Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Pathways Associated diseases
Entrez ID	51652
Gene name	Charged multivesicular body protein 3
Gene symbol	CHMP3
Synonyms (NCBI Gene)	CGI-149NEDFVPS24
Chromosome	2
Chromosome location	2p11.2
Summary	This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds

Show/Hide all (97)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029170	hsa-miR-26b-5p	Microarray	19088304
MIRT032269	hsa-let-7b-5p	Proteomics	18668040
MIRT045931	hsa-miR-125b-5p	CLASH	23622248
MIRT714913	hsa-miR-141-5p	HITS-CLIP	19536157
MIRT714912	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT714911	hsa-miR-4421	HITS-CLIP	19536157
MIRT714910	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT714909	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT714908	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT714907	hsa-miR-3182	HITS-CLIP	19536157
MIRT714906	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT714905	hsa-miR-1225-3p	HITS-CLIP	19536157
MIRT714904	hsa-miR-1233-3p	HITS-CLIP	19536157
MIRT714903	hsa-miR-6740-3p	HITS-CLIP	19536157
MIRT714902	hsa-miR-4303	HITS-CLIP	19536157
MIRT714901	hsa-miR-7152-5p	HITS-CLIP	19536157
MIRT714900	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT714899	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT573175	hsa-miR-3662	PAR-CLIP	20371350
MIRT573174	hsa-miR-3646	PAR-CLIP	20371350
MIRT573173	hsa-miR-888-5p	PAR-CLIP	20371350
MIRT573172	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT573171	hsa-miR-371b-5p	PAR-CLIP	20371350
MIRT573170	hsa-miR-373-5p	PAR-CLIP	20371350
MIRT573169	hsa-miR-616-5p	PAR-CLIP	20371350
MIRT573168	hsa-miR-7850-5p	PAR-CLIP	20371350
MIRT573167	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT538537	hsa-miR-34c-3p	PAR-CLIP	21572407
MIRT538536	hsa-miR-3617-3p	PAR-CLIP	21572407
MIRT538534	hsa-miR-3065-3p	PAR-CLIP	21572407
MIRT538533	hsa-miR-383-3p	PAR-CLIP	21572407
MIRT538532	hsa-miR-9-5p	PAR-CLIP	21572407
MIRT538531	hsa-miR-5587-5p	PAR-CLIP	21572407
MIRT538529	hsa-miR-133a-3p	PAR-CLIP	21572407
MIRT538528	hsa-miR-133b	PAR-CLIP	21572407
MIRT538537	hsa-miR-34c-3p	PAR-CLIP	22012620
MIRT538536	hsa-miR-3617-3p	PAR-CLIP	22012620
MIRT538535	hsa-miR-6760-3p	PAR-CLIP	22012620
MIRT538534	hsa-miR-3065-3p	PAR-CLIP	22012620
MIRT538533	hsa-miR-383-3p	PAR-CLIP	22012620
MIRT538532	hsa-miR-9-5p	PAR-CLIP	22012620
MIRT538531	hsa-miR-5587-5p	PAR-CLIP	22012620
MIRT538530	hsa-miR-3912-5p	PAR-CLIP	22012620
MIRT538529	hsa-miR-133a-3p	PAR-CLIP	22012620
MIRT538528	hsa-miR-133b	PAR-CLIP	22012620
MIRT496489	hsa-miR-500b-3p	PAR-CLIP	22291592
MIRT496488	hsa-miR-8064	PAR-CLIP	22291592
MIRT440946	hsa-miR-432-5p	HITS-CLIP	24374217
MIRT440946	hsa-miR-432-5p	HITS-CLIP	24374217
MIRT726132	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726131	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726129	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726130	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT714913	hsa-miR-141-5p	HITS-CLIP	19536157
MIRT714912	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT714911	hsa-miR-4421	HITS-CLIP	19536157
MIRT714910	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT714909	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT714908	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT714907	hsa-miR-3182	HITS-CLIP	19536157
MIRT714906	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT714905	hsa-miR-1225-3p	HITS-CLIP	19536157
MIRT714904	hsa-miR-1233-3p	HITS-CLIP	19536157
MIRT714903	hsa-miR-6740-3p	HITS-CLIP	19536157
MIRT714902	hsa-miR-4303	HITS-CLIP	19536157
MIRT714901	hsa-miR-7152-5p	HITS-CLIP	19536157
MIRT714900	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT714899	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT573175	hsa-miR-3662	PAR-CLIP	20371350
MIRT573174	hsa-miR-3646	PAR-CLIP	20371350
MIRT573173	hsa-miR-888-5p	PAR-CLIP	20371350
MIRT573172	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT573171	hsa-miR-371b-5p	PAR-CLIP	20371350
MIRT573170	hsa-miR-373-5p	PAR-CLIP	20371350
MIRT573169	hsa-miR-616-5p	PAR-CLIP	20371350
MIRT573168	hsa-miR-7850-5p	PAR-CLIP	20371350
MIRT573167	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT538537	hsa-miR-34c-3p	PAR-CLIP	21572407
MIRT538536	hsa-miR-3617-3p	PAR-CLIP	21572407
MIRT538534	hsa-miR-3065-3p	PAR-CLIP	21572407
MIRT538533	hsa-miR-383-3p	PAR-CLIP	21572407
MIRT538532	hsa-miR-9-5p	PAR-CLIP	21572407
MIRT538531	hsa-miR-5587-5p	PAR-CLIP	21572407
MIRT538529	hsa-miR-133a-3p	PAR-CLIP	21572407
MIRT538528	hsa-miR-133b	PAR-CLIP	21572407
MIRT538537	hsa-miR-34c-3p	PAR-CLIP	22012620
MIRT538536	hsa-miR-3617-3p	PAR-CLIP	22012620
MIRT538535	hsa-miR-6760-3p	PAR-CLIP	22012620
MIRT538534	hsa-miR-3065-3p	PAR-CLIP	22012620
MIRT538533	hsa-miR-383-3p	PAR-CLIP	22012620
MIRT538532	hsa-miR-9-5p	PAR-CLIP	22012620
MIRT538531	hsa-miR-5587-5p	PAR-CLIP	22012620
MIRT538530	hsa-miR-3912-5p	PAR-CLIP	22012620
MIRT538529	hsa-miR-133a-3p	PAR-CLIP	22012620
MIRT538528	hsa-miR-133b	PAR-CLIP	22012620
MIRT496489	hsa-miR-500b-3p	PAR-CLIP	22291592
MIRT496488	hsa-miR-8064	PAR-CLIP	22291592

Show/Hide all (91)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000421	Component	Autophagosome membrane	IDA	17984323
GO:0000776	Component	Kinetochore	IDA	26040712
GO:0000776	Component	Kinetochore	IEA
GO:0000815	Component	ESCRT III complex	IBA
GO:0000815	Component	ESCRT III complex	IDA	18687924, 24878737
GO:0000815	Component	ESCRT III complex	NAS	36107470
GO:0000815	Component	ESCRT III complex	TAS	20588296, 21118109
GO:0001778	Process	Plasma membrane repair	IDA	24482116
GO:0001778	Process	Plasma membrane repair	IEA
GO:0005515	Function	Protein binding	IPI	14505570, 14519844, 16730941, 17146056, 17711858, 18385515, 18687924, 19525971, 19615732, 21543490, 21827950, 23051622, 23105106, 25416956, 26496610, 28514442, 29997244, 31515488, 32296183, 33961781
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IEA
GO:0005643	Component	Nuclear pore	IDA	26040713
GO:0005643	Component	Nuclear pore	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005765	Component	Lysosomal membrane	IDA	17984323
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005770	Component	Late endosome	IDA	16554368
GO:0005770	Component	Late endosome	IEA
GO:0005771	Component	Multivesicular body	IBA
GO:0005828	Component	Kinetochore microtubule	IDA	26040712
GO:0005828	Component	Kinetochore microtubule	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	16740483, 24878737
GO:0006914	Process	Autophagy	IMP	17984323
GO:0006915	Process	Apoptotic process	IEA
GO:0006997	Process	Nucleus organization	IMP	20616062
GO:0006997	Process	Nucleus organization	IMP	20616062
GO:0007034	Process	Vacuolar transport	IEA
GO:0007080	Process	Mitotic metaphase chromosome alignment	IMP	20616062
GO:0007080	Process	Mitotic metaphase chromosome alignment	IMP	20616062
GO:0008333	Process	Endosome to lysosome transport	IEA
GO:0010824	Process	Regulation of centrosome duplication	IMP	20616062
GO:0015031	Process	Protein transport	IBA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016236	Process	Macroautophagy	TAS	20588296
GO:0019076	Process	Viral release from host cell	IGI	23051622
GO:0019076	Process	Viral release from host cell	IMP	23051622
GO:0030496	Component	Midbody	IDA	26040712
GO:0030496	Component	Midbody	IEA
GO:0031210	Function	Phosphatidylcholine binding	IMP	18687924
GO:0031410	Component	Cytoplasmic vesicle	IDA	16740483
GO:0031468	Process	Nuclear membrane reassembly	IMP	26040713
GO:0031902	Component	Late endosome membrane	IEA
GO:0032467	Process	Positive regulation of cytokinesis	IEA
GO:0032509	Process	Endosome transport via multivesicular body sorting pathway	IBA
GO:0032585	Component	Multivesicular body membrane	IDA	16554368
GO:0032585	Component	Multivesicular body membrane	IEA
GO:0036258	Process	Multivesicular body assembly	NAS	16505166
GO:0036258	Process	Multivesicular body assembly	TAS	20588296
GO:0039702	Process	Viral budding via host ESCRT complex	IDA	24878737
GO:0039702	Process	Viral budding via host ESCRT complex	IEA
GO:0039702	Process	Viral budding via host ESCRT complex	IMP	16740483, 23051622
GO:0039702	Process	Viral budding via host ESCRT complex	TAS	20588296
GO:0042802	Function	Identical protein binding	IPI	17146056
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IDA	17984323
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IEA
GO:0044790	Process	Suppression of viral release by host	IMP	16740483
GO:0045324	Process	Late endosome to vacuole transport	IBA
GO:0046761	Process	Viral budding from plasma membrane	IDA	24878737
GO:0046761	Process	Viral budding from plasma membrane	IEA
GO:0046761	Process	Viral budding from plasma membrane	IMP	14505570
GO:0051036	Process	Regulation of endosome size	IEA
GO:0051258	Process	Protein polymerization	IDA	23051622
GO:0051301	Process	Cell division	IEA
GO:0051469	Process	Vesicle fusion with vacuole	NAS	16505166
GO:0061763	Process	Multivesicular body-lysosome fusion	IMP	16554368
GO:0061763	Process	Multivesicular body-lysosome fusion	NAS	16505166
GO:0061952	Process	Midbody abscission	IEA
GO:0061952	Process	Midbody abscission	IMP	20616062
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0071985	Process	Multivesicular body sorting pathway	IDA	16554368
GO:0071985	Process	Multivesicular body sorting pathway	IEA
GO:0071985	Process	Multivesicular body sorting pathway	TAS	21118109
GO:0090148	Process	Membrane fission	NAS	19234443
GO:0097352	Process	Autophagosome maturation	IEA
GO:0097352	Process	Autophagosome maturation	IMP	17984323
GO:0097352	Process	Autophagosome maturation	TAS	21118109
GO:0140678	Function	Molecular function inhibitor activity	EXP	21827950
GO:1901673	Process	Regulation of mitotic spindle assembly	IMP	20616062
GO:1901673	Process	Regulation of mitotic spindle assembly	IMP	20616062
GO:1902774	Process	Late endosome to lysosome transport	IEA
GO:1902774	Process	Late endosome to lysosome transport	IMP	17984323
GO:1903541	Process	Regulation of exosomal secretion	IMP	22660413
GO:1904930	Component	Amphisome membrane	IDA	17984323
GO:1904930	Component	Amphisome membrane	IEA
GO:1990381	Function	Ubiquitin-specific protease binding	IPI	18395747
GO:2000641	Process	Regulation of early endosome to late endosome transport	IMP	16554368

MIM	HGNC	e!Ensembl
610052	29865	ENSG00000115561

Interactions View interactions

	KEGG		Reactome
	Endocytosis Necroptosis		Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
HEART FAILURE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Rheumatoid	Associate	37008939	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Associate	37967346	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Associate	35768804	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Associate	37358014	★★★★★ ★☆☆☆☆ Found in Text Mining only

CHMP3 (charged multivesicular body protein 3)