hsa-miR-3190-5p	PAR-CLIP	22291592
MIRT496515	hsa-miR-198	PAR-CLIP	22291592
MIRT496514	hsa-miR-6512-3p	PAR-CLIP	22291592
MIRT496513	hsa-miR-6720-5p	PAR-CLIP	22291592
MIRT1019196	hsa-miR-1286	CLIP-seq
MIRT1019197	hsa-miR-135a	CLIP-seq
MIRT1019198	hsa-miR-135b	CLIP-seq
MIRT1019199	hsa-miR-2115	CLIP-seq
MIRT1019200	hsa-miR-3185	CLIP-seq
MIRT1019201	hsa-miR-3190	CLIP-seq
MIRT1019202	hsa-miR-3194-3p	CLIP-seq
MIRT1019203	hsa-miR-4491	CLIP-seq
MIRT1019204	hsa-miR-4657	CLIP-seq
MIRT1019205	hsa-miR-4709-3p	CLIP-seq
MIRT1019206	hsa-miR-4722-5p	CLIP-seq
MIRT1019207	hsa-miR-4768-3p	CLIP-seq
MIRT1019208	hsa-miR-576-3p	CLIP-seq
MIRT1019209	hsa-miR-595	CLIP-seq
MIRT1019210	hsa-miR-760	CLIP-seq
MIRT2001803	hsa-miR-1185	CLIP-seq
MIRT2001804	hsa-miR-1237	CLIP-seq
MIRT2001805	hsa-miR-1248	CLIP-seq
MIRT1019196	hsa-miR-1286	CLIP-seq
MIRT2001806	hsa-miR-1321	CLIP-seq
MIRT1019197	hsa-miR-135a	CLIP-seq
MIRT1019198	hsa-miR-135b	CLIP-seq
MIRT1019199	hsa-miR-2115	CLIP-seq
MIRT2001807	hsa-miR-3119	CLIP-seq
MIRT2001808	hsa-miR-3125	CLIP-seq
MIRT2001809	hsa-miR-3157-5p	CLIP-seq
MIRT2001810	hsa-miR-3158-3p	CLIP-seq
MIRT2001811	hsa-miR-3162-5p	CLIP-seq
MIRT1019202	hsa-miR-3194-3p	CLIP-seq
MIRT2001812	hsa-miR-3679-5p	CLIP-seq
MIRT2001813	hsa-miR-3916	CLIP-seq
MIRT2001814	hsa-miR-4310	CLIP-seq
MIRT2001815	hsa-miR-4420	CLIP-seq
MIRT2001816	hsa-miR-4677-3p	CLIP-seq
MIRT2001817	hsa-miR-4679	CLIP-seq
MIRT2001818	hsa-miR-4690-3p	CLIP-seq
MIRT2001819	hsa-miR-4699-3p	CLIP-seq
MIRT1019206	hsa-miR-4722-5p	CLIP-seq
MIRT2001820	hsa-miR-4724-5p	CLIP-seq
MIRT2001821	hsa-miR-4739	CLIP-seq
MIRT2001822	hsa-miR-4756-5p	CLIP-seq
MIRT1019207	hsa-miR-4768-3p	CLIP-seq
MIRT2001823	hsa-miR-4769-3p	CLIP-seq
MIRT2001824	hsa-miR-4777-5p	CLIP-seq
MIRT2001825	hsa-miR-4799-5p	CLIP-seq
MIRT2001826	hsa-miR-518d-5p	CLIP-seq
MIRT2001827	hsa-miR-519b-5p	CLIP-seq
MIRT2001828	hsa-miR-519c-5p	CLIP-seq
MIRT2001829	hsa-miR-520c-5p	CLIP-seq
MIRT2001830	hsa-miR-526a	CLIP-seq
MIRT1019209	hsa-miR-595	CLIP-seq
MIRT1019210	hsa-miR-760	CLIP-seq
MIRT2001831	hsa-miR-767-5p	CLIP-seq
MIRT2001832	hsa-miR-877	CLIP-seq
MIRT2001833	hsa-miR-942	CLIP-seq
MIRT2234850	hsa-miR-1200	CLIP-seq
MIRT1019202	hsa-miR-3194-3p	CLIP-seq
MIRT2234851	hsa-miR-339-3p	CLIP-seq
MIRT2234852	hsa-miR-3691-5p	CLIP-seq
MIRT2234853	hsa-miR-4324	CLIP-seq
MIRT2234854	hsa-miR-4711-5p	CLIP-seq
MIRT2234855	hsa-miR-4752	CLIP-seq
MIRT2234856	hsa-miR-544b	CLIP-seq
MIRT1019210	hsa-miR-760	CLIP-seq

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000727	Process	Double-strand break repair via break-induced replication	IBA
GO:0000811	Component	GINS complex	IBA
GO:0000811	Component	GINS complex	IEA
GO:0000811	Component	GINS complex	IPI	17417653
GO:0005515	Function	Protein binding	IPI	16189514, 17525332, 22540012, 24299456, 25416956, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	22474384
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	17467990
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006260	Process	DNA replication	IDA	22474384
GO:0006260	Process	DNA replication	IEA
GO:0006260	Process	DNA replication	NAS	17467990
GO:0071162	Component	CMG complex	IEA
GO:0071162	Component	CMG complex	IPI	22474384
GO:0071162	Component	CMG complex	ISS

MIM	HGNC	e!Ensembl
610609	24575	ENSG00000131153

Protein

UniProt ID

Q9Y248

Protein name

DNA replication complex GINS protein PSF2 (GINS complex subunit 2)

Protein function

Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653). GINS complex is a core component of CDC45-MCM-GINS (CM

PDB

2E9X , 2EHO , 2Q9Q , 6XTX , 6XTY , 7PFO , 7PLO , 8B9D , 8OK2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05916	Sld5	42 → 153	GINS complex protein	Family

Sequence

MDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFNPGLPVEVPLWLAINLKQRQKCRL
LPPEWMDVEKLEKMRDHERKEETFTPMPSPYYMELTKLLLNHASDNIPKADEIRTLVKDM
WDTRIAKLRVSADSFVRQQEAHAKLDNLTLMEINTSGTFLTQALNHMYKLRTNLQPLEST
QSQDF

Sequence length

185

Interactions

View interactions

	Reactome
			Unwinding of DNA

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS

Show/Hide Text Mining Associations (32)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	24377518
Breast Neoplasms	Associate	21082043, 24273454, 34629365, 36466552
Breast Neoplasms	Stimulate	33725952
Carcinoma Hepatocellular	Associate	24273454
Carcinoma Non Small Cell Lung	Stimulate	32181475
Carcinoma Squamous Cell	Associate	28405687, 36466552
Celiac Disease	Associate	1570316
Colorectal Neoplasms	Associate	35137928, 35496037, 37945594
Craniosynostoses	Associate	34353863
Diabetes Mellitus Type 1	Associate	1570316
Epilepsy Tonic Clonic	Associate	1570316
Glioblastoma	Associate	36466552
Glioma	Associate	36466552
Intervertebral Disc Degeneration	Inhibit	36092790
Leukemia	Associate	24273454
Leukemia Promyelocytic Acute	Associate	24273454
Lymphatic Metastasis	Associate	28405687
Meier Gorlin syndrome	Associate	34353863
Melanoma	Associate	24273454
Neoplasms	Associate	19377277, 21082043, 34629365, 35137928, 36359853, 36466552
Neoplasms	Stimulate	28405687, 35896011
Ovarian Neoplasms	Associate	31703725, 34288816, 35137928
Pancreatic Neoplasms	Associate	35137928
Precancerous Conditions	Associate	36466552
Prostatic Neoplasms	Associate	31810132
Rapadilino syndrome	Associate	34353863
Sarcoma	Stimulate	35896011
Spondylitis Ankylosing	Associate	1570316
Stomach Neoplasms	Associate	34629365, 35137928
Testicular Germ Cell Tumor	Associate	36466552
Thyroid Neoplasms	Associate	33537829, 37745716
Uterine Cervical Neoplasms	Associate	28405687, 33302814

GINS2 (GINS complex subunit 2)